Photoperiod alters autonomic regulation of the heart.

abstract：:Expression of luminescence in Escherichia coli was recently achieved by cloning genes from the marine bacterium Vibrio fischeri. One DNA fragment on a hybrid plasmid encoded regulatory functions and enzymatic activities necessary for light production. We report the results of a genetic analysis to identify the lumines...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Engebrecht J,Silverman M

更新日期：1984-07-01 00:00:00

abstract：:Guanosine 3':5'-cyclic monophosphate (cGMP) increased 7-fold in rat pineal glands incubated in the presence of l-norepinephrine. This response consisted of two components-one was stereospecific and inhibited by alpha-adrenergic antagonists while the other was not stereospecific and not readily inhibited by antagonists...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： O'Dea RF,Zatz M

更新日期：1976-10-01 00:00:00

abstract：:The rpoN gene encoding the transcription factor sigma54 in Myxococcus xanthus has been cloned using a heterologous rpoN probe. The sequence of the cross-hybridizing DNA confirmed the existence of an ORF 1518 bp long that encodes a well conserved member of the sigma54 family of sigma factors. Low- as well as high-strin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Keseler IM,Kaiser D

更新日期：1997-03-04 00:00:00

abstract：:A system is described for assembling infectious bacteriophage phi 6 nucleocapsids in vitro. Procapsids encoded by cDNA copies of genomic segment L in Escherichia coli were used to package and replicate viral RNA segments. The resulting filled particles were shown to be capable of infecting host cell spheroplasts after...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Olkkonen VM,Gottlieb P,Strassman J,Qiao XY,Bamford DH,Mindich L

更新日期：1990-12-01 00:00:00

abstract：:Lod scores provide a method to unify linkage tests based on identity by descent and identity in marker state while permitting selection of the most informative individuals through their disease-related phenotypes and markers in relatives. After parametric lods are reviewed, a nonparametric approach that depends on a s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Morton NE

更新日期：1996-04-16 00:00:00

abstract：:Establishment of functional synaptic connections in a selective manner is essential for nervous system operation. In mammalian retinas, rod and cone photoreceptors form selective synaptic connections with different classes of bipolar cells (BCs) to propagate light signals. While there has been progress in elucidating ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cao Y,Wang Y,Dunn HA,Orlandi C,Shultz N,Kamasawa N,Fitzpatrick D,Li W,Zeitz C,Hauswirth W,Martemyanov KA

更新日期：2020-09-22 00:00:00

abstract：:The two nitrile groups at the wings of the nonnucleoside HIV-1 reverse transcriptase (RT) inhibitor TMC278 are both identified in high-sensitivity 2D IR spectroscopy experiments of the HIV-1 RT/TMC278 complex. The vibrational spectra indicate that the two arms of the inhibitor sense quite different environments within...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fang C,Bauman JD,Das K,Remorino A,Arnold E,Hochstrasser RM

更新日期：2008-02-05 00:00:00

abstract：:Border cell migration is a stereotyped migration occurring during the development of the Drosophila egg chamber. During this process, a cluster composed of six to eight follicle cells migrates between nurse cells toward the oocyte. Receptor tyrosine kinases (RTKs) are enriched at the leading edge of the follicle cells...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Assaker G,Ramel D,Wculek SK,González-Gaitán M,Emery G

更新日期：2010-12-28 00:00:00

abstract：:Aire induces ectopic expression of peripheral tissue antigens (PTAs) in thymic medullary epithelial cells, which promotes immunological tolerance. Beginning with a broad screen of histone peptides, we demonstrate that the mechanism by which this single factor controls the transcription of thousands of genes involves r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Koh AS,Kuo AJ,Park SY,Cheung P,Abramson J,Bua D,Carney D,Shoelson SE,Gozani O,Kingston RE,Benoist C,Mathis D

更新日期：2008-10-14 00:00:00

abstract：:DNA and protein determinants of nucleosome positioning have been examined after in vitro reconstitutions of native or modified histone octamers onto tandem repeats of 207- and 172-base-pair DNA sequences containing the Lytechinus variegatus 5S rRNA gene and onto monomeric sequences derived from these by digestion with...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dong F,Hansen JC,van Holde KE

