Acute hyperketonaemia alters T-cell-related cytokine gene expression within stimulated peripheral blood mononuclear cells following prolonged exercise.

Abstract:

PURPOSE:We investigated the effect of the racemic β-hydroxybutyrate precursor, R,S-1,3-butanediol (BD), on T-cell-related cytokine gene expression within stimulated peripheral blood mononuclear cells (PBMC) following prolonged, strenuous exercise. METHODS:A repeated-measures, randomised, crossover study was conducted in nine healthy, trained male cyclists (age, 26.7 ± 5.2 years; VO2peak, 63.9 ± 2.5 mL kg-1 min-1). Participants ingested 0.35 g kg-1 of BD or placebo 30 min before and 60 min during 85 min of steady-state (SS) exercise, which preceded a ~ 30 min time-trial (TT) (7 kJ kg-1). Blood samples were collected at pre-supplement, pre-exercise, post-SS, post-TT and 1-h post-TT. Whole blood cultures were stimulated with Staphylococcal enterotoxin B (SEB) for 24 h to determine T-cell-related interleukin (IL)-4, IL-10 and interferon (IFN)-γ mRNA expression within isolated PBMCs in vitro. RESULTS:Serum cortisol, total circulating leukocyte and lymphocyte, and T-cell subset concentrations were similar between trials during exercise and recovery (all p > 0.05). BD ingestion increased T-cell-related IFN-γ mRNA expression compared with placebo throughout exercise and recovery (p = 0.011); however, IL-4 and IL-10 mRNA expression and the IFN-γ/IL-4 mRNA expression ratio were unaltered (all p > 0.05). CONCLUSION:Acute hyperketonaemia appears to transiently amplify the initiation of the pro-inflammatory T-cell-related IFN-γ response to an immune challenge in vitro during and following prolonged, strenuous exercise; suggesting enhanced type-1 T-cell immunity at the gene level.

journal_name

Eur J Appl Physiol

authors

Shaw DM,Merien F,Braakhuis A,Keaney L,Dulson DK

doi

10.1007/s00421-019-04263-x

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

191-202

issue

1

eissn

1439-6319

issn

1439-6327

pii

10.1007/s00421-019-04263-x

journal_volume

120

pub_type

杂志文章,随机对照试验
  • A low carbohydrate diet affects autonomic modulation during heavy but not moderate exercise.

    abstract::The aim of this study was to examine the effects of low carbohydrate (CHO) availability on heart rate variability (HRV) responses during moderate and severe exercise intensities until exhaustion. Six healthy males (age, 26.5 +/- 6.7 years; body mass, 78.4 +/- 7.7 kg; body fat %, 11.3 +/- 4.5%; V(O)(2)(max) 39.5 +/- 6....

    journal_title:European journal of applied physiology

    pub_type: 杂志文章

    doi:10.1007/s00421-009-1329-6

    authors: Lima-Silva AE,Bertuzzi RC,Pires FO,Fronchetti L,Gevaerd MS,De-Oliveira FR

    更新日期:2010-04-01 00:00:00

  • Arm insulation and swimming in cold water.

    abstract::To test whether adding insulation to the arms would improve cold water swimming performance by delaying swimming failure (SF). Novice (n = 7) and expert (n = 8) swimmers, clothed and equipped with a personal flotation device, each performed two trials in a swimming flume filled with 10 degrees C water. During free swi...

    journal_title:European journal of applied physiology

    pub_type: 杂志文章

    doi:10.1007/s00421-008-0690-1

    authors: Lounsbury DS,Ducharme MB

    更新日期:2008-09-01 00:00:00

  • Optimal slopes and speeds in uphill ski mountaineering: a field study.

    abstract:PURPOSE:The aim of this study is to describe the effects of speed and gradient during uphill ski mountaineering on energy expenditure, to relate any changes to changes in stride characteristics, and to determine an optimal gradient and speed allowing minimization of energy expenditure. METHODS:11 subjects were tested ...

    journal_title:European journal of applied physiology

    pub_type: 杂志文章

    doi:10.1007/s00421-016-3455-2

    authors: Praz C,Fasel B,Vuistiner P,Aminian K,Kayser B

    更新日期:2016-10-01 00:00:00

  • A comparison of three bioelectrical impedance analyses for predicting lean body mass in a population with a large difference in muscularity.

