Abstract:
PURPOSE:We investigated the effect of the racemic β-hydroxybutyrate precursor, R,S-1,3-butanediol (BD), on T-cell-related cytokine gene expression within stimulated peripheral blood mononuclear cells (PBMC) following prolonged, strenuous exercise. METHODS:A repeated-measures, randomised, crossover study was conducted in nine healthy, trained male cyclists (age, 26.7 ± 5.2 years; VO2peak, 63.9 ± 2.5 mL kg-1 min-1). Participants ingested 0.35 g kg-1 of BD or placebo 30 min before and 60 min during 85 min of steady-state (SS) exercise, which preceded a ~ 30 min time-trial (TT) (7 kJ kg-1). Blood samples were collected at pre-supplement, pre-exercise, post-SS, post-TT and 1-h post-TT. Whole blood cultures were stimulated with Staphylococcal enterotoxin B (SEB) for 24 h to determine T-cell-related interleukin (IL)-4, IL-10 and interferon (IFN)-γ mRNA expression within isolated PBMCs in vitro. RESULTS:Serum cortisol, total circulating leukocyte and lymphocyte, and T-cell subset concentrations were similar between trials during exercise and recovery (all p > 0.05). BD ingestion increased T-cell-related IFN-γ mRNA expression compared with placebo throughout exercise and recovery (p = 0.011); however, IL-4 and IL-10 mRNA expression and the IFN-γ/IL-4 mRNA expression ratio were unaltered (all p > 0.05). CONCLUSION:Acute hyperketonaemia appears to transiently amplify the initiation of the pro-inflammatory T-cell-related IFN-γ response to an immune challenge in vitro during and following prolonged, strenuous exercise; suggesting enhanced type-1 T-cell immunity at the gene level.
journal_name
Eur J Appl Physioljournal_title
European journal of applied physiologyauthors
Shaw DM,Merien F,Braakhuis A,Keaney L,Dulson DKdoi
10.1007/s00421-019-04263-xsubject
Has Abstractpub_date
2020-01-01 00:00:00pages
191-202issue
1eissn
1439-6319issn
1439-6327pii
10.1007/s00421-019-04263-xjournal_volume
120pub_type
杂志文章,随机对照试验abstract::The aim of this study was to examine the effects of low carbohydrate (CHO) availability on heart rate variability (HRV) responses during moderate and severe exercise intensities until exhaustion. Six healthy males (age, 26.5 +/- 6.7 years; body mass, 78.4 +/- 7.7 kg; body fat %, 11.3 +/- 4.5%; V(O)(2)(max) 39.5 +/- 6....
journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-009-1329-6
更新日期:2010-04-01 00:00:00
abstract::To test whether adding insulation to the arms would improve cold water swimming performance by delaying swimming failure (SF). Novice (n = 7) and expert (n = 8) swimmers, clothed and equipped with a personal flotation device, each performed two trials in a swimming flume filled with 10 degrees C water. During free swi...
journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-008-0690-1
更新日期:2008-09-01 00:00:00
abstract:PURPOSE:The aim of this study is to describe the effects of speed and gradient during uphill ski mountaineering on energy expenditure, to relate any changes to changes in stride characteristics, and to determine an optimal gradient and speed allowing minimization of energy expenditure. METHODS:11 subjects were tested ...
journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-016-3455-2
更新日期:2016-10-01 00:00:00
abstract::This study tested the hypothesis that, as compared to whole-body bioelectrical impedance (BI) analysis, segmental BI analysis can estimate lean body mass (LBM) more accurately in a population with a large difference in muscularity. In addition to whole-body BI, which determines impedance (Z) between the wrist and ankl...
journal_title:European journal of applied physiology
pub_type: 临床试验,杂志文章
doi:10.1007/s00421-004-1259-2
更新日期:2005-05-01 00:00:00
abstract:PURPOSE:Polyphenolic curcumin is known to have potent anti-inflammatory effects; thus the present study investigated the hypothesis that curcumin ingestion would attenuate muscle damage after eccentric exercise. METHODS:Fourteen untrained young men (24 ± 1 years) performed 50 maximal isokinetic (120°/s) eccentric cont...
journal_title:European journal of applied physiology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00421-015-3170-4
更新日期:2015-09-01 00:00:00
abstract::Though conventional wisdom suggests that a rise in blood pressure is a reality of advancing age, in fact, it appears that progressive elevation in sympathetic activity, not necessarily accompanied by increased blood pressure, is intrinsic to cardiovascular aging in humans. The mechanism behind this elevation would see...
