当前位置： SCI文献检索 > EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY期刊下所有文献 > Endogenous nitric oxide and pulmonary circulation response to hypoxia in high-altitude adapted Tibetan sheep.

Endogenous nitric oxide and pulmonary circulation response to hypoxia in high-altitude adapted Tibetan sheep.

Abstract：

:Nitric oxide (NO) is important for the pulmonary circulation response to acute and chronic hypoxia. We examined effects of endogenous nitric oxide synthase (NOS) inhibition on pulmonary vascular tone in response to hypoxia in Tibetan sheep dwelling at 3,000 m above sea level using a pressure chamber. Unanaesthetized male sheep living at 2,300 m above sea level ( n=7) were prepared for vascular monitoring. Pulmonary artery ( P(pa)), pulmonary artery wedge ( P(cwp)) and systemic artery pressures together with cardiac output (CO) were measured, and pulmonary vascular resistance (PVR) was calculated as ( P(pa)- P(cwp))/CO. A non-selective NOS inhibitor, N(omega)-nitro- l-arginine (NLA; 20 mg kg(-1)), and a selective NOS inhibitor, ONO-1714 (0.1 mg kg(-1)), were used and measurements were made at 0 m, 2,300 m, and 4,500 m, with and without the NOS inhibitors. After NLA, P(pa) increased slightly and CO decreased in animals at baseline (2,300 m). The increased PVR after NLA at 4,500 m was greater than that at 2,300 m ( P<0.05). Selective NOS inhibition increased PVR at baseline, but not at 4,500 m. The enhanced pulmonary vasoconstriction after NO inhibition at basal and hypoxic conditions suggests a modulating role of NOS bioactivity in the pulmonary circulation and that augmented endothelial NOS plays a counterregulatory role in the pulmonary vasoconstrictor response to acute hypoxia in high-altitude adapted Tibetan sheep.

journal_name

Eur J Appl Physiol

journal_title

European journal of applied physiology

authors

Ruan Z,Koizumi T,Sakai A,Ishizaki T,Wang Z

doi

10.1007/s00421-004-1197-z

keywords:

subject

Has Abstract

pub_date

2004-10-01 00:00:00

pages

190-5

issue

1-2

eissn

1439-6319

issn

1439-6327

journal_volume

93

pub_type

杂志文章

相关文献

EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY文献大全
  • Using three objective criteria to examine pedometer guidelines for free-living individuals.

    abstract：:The purpose was to examine in free-living individuals from a high-density city (1) the objectively determined physical activity levels across quartiles derived from pedometer step counts, (2) the pedometer steps day(-1) required to meet health-enhancing guidelines of accruing 30 min day(-1) of moderate physical activi...

    journal_title：European journal of applied physiology

    pub_type： 杂志文章

    doi：10.1007/s00421-008-0789-4

    authors： Macfarlane DJ,Chan D,Chan KL,Ho EY,Lee CC

    更新日期：2008-10-01 00:00:00

  • Sleep onset is disrupted following pre-sleep exercise that causes large physiological excitement at bedtime.

    abstract：PURPOSE:Many studies have failed to show that pre-sleep exercise has a negative effect on sleep onset. However, since only a moderate level of physiological excitement was observed at bedtime in these studies, it remains unclear whether a larger magnitude of physiologic excitement present at bedtime would disrupt sleep...

    journal_title：European journal of applied physiology

    pub_type： 杂志文章

    doi：10.1007/s00421-014-2873-2

    authors： Oda S,Shirakawa K

    更新日期：2014-09-01 00:00:00

  • Comparison of two waist-mounted and two ankle-mounted electronic pedometers.

    abstract：:This study compared two ankle-mounted pedometers [StepWatch 3 (SW-3(Ankle)) and Activity Monitoring Pod 331 (AMP(Ankle))] and two waist-mounted pedometers [New Lifestyles NL-2000 (NL(Waist)) and Digiwalker SW-701 (SW-701(Waist))] under controlled and free-living conditions. In part I, 20 participants walked on a tread...

