Abstract：
:A combination of sustained release (SR) naltrexone (32 mg/day) and bupropion SR (360 mg/day) plus behavioral counseling was evaluated for the treatment of smoking cessation and mitigation of nicotine withdrawal and weight gain. Thirty overweight or obese nicotine-dependent subjects were enrolled in a 24-week, open-label study; 85% and 63% completed 12 and 2 4weeks, respectively. The target quit date was Week 4. Week 4-12 continuous abstinence rate was 48%, 78% of subjects achieved CO < or = 10 ppm, serum cotinine decreased from 185 to 48 microg/L, and tobacco use decreased from 129 to 14 cigarettes/week. Similar results were seen at Week 24. Body weight was essentially unchanged (Week 12: -0.1%; Week 24: +0.4%). Except for a transient significant increase 1 week after the target quit date (p<0.05), nicotine withdrawal scores did not change. The most common adverse events were nausea, insomnia, and constipation. These tended to be transient and mild or moderate in severity. In overweight or obese smokers, naltrexone/bupropion combination therapy with behavioral counseling was associated with decreased nicotine use, limited nicotine withdrawal symptoms, and no significant weight gain.
journal_name
Addict Behavjournal_title
Addictive behaviorsauthors
Wilcox CS,Oskooilar N,Erickson JS,Billes SK,Katz BB,Tollefson G,Dunayevich Edoi
10.1016/j.addbeh.2009.10.017subject
Has Abstractpub_date
2010-03-01 00:00:00pages
229-34issue
3eissn
0306-4603issn
1873-6327pii
S0306-4603(09)00296-2journal_volume
35pub_type
临床试验,杂志文章abstract：:The goal of the present research was to test the value of evaluative conditioning (EC) to unobtrusively change alcohol-related attitudes and drinking behavior. In the EC paradigm, participants had to spot an irrelevant target picture in a series of trials in which many different stimuli were presented. In the experime...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2010.08.012
更新日期：2010-12-01 00:00:00
abstract：:Within a larger study, 181 female undergraduates completed the Rokeach instrumental value survey and a version of the terminal value survey which included the value 'health', as well as measures of general preventive health behavior and social desirability. Analyses showed that nonsmokers reported better health behavi...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/0306-4603(85)90015-2
更新日期：1985-01-01 00:00:00
abstract：INTRODUCTION:Although psychosocial problems are commonly associated with both alcohol misuse and insomnia, very little is known about the combined effects of insomnia and current alcohol dependence on the severity of psychosocial problems. The present study evaluates whether the co-occurrence of insomnia and alcohol de...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2015.06.021
更新日期：2015-11-01 00:00:00
abstract：:Cigarette smoking-related symptomatology (e.g., craving; SRS) is linked to relapse after a quit attempt. SRS varies by menstrual phase, possibly due to variations in sex hormones (e.g., progesterone), though much of the research to-date has relied on observations from the menstrual cycle acting as a proxy for hormone ...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2019.106148
更新日期：2020-03-01 00:00:00
abstract：OBJECTIVES:(1) To establish the reliability and validity of a modified version of the Self-Rating of Alcohol (SRE) form. (2) To differentiate early subjective alcohol response (SR) from acquired tolerance in the prediction of drinking outcomes. METHOD:353 undergraduates completed an online survey. SR was assessed usin...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2008.06.007
更新日期：2008-10-01 00:00:00
abstract：:In this study, clinical data from 22 obese women who reported a history of sexual abuse were compared to clinical data from 22 obese women who denied a history of sexual abuse. Subjects were matched for body mass index (BMI), sex, and age. All subjects were enrolled in a multidisciplinary outpatient hospital-based ver...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/0306-4603(95)00058-5
更新日期：1996-05-01 00:00:00
abstract：:Internet addiction (IA) is a condition characterized by loss of control over Internet use, leading to a variety of negative psychosocial consequences. Recent neuroimaging studies have begun to identify IA-related changes in specific brain regions and connections. However, whether and how the interactions within and be...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2017.01.021
更新日期：2017-07-01 00:00:00
abstract：BACKGROUND:While parental supervision has been demonstrated to influence adolescent alcohol involvement, lack of a threshold defining inadequate supervision and little study of DSM defined alcohol use disorders (AUDs) have limited clinical applications. Utilizing a four-item supervision scale, this study identified ado...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2005.07.017
更新日期：2005-10-01 00:00:00
abstract：INTRODUCTION:Cue-reactivity is thought to play a fundamental role in the maintenance of addiction. The incentive sensitization theory proposes that conditioned responses are related to increased sensitivity of the reward-related dopaminergic pathways in the brain. However, neuroimaging studies on alcohol cue-reactivity...
