Abstract:
:Recent evidence suggests that deficits of working memory may be a promising neurocognitive endophenotype of bipolar affective disorder. However, little is known about the neurobiological correlates of these deficits. The aim of this study was to determine possible pathophysiological trait markers of bipolar disorder in neural circuits involved in working memory. Functional magnetic resonance imaging was performed in 18 euthymic bipolar patients and 18 matched healthy volunteers using two circuit-specific experimental tasks established by prior systematic neuroimaging studies of working memory. Both euthymic bipolar patients and healthy controls showed working memory-related brain activations that were highly consistent with findings from previous comparable neuroimaging studies in healthy subjects. While these patterns of brain activation were completely preserved in the bipolar patients, only the patients exhibited activation of the right amygdala during the articulatory rehearsal task. In the same task, functional activation in right frontal and intraparietal cortex and in the right cerebellum was significantly enhanced in the patients. These findings indicate that the right amygdala is pathologically activated in euthymic bipolar patients during performance of a circuit-specific working memory task (articulatory rehearsal). This pathophysiological abnormality appears to be a trait marker in bipolar disorders that can be observed even in the euthymic state and that seems to be largely independent of task performance and medication.
journal_name
Hum Brain Mappjournal_title
Human brain mappingauthors
Gruber O,Tost H,Henseler I,Schmael C,Scherk H,Ende G,Ruf M,Falkai P,Rietschel Mdoi
10.1002/hbm.20849subject
Has Abstractpub_date
2010-01-01 00:00:00pages
115-25issue
1eissn
1065-9471issn
1097-0193journal_volume
31pub_type
杂志文章abstract::We investigated brain responses to matching versus nonmatching objects in working memory (WM) with a modified delayed match-to-sample task using event-related potentials (ERPs). In addition, ERP correlates of new items (new matches/new nonmatches) and previously studied items (studied matches/studied nonmatches) were ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20409
更新日期:2008-04-01 00:00:00
abstract::In this communication, we extended a previously described and validated diffusion tensor imaging (DTI) method for segmenting whole brain cerebrospinal fluid (CSF) and gray and white matter (WM) tissue to provide regional volume and DTI metrics of WM tract and cortical and subcortical gray matter. This DTI-based region...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21004
更新日期:2011-01-01 00:00:00
abstract::Subcortical functions for language capacities are poorly defined, but may be investigated in the context of deep brain stimulation. Here, we studied event-related potentials recorded from electrodes in the subthalamic nucleus (STN) and the thalamic ventral intermediate nucleus (VIM) together with surface-EEG. Particip...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23366
更新日期:2017-01-01 00:00:00
abstract::Fine surface texture is best discriminated by touch, in contrast to macro geometric features like shape. We used functional magnetic resonance imaging and a delayed match-to-sample task to investigate the neural substrate for working memory of tactile surface texture. Blindfolded right-handed males encoded the texture...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21500
更新日期:2013-05-01 00:00:00
abstract::Electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) are important tools in cognitive and clinical neuroscience. Combined EEG-fMRI has been shown to help to characterise brain networks involved in epileptic activity, as well as in different sensory, motor and cognitive functions. A good unders...
