Effects of beta-carboline harmine on behavioral and physiological parameters observed in the chronic mild stress model: further evidence of antidepressant properties.

abstract：:Serotonin 5-HT1A receptors belong to the superfamily of G-protein-coupled receptors. Receptor activation of G-proteins can be determined by agonist-stimulated [35S]GTPgammaS binding in the presence of excess GDP, and in vitro autoradiographic adaptation of this technique allows visualization of receptor-activated G-pr...

journal_title：Brain research bulletin

authors： Sim LJ,Xiao R,Childers SR

更新日期：1997-01-01 00:00:00

abstract：:Observation of people performing movements facilitates motor planning, execution and memory formation. Tempo, a crucial aspect involved in the execution of rhythmic movements, is normally perceived and learned through auditory channels. In this work, we ascertained whether: first, the frequency of self-paced finger mo...

journal_title：Brain research bulletin

authors： Bove M,Tacchino A,Pelosin E,Moisello C,Abbruzzese G,Ghilardi MF

更新日期：2009-09-28 00:00:00

abstract：:A cDNA for Drosophila choline acetyltransferase (ChAT) was expressed in E. coli and the recombinant enzyme partially purified. Kinetic analysis yielded the following constants for the recombinant enzyme; KmAcCoA = 29 microM, KmCoA = 25 microM, Kmcholine = 330 microM, and Kmacetylcholine = 2 mM. The recombinant Drosoph...

journal_title：Brain research bulletin

authors： Carbini L,Rodriguez G,Hersh LB

更新日期：1990-01-01 00:00:00

abstract：:Developmental changes in the control of neurite extension by extracellular factors can be examined by utilizing cultures of neurons from various aged embryos. Several conditioned media and tissue extracts were added to cultures of chick embryo retinal neurons on collagen substrates for 1, 3 and 5 days in vitro. Neurit...

journal_title：Brain research bulletin

authors： Thompson JM,Lu AH,Ruch S

更新日期：1987-04-01 00:00:00

abstract：:On the basis of the evidence that approximately 45% of Schaffer collateral boutons are zinc-positive, zinc release from Schaffer collaterals and its action were examined in hippocampal slices. When zinc release from Schaffer collaterals was examined using ZnAF-2, a membrane-impermeable zinc indicator, ZnAF-2 signal in...

journal_title：Brain research bulletin

authors： Takeda A,Nakajima S,Fuke S,Sakurada N,Minami A,Oku N

更新日期：2006-02-15 00:00:00

abstract：:Endogenous adrenergic drive regulates the firing rate of serotonergic neurons. However, advocates of feedback theory assert that 5-hydroxytryptamine (5-HT) released in the somatodendritic region of raphe neurons regulates both rate and release of 5-HT. Experiments were done to determine if the somatodendritic region m...

journal_title：Brain research bulletin

authors： Kalsner S,Abdali SA

更新日期：2001-08-01 00:00:00

abstract：:The analysis of physiological processes in brain by position emission tomography (PET) is facilitated when images are spatially normalized to a standard coordinate system. Thus, PET activation studies of human brain frequently employ the common stereotaxic coordinates of Talairach. We have developed an analogous stere...

journal_title：Brain research bulletin

authors： Andersen F,Watanabe H,Bjarkam C,Danielsen EH,Cumming P,DaNeX Study Group.

更新日期：2005-07-15 00:00:00

abstract：:Stimulation of the dorsal frontal cortex (area 10, FCtx) evoked two negative waves with short latencies (N1 and N2) followed by a large, longlasting positive wave (P) in the ventromedial nucleus (VMH) as well as in the more dorsal structures in the hypothalamus and the ventral thalamus. Since the N1 followed high freq...

journal_title：Brain research bulletin

authors： Ohta M,Oomura Y

更新日期：1979-03-01 00:00:00

abstract：:The role of calmodulin (CaM) in organelle motility (fast axonal transport) in the axoplasm of the squid giant axon was evaluated directly using video-enhanced microscopy. Addition of 6 microM CaM to extruded squid axoplasm produced a 2.6-fold increase in the number of organelles moving per minute per unit area of axop...

journal_title：Brain research bulletin

authors： Rivera DT,Langford GM,Weiss DG,Nelson DJ

更新日期：1995-01-01 00:00:00

abstract：:The brain serotoninergic (5HTergic) system of epileptic subjects can influence their vulnerability to stress. We studied the putative dependency of 5HT neurotransmission parameters on emotional stress, and the presence, types and severity of seizures using rats with genetic generalized (absence and/or audiogenic) epil...

