Abstract：
:The present study examined the effect of hyperbaric oxygen (HBO) on the formation of 2,3-dihydroxybenzoic acid (2,3-DHBA) and 2,5-dihydroxybenzoic acid (2,5-DHBA), the products of salicylate trapping of hydroxyl free radicals, and glutamate release in the striatum during acute ischemia and reperfusion. Non-HBO rats (n = 8) were subjected to 1-h ischemia. Study rats (n = 8) were treated with HBO at 2.8 ATA for 1 h during ischemia. Artificial CSF solution containing 5 mM sodium salicylate was perfused at 1 microl/min. Samples were continuously collected at 15 min intervals and the levels of 2,3-DHBA, 2,5-DHBA, and glutamate were analyzed. The lesion volume was determined by TTC stain. Occlusion of the middle cerebral artery induced a significant increase in the levels of 2,3-DHBA and 2,5-DHBA. A peak of approximately two and fourfold of baseline levels was reached at 45 min and was maintained at elevated levels during reperfusion. The level of glutamate increased approximately two times at 30 min during ischemia, continued to increase, and reached approximately three times baseline level during reperfusion. HBO significantly alleviated brain injury associated with decreased levels of 2,3-DHBA, 2,5-DHBA and glutamate. This study suggests that the decreased glutamate release and the reduced formation of hydroxyl free radicals might contribute to the neuroprotective effect of HBO.
journal_name
Eur J Appl Physioljournal_title
European journal of applied physiologyauthors
Yang ZJ,Xie Y,Bosco GM,Chen C,Camporesi EMdoi
10.1007/s00421-009-1229-9subject
Has Abstractpub_date
2010-02-01 00:00:00pages
513-22issue
3eissn
1439-6319issn
1439-6327journal_volume
108pub_type
杂志文章abstract：:Body tilt angle affects the fatigue of human calf muscle at a high contractile force (i.e. 70 %MVC); but the range of forces across which this effect occurs is not known and we sought to determine this in the present study. Fourteen men performed intermittent calf muscle contractions at either 30, 40, 50 and 60 %MVC (...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-006-0308-4
更新日期：2007-01-01 00:00:00
abstract：PURPOSE:Cardiopulmonary exercise testing (CPX) is used to evaluate functional capacity and assess prognosis in cardiac patients. Ventilatory efficiency (VE/VCO2) reflects ventilation-perfusion mismatch; the minimum VE/VCO2 value (minVE/VCO2) is representative of pulmonary arterial blood flow in individuals without pulm...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-018-3884-1
更新日期：2018-08-01 00:00:00
abstract：:The present study was conducted in order to evaluate whether physiological strain is alleviated by a new personal cooling system (CS) consisting of a layered vest and integrated blower that generate a flow of air. Twelve male volunteers were exposed to climatic conditions of 40 degrees C, 40%RH (40/40), and 35 degrees...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-008-0716-8
更新日期：2008-09-01 00:00:00
abstract：:To identify the effect of normal breathlessness sensation elicited during intense intermittent exercise at exhaustion on limitation of exercise maintenance (Ex), the contribution of the flow-resistive unloading effect of normoxic helium-oxygen breathing on the breathlessness sensation to the change in the Ex was exami...
journal_title：European journal of applied physiology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s00421-004-1094-5
更新日期：2004-07-01 00:00:00
abstract：:Highly trained athletes are associated with high resting antigen-stimulated whole blood culture interleukin (IL)-10 production. The purpose of the present study was to examine the effects of training status on resting circulating T regulatory (Treg) cell counts and antigen-stimulated IL-10 production and the effect of...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-013-2614-y
更新日期：2013-07-01 00:00:00
abstract：PURPOSE:Vascular dysfunction has been demonstrated in patients with Alzheimer's disease (AD). Exercise is known to positively affect vascular function. Thus, the aim of our study was to investigate exercise-induced effects on vascular function in AD. METHODS:Thirty-nine patients with AD (79 ± 8 years) were recruited a...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-020-04447-w
更新日期：2020-10-01 00:00:00
abstract：:Fifteen healthy men performed a 5-week training program comprising four sets of seven unilateral, coupled concentric-eccentric knee extensions 2-3 times weekly. While eight men were assigned to training using a weight stack (WS) machine, seven men trained using a flywheel (FW) device, which inherently provides variabl...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-007-0583-8
更新日期：2008-02-01 00:00:00
abstract：:Session RPE (SRPE) permits subjective ratings of global effort following exercise. SRPE is useful for evaluating training load; however, mediating factors are not well understood. This study compared SRPE among treadmill trials at a clamped workload with a varied duration. Ten subjects (VO(2)max: 48.9 +/- 10.5 ml kg(-...