journal_title:Human brain mapping
pub_type: 杂志文章,评审
doi:10.1002/hbm.22623
更新日期:2015-01-01 00:00:00
abstract::White matter (WM) microstructure, as determined by diffusion tensor imaging (DTI), is increasingly recognized as an important determinant of cognitive function and is also altered in neuropsychiatric disorders. Little is known about genetic and environmental influences on WM microstructure, especially in early childho...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24436
更新日期:2019-03-01 00:00:00
abstract::At present, our knowledge about seasonal affective disorder (SAD) is based mainly up on clinical symptoms, epidemiology, behavioral characteristics and light therapy. Recently developed measures of resting-state functional brain activity might provide neurobiological markers of brain disorders. Studying functional bra...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22164
更新日期:2014-01-01 00:00:00
abstract::A set of cortical and sub-cortical brain structures has been linked with sentence-level semantic processes. However, it remains unclear how these brain regions are organized to support the semantic integration of a word into sentential context. To look into this issue, we conducted a functional magnetic resonance imag...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22182
更新日期:2014-02-01 00:00:00
abstract::Functional neuroimaging studies in adults show that aggression involves reduced brain communication between subcortical and cortical areas dedicated to motivation and control, respectively. Prior research indicates that sex steroid hormone production during adolescence negatively influences the rapid development of wh...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22684
更新日期:2015-03-01 00:00:00
abstract::The role of the right hemisphere (RH) in metaphor comprehension is still controversial. Numerous neuroimaging studies have found that conventionality, sentential context, and task demand can influence the involvement of the RH in metaphor processing. The current meta-analysis used foci from 17 original functional magn...
journal_title:Human brain mapping
pub_type: 杂志文章,meta分析
doi:10.1002/hbm.22160
更新日期:2014-01-01 00:00:00
abstract::Catechol-O-methyltransferase (COMT), located on chromosome 22q11.2, encodes an enzyme critical for dopamine flux in the prefrontal cortex. Genetic variants of COMT have been suggested to functionally manipulate prefrontal morphology and function in healthy adults. This study aims to investigate modulative roles of ind...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23161
更新日期:2016-06-01 00:00:00
abstract::Non-verbal number sense has been shown to significantly correlate with arithmetic fluency. Accumulated behavioral evidence indicates that the cognitive mechanism relies on visual perception. However, few studies have investigated the neural mechanism underlying this association. Following the visual perception account...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.25179
更新日期:2020-12-15 00:00:00
abstract::The orbitofrontal cortex (OFC)-amygdala circuit is critical to goal-directed behavior, learning, and valuation. However, our understanding of the OFC-amygdala connections that support these emergent processes is hampered by our reliance on the primate literature and insufficient knowledge regarding the connectivity pa...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.25300
更新日期:2020-12-03 00:00:00
abstract::Auditory cortex in each hemisphere shows preference to sounds from the opposite hemifield in the auditory space. Besides this contralateral dominance, the auditory cortex shows functional and structural lateralization, presumably influencing the features of subsequent auditory processing. Children have been shown to d...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24553
更新日期:2019-06-15 00:00:00
abstract::The recent ability to measure in vivo beta-amyloid (Aβ), a marker of Alzheimer's disease (AD), has led to an increased focus on the significance of Aβ deposition in clinically normal adults. Evidence suggests that healthy adults with elevated cortical Aβ show differences in neural activity associated with memory encod...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22788
更新日期:2015-07-01 00:00:00
abstract::To evaluate metabolic changes in the ipsi- and contralateral hemisphere in children showing a cognitive profile consistent with early reorganization of cognitive function, we evaluated the regional glucose uptake, interhemispheric metabolic connectivity, and cognitive function in children with unilateral SWS. Interict...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23937
更新日期:2018-04-01 00:00:00
abstract::Coordinate-based, voxel-wise meta-analysis is an exciting recent addition to the human functional brain mapping literature. In view of the critical importance of selection criteria for any valid meta-analysis, a taxonomy of experimental design should be an important tool for aiding in the design of rigorous meta-analy...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20141
更新日期:2005-05-01 00:00:00
