Abstract:
:The role of exercise training (ET) on cardiac renin-angiotensin system (RAS) was investigated in 3-5 month-old mice lacking alpha(2A-) and alpha(2C-)adrenoceptors (alpha(2A)/alpha(2C)ARKO) that present heart failure (HF) and wild type control (WT). ET consisted of 8-week running sessions of 60 min, 5 days/week. In addition, exercise tolerance, cardiac structural and function analysis were made. At 3 months, fractional shortening and exercise tolerance were similar between groups. At 5 months, alpha(2A)/alpha(2C)ARKO mice displayed ventricular dysfunction and fibrosis associated with increased cardiac angiotensin (Ang) II levels (2.9-fold) and increased local angiotensin-converting enzyme activity (ACE 18%). ET decreased alpha(2A)/alpha(2C)ARKO cardiac Ang II levels and ACE activity to age-matched untrained WT mice levels while increased ACE2 expression and prevented exercise intolerance and ventricular dysfunction with little impact on cardiac remodeling. Altogether, these data provide evidence that reduced cardiac RAS explains, at least in part, the beneficial effects of ET on cardiac function in a genetic model of HF.
journal_name
Eur J Appl Physioljournal_title
European journal of applied physiologyauthors
Pereira MG,Ferreira JC,Bueno CR Jr,Mattos KC,Rosa KT,Irigoyen MC,Oliveira EM,Krieger JE,Brum PCdoi
10.1007/s00421-008-0967-4subject
Has Abstractpub_date
2009-04-01 00:00:00pages
843-50issue
6eissn
1439-6319issn
1439-6327journal_volume
105pub_type
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