    abstract::This study tested the hypothesis that, as compared to whole-body bioelectrical impedance (BI) analysis, segmental BI analysis can estimate lean body mass (LBM) more accurately in a population with a large difference in muscularity. In addition to whole-body BI, which determines impedance (Z) between the wrist and ankl...

    journal_title:European journal of applied physiology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00421-004-1259-2

    authors: Ishiguro N,Kanehisa H,Miyatani M,Masuo Y,Fukunaga T

    更新日期:2005-05-01 00:00:00

  • Attenuation of indirect markers of eccentric exercise-induced muscle damage by curcumin.

    abstract:PURPOSE:Polyphenolic curcumin is known to have potent anti-inflammatory effects; thus the present study investigated the hypothesis that curcumin ingestion would attenuate muscle damage after eccentric exercise. METHODS:Fourteen untrained young men (24 ± 1 years) performed 50 maximal isokinetic (120°/s) eccentric cont...

    journal_title:European journal of applied physiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00421-015-3170-4

    authors: Tanabe Y,Maeda S,Akazawa N,Zempo-Miyaki A,Choi Y,Ra SG,Imaizumi A,Otsuka Y,Nosaka K

    更新日期:2015-09-01 00:00:00

  • BP regulation VI: elevated sympathetic outflow with human aging: hypertensive or homeostatic?

    abstract::Though conventional wisdom suggests that a rise in blood pressure is a reality of advancing age, in fact, it appears that progressive elevation in sympathetic activity, not necessarily accompanied by increased blood pressure, is intrinsic to cardiovascular aging in humans. The mechanism behind this elevation would see...

    journal_title:European journal of applied physiology

    pub_type: 杂志文章,评审

    doi:10.1007/s00421-013-2731-7

    authors: Taylor JA,Tan CO

    更新日期:2014-03-01 00:00:00

  • Classical experiments in whole-body metabolism: open-circuit respirometry-diluted flow chamber, hood, or facemask systems.

    abstract::For over two centuries, scientists have measured gas exchange in animals and humans and linked this to energy expenditure of the body. The aim of this review is to provide a comprehensive overview of open-circuit diluted flow indirect calorimetry and to help researchers to make the optimal choice for a certain system ...

    journal_title:European journal of applied physiology

    pub_type: 历史文章,杂志文章,评审

    doi:10.1007/s00421-017-3735-5

    authors: Schoffelen PFM,Plasqui G

    更新日期:2018-01-01 00:00:00

  • Sitting position affects performance in cross-country sit-skiing.

    abstract:PURPOSE:In cross-country sit-skiing (XCSS), athletes with reduced trunk control predominantly sit with the knees higher than the hips (KH); a position often associated with large spinal flexion. Therefore, to improve spinal curvature a new sledge with frontal trunk support, where knees are lower than hips (KL) was crea...

    journal_title:European journal of applied physiology

    pub_type: 杂志文章

    doi:10.1007/s00421-017-3596-y

    authors: Lund Ohlsson M,Laaksonen MS

    更新日期:2017-06-01 00:00:00

  • Are the effects of training on fat metabolism involved in the improvement of performance during high-intensity exercise?

    abstract::The objective of the present study was to relate changes in certain muscle characteristics and indicators of metabolism in response to endurance training to the concomitant changes in time to exhaustion (T(lim)) at a work rate corresponding to maximal oxygen uptake VO(2speak). Eight healthy sedentary subjects pedalled...

    journal_title:European journal of applied physiology

    pub_type: 杂志文章

    doi:10.1007/s00421-005-1325-4

    authors: Messonnier L,Denis C,Prieur F,Lacour JR

    更新日期:2005-07-01 00:00:00

  • Genomic and non-genomic effects of aldosterone on the individual variation of the sweat Na+ concentration during exercise in trained athletes.

    abstract::To clarify whether the resting background effects (genomic) or exercise-related action (non-genomic) of aldosterone (ALD) is primarily affected to an individual variation in the sweat Na+ concentration ([Na+]sweat), we analyzed the cross-sectional relationship between [Na+]sweat and the plasma ALD concentration during...

    journal_title:European journal of applied physiology

    pub_type: 杂志文章

    doi:10.1007/s00421-006-0295-5

    authors: Yoshida T,Shin-ya H,Nakai S,Yorimoto A,Morimoto T,Suyama T,Sakurai M

    更新日期:2006-11-01 00:00:00

  • Effects of glutamine and hyperoxia on pulmonary oxygen uptake and muscle deoxygenation kinetics.