journal_title：Addictive behaviors
pub_type： 杂志文章,评审
doi：10.1016/j.addbeh.2016.02.033
更新日期：2016-07-01 00:00:00
abstract：:Male Sprague-Dawley rats were raised from weaning in one of the three housing conditions: one, two or four per housing unit. At 60 days of age, animals were moved to individual cages and tested in the open field. Following a baseline period in which animals were allowed to adapt to their new housing condition, animals...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/0306-4603(84)90015-7
更新日期：1984-01-01 00:00:00
abstract：:The present study aimed to investigate: a) the contribution of the fear of missing out (FoMO) in explaining social media problematic use taking also into account the fear of being negatively evaluated and the perception of low self-presentational skills; b) the mediating role of positive metacognitions about social me...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2018.05.020
更新日期：2018-10-01 00:00:00
abstract：:This study examined the utility of thin layer chromatography (TLC) for detection of recent use of opioids and benzodiazepines among drug addicts seeking treatment at the Drug Dependence Treatment Centre of All India Institute of Medical Sciences, New Delhi, India. Over a period of 5 years (1991-1995), 6,055 urine samp...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/s0306-4603(99)00015-5
更新日期：2000-05-01 00:00:00
abstract：:Seventeen methadone-maintained cigarette smokers received 4 weeks of contingency management (CM) as a stop-smoking intervention. Results indicated that CM patients significantly reduced breath CO levels from baseline to completion of treatment and that 23.4% of patients maintained 1 week or more of continued smoking a...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/0306-4603(95)00066-6
更新日期：1996-05-01 00:00:00
abstract：:Alcohol and marijuana misuse is prevalent on many university campuses, with high rates of undergraduate students reporting experiencing alcohol and/or marijuana-related problems, which have been consistently associated with coping-motivated use. While previous studies have found dispositional mindfulness to be negativ...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2020.106554
更新日期：2020-12-01 00:00:00
abstract：:Research has shown that metacognitions are associated with addictive behaviors. This study aimed to evaluate the psychometric properties (i.e., factor structure, reliability, and predictive validity) of the Persian Metacognitions about Smartphone Use Questionnaire (Persian MSUQ). A community sample of 618 participants...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2020.106722
更新日期：2021-03-01 00:00:00
abstract：:Three smoking cessation interventions designed for use by general practitioners (GPs) within the routine consultation were evaluated in a field setting using 26 GPs throughout metropolitan Sydney. A total of 450 smoking patients were allocated to either Structured Behavioral Change with nicotine gum (Group SBCN), Stru...
