Pathological amygdala activation during working memory performance: Evidence for a pathophysiological trait marker in bipolar affective disorder.

Abstract:

:Recent evidence suggests that deficits of working memory may be a promising neurocognitive endophenotype of bipolar affective disorder. However, little is known about the neurobiological correlates of these deficits. The aim of this study was to determine possible pathophysiological trait markers of bipolar disorder in neural circuits involved in working memory. Functional magnetic resonance imaging was performed in 18 euthymic bipolar patients and 18 matched healthy volunteers using two circuit-specific experimental tasks established by prior systematic neuroimaging studies of working memory. Both euthymic bipolar patients and healthy controls showed working memory-related brain activations that were highly consistent with findings from previous comparable neuroimaging studies in healthy subjects. While these patterns of brain activation were completely preserved in the bipolar patients, only the patients exhibited activation of the right amygdala during the articulatory rehearsal task. In the same task, functional activation in right frontal and intraparietal cortex and in the right cerebellum was significantly enhanced in the patients. These findings indicate that the right amygdala is pathologically activated in euthymic bipolar patients during performance of a circuit-specific working memory task (articulatory rehearsal). This pathophysiological abnormality appears to be a trait marker in bipolar disorders that can be observed even in the euthymic state and that seems to be largely independent of task performance and medication.

journal_name

Hum Brain Mapp

journal_title

Human brain mapping

authors

Gruber O,Tost H,Henseler I,Schmael C,Scherk H,Ende G,Ruf M,Falkai P,Rietschel M

doi

10.1002/hbm.20849

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

115-25

issue

1

eissn

1065-9471

issn

1097-0193

journal_volume

31

pub_type

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