    abstract::The aim of the present study was to determine whether glutamine ingestion, which has been shown to enhance the exercise-induced increase in the tricarboxylic acid intermediate (TCAi) pool size, resulted in augmentation of the rate of increase in oxidative metabolism at the onset of exercise. In addition, the potential...

    journal_title:European journal of applied physiology

    pub_type: 杂志文章

    doi:10.1007/s00421-006-0324-4

    authors: Marwood S,Bowtell JL

    更新日期:2007-01-01 00:00:00

  • Relative contributions of central and peripheral factors to fatigue during a maximal sustained effort.

    abstract::Local muscle fatigue can originate from both peripheral and central factors. The relative contribution of these factors in the course of a fatiguing contraction in 20 healthy subjects was determined. While subjects made a 2-min sustained maximal voluntary contraction (MVC) of the biceps brachii, muscle fibre conductio...

    journal_title:European journal of applied physiology

    pub_type: 杂志文章

    doi:10.1007/s00421-003-0913-4

    authors: Schillings ML,Hoefsloot W,Stegeman DF,Zwarts MJ

    更新日期:2003-11-01 00:00:00

  • Mechanisms behind inter-individual differences in lung diffusing capacity.

    abstract::We measured diffusing capacity (DLCO), alveolar membrane properties (D (m)), capillary lung volume (V (c)), and alveolar volume (V (A) ) in 20 healthy subjects (12 males; age 32.4 +/- 13 (SD); BMI 21.7 +/- 3; non smokers) at total lung capacity (TLC) and at approximately 80, 60, and 40% TLC. In all subjects, D (m) inc...

    journal_title:European journal of applied physiology

    pub_type: 杂志文章

    doi:10.1007/s00421-007-0625-2

    authors: Miserocchi G,Messinesi G,Tana F,Passoni E,Adamo S,Romano R,Beretta E

    更新日期:2008-03-01 00:00:00

  • The effect of exercise duration and mode on the growth hormone responses in young women on oral contraceptives.

    abstract::Previous research is conflicting concerning the minimum time duration needed to elicit a growth hormone (GH) response to aerobic exercise; thus, the purpose of this project was to examine the effects of mode and duration on exercise-induced GH responses in young women taking oral contraceptives. Nine healthy young fem...

    journal_title:European journal of applied physiology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00421-003-0863-x

    authors: Sauro LM,Kanaley JA

    更新日期:2003-09-01 00:00:00

  • Combining heat stress and moderate hypoxia reduces cycling time to exhaustion without modifying neuromuscular fatigue characteristics.

    abstract:PURPOSE:This study investigated the isolated and combined effects of heat [temperate (22 °C/30 % rH) vs. hot (35 °C/40 % rH)] and hypoxia [sea level (FiO2 0.21) vs. moderate altitude (FiO2 0.15)] on exercise capacity and neuromuscular fatigue characteristics. METHODS:Eleven physically active subjects cycled to exhaust...

    journal_title:European journal of applied physiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00421-014-2883-0

    authors: Girard O,Racinais S

    更新日期:2014-01-01 00:00:00

  • Multilevel allometric modelling of maximum cardiac output, maximum arteriovenous oxygen difference, and peak oxygen uptake in 11-13-year-olds.

    abstract:PURPOSES:To investigate longitudinally (1) the contribution of morphological covariates to explaining the development of maximum cardiac output ([Formula: see text] max) and maximum arteriovenous oxygen difference (a-vO2 diff max), (2) sex differences in [Formula: see text] max and a-vO2 diff max once age, maturity sta...

    journal_title:European journal of applied physiology

    pub_type: 杂志文章

    doi:10.1007/s00421-020-04300-0

    authors: Armstrong N,Welsman J

    更新日期:2020-02-01 00:00:00

  • Effect of electromyostimulation training on soleus and gastrocnemii H- and T-reflex properties.

    abstract::When muscle is artificially activated, as with electromyostimulation (EMS), action potentials are evoked in both intramuscular nerve branches and cutaneous receptors, therefore activating spinal motoneurons reflexively. Maximal soleus and gastrocnemii H- and T-reflex and the respective mechanical output were thus quan...