journal_title：Addictive behaviors
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0306-4603(93)90049-f
更新日期：1993-03-01 00:00:00
abstract：:Parent-adolescent relationship (PAR) factors such as social support and negative interactions are associated with initiation of alcohol and marijuana use during adolescence. However, few studies have examined whether the relationship between PAR, especially the paternal role, and substance use onset varies by ethnicit...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2017.05.029
更新日期：2017-11-01 00:00:00
abstract：BACKGROUND:Heavy episodic drinking is common among college students and remains a serious public health issue. Previous event-level research among college students has examined behaviors and individual-level characteristics that drive consumption and related consequences but often ignores the social network of people w...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2017.12.030
更新日期：2018-04-01 00:00:00
abstract：OBJECTIVES:Drugged driving [DD] is a public health concern, particularly among emerging adults who have the highest rates of drug use. Understanding involvement with DD could inform prevention efforts for this population. We evaluated the prevalence of, motives for, and correlates of past-year DD among emerging adults ...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2017.11.002
更新日期：2018-03-01 00:00:00
abstract：:A number of risk factors have emerged as important correlates of adolescent substance use. In addition, research continues to focus on which factors act as mediators protecting adolescents from negative outcomes. One of these protective factors is religiosity, and the focus of this paper is to examine its role in the ...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2004.03.022
更新日期：2004-08-01 00:00:00
abstract：:The Substance Use Risk Profile Scale (SURPS) is based on a model of personality risk for substance abuse in which four personality dimensions (hopelessness, anxiety sensitivity, impulsivity, and sensation seeking) are hypothesized to differentially relate to specific patterns of substance use. The current series of st...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2009.07.001
更新日期：2009-12-01 00:00:00
abstract：:A growing body of research suggests that mindfulness-based therapies may be effective in treating a variety of disorders including stress, chronic pain, depression and anxiety. However, there are few valid and reliable measures of mindfulness. Furthermore, mindfulness is often thought to be related to spirituality, gi...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2005.01.010
更新日期：2005-08-01 00:00:00
abstract：INTRODUCTION:This study evaluated the cue-reactivity and several psychometric properties of a questionnaire designed to assess marijuana users' self-efficacy to employ 21 specific cognitive-behavioral strategies to reduce their marijuana use. METHOD:Using a web-based recruitment and data-collection procedure, 513 regu...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2014.07.005
更新日期：2014-12-01 00:00:00
abstract：:The commodity model of social support and features of Nondirective Support may clarify varied results of support interventions for smoking cessation. A commodity model views social support as attractive in and of itself and as an alternative to high-risk choices such as smoking. If such support is easily accessible, a...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/s0306-4603(97)00064-6
更新日期：1997-11-01 00:00:00
abstract：:In 2003 the Thai government announced a radical shift in drug policy with the implementation of a War on Drugs. Although consequences of this controversial measure (e.g. drug dealer deaths) have received widespread attention relatively little work has evaluated changes in substance use. We used two anonymous represent...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2006.12.002
更新日期：2007-08-01 00:00:00
abstract：:This study investigated the impact of the affective content of imagery scripts used in an imagery paradigm designed to elicit smoking urges in a laboratory setting. Sixty cigarette smokers were instructed to vividly imagine 10 imagery scripts that described negative affect and explicit smoking urges, positive affect a...
journal_title：Addictive behaviors
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0306-4603(90)90053-z
更新日期：1990-01-01 00:00:00
abstract：INTRODUCTION:In recent literature, abnormalities in the metacognitive domain have been pointed out as psychological variables that may account for a wide range of psychopathologies, including gambling disorder (GD). Considering the growing but scattered nature of the research concerning the relationship between metacog...
journal_title：Addictive behaviors
pub_type： 杂志文章,评审
doi：10.1016/j.addbeh.2020.106600
更新日期：2021-01-01 00:00:00
abstract：OBJECTIVES:This study examined processes linking age cohort, economic stressors, coping strategies and two drinking-related outcomes (i.e., past-month drinking and problematic drinking). METHODS:Structural equation models were conducted utilizing data from a national survey. RESULTS:Findings revealed the associations...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2015.07.016
更新日期：2015-12-01 00:00:00
abstract：:Individuals at high risk for alcoholism have been hypothesized to acquire alcoholic characteristics more rapidly than those at low risk. Two studies examined reactivity to alcohol cues, a phenomenon linked to craving for alcohol in clinical alcoholics, and ad lib drinking behavior in young men at varying risk for alco...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/0306-4603(90)90005-i
更新日期：1990-01-01 00:00:00
abstract：:To examine drinking problems and self concept of college students raised in homes where alcohol is abused, 148 lower division college students were given the following paper and pencil tests: The Michigan Alcoholism Screening Test, The Children of Alcoholics Screening Test, and the "Personal Self" section of The Tenne...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/0306-4603(89)90053-1
更新日期：1989-01-01 00:00:00
