Adiposity, leptin and stress reactivity in humans.

Abstract:

:Evidence suggests that individuals who are more obese may be more responsive to stress. Stress activates the sympathetic nervous system (SNS) and the adipose-tissue cytokine leptin stimulates SNS activity in animals. We examined the relationship between adiposity, leptin and physiological responses to acute laboratory stress in 67 women. We predicted that individuals with greater adiposity and/or higher plasma leptin would be more stress-responsive. Adiposity was unrelated to cardiovascular or neuroendocrine stress reactivity. However, women with larger waists had greater stress-induced increases in plasma leptin and interleukin-1 receptor antagonist (IL-1Ra). Similarly, women with higher basal leptin displayed greater stress-induced increases in heart rate and plasma interleukin-6, and larger decreases in heart rate variability and cardiac pre-ejection period. Heightened cardiovascular and inflammatory stress responses are predictive of future cardiovascular risk. Our findings suggest that the cytokines leptin and IL-1Ra may play a role in the association between obesity, stress and cardiovascular health.

journal_name

Biol Psychol

journal_title

Biological psychology

authors

Brydon L

doi

10.1016/j.biopsycho.2010.02.010

subject

Has Abstract

pub_date

2011-02-01 00:00:00

pages

114-20

issue

2

eissn

0301-0511

issn

1873-6246

pii

S0301-0511(10)00066-9

journal_volume

86

pub_type

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