journal_title：Brain research bulletin

authors： Midzyanovskaya IS,Kuznetsova GD,van Luijtelaar EL,van Rijn CM,Tuomisto L,Macdonald E

更新日期：2006-05-31 00:00:00

abstract：:Bone marrow stromal cells (BMSCs) are promising donor cells for transplantation therapies for a variety of diseases. However, there still lack efficient ways to induce directional differentiation of BMSCs to promote their practical use in transplantation therapy. In this study, we constructed hybrid cells by transferr...

journal_title：Brain research bulletin

authors： Zhou Z,Xu Y,Zhong Q,Zheng J

更新日期：2012-02-10 00:00:00

abstract：:miR-196a is located in the posterior trunk and plays a role in limb development. Here we show that miR-196a is able to induce eye anomaly in Xenopus laevis. Microinjection of synthetic miRNA precursor molecule for mammalian miR-196a into Xenopus embryo is sufficient for miR-196a overexpression during early development...

journal_title：Brain research bulletin

authors： Qiu R,Liu Y,Wu JY,Liu K,Mo W,He R

更新日期：2009-04-06 00:00:00

abstract：:Cranioplasty is a challenge to neurosurgeons, especially considering protection of intracranial contents. In recent years, material choice for cranioplasty is still controversial, which brings complexity to this seemingly straightforward procedure. PEEK, a tough, rigid, biocompatible material, has been used more recen...

journal_title：Brain research bulletin

authors： Zhang J,Tian W,Chen J,Yu J,Zhang J,Chen J

更新日期：2019-11-01 00:00:00

abstract：:The glucostatic theory supports the role of central and peripheral substrate "sensors" in monitoring cellular glucose metabolism. Induction of hyperphagia and hyperglycemia by intracerebroventricular (i.c.v.) delivery of drugs inhibiting glucose uptake or oxidation suggests that glucose "sensors" are accessible from t...

journal_title：Brain research bulletin

authors： Briski KP

更新日期：2000-02-01 00:00:00

abstract：:The changes of characteristics of dopamine (D1 and D2) and muscarinic receptors after acute and subacute administration of bicuculline were examined in rat brain. The results demonstrated that in striatal region, the Bmax of D2 receptor was significantly increased with no change of affinity after subacute administrati...

journal_title：Brain research bulletin

authors： Lim DK,Ito Y,Hoskins B,Ho IK

更新日期：1988-07-01 00:00:00

abstract：:Spontaneous locomotion and motor coordination was evaluated in young (5-6 month old) and aged (24-25 month old) rats. Animals were tested for spontaneous locomotor activity in Digiscan Animal Activity Monitors during the nocturnal cycle. Aged animals exhibited a significant hypoactivity compared to their young counter...

journal_title：Brain research bulletin

authors： Emerich DF,McDermott P,Krueger P,Banks M,Zhao J,Marszalkowski J,Frydel B,Winn SR,Sanberg PR

更新日期：1993-01-01 00:00:00

abstract：:Fluoro-Ruby (tetramethylrhodamine-dextran amine conjugate) has been shown recently to be an effective anterograde tracer readily visible in brain sections with fluorescence microscopy. We show in this study that further microscopic analysis of Fluoro-Ruby-labeled elements is feasible with a conventional immunoperoxida...

journal_title：Brain research bulletin

authors： Chang HT

更新日期：1993-01-01 00:00:00

abstract：:The developmental neurotoxicity of organophosphate pesticides targets serotonin (5HT) systems, which are involved in emotional and appetitive behaviors. We exposed neonatal rats to daily doses of diazinon on postnatal days 1-4, using doses (0.5 or 2mg/kg) spanning the threshold for barely-detectable cholinesterase inh...

journal_title：Brain research bulletin

authors： Slotkin TA,Ryde IT,Levin ED,Seidler FJ

更新日期：2008-03-28 00:00:00

abstract：:The present study investigated whether the raphe neurons which give rise to the transient serotonergic fibers in the visual cortex of neonatal rats persist or disappear as the rats mature. Three experiments were performed employing the WGA-apoHRP-Au retrograde transport technique in conjunction with 5-HT or WGA-HRP im...

journal_title：Brain research bulletin

authors： Koh T,Nakazawa M,Kani K,Maeda T

更新日期：1991-11-01 00:00:00

abstract：:The effects of cholinergic agents on isolated dentate neurons were studied to characterize cellular mechanisms underlying carbachol-induced 'theta' EEG activity. Carbachol, eserine, and acetylcholine produced a synchronization of slow wave activity (theta) accompanied by depression of perforant path to dentate field p...