    journal_title:European journal of applied physiology

    pub_type: 杂志文章

    doi:10.1007/s00421-003-0914-3

    authors: Maffiuletti NA,Pensini M,Scaglioni G,Ferri A,Ballay Y,Martin A

    更新日期:2003-11-01 00:00:00

  • The effects of supramaximal versus submaximal intensity eccentric training when performed until volitional fatigue.

    abstract:PURPOSE:Our purpose was to compare supramaximal versus submaximal intensity eccentric training performed until volitional fatigue. METHODS:Thirty-two young adults (19 males) were randomized into one of three groups: (1) ECC110 performed eccentric (ECC) only contractions at 110% of concentric (CON) 1-repetition maximum...

    journal_title:European journal of applied physiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00421-017-3700-3

    authors: Krentz JR,Chilibeck PD,Farthing JP

    更新日期:2017-10-01 00:00:00

  • Effects of prolonged recombinant human erythropoietin administration on muscle membrane transport systems and metabolic marker enzymes.

    abstract::Adaptations to chronic hypoxia involve changes in membrane transport proteins. The underlying mechanism of this response may be related to concomitant occurring changes in erythropoietin (Epo) levels. We therefore tested the direct effects of recombinant human erythropoietin (rHuEpo) treatment on the expression of mus...

    journal_title:European journal of applied physiology

    pub_type: 杂志文章

    doi:10.1007/s00421-007-0567-8

    authors: Juel C,Thomsen JJ,Rentsch RL,Lundby C

    更新日期:2007-12-01 00:00:00

  • Normalized EMG to normalized torque relationship of vastus intermedius muscle during isometric knee extension.

    abstract::The purpose of the present study was to investigate the electromyography (EMG) to torque relationship of the vastus intermedius (VI) muscle. Thirteen healthy men performed maximal voluntary contraction (MVC) and submaximal contraction during isometric knee extension at 10% of the MVC to 90% of the MVC at intervals of ...

    journal_title:European journal of applied physiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00421-009-1064-z

    authors: Watanabe K,Akima H

    更新日期:2009-07-01 00:00:00

  • Satellite cell response to concurrent resistance exercise and high-intensity interval training in sedentary, overweight/obese, middle-aged individuals.

    abstract:PURPOSE:Sarcopenia can begin from the 4-5th decade of life and is exacerbated by obesity and inactivity. A combination of resistance exercise (RE) and endurance exercise is recommended to combat rising obesity and inactivity levels. However, work continues to elucidate whether interference in adaptive outcomes occur wh...

    journal_title:European journal of applied physiology

    pub_type: 杂志文章

    doi:10.1007/s00421-017-3721-y

    authors: Pugh JK,Faulkner SH,Turner MC,Nimmo MA

    更新日期:2018-02-01 00:00:00

  • Isometric force production during changed-Gz episodes of parabolic flight.

    abstract::Changes of the normal gravitational acceleration are known to affect sensorimotor performance. For example, subjects exposed to three times the normal terrestrial acceleration (+3 Gz) in a centrifuge will produce exaggerated isometric force. The present study compares the effects of high-Gz to that of micro-Gz on isom...

    journal_title:European journal of applied physiology

    pub_type: 杂志文章

    doi:10.1007/s00421-007-0591-8

    authors: Mierau A,Girgenrath M,Bock O

    更新日期:2008-02-01 00:00:00

  • The application of repeated testing and monoexponential regressions to classify individual cardiorespiratory fitness responses to exercise training.

    abstract:PURPOSE:We tested the hypothesis that monoexponential regressions will increase the certainty in response estimates and confidence in classification of cardiorespiratory fitness (CRF) responses compared to a recently proposed linear regression approach. METHODS:We used data from a previously published RCT that involve...

    journal_title:European journal of applied physiology

    pub_type: 杂志文章

    doi:10.1007/s00421-019-04078-w

    authors: Bonafiglia JT,Ross R,Gurd BJ

    更新日期:2019-04-01 00:00:00

  • Prolonged standing increases lower limb arterial stiffness.

    abstract:PURPOSE:Standing workstations have recently been promoted as a healthy alternative to sitting. However, it is unknown how prolonged standing affects arterial stiffness, a prognostic indicator of cardiovascular health. The purpose of this study was twofold: to observe changes in arterial stiffness, as assessed by pulse ...

