Abstract:
BACKGROUND:The adequate control of phosphataemia is of major importance in end-stage renal disease patients on maintenance dialysis. Recently, lanthanum carbonate (LC) has been added to the phosphate binder armamentarium. To our knowledge, no studies have yet evaluated the usefulness of this drug in uncontrolled hyperphosphataemic patients. METHODS:This was a 6-month prospective observational study. Patients on chronic hemodialysis who had previously failed to achieve serum phosphate control were enrolled. Thirty-four patients (i.e. 11% out of 305 from three dialysis units) met the inclusion criteria. Lanthanum carbonate was introduced and titrated to achieve serum phosphate control, according to the KDOQI guidelines. Clinical targets, gastrointestinal symptoms, and patients' satisfaction with therapy were assessed at baseline and after 6 months. RESULTS:Eight patients (23.5%) were withdrawn from the study due to side effects. In the remaining patients, serum phosphate level significantly decreased from 5.8 to 4.4 mg/dl and calcium-phosphate product also decreased significantly from 55.6 to 41.8 mg(2)/dl(2). The average number of all phosphate binder tablets taken per day was reduced from 6.7 to 4.7. Evaluation scores of dyspeptic symptoms and of patient's satisfaction with therapy also improved: from 7.5 to 5.3 and from 6.6 to 8.1, respectively. CONCLUSIONS:The introduction of LC improved serum phosphate control in over 70% of these "difficult patients". A lower pill burden was also obtained, which might help to simplify treatment and increase patients' compliance. Dyspeptic symptoms and overall satisfaction with treatment also improved.
journal_name
Int Urol Nephroljournal_title
International urology and nephrologyauthors
Almirall J,Betancourt L,Esteve V,Valenzuela MP,López T,Ruiz A,Martínez-Ocaña JC,Calvet Xdoi
10.1007/s11255-010-9860-2subject
Has Abstractpub_date
2012-02-01 00:00:00pages
231-6issue
1eissn
0301-1623issn
1573-2584journal_volume
44pub_type
杂志文章abstract:PURPOSE AND METHODS:The accurate estimation of volume status is a central problem in dialysis patients. Recently, a bioimpedance spectroscopy (BIS) device (BCM Body Composition Monitor FMC, Germany) has attained growing interest in this regard. By processing the raw data for extracellular water (ECW) and intracellular ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-012-0216-y
更新日期:2013-02-01 00:00:00
abstract:OBJECTIVES:According to current guidelines, radical cystectomy (RC) should be combined with an extended pelvic lymphadenectomy (PLND) as therapeutic and staging instrument. Objective of this study was to analyze the influence of PLND on survival rates and complication rates in a selected group of elderly patients with ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-017-1699-3
更新日期:2017-12-01 00:00:00
abstract:PURPOSE:To compare the economic burden and cost-utility analysis of the renal replacement therapies, including hemodialysis (HD), peritoneal dialysis (PD), and allograft kidney transplantation (KT) among end-stage renal disease (ESRD) patients from Yunnan Province, China. METHODS:Multistage stratified random sampling ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-020-02394-1
更新日期:2020-03-01 00:00:00
abstract::Sickle cell nephropathy is a major complication of sickle cell disease. It manifests in different forms, including glomerulopathy, proteinuria, hematuria, and tubular defects, and frequently results in end-stage renal disease (ESRD). Different pathophysiologic mechanisms have been proposed to explain the development o...
