Abstract：
BACKGROUND:Understanding aneurysm growth rate allows us to predict not only the current rupture risk, but also accumulated rupture risk in the future. However, determining growth rate of unruptured intracranial aneurysms often requires follow-up of patients for a long period of time so that significant growth can be observed and measured. We investigate a relationship between growth rate and rupture rate and develop a theoretical model that can predict average behavior of unruptured intracranial aneurysms based on existing clinical data. METHODS:A mathematical model is developed that links growth rate and rupture rate. This model assumes a stable aneurysm size distribution so the number of aneurysm ruptures is balanced by the growth of aneurysms. Annual growth rates and growth profiles are calculated from a hypothetical size distribution and data from a previous clinical study. RESULTS:Our model predicts a growth rate of 0.34-1.63 mm/yr for three different growth models when the rupture rate at 10 mm is 1%. The growth rate is 0.56-0.65 mm/yr if annual rupture rate averaged over all aneurysm sizes is assumed to be 2%. The peak of aneurysm size distribution coincides with a period of slow growth between 5 mm and 8 mm. CONCLUSION:This mathematical model can be used to predict aneurysm growth rate, and the results are consistent with previous clinical studies. Predictions from both hypothetical and clinical cases agree very well. This model explains why some aneurysms may grow into a stable size and remain so without rupture.
journal_name
Biomed Eng Onlinejournal_title
Biomedical engineering onlineauthors
Jou LD,Mawad MEdoi
10.1186/1475-925X-8-11subject
Has Abstractpub_date
2009-06-18 00:00:00pages
11issn
1475-925Xpii
1475-925X-8-11journal_volume
8pub_type
杂志文章abstract：BACKGROUND:Frequency selectivity (FS) of the auditory system is established at the level of the cochlea and it is important for the perception of complex sounds. Although direct measurements of cochlear FS require surgical preparation, it can also be estimated with the measurements of otoacoustic emissions or behaviora...
journal_title：Biomedical engineering online
pub_type： 杂志文章
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