Abstract:
OBJECTIVE:To compare the efficacy, safety, and tolerability of olanzapine and quetiapine in adolescents with first episode psychosis. METHOD:Fifty adolescents (age 16 +/- 1.25) with a first episode of psychosis were randomized to quetiapine or olanzapine in a 6-month open label study. Efficacy and side effect scales, as well as vital signs and laboratory data were recorded at baseline, 7, 15, 30, 90, and 180 days (end of study). RESULTS:Out of the total sample included in the study, 32 patients completed the trial (quetiapine n = 16, olanzapine n = 16). Patients in both treatment groups had a significant reduction in all clinical scales with the exception of the negative scale of the Positive and Negative Symptom Scale (PANSS) for olanzapine and the general psychopathology scale of the PANSS for quetiapine. The only difference between treatment arms on the clinical scales was observed on the patients' strength and difficulties questionnaire (SDQ) scale, with greater improvement for olanzapine. Patients on olanzapine gained 15.5 kg and patients on quetiapine gained 5.5 kg. CONCLUSION:Olanzapine and quetiapine reduced psychotic symptoms in this adolescent sample. Patients on olanzapine gained significantly more weight. Side effects with both drugs seemed to be more prevalent than those reported in adult studies.
journal_name
Eur Child Adolesc Psychiatryjournal_title
European child & adolescent psychiatryauthors
Arango C,Robles O,Parellada M,Fraguas D,Ruiz-Sancho A,Medina O,Zabala A,Bombín I,Moreno Ddoi
10.1007/s00787-009-0749-5subject
Has Abstractpub_date
2009-07-01 00:00:00pages
418-28issue
7eissn
1018-8827issn
1435-165Xjournal_volume
18pub_type
杂志文章,随机对照试验abstract::Nine people from the high functioning end of the autistic spectrum and eight non-handicapped controls matched on verbal IQ were given two tests of second-order false belief understanding. On the basis of previous research, it was hypothesised that the subjects with autism used different mechanisms to process mental st...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/BF00538988
更新日期:1997-09-01 00:00:00
abstract::A crossover 'placebo'-controlled, double-blind design was used to examine the effectiveness of an oligoantigenic diet in 49 children with hyperactive/disruptive behavior disorder. Effects of diet were compared with those yielded by stimulant medication (methylphenidate). The study was conducted in an inpatient unit at...
journal_title:European child & adolescent psychiatry
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF00566671
更新日期:1997-06-01 00:00:00
abstract::Given the known behavior effects of oxytocin,and in particular its putative effect on trust, affiliation and anxiety, we hypothesized that oxytocin may be involved in the development and expression of callous-unemotional traits in children with aggressive antisocial behavior. We recruited 162 children between the ages...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-012-0240-6
更新日期:2012-03-01 00:00:00
abstract::The BELLA study on mental health and well-being in children and adolescents is the mental health module of the German Health Interview and Examination Survey for Children and Adolescents (KiGGS). The cross-sectional KiGGS survey collected comprehensive data on the health status of 17,641 children and adolescents, aged...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章,评审
doi:10.1007/s00787-008-1002-3
更新日期:2008-12-01 00:00:00
abstract::This is the first clinical description of a detailed psychological, speech, and language phenotype of four young children (< 5 years) with Velo-Cardio-Facial syndrome (VCFS) due to a deletion on chromosome 22 (22q11.2). The reported elevated risk of developing schizophrenia or bipolar disorder in adolescence for indiv...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s007870050005
更新日期:2000-06-01 00:00:00
abstract::The main behavioral characteristic of subthreshold depression that is observed in adolescents is the low frequency of exposure to environmental rewards. Therefore, it was considered that a simple intervention conducted in short sessions, focusing on increasing access to positively reinforcing activities, would be effi...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00787-016-0842-5
更新日期:2016-11-01 00:00:00
abstract::Half of mental disorders have their first onset before adulthood when the presence of a disorder may be particularly disruptive to developmental milestones. Retrospective prevalence estimates have been shown to underestimate the burden of mental illness and scarce data are available on the incidence of disorders throu...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-015-0721-5
更新日期:2016-02-01 00:00:00
