Abstract:
:To assess the non-LDL-C-related dyslipidaemia risk of MI, 823 men aged 23 to 65 with a first MI were compared with 823 MI-free PROCAM controls matched for sex, age, smoking, DM, BP and LDL-C. Overall, the odds of MI in men with HDL-C < 1.15 mmol/L were 2.6 times those of men with HDL-C >or= 1.15 mmol/L, and the odds of MI in men with triglycerides >or= 1.71 mmol/L were 1.4 times those of men with lower triglycerides. If LDL-C was < 2.58 mmol/L, relative MI odds attributed to HDL-C < 1.15 mmol/L increased to 3.4, while relative odds attributed to triglycerides >or= 1.71 mmol/L increased to 2.6; men in this LDL category with HDL-C < 1.15 mmol/L and/or triglycerides >or= 1.71 mmol/L displayed an MI odds ratio of 5.0. MI risk associated with low HDL-C and/or high triglycerides is substantial, particularly if LDL-C is low.
journal_name
Diab Vasc Dis Resjournal_title
Diabetes & vascular disease researchauthors
Assmann G,Cullen P,Schulte Hdoi
10.1177/1479164110372640subject
Has Abstractpub_date
2010-07-01 00:00:00pages
204-12issue
3eissn
1479-1641issn
1752-8984pii
1479164110372640journal_volume
7pub_type
杂志文章abstract:OBJECTIVE:We conducted a prospective pilot study in patients with diabetes to analyse the interobserver reliability of the ankle-brachial index, toe-brachial index and distal pulse palpation depending on the training of the professional involved. MATERIALS AND METHODS:The ankle-brachial index, toe-brachial index and d...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164118767599
更新日期:2018-07-01 00:00:00
abstract::Peripheral artery disease is a severe complication of diabetes. We have reported that the deletion of angiotensin type 2 receptor in diabetic mice promoted vascular angiogenesis in the ischaemic muscle 4 weeks following ischaemia. However, the angiotensin type 2 receptor deletion beneficial effects occurred 2 weeks po...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164119883978
更新日期:2020-01-01 00:00:00
abstract:PURPOSE:To examine the relationship between leisure-time physical activity (LTPA) and the metabolic syndrome in the U.S. adult population. METHODS:The sample (N=5,620) in this cross-sectional study included adults aged 20 years and older. Physical activity was measured in two ways: a six-level measure based upon those...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164109336040
更新日期:2009-04-01 00:00:00
abstract::The aim of this study was to test the hypothesis that cardiovascular disease occurs to the greatest extent in persons with prediabetes mellitus who are also insulin resistant. In 2003, 664 non-diabetic women (n = 457) and men (n = 207), aged 52 ± 16 and 53 ± 15 years, were surveyed during a programme for cardiovascula...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164115610057
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:C-type lectin receptors, including Dectin-2, are pattern recognition receptors on monocytes and macrophages that mainly recognize sugars and sugar-like structures present on fungi. Activation of C-type lectin receptors induces downstream CARD9 signalling, leading to the production of cytokines. We hypothesiz...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164119892140
更新日期:2020-01-01 00:00:00
abstract::Chronic diseases account for approximately 45% of all deaths in developed countries and are particularly prevalent in countries with the most sophisticated and robust public health systems. Chronic metabolic diseases, specifically lifestyle-related diseases pertaining to diet and exercise, continue to be difficult to ...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,评审
doi:10.1177/1479164117738442
更新日期:2018-01-01 00:00:00
abstract::A cross-sectional analysis of ethnic differences in dietary intake, insulin sensitivity and beta-cell function, using the intravenous glucose tolerance test (IVGTT), was conducted on 497 healthy adult participants of the 'Reading, Imperial, Surrey, Cambridge, and Kings' (RISCK) study. Insulin sensitivity (Si) was sign...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164112467545
更新日期:2013-07-01 00:00:00
abstract::Cardiovascular disease is the most common complication of type 2 diabetes mellitus (type 2 DM), accounting for approximately 80% of deaths. While atherosclerotic vascular disease accounts for much of the cardiovascular morbidity and mortality among diabetic patients, congestive heart failure (CHF) is another key compl...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,评审
doi:10.3132/dvdr.2005.010
更新日期:2005-05-01 00:00:00
