The use of higher dose clofarabine in adults with relapsed acute lymphoblastic leukemia.

abstract：:Intravenous morphine is the treatment of choice for severe pain during vaso- occlusive crisis in sickle cell disease (SCD). However, side effects of morphine may hamper effective treatment, and high plasma levels of morphine are associated with severe complications such as acute chest syndrome. Furthermore, adequate d...

journal_title：American journal of hematology

authors： van Beers EJ,van Tuijn CF,Nieuwkerk PT,Friederich PW,Vranken JH,Biemond BJ

更新日期：2007-11-01 00:00:00

abstract：:Responsiveness of bone marrow erythropoietic stem cells (CFU-E and BFU-E) to recombinant human erythropoietin (rh-Ep) was examined in vitro in 23 patients with aplastic anemia and 14 with myelodysplastic syndrome (MDS) to investigate the clinical use of rh-Ep for these diseases. Bone marrow mononuclear cells were cult...

journal_title：American journal of hematology

authors： Aoki I,Higashi K,Homori M,Chikazawa H,Ishikawa K

更新日期：1990-09-01 00:00:00

abstract：:Nucleotide sequence analysis of the 5' beta-globin gene flanking region has been carried out for numerous homozygous beta-thalassemia patients with different mutations and of various ethnic backgrounds. Four different rearrangements were found associated with numerous beta-thalassemia mutations. The (AT)X(T)Y repeat m...

journal_title：American journal of hematology

authors： Dimovski AJ,Adekile AD,Divoky V,Baysal E,Huisman TH

更新日期：1994-01-01 00:00:00

abstract：:Coagulation factor VIII and von Willebrand factor (VWF) are key proteins in procoagulant activation. Higher FVIII coagulant activity (FVIII :C) and VWF antigen (VWF :Ag) are risk factors for cardiovascular disease and venous thromboembolism. Beyond associations with ABO blood group, genetic determinants of FVIII and V...

journal_title：American journal of hematology

authors： Tang W,Cushman M,Green D,Rich SS,Lange LA,Yang Q,Tracy RP,Tofler GH,Basu S,Wilson JG,Keating BJ,Weng LC,Taylor HA,Jacobs DR Jr,Delaney JA,Palmer CD,Young T,Pankow JS,O'Donnell CJ,Smith NL,Reiner AP,Folsom AR

更新日期：2015-06-01 00:00:00

abstract：:After the patents of biopharmaceuticals have expired, based on specific regulatory approval pathways copied products ("biosimilars" or "follow-on biologics") have been launched in the EU. This article summarizes experiences with hematopoietic medicines, namely the epoetins (two biosimilars traded under five different ...

journal_title：American journal of hematology

authors： Jelkmann W

更新日期：2010-10-01 00:00:00

abstract：:Cerebrospinal fluid beta-2-microglobulin (CSF-beta 2m) was measured longitudinally in 48 patients affected by acute lymphoblastic leukemia (ALL). Thirteen developed a central nervous system (CNS) involvement during the course of the disease; although moderately higher mean CSF-beta 2m levels were found in these subjec...

journal_title：American journal of hematology

authors： Musto P,Tomasi P,Cascavilla N,Ladogana S,La Sala A,Melillo L,Nobile M,Castoldi G,Carotenuto M

更新日期：1988-08-01 00:00:00

abstract：:We studied the prognostic value of parameters of angiogenesis on bone marrow biopsies in newly diagnosed multiple myeloma (MM) patients. Angiogenesis parameters studied were the microvessel count done manually on light microscopy (MVD-A), microvessel count done by using computerized image analyzer (MVD-B), and total v...

journal_title：American journal of hematology

authors： Bhatti SS,Kumar L,Dinda AK,Dawar R

更新日期：2006-09-01 00:00:00

abstract：:We report a family with a dominantly transmitted syndrome resembling Fanconi's anemia and spanning two generations. This syndrome was characterized by an ill-defined hematologic stem cell disorder, immune dysfunction, poor dentition, hyperpigmented skin, warts, and multiple second trimester spontaneous abortions and i...

journal_title：American journal of hematology

authors： Alter CL,Levine PH,Bennett J,Kessler C,Rick M,Washburn RG,Gallin JI,Miller RW,Auerbach AD

更新日期：1989-12-01 00:00:00

abstract：:Matching for HLA-A, -B, -C, and -DRB1 loci (8/8 match) is currently the gold standard for unrelated donor hematopoietic cell transplantation (HCT). In Europe, patients are also matched at the HLA-DQB1 loci (10/10 match). However, there is increasing evidence that matching at HLA-DRB3/4/5 loci may help to lower transpl...

journal_title：American journal of hematology

authors： Ducreux S,Dubois V,Amokrane K,Yakoub-Agha I,Labalette M,Michallet M,Rubio MT,Kennel A,Forcade E,Lafarge X,Bulabois CE,Masson D,Daguindau E,Devys A,Moalic V,Quelvennec E,Boudifa A,Picard C,Van Endert P,de Matteis M,