    journal_title：European journal of applied physiology

    pub_type： 杂志文章

    doi：10.1007/s00421-005-0018-3

    authors： Karabulut M,Crouter SE,Bassett DR Jr

    更新日期：2005-10-01 00:00:00

  • K+ potentiates hyperosmolarity-induced vasorelaxations in rat skeletal muscle arterioles.

    abstract：:Several regulatory mechanisms have been proposed for the exercise hyperemia in skeletal muscles. Since different vasoactive factors might interact during the hyperemic response, we investigated the influence of elevated K(+) concentrations on hyperosmolarity (HO)-induced vasorelaxations. Small gluteal rat arteries wer...

    journal_title：European journal of applied physiology

    pub_type： 杂志文章

    doi：10.1007/s00421-005-0128-y

    authors： De Clerck I,Pannier JL,Van de Voorde J

    更新日期：2006-04-01 00:00:00

  • Fasudil, a Rho-kinase inhibitor, protects against excessive endurance exercise training-induced cardiac hypertrophy, apoptosis and fibrosis in rats.

    abstract：:Excessive endurance exercise training (EEET) is accompanied by cardiac remodeling, changes in ventricular function and increased heart failure risk. Fasudil, a potent Rho-kinase inhibitor, has been demonstrated to blunt cardiomyocyte hypertrophy, cardiac remodeling, and heart failure progression in pre-clinical trials...

    journal_title：European journal of applied physiology

    pub_type： 杂志文章

    doi：10.1007/s00421-011-2270-z

    authors： Ho TJ,Huang CC,Huang CY,Lin WT

    更新日期：2012-08-01 00:00:00

  • Transient ischemic attacks from arterial gas embolism induced by glossopharyngeal insufflation and a possible method to identify individuals at risk.

    abstract：:Breath-hold divers report transient, severe neurological symptoms that could be caused by arterial gas embolism after glossopharyngeal insufflation. This technique is often used to overinflate the lungs and stretch the chest prior to breath-holding and can increase the transpulmonary pressure to around 7-8 kPa, so int...

    journal_title：European journal of applied physiology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s00421-012-2494-6

    authors： Schiffer TA,Lindholm P

    更新日期：2013-03-01 00:00:00

  • Exercise-induced changes in circulating levels of transforming growth factor-beta-1 in humans: methodological considerations.

    abstract：:Mechanical loading of cells induces the expression of transforming growth factor-beta-1, and acute exercise, which involves mechanical loading of several tissues, could thus increase its circulating level in humans. However, no consensus exists regarding the plasma concentration of this cytokine in resting subjects (r...

    journal_title：European journal of applied physiology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s00421-003-0881-8

    authors： Heinemeier K,Langberg H,Kjaer M

    更新日期：2003-09-01 00:00:00

  • Changes in blood lactate and respiratory gas exchange measures in sports with discontinuous load profiles.

    abstract：:This study compares two different sport events (orienteering = OTC; tennis = TEC) with discontinuous load profiles and different activity/recovery patterns by means of blood lactate (LA), heart rate (HR), and respiratory gas exchange measures (RGME) determined via a portable respiratory system. During the TEC, 20 tenn...

    journal_title：European journal of applied physiology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s00421-003-0824-4

    authors： Smekal G,von Duvillard SP,Pokan R,Tschan H,Baron R,Hofmann P,Wonisch M,Bachl N

    更新日期：2003-06-01 00:00:00

  • Effects of lumbar extensor fatigue and fatigue rate on postural sway.

    abstract：:Falls from heights resulting from a loss of balance are a major concern in the occupational setting. Previous studies have documented a deleterious effect of lower extremity fatigue on balance. The purpose of this study was to investigate the effect of lumbar extensor fatigue on balance during quiet standing. Addition...

    journal_title：European journal of applied physiology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s00421-004-1195-1

    authors： Davidson BS,Madigan ML,Nussbaum MA

    更新日期：2004-10-01 00:00:00

  • The separate and combined effects of hypoxia and sustained recumbency/inactivity on sleep architecture.

    abstract：PURPOSE:The objective was to determine the separate and combined effects of hypoxia and inactivity/unloading on sleep architecture during a 10-day period of confinement. METHODS:Ten subjects participated in three 10-day trials in random order: hypoxic ambulatory (HAMB), hypoxic bedrest (HBR), and normoxic bedrest (NBR...