abstract::An increasing amount of studies apply repetetive transcranial magnetic stimulation (rTMS) to treat chronic tinnitus, yet the neurophysiological impacts have remained largely obscure. Several studies show that endogenous brain rhythms may be enhanced via diverse brain stimulation techniques applying rhythmic stimulatio...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22152
更新日期:2014-01-01 00:00:00
abstract::Thalamic abnormalities have been implicated in the pathogenesis of schizophrenia, although the majority of studies used chronic samples treated extensively with antipsychotics. Moreover, the clinical and neuropsychological correlates of these abnormalities remain largely unknown. Using high-resolution MR imaging and n...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20595
更新日期:2009-04-01 00:00:00
abstract::During the last 20 years, predictive modeling in epilepsy research has largely been concerned with the prediction of seizure events, whereas the inference of effective brain targets for resective surgery has received surprisingly little attention. In this exploratory pilot study, we describe a distributional clusterin...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23537
更新日期:2017-05-01 00:00:00
abstract::The arcuate fasciculus (AF) connects cortical regions important in language processing, but how fiber coherence and organization relates to gray matter macrostructure remains uncharacterized. We used high-resolution structural and 30-direction diffusion imaging data from 36 healthy adults (24 male/12 female; mean age,...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21147
更新日期:2011-11-01 00:00:00
abstract::Months, days of the week, and numbers differ from other verbal concepts because they are ordered in a sequence, whereas no order is imposed on members of other categories, such as animals or tools. Recent studies suggest that numbers activate a representation of their quantity within the intraparietal sulcus (IPS) aut...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20433
更新日期:2008-08-01 00:00:00
abstract::Although elevated serum high-sensitivity C-reactive protein (hsCRP) is related to atherosclerosis, brain infarction, and cognitive decline, it has not been clarified whether increased hsCRP is associated with the decline in brain gray matter volume. Therefore, the purpose of this study was to determine the relationshi...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22073
更新日期:2013-10-01 00:00:00
abstract::The reason why human beings are inclined to overestimate the duration of highly arousing negative events remains enigmatic. The issue about what neurocognitive mechanisms and neural structures support the connection between time perception and emotion was addressed here by an event-related neuroimaging study involving...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22680
更新日期:2015-03-01 00:00:00
abstract::Increased cerebral blood flow in the anterior cingulate cortex (ACC) has been noted in a range of cognitively demanding tasks studied with PET. A PET study of 10 normal males was carried out using the bolus H2(15)O intravenous injection technique to examine the effects of anticipation on blood flow to the ACC. In a se...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0193(1996)4:2<103::AID-HBM2>3.0
更新日期:1996-01-01 00:00:00
abstract::Functional organization units of the cerebral cortex exist over a wide range of spatial scales, from local circuits to entire cortical areas. In the last decades, scale-space representations of neuroimaging data suited to probe the multi-scale nature of cortical functional organization have been introduced and methodo...
journal_title:Human brain mapping
pub_type: 杂志文章,随机对照试验
doi:10.1002/hbm.21274
更新日期:2012-05-01 00:00:00
abstract::In this article we describe a new method, using SPM99, that searches explicitly for bilateral structural abnormalities. Children with bilateral pathology have a poorer prognosis than children with unilateral damage. After brain injury or disease in childhood, it is thought that rescue of function is only possible if t...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:
更新日期:2000-11-01 00:00:00
abstract::The dopaminergic system plays a key role in motor function and motor abnormalities have been shown to be a specific feature of psychosis. Due to their dopaminergic action, antipsychotic drugs may be expected to modulate motor function, but the precise effects of these drugs on motor function remain unclear. We carried...
journal_title:Human brain mapping
pub_type: 杂志文章,随机对照试验
doi:10.1002/hbm.23485
更新日期:2017-04-01 00:00:00
abstract::The anterior limb of the internal capsule (ALIC) is an important locus of frontal-subcortical fiber tracts involved in cognitive and limbic feedback loops. However, the structural organization of its component fiber tracts remains unclear. Therefore, although the ALIC is a promising target for various neurosurgical pr...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23815
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:The serotonin transporter (5-HTT) and the 5-HTTLPR/rs25531 polymorphisms in its gene (SLC6A4) have been associated with depression, increased stress-response, and brain structural alterations such as reduced hippocampal volumes. Recently, epigenetic processes including SLC6A4 promoter methylation were shown ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22555
更新日期:2014-11-01 00:00:00