更新日期：2018-05-04 00:00:00

abstract：:We have studied 91 patients with SS genotype, 44 children and 47 adults. Excluding the Cameroon and atypical haplotypes, the distribution in the children's sample exhibited 43% Benin, 38% Bantu, and 3% Senegal. In adults, the sample exhibited 46% Benin, 30% Bantu, and 9% Senegal (chi 2: 13.511, 2 df, P = 0.001). When ...

journal_title：American journal of hematology

authors： Muniz A,Corral L,Alaez C,Svarch E,Espinosa E,Carbonell N,di Leo R,Felicetti L,Nagel RL,Martinez G

更新日期：1995-06-01 00:00:00

abstract：:Zoledronic acid (ZOL), an intravenous bisphosphonate, has been shown to reduce and delay the incidence of skeletal-related events (SREs) in multiple myeloma (MM) patients with bone disease. A retrospective claims-based analysis was conducted that used two distinct US managed care databases to examine the relationship ...

journal_title：American journal of hematology

authors： Henk HJ,Teitelbaum A,Perez JR,Kaura S

更新日期：2012-05-01 00:00:00

abstract：:The case of a 21 year-old female with echinocytosis and a littoral cell hemangioma is reported. The patient had no significant past medical history and presented with abdominal pain and splenomegaly. A large percentage of echinocytes were noted on her peripheral smear in the absence of any known causes. A CT-recognize...

journal_title：American journal of hematology

authors： Altomare I,Desman G,Aledort LM

更新日期：2006-07-01 00:00:00

abstract：:Prenatal diagnosis was carried out on a woman who had previously given birth to a son with a spontaneous mutation of C-->T transition at nt 31133 of the factor IX (F.IX) gene. The diagnosis was performed on chorionic villi sampling by the method of amplification-created restriction site (ACRS). It revealed a female fe...

journal_title：American journal of hematology

authors： Young JH,Wang JC,Gau JP,Hu HT

更新日期：1996-08-01 00:00:00

abstract：:One of the more intriguing aspects of the spleen is the protection against certain bacterial infections afforded by its unique vascular and immune function. There have been extensive clinical surveys which indicate an incidence of overwhelming postsplenectomy infection (OPSI) above that of the disease for which the sp...

journal_title：American journal of hematology

authors： Krivit W

更新日期：1977-01-01 00:00:00

abstract：:CD19+CD5+ lymphocytes constitute a minority of peripheral blood B cells. In view of the importance of these cells in the pathogenesis of the immunoregulation of myeloma, their incidence in another lymphoid organ was determined. CD5+ B cells were studied in 9 spleens from patients with multiple myeloma and in 10 spleen...

journal_title：American journal of hematology

authors： MacKenzie MR,Paglieroni T,Caggiano V

更新日期：1991-07-01 00:00:00

abstract：:We report here the haplotypes of 10 MstII-defined SS patients and a S/beta o thalassemia from the Central African Republic, exhibiting 7 different atypical haplotypes that are different from the typical Bantu haplotype that characterize over 93% of the beta s bearing chromosomes in that region of Africa. Of the seven ...

journal_title：American journal of hematology

authors： Srinivas R,Dunda O,Krishnamoorthy R,Fabry ME,Georges A,Labie D,Nagel RL

更新日期：1988-09-01 00:00:00

abstract：:Familial and metachronous aggregations of malignant lymphoma are well-documented, but the molecular basis of a predisposition for development of lymphoma is as yet unclear. Malignant lymphomas have been described as part of the spectrum of neoplasias in Li-Fraumeni syndrome (LFS), which is associated with constitution...

journal_title：American journal of hematology

authors： Pötzsch C,Schaefer HE,Lübbert M

更新日期：1999-11-01 00:00:00

abstract：:Most cases of immune hemolytic anemia are associated with a positive direct antiglobulin test. However, in some cases, the antiglobulin test is not sensitive enough to detect low levels of red-cell bound antibodies. This report describes a method using radiolabelled purified staphylococcal protein A which is capable o...

journal_title：American journal of hematology

authors： Yam P,Petz LD,Spath P

更新日期：1982-06-01 00:00:00

abstract：:Cyclooxygenases (COX) are key enzymes in the conversion of arachidonic acid to prostaglandins. Several studies have shown a relation between angiogenesis and COX-2 expression. Elevated expression of cyclooxygenase-2 (COX-2), however, has not been reported in multiple myeloma (MM) in the literature. The aim of this stu...

journal_title：American journal of hematology

authors： Cetin M,Buyukberber S,Demir M,Sari I,Sari I,Deniz K,Eser B,Altuntas F,Camci C,Oztürk A,Turgut B,Vural O,Unal A

更新日期：2005-11-01 00:00:00

abstract：:We recently defined event-free survival at 24 months (EFS24) as a clinically relevant outcome for patients with DLBCL. Patients who fail EFS24 have very poor overall survival, while those who achieve EFS24 have a subsequent overall survival equivalent to that of the age- and sex-matched general population. Here, we de...

