Abstract:
INTRODUCTION:Chronic pulmonary aspergillosis (CPA) is a chronic lung infection caused by Aspergillus fumigatus, that complicates structural lung diseases. Of the different types of CPA, chronic cavitary pulmonary aspergillosis (CCPA) is the most common form. The mainstay of treatment of CCPA is oral triazoles. However, many gaps exist in clinical decision-making about the agent of choice, the duration, and the assessment of treatment response. AREAS COVERED:We discuss the approach to diagnosis and treatment of CCPA. We have searched the PubMed and EmBase databases (from inception till 31 October 2019) to identify studies describing the use of anti-fungal agents in CCPA. EXPERT OPINION:Treatment for CCPA should be initiated with oral itraconazole for at least six months. In case of poor response or intolerance to itraconazole, voriconazole should be considered. Intravenous agents, including amphotericin B and echinocandins, may be used in those with either treatment failure or those who are intolerant to oral antifungal agents. Posaconazole and isavuconazole may be used as salvage therapy due to a better pharmacokinetic/pharmacodynamic profile of the former and reduced drug-drug interactions with the latter.
journal_name
Expert Rev Respir Medjournal_title
Expert review of respiratory medicineauthors
Sehgal IS,Dhooria S,Muthu V,Prasad KT,Agarwal Rdoi
10.1080/17476348.2020.1750956subject
Has Abstractpub_date
2020-07-01 00:00:00pages
715-727issue
7eissn
1747-6348issn
1747-6356journal_volume
14pub_type
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journal_title:Expert review of respiratory medicine
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journal_title:Expert review of respiratory medicine
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journal_title:Expert review of respiratory medicine
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journal_title:Expert review of respiratory medicine
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pub_type: 杂志文章,评审
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journal_title:Expert review of respiratory medicine
pub_type: 杂志文章,评审
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journal_title:Expert review of respiratory medicine
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journal_title:Expert review of respiratory medicine
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:Expert review of respiratory medicine
pub_type: 杂志文章,评审
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更新日期:2016-01-01 00:00:00
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journal_title:Expert review of respiratory medicine
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journal_title:Expert review of respiratory medicine
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journal_title:Expert review of respiratory medicine
pub_type: 杂志文章
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