journal_title:International urology and nephrology
pub_type: 杂志文章,评审
doi:10.1007/s11255-018-1803-3
更新日期:2018-06-01 00:00:00
abstract:PURPOSE:Obstructive pyelonephritis is a common urologic emergency that requires prompt decompression of the collecting system. The COVID-19 pandemic has changed patient flow and healthcare strategies at numerous emergency departments across Brazil with still unknown consequences for the population. This study sought to...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-020-02708-3
更新日期:2020-11-21 00:00:00
abstract:INTRODUCTION:Erectile dysfunction (ED) is one of the most encountered male health problem and sildenafil citrate is used worldwide for treatment of ED. Aim of the present study was to determine and evaluate hemodynamic effects of sildenafil citrate on segmental branches of bilateral renal arteries of cases with ED. PA...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-005-3621-7
更新日期:2005-01-01 00:00:00
abstract::A 40-year-old man was referred to our hospital with gynecomastia and painless swelling of the right scrotum. Ultrasonography revealed a 15 x 10 mm mass with low echogenicity of the right testis. We performed right high orchiectomy. Histologically, Reinke's crystals and capsular invasion by tumor cells were found. Fina...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-006-6661-8
更新日期:2006-01-01 00:00:00
abstract:INTRODUCTION:Impaired kidney function is common in kidney-transplanted patients and complications of chronic kidney disease (CKD), such as mineral and bone disorders (MBD) are also prevalent in this population. Similarly to other stages of CKD, increasing evidence supports the association between MBD and cardiovascular...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-009-9631-0
更新日期:2009-12-01 00:00:00
abstract:OBJECTIVE:To analyze the effect of age on nutrition indices in subjects on the same continuous ambulatory peritoneal dialysis (CAPD) schedule. METHODS:We analyzed 613 sets of clearance values and nutrition indices in 302 CAPD patients. Small solute clearances included urea clearance (Kt/Vurea) and creatinine clearance...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/a:1017579105158
更新日期:2001-01-01 00:00:00
abstract:PURPOSE:Metabolic syndrome (MetS) is increasing worldwide with the continuous increase in obesity prevalence. Chronic kidney disease (CKD) is also a major public health problem, but there is controversy over whether baseline MetS is a predictor of decreased renal function among Japanese community-dwelling middle-aged a...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-019-02320-0
更新日期:2019-12-01 00:00:00
abstract:PURPOSE:Androgen replacement therapy is a widely accepted form of treatment worldwide for aging men with late-onset hypogonadism (LOH) syndrome. Urologists have been concerned with the use of androgen supplements due to the possibility of enhancing prostate growth. We performed a systematic review and meta-analysis to ...
journal_title:International urology and nephrology
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s11255-013-0477-0
更新日期:2013-08-01 00:00:00
abstract:BACKGROUND:Uremic pruritus (UP) is a highly prevalent and disturbing problem in patients with advanced chronic kidney disease (CKD); however, treatment of UP is largely unsatisfactory. The present study was designed to investigate the effectiveness of mirtazapine, an atypical antidepressant agent with potent antagonist...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-020-02473-3
更新日期:2020-06-01 00:00:00
abstract::Sirolimus is an immunosupressor of the mammalian target of rapamycin inhibitors (mTOR-I) group. Recent studies have emphasized a potential impact of sirolimus on male gonadal function. We report our clinical experience with sirolimus-induced gonadal dysfunction and infertility in both male and female kidney transplant...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-009-9644-8
更新日期:2010-06-01 00:00:00
abstract::Cyproterone acetate was given as monotherapy to 18 patients with advanced prostatic carcinoma at a weekly dose of 300 mg. Progression was observed in all of the patients; median time to progression was 35 months and median survival time was 48 months. Partial response, stabilization, progression and exitus rates by ye...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02551344
更新日期:1997-01-01 00:00:00
abstract::Authors report on a case of Pseudomonas prostatitis complicated with a prostatoperineal fistula in continuity with the urethra that has been successfully treated with human fibrin sealant (Tissucol). ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02564742
更新日期:1995-01-01 00:00:00
abstract:OBJECTIVES:To introduce a novel surgical technique for the reconstruction of distal urethral strictures using buccal mucosal graft (BMG) through a transurethral approach. METHODS:A retrospective institution chart review was conducted of all the patients who underwent a transurethral ventral BMG inlay urethroplasty fro...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-016-1381-1
更新日期:2016-11-01 00:00:00
abstract::Register and Multicenter Study for Testicular Tumours Bonn was founded in September 1976. Until August 1981, from 46 institutions participating in Austria and the Federal Republic of Germany the data from a total of 1508 patients with testicular tumours have been collected and evaluated. This paper gives an overview o...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02082779
更新日期:1984-01-01 00:00:00
abstract:PURPOSE:To compare the therapeutic effects and adverse events (AE) of current first-line treatments of advanced RCC, including sorafenib, sunitinib, temsirolimus, and the combination of bevacizumab and IFN-α. METHODS:We performed a meta-analysis of randomized controlled trials of the effectiveness of the five treatmen...
