Abstract:
:The polymorphisms of endothelial nitric oxide synthase (eNOS) are associated with reduced eNOS activity. Aerobic exercise training (AEX) may influence resting nitric oxide (NO) production, oxidative stress and blood pressure. The purpose of this study was to investigate the effect of AEX on the relationship among blood pressure, eNOS gene polymorphism and oxidative stress in pre-hypertensive older people. 118 pre-hypertensive subjects (59 ± 6 years) had blood samples collected after a 12 h overnight fast for assessing plasma NO metabolites (NOx) assays, thiobarbituric acid reactive substances (T-BARS) and superoxide dismutase activity (ecSOD). eNOS polymorphism (T-786C and G-894T) was done by standard PCR methods. All people were divided according to the genotype results (G1: TT/GG, G2: TT/GT + TT, G3: TC + CC/GG, G4: TC + CC/GT + TT). All parameters were measured before and after 6 months of AEX (70% of VO(2 max)). At baseline, no difference was found in systolic and diastolic blood pressure, ecSOD and T-BARS activity. Plasma NOx levels were significantly different between G1 (19 ± 1 μM) and G4 (14.2 ± 0.6 μM) and between G2 (20.1 ± 1.7 μM) and G4 (14.2 ± 0.6 μM). Therefore, reduced NOx concentration in G4 group occurred only when the polymorphisms were associated, suggesting that these results are more related to genetic factors than NO-scavenging effect. After AEX, the G4 increased NOx values (17.2 ± 1.2 μM) and decreased blood pressure. G1, G3 and G4 decreased T-BARS levels. These results suggest the AEX can modulate the NOx concentration, eNOS activity and the relationship among eNOS gene polymorphism, oxidative stress and blood pressure especially in C (T-786C) and T (G-894T) allele carriers.
journal_name
Eur J Appl Physioljournal_title
European journal of applied physiologyauthors
Zago AS,Park JY,Fenty-Stewart N,Kokubun E,Brown MDdoi
10.1007/s00421-010-1568-6subject
Has Abstractpub_date
2010-11-01 00:00:00pages
825-32issue
4eissn
1439-6319issn
1439-6327journal_volume
110pub_type
杂志文章abstract::Measuring maximal sniff pressures is an easy way of assessing inspiratory muscle strength. During a static manoeuvre, the pattern of inspiratory muscle recruitment during a sniff can vary from one individual to another. We therefore assessed how voluntarily changing muscle recruitment would affect sniff oesophageal, g...
journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s004210100469
更新日期:2001-10-01 00:00:00
abstract::To identify the effect of normal breathlessness sensation elicited during intense intermittent exercise at exhaustion on limitation of exercise maintenance (Ex), the contribution of the flow-resistive unloading effect of normoxic helium-oxygen breathing on the breathlessness sensation to the change in the Ex was exami...
journal_title:European journal of applied physiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00421-004-1094-5
更新日期:2004-07-01 00:00:00
abstract::No studies have considered whether a firefighter's boots are a factor influencing physiological responses. The purpose of this study was to examine physiological responses to a fire simulation activity (stair climb) in professional firefighters wearing rubber boots (RB) and leather boots (LB). Twelve professional fire...
journal_title:European journal of applied physiology
pub_type: 临床试验,杂志文章
doi:10.1007/s00421-009-1092-8
更新日期:2009-09-01 00:00:00
abstract::This study compared the rate of fatigue and lower limb EMG activities during high-intensity constant-load cycling in upright and supine postures. Eleven active males performed seven cycling exercise tests: one upright graded test, four fatigue tests (two upright, two supine) and two EMG tests (one upright, one supine)...
journal_title:European journal of applied physiology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00421-009-1254-8
更新日期:2010-03-01 00:00:00
abstract::Local muscle fatigue can originate from both peripheral and central factors. The relative contribution of these factors in the course of a fatiguing contraction in 20 healthy subjects was determined. While subjects made a 2-min sustained maximal voluntary contraction (MVC) of the biceps brachii, muscle fibre conductio...
journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-003-0913-4
更新日期:2003-11-01 00:00:00
abstract:INTRODUCTION:The interchangeability analysis has been recently proposed to objectively assess whether a newly developed measurement tool can substitute the older ones; this analysis assumes that the measures yielded by the compared tools should differ less than a maximum acceptable value. We aimed to assess the interch...
journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-020-04374-w
更新日期:2020-06-01 00:00:00
abstract::Limited evidence suggests renin-angiotensin-aldosterone system (RAAS) polymorphisms alter the blood pressure (BP) response to aerobic exercise training. We examined if RAAS polymorphisms influenced postexercise hypotension in men with high normal to Stage 1 hypertension. Forty-seven men (44.2+/-1.4 years, 145.1+/-1.6/...
journal_title:European journal of applied physiology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00421-006-0142-8
更新日期:2006-05-01 00:00:00
abstract::Differences in physiological functioning in the hypothalamus-pituitary-adrenal cortex axis and the autonomic nervous system have been suggested to contribute to many of the health differences that may be observed between men and women as well as being relevant for the development of musculoskeletal pain. To clarify wh...
journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-008-0939-8
更新日期:2009-03-01 00:00:00
abstract::The influence of ACE gene on athletic performance has been widely explored, and most of the published data refers to an I/D polymorphism leading to the presence (I allele) or absence (D allele) of a 287-bp sequence in intron 16, determining ACE activity in serum and tissues. A higher I allele frequency has been report...
journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-009-1080-z
更新日期:2009-08-01 00:00:00
abstract::Mechanical loading of cells induces the expression of transforming growth factor-beta-1, and acute exercise, which involves mechanical loading of several tissues, could thus increase its circulating level in humans. However, no consensus exists regarding the plasma concentration of this cytokine in resting subjects (r...
journal_title:European journal of applied physiology
pub_type: 临床试验,杂志文章
doi:10.1007/s00421-003-0881-8
更新日期:2003-09-01 00:00:00
abstract:OBJECTIVE:Our purpose was to study the effects of aerobic, resistance, and mixed (aerobic and resistance) training programs on blood pressure, both at rest and during submaximal exercise in healthy people. METHODS:We randomized 39 physically active, healthy participants into aerobic, resistance, and mixed (aerobic and...
journal_title:European journal of applied physiology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00421-017-3706-x
更新日期:2017-11-01 00:00:00
abstract::Physiological hypertrophy in response to physical training is important in the differentiation of physiological and pathological left ventricular hypertrophy. The goal of our study was to define the structural characteristics of the heart in Chinese athletes. Between June 2005 and August 2005, 339 (165 male, 174 femal...
journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-007-0517-5
更新日期:2007-11-01 00:00:00
abstract::The role of exercise training (ET) on cardiac renin-angiotensin system (RAS) was investigated in 3-5 month-old mice lacking alpha(2A-) and alpha(2C-)adrenoceptors (alpha(2A)/alpha(2C)ARKO) that present heart failure (HF) and wild type control (WT). ET consisted of 8-week running sessions of 60 min, 5 days/week. In add...
journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-008-0967-4
更新日期:2009-04-01 00:00:00
abstract::Cardiopulmonary exercise test is the gold standard for the identification of the ventilatory compensation point (VCP), an important threshold for exercise training prescription. We hypothesized that changes in the slope of increment in minute ventilation (V'(E)) over heart rate (HR) during incremental exercise can be ...
journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-008-0777-8
更新日期:2008-09-01 00:00:00
abstract::Cardiovascular autonomic function is associated with physical performance and exercise training adaptation. The association between physical performance and sympathetic regulation is not well known. We hypothesized that sympathetic nervous system activity is associated with physical performance among male runners. The...
journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-007-0618-1
更新日期:2008-03-01 00:00:00
abstract:PURPOSE:Brain hemodynamics is fundamental for the functioning of the human being. Many biophysical factors affect brain circulation, so that a satisfactory understanding of its behavior is challenging. We developed a mathematical model to simulate cerebral and extracerebral flows and pressures in humans. METHODS:The m...
journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-018-3971-3
更新日期:2018-11-01 00:00:00
abstract::Muscle fiber conduction velocity (MFCV) has often been shown to decrease during standardized fatiguing isometric contractions. However, several studies have indicated that the MFCV may remain constant during fatiguing dynamic exercise. It was investigated if these observations can be related to the absence of a large ...
journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-011-2119-5
更新日期:2012-05-01 00:00:00
abstract::The bilateral deficit phenomenon, characterized by a reduction in the amount of force from a single limb during maximal bilateral actions, has been shown in various movement tasks, contraction types and different populations. However, bilateral deficit appears to be an inconsistent phenomenon, with high variability in...
journal_title:European journal of applied physiology
pub_type: 杂志文章,评审
doi:10.1007/s00421-016-3458-z
更新日期:2016-12-01 00:00:00
abstract::The purpose of this study was to investigate whether different modes of single-bout exercise would cause different responses in short-term bone metabolism. 24 untrained male college students (19.1 ± 0.1 years old) were recruited and randomly assigned to three groups: (1) a single-bout plyometric exercise group (the PL...