    journal_title：European journal of applied physiology

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00421-014-2909-7

    authors： Rojc B,Morrison SA,Eiken O,Mekjavic IB,Dolenc-Grošelj L

    更新日期：2014-09-01 00:00:00

  • Effect of a personal ambient ventilation system on physiological strain during heat stress wearing a ballistic vest.

    abstract：:The present study was conducted in order to evaluate whether physiological strain is alleviated by a new personal cooling system (CS) consisting of a layered vest and integrated blower that generate a flow of air. Twelve male volunteers were exposed to climatic conditions of 40 degrees C, 40%RH (40/40), and 35 degrees...

    journal_title：European journal of applied physiology

    pub_type： 杂志文章

    doi：10.1007/s00421-008-0716-8

    authors： Hadid A,Yanovich R,Erlich T,Khomenok G,Moran DS

    更新日期：2008-09-01 00:00:00

  • The influences of muscle fibre proportions and areas upon EMG during maximal dynamic knee extensions.

    abstract：:This study is an investigation of the relationship between muscle morphology and surface electromyographic (EMG) parameters [mean frequency of the power spectrum (MNF), signal amplitude (root mean square, RMS) and the signal amplitude ratio (SAR; i.e. the ratio between the RMS level during the passive part of the cont...

    journal_title：European journal of applied physiology

    pub_type： 杂志文章

    doi：10.1007/PL00013792

    authors： Gerdle B,Karlsson S,Crenshaw AG,Elert J,Fridén J

    更新日期：2000-01-01 00:00:00

  • The effect of load carriage on movement kinematics and respiratory parameters in children during walking.

    abstract：:The objective of this study was to investigate the influence of different backpack weights on trunk kinematics and respiratory parameters during walking in 10-year-old children. Fifteen boys with a mean age of 10.31 (0.26) years were selected from a primary school to participate in four walking trials on a treadmill: ...

    journal_title：European journal of applied physiology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/s00421-003-0848-9

    authors： Li JX,Hong Y,Robinson PD

    更新日期：2003-09-01 00:00:00

  • Combined cycle and run performance is maximised when the cycle is completed at the highest sustainable intensity.

    abstract：:The aim of this study was to determine the effect of cycle intensity on subsequent running performance and combined cycle-run (CR) performance. Seven triathletes undertook a cycling graded exercise test to exhaustion, an isolated 500-kJ cycle time trial (CTT) and an isolated 5-km running time trial. Then they performe...

    journal_title：European journal of applied physiology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s00421-010-1547-y

    authors： Suriano R,Bishop D

    更新日期：2010-11-01 00:00:00

  • The effects of exercise-induced muscle damage on maximal intensity intermittent exercise performance.

    abstract：:Exercise-induced muscle damage (EIMD) is a common occurrence following activities with a high eccentric component. Alterations to the torque-velocity relationship following EIMD would appear to have serious implications for athletic performance, particularly as they relate to impairment of maximal intensity exercise. ...

    journal_title：European journal of applied physiology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s00421-005-1357-9

    authors： Twist C,Eston R

    更新日期：2005-08-01 00:00:00

  • Quality control of open-circuit respirometry: real-time, laboratory-based systems. Let's spread "good practice".

    abstract：: ...

    journal_title：European journal of applied physiology

    pub_type： 评论,信件

    doi：10.1007/s00421-018-3990-0

    authors： Garcia-Tabar I,Eclache JP,Aramendi JF,Gorostiaga EM

    更新日期：2018-12-01 00:00:00

  • Age differences in physiological responses to self-paced and incremental [Formula: see text] testing.

    abstract：PURPOSE:A self-paced maximal exercise protocol has demonstrated higher [Formula: see text] values when compared against traditional tests. The aim was to compare physiological responses to this self-paced [Formula: see text] protocol (SPV) in comparison to a traditional ramp [Formula: see text] (RAMP) protocol in young...

    journal_title：European journal of applied physiology

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00421-016-3508-6

    authors： Jenkins LA,Mauger AR,Hopker JG

    更新日期：2017-01-01 00:00:00

  • A combination of oral L-citrulline and L-arginine improved 10-min full-power cycling test performance in male collegiate soccer players: a randomized crossover trial.