journal_title:International urology and nephrology
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s11255-015-0932-1
更新日期:2015-04-01 00:00:00
abstract:PURPOSE:To suggest a different method for diagnosing vesicoureteral reflux (VUR) in lieu of voiding cystourethrography (VCU), in order to prevent radiation exposure. MATERIALS AND METHODS:Fifty-two ureterorenal units of 26 patients were evaluated ultrasonographically for visualizing the renal collecting systems, both ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02550307
更新日期:1998-01-01 00:00:00
abstract::Tubular reabsorption of magnesium ( TRMg ) was calculated from the values of plasma ultrafiltrable Mg and urinary Mg in 36 patients with transplanted kidneys. The study revealed a defect in TRMg in all investigated patients. The lowest TRMg values were found in patients with poor function of the transplanted kidneys. ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02082706
更新日期:1984-01-01 00:00:00
abstract:PURPOSE:Cognitive dysfunction (CO/DY) in chronic kidney disease (CKD) patients has long been recognized. Hypertension is also associated with CO/DY. The study describes associated factors with CO/DY in CKD patients compared to hypertensive subjects. METHODS:Ninety-six hypertensive subjects without CKD, 19 patients wit...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-013-0450-y
更新日期:2013-12-01 00:00:00
abstract:OBJECTIVE:The current study was carried out to assess the effects of omega-3 fatty acid and alpha-tocopherol co-supplementation on malnutrition-inflammation score (MIS), biomarkers of inflammation and oxidative stress in chronic hemodialysis (HD) patients. METHODS:In a randomized double-blind placebo-controlled clinic...
journal_title:International urology and nephrology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s11255-016-1399-4
更新日期:2016-11-01 00:00:00
abstract:PURPOSE:We have recently reported lipopolysaccharide (LPS) pretreatment attenuated renal ischemia/reperfusion injury (IRI), but the exact mechanism remains to be well elucidated. It was reported that heat shock protein (Hsp) 27 was up-regulated after administration of LPS, but whether a direct link existed between Hsp2...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-017-1735-3
更新日期:2018-03-01 00:00:00
abstract:INTRODUCTION:We investigated the effect of ginkgo biloba on testicular ischemia-reperfusion (IR) injury. MATERIALS AND METHODS:Thirty-two Wistar Albino rats were randomly assigned into four groups. Torsion/detorsion (T/D) performed to the rats in group 1, group 2 received ginkgo biloba (50 mg/day) for a month before T...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-007-9296-5
更新日期:2008-01-01 00:00:00
abstract::Peripheral PRA was examined in 11 patients with graft artery stenosis after the onset and throughout the course of hypertension. In the acute stage PRA was elevated in 9 patients and decreased to normal in the later stage of hypertension in all but 1 patient with malignant hypertension. The findings suggest that the d...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02082428
更新日期:1981-01-01 00:00:00
abstract::Relying on their own observations, the authors describe nine patients in whom Fraley's syndrome was diagnosed and treated operatively. In six of them, calycopyeloneostomy was performed. In three of the patients, because of complications, the upper pole of the kidney was excised together with the changed calyx. In nonc...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02082129
更新日期:1978-01-01 00:00:00
abstract::The concentrations of prostaglandin E2 (PGE2), sodium, potassium and creatinine were determined in the blood and urine of 50 renal transplant recipients treated with cyclosporine A or azathioprine, as immunosuppressive agents, for at least one year post transplantation. Fourteen healthy subjects served as control grou...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02550640
更新日期:1992-01-01 00:00:00
abstract:PURPOSE:To evaluate the role of microvessel density (MVD) in predicting lymph node (LN) metastasis in penile squamous cell carcinoma (PSCC). MATERIALS AND METHODS:Records of 266 patients with PSCC were analyzed. Parameters examined were tumor stage, grade, nodal status, intratumoral and peritumoral MVD. Univariate and...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-017-1565-3
更新日期:2017-06-01 00:00:00
abstract:PURPOSE:Tolvaptan exerts an aquaretic effect by blocking vasopressin V2 receptor. Although tolvaptan ameliorates body fluid retention even in patients with chronic kidney disease (CKD), predictors of body fluid reduction induced by tolvaptan remain unclear. We, therefore, examined the clinical parameters associated wit...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-019-02180-8
更新日期:2019-09-01 00:00:00
abstract:AIM:Chronic prostatitis (CP) and chronic pelvic pain syndrome (CPPS) is a common disabling condition that is primarily associated with pain in the urogenital region and disturbances in urinary and sexual function. Chronic pelvic pain symptoms are the most common presentation, especially perineal, lower abdominal, testi...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-010-9809-5
更新日期:2011-06-01 00:00:00