journal_title:European journal of applied physiology
pub_type: 杂志文章,评审
doi:10.1007/s00421-013-2731-7
更新日期:2014-03-01 00:00:00
abstract::For over two centuries, scientists have measured gas exchange in animals and humans and linked this to energy expenditure of the body. The aim of this review is to provide a comprehensive overview of open-circuit diluted flow indirect calorimetry and to help researchers to make the optimal choice for a certain system ...
journal_title:European journal of applied physiology
pub_type: 历史文章,杂志文章,评审
doi:10.1007/s00421-017-3735-5
更新日期:2018-01-01 00:00:00
abstract:PURPOSE:In cross-country sit-skiing (XCSS), athletes with reduced trunk control predominantly sit with the knees higher than the hips (KH); a position often associated with large spinal flexion. Therefore, to improve spinal curvature a new sledge with frontal trunk support, where knees are lower than hips (KL) was crea...
journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-017-3596-y
更新日期:2017-06-01 00:00:00
abstract::The objective of the present study was to relate changes in certain muscle characteristics and indicators of metabolism in response to endurance training to the concomitant changes in time to exhaustion (T(lim)) at a work rate corresponding to maximal oxygen uptake VO(2speak). Eight healthy sedentary subjects pedalled...
journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-005-1325-4
更新日期:2005-07-01 00:00:00
abstract::To clarify whether the resting background effects (genomic) or exercise-related action (non-genomic) of aldosterone (ALD) is primarily affected to an individual variation in the sweat Na+ concentration ([Na+]sweat), we analyzed the cross-sectional relationship between [Na+]sweat and the plasma ALD concentration during...
journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-006-0295-5
更新日期:2006-11-01 00:00:00
abstract::The aim of the present study was to determine whether glutamine ingestion, which has been shown to enhance the exercise-induced increase in the tricarboxylic acid intermediate (TCAi) pool size, resulted in augmentation of the rate of increase in oxidative metabolism at the onset of exercise. In addition, the potential...
journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-006-0324-4
更新日期:2007-01-01 00:00:00
abstract::Local muscle fatigue can originate from both peripheral and central factors. The relative contribution of these factors in the course of a fatiguing contraction in 20 healthy subjects was determined. While subjects made a 2-min sustained maximal voluntary contraction (MVC) of the biceps brachii, muscle fibre conductio...
journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-003-0913-4
更新日期:2003-11-01 00:00:00
abstract::We measured diffusing capacity (DLCO), alveolar membrane properties (D (m)), capillary lung volume (V (c)), and alveolar volume (V (A) ) in 20 healthy subjects (12 males; age 32.4 +/- 13 (SD); BMI 21.7 +/- 3; non smokers) at total lung capacity (TLC) and at approximately 80, 60, and 40% TLC. In all subjects, D (m) inc...
journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-007-0625-2
更新日期:2008-03-01 00:00:00
abstract::Previous research is conflicting concerning the minimum time duration needed to elicit a growth hormone (GH) response to aerobic exercise; thus, the purpose of this project was to examine the effects of mode and duration on exercise-induced GH responses in young women taking oral contraceptives. Nine healthy young fem...
journal_title:European journal of applied physiology
pub_type: 临床试验,杂志文章
doi:10.1007/s00421-003-0863-x
更新日期:2003-09-01 00:00:00
abstract:PURPOSE:This study investigated the isolated and combined effects of heat [temperate (22 °C/30 % rH) vs. hot (35 °C/40 % rH)] and hypoxia [sea level (FiO2 0.21) vs. moderate altitude (FiO2 0.15)] on exercise capacity and neuromuscular fatigue characteristics. METHODS:Eleven physically active subjects cycled to exhaust...
journal_title:European journal of applied physiology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00421-014-2883-0
更新日期:2014-01-01 00:00:00
abstract:PURPOSES:To investigate longitudinally (1) the contribution of morphological covariates to explaining the development of maximum cardiac output ([Formula: see text] max) and maximum arteriovenous oxygen difference (a-vO2 diff max), (2) sex differences in [Formula: see text] max and a-vO2 diff max once age, maturity sta...
journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-020-04300-0
更新日期:2020-02-01 00:00:00
abstract::When muscle is artificially activated, as with electromyostimulation (EMS), action potentials are evoked in both intramuscular nerve branches and cutaneous receptors, therefore activating spinal motoneurons reflexively. Maximal soleus and gastrocnemii H- and T-reflex and the respective mechanical output were thus quan...
journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-003-0914-3
更新日期:2003-11-01 00:00:00
abstract:PURPOSE:Our purpose was to compare supramaximal versus submaximal intensity eccentric training performed until volitional fatigue. METHODS:Thirty-two young adults (19 males) were randomized into one of three groups: (1) ECC110 performed eccentric (ECC) only contractions at 110% of concentric (CON) 1-repetition maximum...
