Aromatic acid metabolites of Escherichia coli K-12 can induce the marRAB operon.

Abstract:

:MarR is a key regulator of the marRAB operon involved in antibiotic resistance and solvent stress tolerance in Escherichia coli. We show that two metabolic intermediates, 2,3-dihydroxybenzoate and anthranilate, involved in enterobactin and tryptophan biosynthesis, respectively, can activate marRAB transcription. We also found that a third intermediate involved in ubiquinone biosynthesis, 4-hydroxybenzoate, activates marRAB transcription in the absence of TolC. Of the three, however, only 2,3-dihydroxybenzoate directly binds MarR and affects its activity.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Chubiz LM,Rao CV

doi

10.1128/JB.00371-10

subject

Has Abstract

pub_date

2010-09-01 00:00:00

pages

4786-9

issue

18

eissn

0021-9193

issn

1098-5530

pii

JB.00371-10

journal_volume

192

pub_type

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