更新日期：1990-08-01 00:00:00

abstract：:Adaptive behavior requires animals to learn from experience. Ideally, learning should both promote choices that lead to rewards and reduce choices that lead to losses. Because the ventral striatum (VS) contains neurons that respond to aversive stimuli and aversive stimuli can drive dopamine release in the VS, it is po...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Taswell CA,Costa VD,Murray EA,Averbeck BB

更新日期：2018-12-26 00:00:00

abstract：:A key challenge in ecology is to define species' niches on the basis of functional traits. Size and shape are important determinants of a species' niche but their causal role is often difficult to interpret. For endotherms, size and shape define the thermal niche through their interaction with core temperature, insula...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Porter WP,Kearney M

更新日期：2009-11-17 00:00:00

abstract：:Valproic acid (VPA) is an anticonvulsant drug that is also used to treat migraines and bipolar disorder. Its proposed biological targets include human voltage-gated sodium channels, among other membrane proteins. We used the prokaryotic NavMs sodium channel, which has been shown to be a good exemplar for drug binding ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zanatta G,Sula A,Miles AJ,Ng LCT,Torella R,Pryde DC,DeCaen PG,Wallace BA

更新日期：2019-12-10 00:00:00

abstract：:A single mutation altering the transmembrane domain of the receptor-like p185 protein encoded by the rat neu gene converts the normal neu gene into a potent oncogene. The biochemical consequences of this mutation were studied by examining phosphorylation of the normal and transforming p185 molecules in membrane prepar...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bargmann CI,Weinberg RA

更新日期：1988-08-01 00:00:00

abstract：:Arachidonic acid (AA) has recently been shown to influence various cellular functions in the central nervous system. Here we report that AA increases, in a time- and concentration-dependent manner, 2-deoxy-D-[1-3H]glucose ([3H]2DG) uptake in primary cultures of astrocytes prepared from the cerebral cortex of neonatal ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yu N,Martin JL,Stella N,Magistretti PJ

更新日期：1993-05-01 00:00:00

abstract：:We have investigated the biochemical basis for negative regulation of interleukin 2 receptor alpha-chain (IL-2R alpha) gene expression. Transient transfection studies employing internally deleted forms of the IL-2R alpha promoter localized a negative regulatory element (NRE) between nucleotides -400 and -368 relative ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smith MR,Greene WC

更新日期：1989-11-01 00:00:00

abstract：:alpha-1-Antitrypsin is a serum protein that inhibits many proteolytic enzymes. Recently, it was suggested that the alpha-1-antitrypsin-trypsin complex is an acyl ester analogous to the acyl intermediate that forms between trypsin and its substrates. In previous work we showed that the alpha-1-antitrypsin-trypsin compl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cohen AB,Gruenke LD,Craig JC,Geczy D

更新日期：1977-10-01 00:00:00

abstract：:Positive-strand RNA viruses are the largest virus class and include many pathogens such as hepatitis C virus and the severe acute respiratory syndrome coronavirus (SARS). Brome mosaic virus (BMV) is a representative positive-strand RNA virus whose RNA replication, gene expression, and encapsidation have been reproduce...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kushner DB,Lindenbach BD,Grdzelishvili VZ,Noueiry AO,Paul SM,Ahlquist P

更新日期：2003-12-23 00:00:00

abstract：:The number of sensory receptor genes varies extensively among different mammalian species. This variation is believed to be caused partly by physiological requirements of animals and partly by genomic drift due to random duplication and deletion of genes. If the contribution of genomic drift is substantial, each speci...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nozawa M,Kawahara Y,Nei M

更新日期：2007-12-18 00:00:00

abstract：:A site that is preferentially cleaved by the single-strand-specific endonuclease from Aspergillus oryzae was located in vitro 180 base pairs upstream from the 5' end of the chicken pro-alpha 2(I) collagen gene. It is found in supercoiled plasmids with a negative superhelical density of -0.024 or more but not in linear...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Finer MH,Fodor EJ,Boedtker H,Doty P