journal_title：Brain research bulletin

authors： Konopacki J,Maciver MB,Bland BH,Roth SH

更新日期：1987-01-01 00:00:00

abstract：:Electrical stimulation of the periaqueductal gray of the rat's midbrain analgesia leads to an increase in the number of artificial pulmonary metastases from the Walker 256 tumor. In an effort to investigate the influence of the pain suppression system and its associated peptides on this phenomenon, we activated the pa...

journal_title：Brain research bulletin

authors： Simon RH,Arbo TE,Lundy J

更新日期：1984-05-01 00:00:00

abstract：:Nicotinic acetylcholine (ACh) and dopamine (DA) receptor activation has been found to be important for working memory. The regional distribution of these receptors in the brain has been well characterized. However, the relationship of the region-specific nicotinic ACh and DA binding density to memory performance has n...

journal_title：Brain research bulletin

authors： Levin ED,Torry D,Christopher NC,Yu X,Einstein G,Schwartz-Bloom RD

更新日期：1997-01-01 00:00:00

abstract：:Spinocerebellar ataxia type 2 is caused by a polyglutamine stretch in the protein ataxin-2 that is due to an expansion of a CAG repeat in the spinocerebellar ataxia-2 gene. The function of wild-type ataxin-2 has not been clarified. A widespread distribution of this protein throughout the brain has been reported. We ex...

journal_title：Brain research bulletin

authors： Fusco FR,Viscomi MT,Bernardi G,Molinari M

更新日期：2001-10-01 00:00:00

abstract：:Tetramethylrhodamine-dextran is a highly fluorescent neuroanatomical tracer that, in its 10,000 MW form, has seen widespread use as a sensitive anterograde tract-tracing label. We report here the use of a lower molecular weight tetramethylrhodamine-dextran (3000 MW; Molecular Probes, OR) as an in vivo intracellular ma...

journal_title：Brain research bulletin

authors： Carr PA,Noga BR,Nance DM,Jordan LM

更新日期：1994-01-01 00:00:00

abstract：:The electroencephalographic (EEG) activity of the hippocampus was examined in adult freely moving rats that had had all of the neocortex, including the cingulate cortex and cingulum, removed at birth. Both the cholinergic and serotonergic forms of rhythmical slow activity (RSA or theta) were present in the dorsal hipp...

journal_title：Brain research bulletin

authors： Whishaw IQ,Dyck R,Kolb B

更新日期：1991-03-01 00:00:00

abstract：:The susceptibility of the developing brain to hypoxia should depend on the lipid composition of the brain cell membrane; the rate of lipid peroxidation; the presence of antioxidant defenses; and the development and modulation of the excitatory neurotransmitter receptors such as the N-methyl-D-aspartate (NMDA) receptor...

journal_title：Brain research bulletin

authors： Mishra OP,Delivoria-Papadopoulos M

更新日期：1999-02-01 00:00:00

abstract：:Adult female Zucker lean and obese rats were treated for 14 days with 3.5 nm/kg oleoyl-estrone (OE) in liposomes (Merlin-2) through continuous i.v. injection with osmotic minipumps. Rat wt. and food intake were measured daily. On days 0, 3, 6, 10, and 14, groups of rats were killed and their hypothalamic nuclei [later...

journal_title：Brain research bulletin

authors： Cabot C,del Mar Grasa M,Estruch J,Fernández-López JA,Remesar X,Alemany M

更新日期：1998-08-01 00:00:00

abstract：:Nine healthy subjects standing upright, initiated small, medium and large (S, M and L conditions, respectively) forward movements of their right (Rt) arm together with backward movements of their left (Lt) arm. They also performed medium-size movements while holding a 3 kg dumbbell in each hand (D condition). Movement...

journal_title：Brain research bulletin

authors： Yamazaki Y,Suzuki M,Ohkuwa T,Itoh H

更新日期：2005-09-30 00:00:00

abstract：:Spinal neurons projecting to the facial nucleus, located in the lateral portion of lamina V from the C1 to C4 segments, had long dendrites extending into lamina IV. The detailed morphology of these spinal neurons was confirmed using the Golgi impregnation method. Dorsal root fibers were distributed mainly to lamina IV...

journal_title：Brain research bulletin

authors： Takeuchi Y,Takahashi O,Satoda T,Matsushima R

更新日期：1987-10-01 00:00:00

abstract：:It is now generally accepted that adenosine has a neuroprotective role in the central nervous system. Agonists of adenosine such as 2-chloroadenosine (2-ClA) have been shown to be neuroprotective, while antagonists such as 8-phenyltheophylline (8-PT) increase neurotoxicity. However, paradoxical results have been repor...

journal_title：Brain research bulletin

authors： Brooke SM,Sapolsky RM

更新日期：2000-03-01 00:00:00