journal_title:European journal of applied physiology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00421-011-2108-8
更新日期:2012-04-01 00:00:00
abstract::Mathematical models of the acid-base chemistry of blood based upon mass action and mass balance equations have become popular as diagnostic tools in intensive care. The reference models using this approach are those based on the strong ion approach, but these models do not currently take into account the effects of ox...
journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-009-1244-x
更新日期:2010-02-01 00:00:00
abstract::This study tested the hypothesis that changes in indirect markers of muscle damage following maximal eccentric exercise would be smaller for the knee extensors (KE) and flexors (KF) compared with the elbow flexors (EF) and extensors (EE). A total of 17 sedentary men performed five sets of six maximal isokinetic (90° s...
journal_title:European journal of applied physiology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00421-010-1648-7
更新日期:2011-02-01 00:00:00
abstract::We summarise recent results obtained in testing some of the algorithms utilised for estimating breath-by-breath (BB) alveolar O2 transfer (VO2A) in humans. VO2A is the difference of the O2 volume transferred at the mouth minus the alveolar O2 stores changes. These are given by the alveolar volume change at constant O2...
journal_title:European journal of applied physiology
pub_type: 杂志文章,评审
doi:10.1007/s00421-003-0951-y
更新日期:2003-10-01 00:00:00
abstract::The thermal insulation properties of a military wet/cold protection glove of the German Bundeswehr were investigated using the thermophysiological simulation device CYBOR with a heated full-scale hand model. The aim of this study was the physiology related and more reliable estimation of a database for the thermal com...
journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-007-0660-z
更新日期:2008-09-01 00:00:00
abstract::The purpose of this study was to examine the effect of exercise and pre-exercise dietary manipulation on hepatic triglyceride concentration (HTGC). HTGC was measured by proton magnetic resonance spectroscopy ((1)H-MRS) before and after 90 min of moderate intensity cycling in six endurance trained males following 67 h ...
journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-011-2158-y
更新日期:2012-05-01 00:00:00
abstract:PURPOSE:This study compared the effect of periodised versus non-periodised (NP) resistance training on neuromuscular adaptions in older adults. METHODS:Forty-one apparently healthy untrained older adults (female = 21, male = 20; 70.9 ± 5.1 years; 166.3 ± 8.2 cm; 72.9 ± 13.4 kg) were recruited and randomly stratified t...
journal_title:European journal of applied physiology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00421-017-3605-1
更新日期:2017-06-01 00:00:00
abstract::The aim of this study was to employ neuro-fuzzy logic and regression calculations to determine the accuracy of prediction of the power output ( P) of the maximal lactate steady-state (MLSS) on a cycle ergometer calculated from the results of incremental tests. A group of 17 male and 17 female sports students underwent...
journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-002-0702-5
更新日期:2002-12-01 00:00:00
abstract::The association of expertness in specific motor activities with a higher ability to sustain a constant application of force, regardless of muscle length, has been hypothesized. Ten highly skilled (HS group) young tennis and handball athletes and 10 sedentary (S group) individuals performed maximal and submaximal (5, 1...
journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-009-1184-5
更新日期:2009-12-01 00:00:00
abstract::The aim of this study was to analyze the dynamic behavior of the high-frequency component (HF > 0.15 Hz) of heart rate variability (HRV) and the respiratory frequency in relation to the anaerobic threshold (AT). Twenty-two healthy subjects [mean (SD) age: 24 (6) years, height: 175 (10) cm, body mass: 65 (11) kg] compl...
journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s004210000302
更新日期:2000-11-01 00:00:00
abstract::Measuring physical workload in occupational medicine is fundamental for risk prevention. An indirect measurement of total and relative energy expenditure (EE) from heart rate (HR) is widely used but it has never been validated. The aim of this study was to validate this HR-estimated energy expenditure (HREEE) method a...
journal_title:European journal of applied physiology
pub_type: 临床试验,杂志文章
doi:10.1007/s00421-004-1228-9
更新日期:2005-05-01 00:00:00
abstract:PURPOSE:Asprosin, an orexigenic hormone that stimulates hepatic glucose release, is elevated in insulin resistance and associated with obesity. Plasma asprosin concentrations may also be related to female sex hormone levels; higher levels are reported in women with polycystic ovary syndrome (PCOS) but this may be relat...
journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-020-04570-8
更新日期:2020-12-08 00:00:00