Abstract：
:Highly trained athletes are associated with high resting antigen-stimulated whole blood culture interleukin (IL)-10 production. The purpose of the present study was to examine the effects of training status on resting circulating T regulatory (Treg) cell counts and antigen-stimulated IL-10 production and the effect of acute bout of exercise on the Treg response. Forty participants volunteered to participate and were assigned to one of the four groups: sedentary (SED), recreationally active (REC), sprint-trained athletes and endurance-trained athletes (END). From the resting blood sample, CD4(+)CD25(+)CD127(low/-) Treg cells and in vitro antigen-stimulated IL-10 production were assessed. Ten REC subjects performed 60 min cycling at 70 % of maximal oxygen uptake and blood samples for Treg analysis were collected post- and 1 h post-exercise. IL-10 production was greater in END compared with the other groups (P < 0.05). END had a higher Treg percentage of total lymphocyte count compared with SED (P < 0.05). A smaller proportion of Treg CD4(+) cells were observed in SED compared with all other groups (P < 0.05). IL-10 production significantly correlated with the proportion of Tregs within the total lymphocyte population (r s = 0.51, P = 0.001). No effect of acute exercise was evident for Treg cell counts in the REC subjects (P > 0.05). Our results demonstrate that high training loads in END are associated with greater resting IL-10 production and Treg cell count and suggest a possible mechanism for depression of immunity commonly reported in athletes engaged in high training loads.
journal_name
Eur J Appl Physioljournal_title
European journal of applied physiologyauthors
Handzlik MK,Shaw AJ,Dungey M,Bishop NC,Gleeson Mdoi
10.1007/s00421-013-2614-ysubject
Has Abstractpub_date
2013-07-01 00:00:00pages
1839-48issue
7eissn
1439-6319issn
1439-6327journal_volume
113pub_type
杂志文章abstract：:Acute physical exercise may affect cardiac autonomic modulation hours or even days during the recovery phase. Although sleep is an essential recovery period, the information on nocturnal autonomic modulation indicated by heart rate variability (HRV) after different exercises is mostly lacking. Therefore, this study in...
journal_title：European journal of applied physiology
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journal_title：European journal of applied physiology
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journal_title：European journal of applied physiology
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：European journal of applied physiology
pub_type： 杂志文章
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journal_title：European journal of applied physiology
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journal_title：European journal of applied physiology
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journal_title：European journal of applied physiology
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journal_title：European journal of applied physiology
pub_type： 临床试验,杂志文章
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journal_title：European journal of applied physiology
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：European journal of applied physiology
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更新日期：2008-10-01 00:00:00