journal_title:European journal of applied physiology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00421-017-3700-3
更新日期:2017-10-01 00:00:00
abstract::Adaptations to chronic hypoxia involve changes in membrane transport proteins. The underlying mechanism of this response may be related to concomitant occurring changes in erythropoietin (Epo) levels. We therefore tested the direct effects of recombinant human erythropoietin (rHuEpo) treatment on the expression of mus...
journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-007-0567-8
更新日期:2007-12-01 00:00:00
abstract::The purpose of the present study was to investigate the electromyography (EMG) to torque relationship of the vastus intermedius (VI) muscle. Thirteen healthy men performed maximal voluntary contraction (MVC) and submaximal contraction during isometric knee extension at 10% of the MVC to 90% of the MVC at intervals of ...
journal_title:European journal of applied physiology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00421-009-1064-z
更新日期:2009-07-01 00:00:00
abstract:PURPOSE:Sarcopenia can begin from the 4-5th decade of life and is exacerbated by obesity and inactivity. A combination of resistance exercise (RE) and endurance exercise is recommended to combat rising obesity and inactivity levels. However, work continues to elucidate whether interference in adaptive outcomes occur wh...
journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-017-3721-y
更新日期:2018-02-01 00:00:00
abstract::Changes of the normal gravitational acceleration are known to affect sensorimotor performance. For example, subjects exposed to three times the normal terrestrial acceleration (+3 Gz) in a centrifuge will produce exaggerated isometric force. The present study compares the effects of high-Gz to that of micro-Gz on isom...
journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-007-0591-8
更新日期:2008-02-01 00:00:00
abstract:PURPOSE:We tested the hypothesis that monoexponential regressions will increase the certainty in response estimates and confidence in classification of cardiorespiratory fitness (CRF) responses compared to a recently proposed linear regression approach. METHODS:We used data from a previously published RCT that involve...
journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-019-04078-w
更新日期:2019-04-01 00:00:00
abstract:PURPOSE:Standing workstations have recently been promoted as a healthy alternative to sitting. However, it is unknown how prolonged standing affects arterial stiffness, a prognostic indicator of cardiovascular health. The purpose of this study was twofold: to observe changes in arterial stiffness, as assessed by pulse ...
journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-018-3956-2
更新日期:2018-10-01 00:00:00
abstract::The objective of this study was to investigate the influence of different backpack weights on trunk kinematics and respiratory parameters during walking in 10-year-old children. Fifteen boys with a mean age of 10.31 (0.26) years were selected from a primary school to participate in four walking trials on a treadmill: ...
journal_title:European journal of applied physiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00421-003-0848-9
更新日期:2003-09-01 00:00:00
abstract::The purpose of this study was to examine the effect of exercise and pre-exercise dietary manipulation on hepatic triglyceride concentration (HTGC). HTGC was measured by proton magnetic resonance spectroscopy ((1)H-MRS) before and after 90 min of moderate intensity cycling in six endurance trained males following 67 h ...
journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-011-2158-y
更新日期:2012-05-01 00:00:00
abstract:PURPOSE:Oral L-citrulline (Cit) increases plasma L-arginine (Arg) concentration and the production of nitric oxide (NO). NO dilates blood vessels and potentially improves sports performance. The combination of oral Arg and Cit (Arg + Cit) immediately and synergistically increases plasma Arg and nitrite/nitrate (NOx) co...
journal_title:European journal of applied physiology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00421-019-04097-7
更新日期:2019-05-01 00:00:00
abstract:PURPOSE:The aim of the study was to examine the effects of a post-prandial 20 min nap on a short-term physical exercise and subsequent sleep in athletes keeping their usual sleep schedules and in 5-h phase-advance condition. METHODS:Sixteen healthy young male athletes (age 22.2 ± 1.7 years, non-habitual nappers) parti...
journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-013-2776-7
更新日期:2014-02-01 00:00:00
abstract:PURPOSE:The purpose of this study was to compare the effects of squat training with different depths on lower limb muscle volumes. METHODS:Seventeen males were randomly assigned to a full squat training group (FST, n = 8) or half squat training group (HST, n = 9). They completed 10 weeks (2 days per week) of squat tra...
journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-019-04181-y
更新日期:2019-09-01 00:00:00
abstract::Free radical production and high catecholamine levels are implicated in the modulation of Na(+), K(+)-ATPase, and Mg(2+)-ATPase activities. The aim of this study was to investigate the effect of the mode of delivery on the above-mentioned enzyme activities in maternal-neonatal erythrocyte membrane. Women with normal p...
journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-008-0744-4
更新日期:2008-07-01 00:00:00