更新日期：1984-03-01 00:00:00

abstract：:A wide range of research has promised new tools for forecasting infectious disease dynamics, but little of that research is currently being applied in practice, because tools do not address key public health needs, do not produce probabilistic forecasts, have not been evaluated on external data, or do not provide suff...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Johansson MA,Apfeldorf KM,Dobson S,Devita J,Buczak AL,Baugher B,Moniz LJ,Bagley T,Babin SM,Guven E,Yamana TK,Shaman J,Moschou T,Lothian N,Lane A,Osborne G,Jiang G,Brooks LC,Farrow DC,Hyun S,Tibshirani RJ,Rosenfe

更新日期：2019-11-26 00:00:00

abstract：:It is generally believed that serial passage at high multiplicity of infection (moi) is required for the generation of defective interfering (DI) particles. High levels of DI RNAs are found associated with persistent infections initiated with laboratory cultures of cucumber necrosis virus (CNV). Two synthetic CNV tran...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rochon DM

更新日期：1991-12-15 00:00:00

abstract：:For a constant membrane potential, a predominantly inhibitory GABAergic synaptic response is shown to undergo long-term transformation into an excitatory response after pairing of exogenous gamma-aminobutyric acid (GABA) with postsynaptic depolarization or pairing of pre- and postsynaptic stimulation. Current- and vol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Alkon DL,Sánchez-Andrés JV,Ito E,Oka K,Yoshioka T,Collin C

更新日期：1992-12-15 00:00:00

abstract：:The secreted Bv8 protein has been recently characterized as a regulator of myeloid cell mobilization and a neutrophil-derived mediator of tumor angiogenesis in several xenografts, but its role in tumor progression in an endogenous setting was unknown. The rat insulin promoter (RIP)-T-antigen (Tag) is a well characteri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shojaei F,Singh M,Thompson JD,Ferrara N

更新日期：2008-02-19 00:00:00

abstract：:We have measured the quantities of naturally occurring autoantibodies in the serum of normal, unmanipulated individuals. These changes over time following broad-band complex dynamical patterns that are similar in mouse and man. The patterns more likely reflect the network architecture of the natural antibody repertoir...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Varela F,Andersson A,Dietrich G,Sundblad A,Holmberg D,Kazatchkine M,Coutinho A

更新日期：1991-07-01 00:00:00

abstract：:Assembly of light-harvesting complexes requires synchronization of chlorophyll (Chl) biosynthesis with biogenesis of light-harvesting Chl a/b-binding proteins (LHCPs). The chloroplast signal recognition particle (cpSRP) pathway is responsible for transport of nucleus-encoded LHCPs in the stroma of the plastid and thei...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang P,Liang FC,Wittmann D,Siegel A,Shan SO,Grimm B

更新日期：2018-04-10 00:00:00

abstract：:Cachectin (tumor necrosis factor) is a powerful macrophage hormone released during infection, which circulates in blood to produce diverse effects in the organism. We examined the effect of cachectin on release of anterior pituitary hormones from either hemipituitaries or dispersed pituitary cells incubated in vitro. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Milenkovic L,Rettori V,Snyder GD,Beutler B,McCann SM

更新日期：1989-04-01 00:00:00

abstract：:The thymus lacks self-renewing hematopoietic cells, and thymopoiesis fails rapidly when the migration of progenitor cells to the thymus ceases. Hence, the process of thymus homing is an essential step for T-cell development and cellular immunity. Despite decades of research, the molecular details of thymus homing have...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Calderón L,Boehm T

更新日期：2011-05-03 00:00:00

abstract：:Polypeptide chains of 19 previously studied Escherichia coli aminoacyl-tRNA synthetases are as large as 951 amino acids and, depending on the enzyme, have quaternary structures of alpha, alpha 2, alpha 2 beta 2, and alpha 4. These enzymes have been organized into two classes which are defined by sequence motifs that a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hou YM,Shiba K,Mottes C,Schimmel P

更新日期：1991-02-01 00:00:00

abstract：:The synaptonemal complex (SC) is a conserved meiotic structure that regulates the repair of double-strand breaks (DSBs) into crossovers or gene conversions. The removal of any central-region SC component, such as the Drosophila melanogaster transverse filament protein C(3)G, causes a complete loss of SC structure and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Billmyre KK,Cahoon CK,Heenan GM,Wesley ER,Yu Z,Unruh JR,Takeo S,Hawley RS

更新日期：2019-10-22 00:00:00