abstract::The objective of this study is to compare the cognitive profile, the motor and language functioning and the psychosocial adaptation of children with Asperger syndrome (AS) and with high-functioning autism (HFA). Subjects were recruited through the department Autism and Developmental Disorders of the Heckscher-Klinikum...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-009-0057-0
更新日期:2010-06-01 00:00:00
abstract::Previous studies have suggested environmental factors may contribute to the risk of attention-deficit/hyperactivity disorder (ADHD). The current meta-analysis examined (1) the difference in the duration of maternal breastfeeding between children with and without ADHD, and (2) the association between maternal breastfee...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章,meta分析
doi:10.1007/s00787-018-1182-4
更新日期:2019-01-01 00:00:00
abstract::Academic impairment in individuals with attention-deficit/hyperactivity disorder (ADHD) is in part due to reduced motivation for academic tasks, which is likely to vary as a function of task characteristics. The current study employed a new questionnaire-the Child and Adolescent Motivational Profile (CHAMP)-to examine...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-020-01494-8
更新日期:2020-03-10 00:00:00
abstract::Infant mental health problems include difficulties to regulate emotions or attention, crying, sleeping or feeding problems as well as aggressive behavior. Early identifications of these problems help to change developmental trajectories and improve developmental outcomes. Psychiatric assessment and classification have...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章,评审
doi:10.1007/s00787-012-0364-8
更新日期:2013-02-01 00:00:00
abstract::Anorexia nervosa (AN) and bulimia nervosa (BN) are complex disorders characterized by disordered eating behavior where the patient's attitude towards weight and shape, as well as their perception of body shape, are disturbed. Formal genetic studies on twins and families suggested a substantial genetic influence for AN...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章,评审
doi:10.1007/s00787-009-0085-9
更新日期:2010-03-01 00:00:00
abstract::Children with infantile autism and children with a specific receptive language disorder often show similar behavioural problems, making the differentiation between these two diagnostic categories difficult. The purpose of this study is to evaluate the usefulness of parental information in the differential diagnosis of...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s007870170014
更新日期:2001-12-01 00:00:00
abstract::Research consistently chronicles a variety of mental health difficulties that plague institutionally reared children, including attention-deficit/hyperactivity disorder (ADHD), even if not all institutionalized children evince such problems. In seeking to extend work in this area, this research on gene × environment (...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-016-0890-x
更新日期:2017-03-01 00:00:00
abstract::Alterations in fear learning/generalization are considered to be relevant mechanisms engendering the development of anxiety disorders being the most prevalent mental disorders. Although anxiety disorders almost exclusively have their first onset in childhood and adolescence, etiological research focuses on adult indiv...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-019-01458-7
更新日期:2020-09-01 00:00:00
abstract::The purpose of this study was to estimate the prevalence rates of probable posttraumatic stress disorder (PTSD) and depression and to explore potential risk factors among child and adolescent survivors 1 year following the 2008 Wenchuan earthquake. 3052 participants were administered the Child PTSD Symptom Scale, the ...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-013-0400-3
更新日期:2013-09-01 00:00:00
abstract::The purpose of this study was to evaluate the relationships between severe asthma, type and incidence of psychiatric problems in a pediatric population. A group of 92 children and adolescents (63 boys and 29 girls) (mean age 11.7) was investigated over one year by a pediatric pneumology/allergy service unit. The psych...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s007870050059
更新日期:1998-09-01 00:00:00
abstract::One third of children with autistic spectrum disorders (or pervasive developmental disorders) enter that state by regression from a more normal prior development at the onset of epilepsy or epileptiform abnormality in the electroencephalogram. In a very small proportion structural lesions of the temporal lobes are dis...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s007870050128
更新日期:1999-09-01 00:00:00
abstract::Autistic spectrum disorders (ASD) are characterised by attention deficits in communication and social interactions and a lack of interest in people. Data are mostly based on clinical situations. However, recent studies have shown a more mixed situation where children with ASD (ASD children) displayed interest towards ...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-014-0528-9