journal_title：European journal of applied physiology
pub_type： 临床试验,杂志文章
doi：10.1007/s00421-009-1153-z
更新日期：2009-11-01 00:00:00
abstract：:Changes of venous compliance may contribute in part to postflight orthostatic intolerance. The purpose of the present study was to determine whether intermittent artificial gravity exposure with ergometric exercise could prevent venous compliance changes in the lower limbs due to simulated weightlessness. Twelve healt...
journal_title：European journal of applied physiology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00421-011-2083-0
更新日期：2012-04-01 00:00:00
abstract：PURPOSE:Our purpose was to compare supramaximal versus submaximal intensity eccentric training performed until volitional fatigue. METHODS:Thirty-two young adults (19 males) were randomized into one of three groups: (1) ECC110 performed eccentric (ECC) only contractions at 110% of concentric (CON) 1-repetition maximum...
journal_title：European journal of applied physiology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00421-017-3700-3
更新日期：2017-10-01 00:00:00
abstract：PURPOSE:We investigated the consequence of varying hypoxia severity during an initial set of repeated cycling sprints on performance, neuromuscular fatigability, and exercise-related sensations during a subsequent set of repeated sprints in normoxia. METHODS:Nine active males performed ten 4-s sprints (recovery = 30 s...
journal_title：European journal of applied physiology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00421-020-04327-3
更新日期：2020-04-01 00:00:00
abstract：:To examine sex- and menstrual cycle-related differences in thermoregulatory responses to heat exposure, ten young women and six young men were heated passively by immersing their legs in water heated to 42 degrees C for 60 min (in ambient conditions of 30 degrees C and 45% relative humidity). The women underwent heat ...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-004-1303-2
更新日期：2005-06-01 00:00:00
abstract：:The purpose of this study was to determine the impact of high-intensity intermittent exercise on the presence of circulating growth hormone (GH) aggregates measured using two different assay techniques. Six male subjects with endurance training background participated in this study under both exercise and no-exercise ...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-002-0774-2
更新日期：2003-04-01 00:00:00
abstract：:Skin surface cooling has been shown to improve orthostatic tolerance; however, the influence of severe heat stress on cardiovascular and cerebrovascular responses to skin cooling remains unknown. Nine healthy males, resting supine in a water-perfusion suit, were heated to +1.0 and +2.0 degrees C elevation in body core...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-009-1298-9
更新日期：2010-05-01 00:00:00
abstract：:To examine the effects of thermal stress on the blood pressure variability and the arterial baroreceptor-cardiac reflex during orthostatic stress, 11 male volunteers underwent whole body thermal stress using a cool or hot water-perfused suit during 5 min of 70 degrees head-up tilt (HUT). The spontaneous variability in...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s004210100387
更新日期：2001-04-01 00:00:00
abstract：:The most important anatomical determinants of in vivo joint moment magnitude have yet to be defined. Relationships between maximal knee extensor moment and quadriceps muscle volume, anatomical (ACSA) and physiological (PCSA) cross-sectional area, muscle architecture and moment arm (MA) were compared. Nineteen untraine...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-008-0972-7
更新日期：2009-04-01 00:00:00
abstract：:The purpose of this study was to clarify the effect of acute exercise in hypoxia on flow-mediated vasodilation (FMD). Eight males participated in this study. Two maximal exercise tests were performed using arm cycle ergometry to estimate peak oxygen uptake [Formula: see text] while breathing normoxic [inspired O(2) fr...
journal_title：European journal of applied physiology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00421-012-2442-5
更新日期：2013-02-01 00:00:00
abstract：:The aim of this study was to determine the effect of cycle intensity on subsequent running performance and combined cycle-run (CR) performance. Seven triathletes undertook a cycling graded exercise test to exhaustion, an isolated 500-kJ cycle time trial (CTT) and an isolated 5-km running time trial. Then they performe...
journal_title：European journal of applied physiology
pub_type： 临床试验,杂志文章
doi：10.1007/s00421-010-1547-y
更新日期：2010-11-01 00:00:00
abstract：:Single bout whole-body vibration (WBV) exercise has been shown to produce small but significant increases in oxygen consumption (VO(2)). How much more a complete whole-body exercise session (multiple dynamic exercises targeting both upper and lower body muscles) can increase VO(2) is unknown. The purpose of this study...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-011-1984-2
更新日期：2012-02-01 00:00:00
abstract：:The original version of this article unfortunately contained a mistake. ...