    abstract：PURPOSE:Oral L-citrulline (Cit) increases plasma L-arginine (Arg) concentration and the production of nitric oxide (NO). NO dilates blood vessels and potentially improves sports performance. The combination of oral Arg and Cit (Arg + Cit) immediately and synergistically increases plasma Arg and nitrite/nitrate (NOx) co...

    journal_title：European journal of applied physiology

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00421-019-04097-7

    authors： Suzuki I,Sakuraba K,Horiike T,Kishi T,Yabe J,Suzuki T,Morita M,Nishimura A,Suzuki Y

    更新日期：2019-05-01 00:00:00

  • Independent or simultaneous lowering of core and skin temperature has no impact on self-paced intermittent running performance in hot conditions.

    abstract：PURPOSE:To investigate the effects of lowering core (Tgi) and mean skin temperature (Tsk) concomitantly and independently on self-paced intermittent running in the heat. METHODS:10 males (30.5 ± 5.8 years, 73.2 ± 14.5 kg, 176.9 ± 8.0 cm, 56.2 ± 6.6 ml/kg/min) completed four randomised 46-min self-paced intermittent pr...

    journal_title：European journal of applied physiology

    pub_type： 杂志文章

    doi：10.1007/s00421-019-04173-y

    authors： Thomas G,Cullen T,Davies M,Hetherton C,Duncan B,Gerrett N

    更新日期：2019-08-01 00:00:00

  • Physiological and psychological reactions to work in men and women with identical job tasks.

    abstract：:Differences in physiological functioning in the hypothalamus-pituitary-adrenal cortex axis and the autonomic nervous system have been suggested to contribute to many of the health differences that may be observed between men and women as well as being relevant for the development of musculoskeletal pain. To clarify wh...

    journal_title：European journal of applied physiology

    pub_type： 杂志文章

    doi：10.1007/s00421-008-0939-8

    authors： Persson R,Hansen AM,Ohlsson K,Balogh I,Nordander C,Orbaek P

    更新日期：2009-03-01 00:00:00

  • Differences in metabolic and inflammatory responses in lower and upper body high-intensity intermittent exercise.

    abstract：PURPOSE:The purpose of this study was to compare the effect of upper and lower body high-intensity intermittent exercise (HIIE) on immunometabolism profile. METHODS:Seven male judo athletes completed two experimental sessions separated by at least 48 h. The athletes completed four bouts of the upper and lower body Win...

    journal_title：European journal of applied physiology

    pub_type： 杂志文章

    doi：10.1007/s00421-015-3127-7

    authors： Lira FS,Panissa VL,Julio UF,Franchini E

    更新日期：2015-07-01 00:00:00

  • The effect of 4-week training period on plasma neuropeptide Y, leptin and ghrelin responses in male rowers.

    abstract：:The aim was to investigate the effect of high-volume low intensity resistance training protocol combined with endurance training on plasma neuropeptide Y (NPY) concentration in rowers. Additionally, leptin and ghrelin, as markers for body energy balance concentrations, were monitored. 12 highly trained national and in...

    journal_title：European journal of applied physiology

    pub_type： 杂志文章

    doi：10.1007/s00421-011-2166-y

    authors： Rämson R,Jürimäe J,Jürimäe T,Mäestu J

    更新日期：2012-05-01 00:00:00

  • The acute effect of Quercetin on muscle performance following a single resistance training session.

    abstract：PURPOSE:To examine the effect of acute quercetin (Q) ingestion on neuromuscular function, biomarkers of muscle damage, and rate of perceived exertion (RPE) in response to an acute bout of resistance training. METHODS:10 young men (22.1 ± 1.8 years, 24.1 ± 3.1 BMI) participated in a randomized, double-blind, crossover ...

    journal_title：European journal of applied physiology

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00421-018-3834-y

    authors： Patrizio F,Ditroilo M,Felici F,Duranti G,De Vito G,Sabatini S,Sacchetti M,Bazzucchi I

    更新日期：2018-05-01 00:00:00

  • Validity and reliability of three commercially available breath-by-breath respiratory systems.