abstract::While few dispute the existence of the metabolic syndrome as a clustering of factors indicative of poor metabolic health, its utility above that of its individual components in the clinical care of individual patients is questioned. This is likely a consequence of the failure of clinicians and scientists to agree on a...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,评审
doi:10.1177/1479164119827611
更新日期:2019-03-01 00:00:00
abstract:OBJECTIVES:Assess the effect of risk factors changes on risk for cardiovascular disease and mortality in patients with type 2 diabetes selected from the Swedish National Diabetes Register. METHODS:Observational study of 13,477 females and males aged 30-75 years, with baseline HbA1c 41-67 mmol/mol, systolic blood press...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164116637311
更新日期:2016-07-01 00:00:00
abstract::Antidiabetic thiazolidinediones (TZDs) improve endothelial function in patients with or without type 2 diabetes. The present randomised, placebo-controlled, double-blind study examined the time course of a single dose of rosiglitazone on flow-mediated endothelium-dependent vasodilation (FMD), metabolic parameters, and...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,随机对照试验
doi:10.1177/1479164110367812
更新日期:2010-07-01 00:00:00
abstract::The global prevalence of diabetes mellitus (DM) continues to climb, and is accompanied by an increase in DM associated complications, most often manifesting as coronary heart disease. Platelet dysfunction has been implicated as a central contributor to the increased risk of coronary artery disease in patients with DM,...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,评审
doi:10.1177/1479164111420890
更新日期:2011-10-01 00:00:00
abstract::More than 1 in 10 US adolescents have prediabetes or diabetes, and elevated glycosylated haemoglobin (HbA1C) in youth is associated with increased risk of death before the age of 55 years. We conducted a prospective, cross-sectional study of 31,546 consecutive volunteer blood donors, 16-19 years of age, who donated bl...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164115579799
更新日期:2015-07-01 00:00:00
abstract::Insulin resistance has a broad pathogenic impact affecting metabolic, cardio-renal and other disease areas. Extensive studies to dissect the mechanisms of insulin resistance have provided valuable insights to shape current clinical awareness and advance therapeutic practice. However, the development of direct interven...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,评审
doi:10.1177/1479164119827570
更新日期:2019-03-01 00:00:00
abstract::Glucose-lowering treatment options for type 2 diabetes mellitus patients with chronic kidney disease are limited. We evaluated the potential for linagliptin in combination with insulin in type 2 diabetes mellitus patients with mild-to-severe renal impairment. Data for participants in two phase 3 trials with linaglipti...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,随机对照试验
doi:10.1177/1479164115579001
更新日期:2015-07-01 00:00:00
abstract:OBJECTIVE:Reduced renal function and albuminuria predict cardiovascular (CV) events and mortality in type 2 diabetes (T2D). In addition, we evaluated the role of co-existing congestive heart failure (CHF) and other CV risk factors on CV events in a large observational population-based cohort of T2D patients. RESEARCH ...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164113500798
更新日期:2013-11-01 00:00:00
abstract::Prehypertension is considered to be associated with increased cardiovascular disease (CVD), and some data suggest that insulin resistance is common in this group. The goal of this study was to quantify insulin action by determining the steady-state plasma glucose (SSPG) concentration during the insulin suppression tes...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164110396919
更新日期:2011-01-01 00:00:00
abstract::Doppler waveforms analysis is a interesting to diagnose peripheral artery disease as suggested by the international recommendations. However as mentioned in the present letter, there is a lack of consensus about the terminology that should be used. ...
journal_title:Diabetes & vascular disease research
pub_type: 评论,信件
doi:10.1177/1479164118809527
更新日期:2019-01-01 00:00:00
abstract::The aim of this study was to evaluate changes in lipid profiles in patients with type 2 diabetes after treatment conversion from rosiglitazone to pioglitazone while maintaining stable statin and other lipid-altering therapies. A total of 305 patients were enrolled in this open-label study. Patients had been taking sta...