    journal_title:European journal of applied physiology

    pub_type: 杂志文章

    doi:10.1007/s00421-018-3956-2

    authors: Caldwell AR,Gallagher KM,Harris BT,Rosa-Caldwell ME,Payne M,Daniels B,Ganio MS

    更新日期:2018-10-01 00:00:00

  • The effect of load carriage on movement kinematics and respiratory parameters in children during walking.

    abstract::The objective of this study was to investigate the influence of different backpack weights on trunk kinematics and respiratory parameters during walking in 10-year-old children. Fifteen boys with a mean age of 10.31 (0.26) years were selected from a primary school to participate in four walking trials on a treadmill: ...

    journal_title:European journal of applied physiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/s00421-003-0848-9

    authors: Li JX,Hong Y,Robinson PD

    更新日期:2003-09-01 00:00:00

  • Effect of prolonged exercise and pre-exercise dietary manipulation on hepatic triglycerides in trained men.

    abstract::The purpose of this study was to examine the effect of exercise and pre-exercise dietary manipulation on hepatic triglyceride concentration (HTGC). HTGC was measured by proton magnetic resonance spectroscopy ((1)H-MRS) before and after 90 min of moderate intensity cycling in six endurance trained males following 67 h ...

    journal_title:European journal of applied physiology

    pub_type: 杂志文章

    doi:10.1007/s00421-011-2158-y

    authors: Johnson NA,van Overbeek D,Chapman PG,Thompson MW,Sachinwalla T,George J

    更新日期:2012-05-01 00:00:00

  • A combination of oral L-citrulline and L-arginine improved 10-min full-power cycling test performance in male collegiate soccer players: a randomized crossover trial.

    abstract:PURPOSE:Oral L-citrulline (Cit) increases plasma L-arginine (Arg) concentration and the production of nitric oxide (NO). NO dilates blood vessels and potentially improves sports performance. The combination of oral Arg and Cit (Arg + Cit) immediately and synergistically increases plasma Arg and nitrite/nitrate (NOx) co...

    journal_title:European journal of applied physiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00421-019-04097-7

    authors: Suzuki I,Sakuraba K,Horiike T,Kishi T,Yabe J,Suzuki T,Morita M,Nishimura A,Suzuki Y

    更新日期:2019-05-01 00:00:00

  • A 20-min nap in athletes changes subsequent sleep architecture but does not alter physical performances after normal sleep or 5-h phase-advance conditions.

    abstract:PURPOSE:The aim of the study was to examine the effects of a post-prandial 20 min nap on a short-term physical exercise and subsequent sleep in athletes keeping their usual sleep schedules and in 5-h phase-advance condition. METHODS:Sixteen healthy young male athletes (age 22.2 ± 1.7 years, non-habitual nappers) parti...

    journal_title:European journal of applied physiology

    pub_type: 杂志文章

    doi:10.1007/s00421-013-2776-7

    authors: Petit E,Mougin F,Bourdin H,Tio G,Haffen E

    更新日期:2014-02-01 00:00:00

  • Effects of squat training with different depths on lower limb muscle volumes.

    abstract:PURPOSE:The purpose of this study was to compare the effects of squat training with different depths on lower limb muscle volumes. METHODS:Seventeen males were randomly assigned to a full squat training group (FST, n = 8) or half squat training group (HST, n = 9). They completed 10 weeks (2 days per week) of squat tra...

    journal_title:European journal of applied physiology

    pub_type: 杂志文章

    doi:10.1007/s00421-019-04181-y

    authors: Kubo K,Ikebukuro T,Yata H

    更新日期:2019-09-01 00:00:00

  • Maternal-neonatal erythrocyte membrane Na(+), K (+)-ATPase and Mg (2+)-ATPase activities in relation to the mode of delivery.

    abstract::Free radical production and high catecholamine levels are implicated in the modulation of Na(+), K(+)-ATPase, and Mg(2+)-ATPase activities. The aim of this study was to investigate the effect of the mode of delivery on the above-mentioned enzyme activities in maternal-neonatal erythrocyte membrane. Women with normal p...

    journal_title:European journal of applied physiology

    pub_type: 杂志文章

    doi:10.1007/s00421-008-0744-4

    authors: Vlachos DG,Schulpis KH,Parthimos T,Mesogitis S,Vlachos GD,Antsaklis A,Tsakiris S

    更新日期:2008-07-01 00:00:00