更新日期:2015-01-01 00:00:00
abstract::Evidence points to an independent relationship among childhood maltreatment, impairments in executive functions (EF) and disruptive behavior disorders (DBD). However, it is still not fully understood how these three factors are interrelated. This study evaluated the association between childhood maltreatment and DBD t...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-019-01408-3
更新日期:2020-07-01 00:00:00
abstract::The objective of this study was to examine the relationship between pre-pregnancy maternal weight status and offspring physician visits for mental health conditions in childhood and adolescence. We conducted a population-based retrospective cohort study of singleton infants born between the years of 1989 and 1993 usin...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-019-01312-w
更新日期:2019-11-01 00:00:00
abstract::What dimensions of maternal psychopathology predict internalising or externalising disorder in children? We conducted a study of maternal axis I and axis II psychopathology in a group of children 8-12 years of age with Generalised Anxiety Disorder (GAD), Oppositional Defiant Disorder (ODD) and non-patient controls (NC...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-006-0578-8
更新日期:2007-03-01 00:00:00
abstract::Non-suicidal self-injury (NSSI) is a considerable health problem among adolescents. Affect regulation by means of self-injury may promote the maintenance of NSSI. However, existing findings have limited ecological validity. The present study aimed to assess emotional and interpersonal states preceding and following in...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-020-01626-0
更新日期:2020-08-29 00:00:00
abstract::While parental psychological distress is a commonly examined risk factor in the development and maintenance of child's emotional and behavioral problems, there is an incomplete understanding of the unique contribution of the father. The current study examines whether paternal psychological distress (i.e., depression, ...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-020-01613-5
更新日期:2020-08-09 00:00:00
abstract::Functional enuresis is a heterogeneous group of syndromes with different aetiology and pathophysiology. The aim was to identify specific somatic correlates of enuresis non-invasively in child psychiatric patients after exclusion of neurologic and structural forms of incontinence. One hundred sixty-seven consecutive ch...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s007870050092
更新日期:1999-06-01 00:00:00
abstract::There is increasing evidence that prenatal stressful life events (SLEs) may be a potential risk factor for attention-deficit hyperactivity disorder (ADHD), but the sex-specific and time-dependent effects of prenatal stress on ADHD are less clear. In this prospective longitudinal study, data on prenatal SLEs during dif...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-015-0701-9
更新日期:2015-09-01 00:00:00
abstract::Few studies have examined the effectiveness of outpatient cognitive-behavioral therapy (CBT) delivered in routine care settings for children and adolescents with mental disorders. This observational study examined changes in behavioral and emotional problems of adolescents with mental disorders during routine outpatie...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-017-1021-z
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:The process of childbirth and its complications have been related to the newborn's condition and to development at later ages. In this study, we examine how mode of delivery and delivery complications are related to the behavior and cortisol reactivity of infants during the first 2 months. METHODS:Delivery ...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-007-0610-7
更新日期:2007-09-01 00:00:00
abstract::The aims of this study were, firstly, to study the association between parents' and teachers' ratings for the Finnish version of the Autism Spectrum Screening Questionnaire (ASSQ), secondly, to find out whether the original cut-off scores of the ASSQ identify primary school-aged children with Asperger syndrome (AS) or...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-009-0044-5
更新日期:2009-08-01 00:00:00
abstract::The importance of paying attention to scale levels is emphasized and it is pointed out that Steven's hierarchy of ratio, interval, ordinal, and nominal scales is too narrow; other important scale properties have to be considered. For instance, sometimes a carefully constructed variable on a nominal scale contains more...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/BF00538540
更新日期:1996-01-01 00:00:00