Abstract:
:Lactate (La-) has long been at the center of controversy in research, clinical, and athletic settings. Since its discovery in 1780, La- has often been erroneously viewed as simply a hypoxic waste product with multiple deleterious effects. Not until the 1980s, with the introduction of the cell-to-cell lactate shuttle did a paradigm shift in our understanding of the role of La- in metabolism begin. The evidence for La- as a major player in the coordination of whole-body metabolism has since grown rapidly. La- is a readily combusted fuel that is shuttled throughout the body, and it is a potent signal for angiogenesis irrespective of oxygen tension. Despite this, many fundamental discoveries about La- are still working their way into mainstream research, clinical care, and practice. The purpose of this review is to synthesize current understanding of La- metabolism via an appraisal of its robust experimental history, particularly in exercise physiology. That La- production increases during dysoxia is beyond debate, but this condition is the exception rather than the rule. Fluctuations in blood [La-] in health and disease are not typically due to low oxygen tension, a principle first demonstrated with exercise and now understood to varying degrees across disciplines. From its role in coordinating whole-body metabolism as a fuel to its role as a signaling molecule in tumors, the study of La- metabolism continues to expand and holds potential for multiple clinical applications. This review highlights La-'s central role in metabolism and amplifies our understanding of past research.
journal_name
Eur J Appl Physioljournal_title
European journal of applied physiologyauthors
Ferguson BS,Rogatzki MJ,Goodwin ML,Kane DA,Rightmire Z,Gladden LBdoi
10.1007/s00421-017-3795-6subject
Has Abstractpub_date
2018-04-01 00:00:00pages
691-728issue
4eissn
1439-6319issn
1439-6327pii
10.1007/s00421-017-3795-6journal_volume
118pub_type
杂志文章,评审abstract::A number of mechanisms have been proposed to explain the elevation in oxygen consumption following exercise. Biochemical processes that return muscle to its pre-exercise state do not account for all of the extra oxygen consumed after exercise (excess post-exercise oxygen consumption, EPOC). Muscle at rest after aerobi...
journal_title:European journal of applied physiology
pub_type: 杂志文章
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更新日期:2007-12-01 00:00:00
abstract::This study evaluated time-dependent alterations in pulmonary vascular reactivity to acute hypoxia and to the administration of angiotensin II (AT-II) during and after chronic exposure to cold using isolated perfused lung specimens from rats. Animals were exposed to a cold environment (3.5 (mean) +/- 1.0 (SD) degrees C...
journal_title:European journal of applied physiology
pub_type: 杂志文章
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journal_title:European journal of applied physiology
pub_type: 杂志文章,随机对照试验
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更新日期:2017-03-01 00:00:00
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journal_title:European journal of applied physiology
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更新日期:2010-07-01 00:00:00
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journal_title:European journal of applied physiology
pub_type: 临床试验,杂志文章
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更新日期:2006-09-01 00:00:00
abstract::The purpose of this study was to determine for the first time by repeated non-invasive 13C-NMR spectrometry whether blood lactate concentration affects glycogen reduction in non-exercising muscle during prolonged (6 h) physical exercise in healthy adult males. Such an effect would indirectly show that glycogenolysis i...
journal_title:European journal of applied physiology
pub_type: 临床试验,杂志文章
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更新日期:2004-08-01 00:00:00
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journal_title:European journal of applied physiology
pub_type: 杂志文章,随机对照试验
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更新日期:2018-02-01 00:00:00
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journal_title:European journal of applied physiology
pub_type: 杂志文章
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journal_title:European journal of applied physiology
pub_type: 临床试验,杂志文章
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更新日期:2003-02-01 00:00:00
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journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-017-3721-y
更新日期:2018-02-01 00:00:00
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journal_title:European journal of applied physiology
pub_type: 杂志文章
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更新日期:2010-08-01 00:00:00
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journal_title:European journal of applied physiology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00421-012-2511-9
更新日期:2013-04-01 00:00:00
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journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s004210100460
更新日期:2001-08-01 00:00:00
abstract:AIMS:To determine the effects of high-intensity interval training (HIIT) following cardiac resynchronization therapy (CRT) implantation in patients with chronic heart failure (CHF), on noninvasive estimates of systolic ventricular function, exercise performance, severity of symptoms and quality of life. METHODS:Cardio...
journal_title:European journal of applied physiology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00421-019-04165-y
更新日期:2019-08-01 00:00:00
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journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-018-4019-4
更新日期:2019-01-01 00:00:00
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journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-011-2166-y
更新日期:2012-05-01 00:00:00
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journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s004210000309
更新日期:2000-12-01 00:00:00
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journal_title:European journal of applied physiology
pub_type: 临床试验,杂志文章
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journal_title:European journal of applied physiology
pub_type: 杂志文章
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更新日期:2010-05-01 00:00:00
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更新日期:2001-01-01 00:00:00
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更新日期:2020-10-01 00:00:00
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journal_title:European journal of applied physiology
pub_type: 杂志文章
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更新日期:2015-04-01 00:00:00
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journal_title:European journal of applied physiology
pub_type: 杂志文章
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更新日期:2007-04-01 00:00:00
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更新日期:2015-02-01 00:00:00
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更新日期:2010-03-01 00:00:00
abstract::Physical inactivity in response to a spinal cord injury (SCI) represents a potent stimulus for conduit artery remodelling. Changes in conduit artery characteristics may be induced by the local effects of denervation (and consequent extreme inactivity below the level of the lesion), and also by systemic adaptations due...
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更新日期:2012-12-01 00:00:00
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