journal_title：European journal of applied physiology
pub_type： 已发布勘误
doi：10.1007/s00421-020-04497-0
更新日期：2020-12-01 00:00:00
abstract：PURPOSE:23Na MRI demonstrated increased tissue sodium concentrations in a number of pathologies. Acute atrophy results in muscle fibre volume shrinking that may result in a relative increase of extracellular volume and might affect sodium concentration. Thus, we hypothesized that local unloading of the calf muscles wou...
journal_title：European journal of applied physiology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00421-017-3647-4
更新日期：2017-08-01 00:00:00
abstract：:This study aimed to determine whether brief hypoxic stimuli in a hypobaric chamber are able to elicit erythropoietin (EPO) secretion, and to effectively stimulate erythropoiesis in the short term. In two different experiments, a set of haematological, biochemical, haemorheological, aerobic performance, and medical tes...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s004210050669
更新日期：2000-06-01 00:00:00
abstract：:The purpose of this study was to test the effect of a 3-week strength training program of knee extensor muscles on cycling delta efficiency in master endurance athletes. Nine master (age 51.5 ± 5.5 years) and 8 young (age 25.6 ± 5.9 years) endurance athletes with similar training levels participated in this study. Dur...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-011-2013-1
更新日期：2012-02-01 00:00:00
abstract：PURPOSE:Dietary nitrate (NO3 (-)) supplementation reduces the O2 cost of fixed-workload tasks performed in temperate environments but has not been examined in the heat. If this effect were retained it could reduce heatstroke risk in military personnel that are deployed for desert combat. METHODS:Nine men completed thr...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-015-3255-0
更新日期：2015-12-01 00:00:00
abstract：PURPOSE:The aim is to provide better understanding of carbon dioxide (CO2) elimination during ventilation for both the healthy and atelectatic condition, derived in a pressure-controlled mode. Therefore, we present a theoretical analysis of CO2 elimination of healthy and diseased lungs. METHODS:Based on a single-compa...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-013-2754-0
更新日期：2014-01-01 00:00:00
abstract：:The polymorphisms of endothelial nitric oxide synthase (eNOS) are associated with reduced eNOS activity. Aerobic exercise training (AEX) may influence resting nitric oxide (NO) production, oxidative stress and blood pressure. The purpose of this study was to investigate the effect of AEX on the relationship among bloo...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-010-1568-6
更新日期：2010-11-01 00:00:00
abstract：:In this study, we compared the biomechanical and physiological responses of healthy men and women during bilateral load carriage while they walked on a treadmill at their self-selected velocity. Eleven men mean (SD) maximal oxygen uptake, [VO(2)(max) = 56.0 (7.1) ml x kg(-1) x min(-1)] and 11 women [VO(2)(max) = 44.6 ...
journal_title：European journal of applied physiology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/PL00013800
更新日期：2000-01-01 00:00:00
abstract：:The impact of resistance training has not been thoroughly examined in overweight older adults undergoing weight loss. Subjects (n = 27) were overweight and obese (BMI 31.7 +/- 3.6 kg/m(2)) older (age 67 +/- 4 years) adults and were randomized into either a 10-week Dietary Approaches to Stop Hypertension for weight los...
journal_title：European journal of applied physiology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00421-010-1387-9
更新日期：2010-06-01 00:00:00
abstract：:Continuous assessment of mixed venous oxygen saturation (cSvO(2)) during exercise using a fiber optic pulmonary artery catheter can provide valuable information on the physiological determinants of the exercise capacity in patients with chronic heart failure (CHF). Since its accuracy is not well established during exe...
journal_title：European journal of applied physiology
pub_type： 临床试验,杂志文章
doi：10.1007/s00421-007-0597-2
更新日期：2008-03-01 00:00:00
abstract：PURPOSE:The aim of this study was to compare the effects of two different kinds of prior exercise protocols [continuous exercise (CE) versus intermittent repeated sprint (IRS)] on oxygen uptake (VO2) kinetics parameters during high-intensity running. METHODS:Thirteen male amateur futsal players (age 22.8 ± 6.1 years; ...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-014-3000-0
更新日期：2015-01-01 00:00:00