journal_title:Diabetes & vascular disease research
pub_type: 临床试验,杂志文章,多中心研究
doi:10.3132/dvdr.2006.005
更新日期:2006-05-01 00:00:00
abstract::We investigated the usefulness of Holter monitoring to detect cardiac disease and predict future cardiovascular risk in asymptomatic diabetic patients. This is a multi-centre, prospective study in 406 asymptomatic diabetic patients. They were categorized into three groups based on findings of Holter monitoring. A tota...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164115595523
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND:The main manifestation of hyperglycaemia during pregnancy is gestational diabetes mellitus. It can herald diabetes mellitus type 2 and its deleterious long-term effects, such as hypertension and cardiovascular disease. The aim of this study was to assess diastolic function in women with gestational diabetes ...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164114563302
更新日期:2015-05-01 00:00:00
abstract::Diabetes mellitus and angina pectoris are important conditions in older persons. The utility of pre-diabetes mellitus, diabetes mellitus and other risk factors as predictors of incident angina pectoris among older adults has not been characterized. We examined incident angina pectoris rates by sex and diabetes mellitu...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,多中心研究
doi:10.1177/1479164119888476
更新日期:2020-01-01 00:00:00
abstract:AIM:We examined eligibility and preventable cardiovascular disease events in US adults with diabetes mellitus from the Empagliflozin Cardiovascular Outcome Event Trial in Type 2 Diabetes Mellitus Patients (EMPA-REG OUTCOME). METHODS:We identified adults with diabetes mellitus eligible for EMPA-REG OUTCOME based on tri...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164120945674
更新日期:2020-07-01 00:00:00
abstract::Patients with diabetes mellitus (DM) have accelerated atherosclerosis, which is the main underlying factor contributing to the high risk of atherothrombotic events in these patients. Atherothrombotic complications are the leading cause of morbidity and mortality in patients with DM. Among factors contributing to the p...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,评审
doi:10.1177/1479164110383994
更新日期:2010-10-01 00:00:00
abstract::With the growing prevalence of childhood obesity and type 2 diabetes mellitus (T2DM) in youth, the challenge of cardiovascular disease risk management has entered the paediatric realm, affecting specialists, family physicians and allied healthcare professionals alike. Currently, there is little evidence to support opt...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,评审
doi:10.3132/dvdr.2007.057
更新日期:2007-12-01 00:00:00
abstract:OBJECTIVE:To characterize copeptin levels and to explore its prognostic importance in patients with acute myocardial infarction with newly detected glucose abnormalities. METHODS:Copeptin was measured in 166 patients with acute myocardial infarction without known diabetes and in 168 age- and gender-matched controls. P...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,多中心研究
doi:10.1177/1479164116664490
更新日期:2017-03-01 00:00:00
abstract::Angiotensin II receptor blockers (ARB) are often co-administered with a calcium channel blocker (CCB) for treating hypertension. In this open-label randomised study, untreated diabetic hypertensive patients were randomised to receive either olmesartan 20 mg/day or candesartan 8 mg/day for 12 weeks. Patients with blood...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,随机对照试验
doi:10.1177/1479164112447310
更新日期:2012-10-01 00:00:00
abstract::The first objective of this study was to determine the baseline prevalence of metabolic syndrome and its individual components using the NCEP-R/ATPIII criteria, IDF criteria for Europe, and IDF criteria for Africa: waist circumference of at least 94 cm for men and women. The second objective was to investigate the inc...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164109346362
更新日期:2010-01-01 00:00:00
abstract::Metabolic syndrome (MetS) is a clustering of atherosclerotic coronary heart disease risk factors. This post-hoc analysis compared the effects of switching to ezetimibe/simvastatin 10/20 mg or rosuvastatin 10 mg in a cohort of 618 high-risk hypercholesterolaemic patients with (n=368) and without (n=217) MetS who had pr...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1177/1479164111418136
更新日期:2011-10-01 00:00:00
abstract::Telmisartan partially activates the peroxisome proliferator-activated receptor γ (PPARγ), which may ameliorate the accumulation of visceral adipose tissues and sensitise insulin action. Nineteen patients with essential hypertension and metabolic syndrome were randomly assigned to receive 40 mg of telmisartan (TELMI gr...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,随机对照试验
doi:10.1177/1479164112444640
更新日期:2013-01-01 00:00:00