journal_title：American journal of hematology

authors： Maurer MJ,Jais JP,Ghesquières H,Witzig TE,Hong F,Haioun C,Thompson CA,Thieblemont C,Micallef IN,Porrata LF,Ribrag V,Nowakowski GS,Casasnovas O,Bologna S,Morschhauser F,Morrison VA,Peterson BA,Macon WR,Copie-Bergman C

更新日期：2016-02-01 00:00:00

abstract：:Red blood cell (RBC) autoantibodies are a relatively uncommon cause of anemia. However, autoimmune hemolytic anemia (AIHA) must be considered in the differential diagnosis of hemolytic anemias, especially if the patient has a concomitant lymphoproliferative disorder, autoimmune disease, or viral or mycoplasmal infecti...

journal_title：American journal of hematology

authors： Gehrs BC,Friedberg RC

更新日期：2002-04-01 00:00:00

abstract：:Clinical trials in hemostasis and thrombosis (HT) are needed to guide medical practice and future research. Providing public support for trials that could have the greatest impact on clinical care has been a major challenge. The National Heart, Lung and Blood Institute (NHLBI) convened a State-of-the-Science meeting i...

journal_title：American journal of hematology

authors： Cines DB,Blajchman MA,High KA,Bussel JB,State-of-the Science Symposium Hemostasis-Thrombosis Committee.

更新日期：2012-02-01 00:00:00

abstract：:The increased adhesiveness of sickle erythrocytes (SS RBC) to endothelial cells has been confirmed in a static system utilizing fresh umbilical vein endothelium. Adherence of SS RBC to the endothelium was as great in the presence of calcium-containing buffer as when incubated in plasma. SS RBC suspended in autologous ...

journal_title：American journal of hematology

authors： Antonucci R,Walker R,Herion J,Orringer E

更新日期：1990-05-01 00:00:00

abstract：:Therapies engineered to prolong clotting factor protein circulation time, manipulate the balance of pro-coagulant and anti-coagulant proteins, or introduce new genetic material to enable endogenous factor protein production dominate the clinical trial landscape of hemophilia. The availability of clotting factor concen...

journal_title：American journal of hematology

authors： Croteau SE,Wang M,Wheeler AP

更新日期：2021-01-01 00:00:00

abstract：:The objective of the study was to explore the risks and benefits of splenectomy in advanced agnogenic myeloid metaplasia (AMM). We searched the literature (Medline, 1970-1987) for studies of postoperative survival, operative mortality and effects of splenectomy on painful splenomegaly, and portal hypertension or trans...

journal_title：American journal of hematology

authors： Benbassat J,Gilon D,Penchas S

更新日期：1990-02-01 00:00:00

abstract：:Autoimmune hemolytic anemia (AIHA) associated with giant cell hepatitis (GCH) is a rare disorder in infants. AIHA usually precedes the development of liver disease by months to years. Early recognition of the disease and prompt institution of immunosuppressive therapy results in clinical remission and prevents liver d...

journal_title：American journal of hematology

authors： Kashyap R,Sarangi JN,Choudhry VP

更新日期：2006-03-01 00:00:00

abstract：:The effect of the synthetic vasopressin derivative 1-desamino-8D-arginine vasopressin (DDAVP = desmopressin) on bleeding time was studied in three patients with Hermansky Pudlak syndrome. A good response was observed in this type of storage pool disease. DDAVP might be useful in managing the bleeding disorder found in...

journal_title：American journal of hematology

authors： Wijermans PW,van Dorp DB

更新日期：1989-03-01 00:00:00

abstract：:Unprecedented advances in our understanding of the pathobiology, prognostication, and therapeutic options in mantle cell lymphoma (MCL) have taken place in the last few years. Heterogeneity in the clinical course of MCL-indolent vs aggressive-is further delineated by a correlation with the mutational status of the var...

journal_title：American journal of hematology

authors： Jain P,Wang M

更新日期：2019-06-01 00:00:00

abstract：:Erythrocytes from ten patients with severe liver disease displayed low methylene blue-stimulated hexose monophosphate (HMP) shunt activity and glucose recycling despite elevated total glucose consumption when compared to controls. Heinz body formation was increased and reduced glutathione concentration significantly d...

journal_title：American journal of hematology

authors： Smith JR,Kay NE,Gottlieb AJ,Oski FA

更新日期：1979-01-01 00:00:00

abstract：:Most reports of prognosis and therapy in diffuse small non-cleaved cell lymphoma (DSNCL), an aggressive high-grade non-Hodgkin's lymphoma (NHL) which appears to be of two histopathologic subtypes, have included predominantly a pediatric population and very few adults. We studied 20 newly diagnosed, previously untreate...

journal_title：American journal of hematology

authors： Morrison VA,Frizzera G,Arthur DC,Ogle KM,Hurd DD,Bloomfield CD,Peterson BA

更新日期：1994-08-01 00:00:00