    abstract：:Information concerning the validity and reliability of commercial on-line gas analysis systems is limited. The aim of this study was to provide a comparison of the validity and reliability of three on-line systems (Oxycon Alpha, Oxycon Pro and Pulmolab EX670) with that of Douglas bags. Two separate studies were conduc...

    journal_title：European journal of applied physiology

    pub_type： 杂志文章

    doi：10.1007/s00421-001-0572-2

    authors： Carter J,Jeukendrup AE

    更新日期：2002-03-01 00:00:00

  • The effect of strength training on the apparent inhibition of eccentric force production in voluntarily activated human quadriceps.

    abstract：:Ten male and ten female young adults trained the knee extensors of one leg eccentrically and those of the other concentrically for 6 weeks, using a gymnasium leg-extension machine. Before and after training, both legs of each subject were tested isometrically for maximum voluntary knee-extensor force, and in both ecce...

    journal_title：European journal of applied physiology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s004210000221

    authors： Spurway NC,Watson H,McMillan K,Connolly G

    更新日期：2000-08-01 00:00:00

  • Hemodynamic adjustments during breath-holding in trained divers.

    abstract：PURPOSE:Voluntary breath-holding (BH) elicits several hemodynamic changes, but little is known about maximal static immersed-body BH. We hypothesized that the diving reflex would be strengthened with body immersion and would spare more oxygen than maximal dry static BH, resulting in a longer BH duration. METHODS:Eleve...

    journal_title：European journal of applied physiology

    pub_type： 杂志文章

    doi：10.1007/s00421-013-2690-z

    authors： Costalat G,Coquart J,Castres I,Tourny C,Lemaitre F

    更新日期：2013-10-01 00:00:00

  • The effect of exhaustive exercise on the choice of technique and physiological response in classical roller skiing.

    abstract：PURPOSE:The aim of this study was to investigate the effect of exhaustive exercise on technique preference and the accompanying physiological response during classic skiing at constant workload, but with varying incline-speed combinations. METHODS:Seven male competitive cross-country skiers performed four tests, each ...

    journal_title：European journal of applied physiology

    pub_type： 杂志文章

    doi：10.1007/s00421-018-3965-1

    authors： Ettema G,Øksnes M,Kveli E,Sandbakk Ø

    更新日期：2018-11-01 00:00:00

  • Sprint running: from fundamental mechanics to practice-a review.

    abstract：:In this review, we examine the literature in light of the mechanical principles that govern linear accelerated running. While the scientific literature concerning sprint mechanics is comprehensive, these principles of fundamental mechanics present some pitfalls which can (and does) lead to misinterpretations of findin...

    journal_title：European journal of applied physiology

    pub_type： 杂志文章,评审

    doi：10.1007/s00421-019-04139-0

    authors： Haugen T,McGhie D,Ettema G

    更新日期：2019-06-01 00:00:00

  • A low carbohydrate diet affects autonomic modulation during heavy but not moderate exercise.

    abstract：:The aim of this study was to examine the effects of low carbohydrate (CHO) availability on heart rate variability (HRV) responses during moderate and severe exercise intensities until exhaustion. Six healthy males (age, 26.5 +/- 6.7 years; body mass, 78.4 +/- 7.7 kg; body fat %, 11.3 +/- 4.5%; V(O)(2)(max) 39.5 +/- 6....

    journal_title：European journal of applied physiology

    pub_type： 杂志文章

    doi：10.1007/s00421-009-1329-6

    authors： Lima-Silva AE,Bertuzzi RC,Pires FO,Fronchetti L,Gevaerd MS,De-Oliveira FR

    更新日期：2010-04-01 00:00:00

  • Acute effects of continuous and interval low-intensity exercise on arterial stiffness in healthy young men.

    abstract：PURPOSE:To examine and compare systemic arterial stiffness responses in humans to acute continuous and interval low-intensity exercise. METHODS:Fifteen healthy young men (21.2 ± 0.4 years) underwent non-exercise control (CON), continuous exercise (CE), and interval exercise trial (IE) in a randomized balanced self-con...

    journal_title：European journal of applied physiology

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00421-014-2869-y

    authors： Wang H,Zhang T,Zhu W,Wu H,Yan S

    更新日期：2014-01-01 00:00:00