Abstract:
:It is widely accepted that noninvasive glucose monitoring (NIGM) has the potential to revolutionize diabetes therapy. However, current approaches to NIGM studied to date have not yet demonstrated a level of acceptable functionality to allow real-time use, beyond restricted fields of application. A number of reviews have been devoted to the subject of NIGM with different focuses related to challenges and a description of the respective underlying problems. This review is aimed at addressing a fundamental topic in the application of NIGM that seems to have received less attention, by describing the perturbations that result in a reduced functionality of NIGM in daily use. Here we provide a short general introduction to glucose monitoring and a basic illustration of the electromagnetic spectrum with a description of the respective physical mechanisms underlying the measurement techniques. This allows for a better understanding of how these perturbing factors affect the measured properties. Cutaneous blood perfusion is one of the major perturbing factors to NIGM, along with variations in temperature, migration of water, and the effect of attachment of the sensor to the skin. An understanding of the mechanisms underlying perfusion variation over time and within the measured human skin tissue matrix is required to enable a discrimination between glucose-induced effects within the tissue and various biophysical impacts to be made. It is suggested that a plurality of probing frequencies is required to discriminate glucose-related changes from the perturbations. A system designed to perform the measurements in different regions of the electromagnetic spectrum with dedicated sensors (multisensor approach) has the potential to more efficiently and reliably discriminate glucose-related information from perturbations. This can be achieved by combining signals related to measurements with different physical underlying mechanisms of the interaction between the probing field propagation and the tissue to help account for the different sources of perturbations.
journal_name
Diabetes Technol Therjournal_title
Diabetes technology & therapeuticsauthors
Caduff A,Talary MS,Zakharov Pdoi
10.1089/dia.2009.0095subject
Has Abstractpub_date
2010-01-01 00:00:00pages
1-9issue
1eissn
1520-9156issn
1557-8593journal_volume
12pub_type
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journal_title:Diabetes technology & therapeutics
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journal_title:Diabetes technology & therapeutics
pub_type: 临床试验,杂志文章
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journal_title:Diabetes technology & therapeutics
pub_type: 杂志文章,评审
doi:10.1089/dia.2012.0105
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pub_type: 杂志文章
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journal_title:Diabetes technology & therapeutics
pub_type: 杂志文章
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journal_title:Diabetes technology & therapeutics
pub_type: 杂志文章
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pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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pub_type: 杂志文章
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journal_title:Diabetes technology & therapeutics
pub_type: 杂志文章
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pub_type: 临床试验,杂志文章,多中心研究
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更新日期:2015-06-01 00:00:00
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journal_title:Diabetes technology & therapeutics
pub_type: 杂志文章
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更新日期:2019-01-01 00:00:00
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journal_title:Diabetes technology & therapeutics
pub_type: 杂志文章,随机对照试验
doi:10.1089/dia.2006.0034
更新日期:2007-06-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,多中心研究,随机对照试验
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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更新日期:2014-11-01 00:00:00
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pub_type: 杂志文章
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