Sex-specific and time-dependent effects of prenatal stress on the early behavioral symptoms of ADHD: a longitudinal study in China.

Abstract:

:There is increasing evidence that prenatal stressful life events (SLEs) may be a potential risk factor for attention-deficit hyperactivity disorder (ADHD), but the sex-specific and time-dependent effects of prenatal stress on ADHD are less clear. In this prospective longitudinal study, data on prenatal SLEs during different stages of gestation and indicators of buffers against stress, including maternal social support and avoidance coping, were obtained from 1765 pregnant women at 32 weeks of gestation. The behavioral symptoms of ADHD in children aged 48-54 months were evaluated by reports from the parents. There were 226 children (12.8%) above the clinically significant cutoff for ADHD. After adjusting for potential confounders, boys whose mother experienced severe SLEs in the second trimester had a significantly increased risk (OR = 2.41, 95% CI: 1.03-5.66) of developing ADHD symptoms compared with boys whose mothers did not experience severe SLEs at this time. However, no significantly increased risk of ADHD symptoms was observed in girls born to mothers experienced prenatal severe SLEs. Additionally, significant interaction effects of prenatal SLEs, social support and coping style on ADHD symptoms were found in males. Boys whose mothers experienced severe SLEs during the second trimester accompanied by a higher score for avoidance coping (OR = 3.31, 95% CI: 1.13-9.70) or a lower score for social support (OR = 4.39, 95% CI: 1.05-18.31) were likely to be at a higher risk for ADHD symptoms. The epidemiological evidence in this prospective follow-up study suggests that the effect of prenatal SLEs on ADHD symptoms in offspring may depend on the timing of prenatal stress and may vary according to the sex of the offspring.

authors

Zhu P,Hao JH,Tao RX,Huang K,Jiang XM,Zhu YD,Tao FB

doi

10.1007/s00787-015-0701-9

subject

Has Abstract

pub_date

2015-09-01 00:00:00

pages

1139-47

issue

9

eissn

1018-8827

issn

1435-165X

journal_volume

24

pub_type

杂志文章
  • Medical comorbidities in children and adolescents with autism spectrum disorders and attention deficit hyperactivity disorders: a systematic review.

    abstract::Somatic disorders occur more often in adult psychiatric patients than in the general adult population. However, in child and adolescent psychiatry this association is unclear, mainly due to a lack of integration of existing data. To address this issue, we here present a systematic review on medical comorbidity in the ...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章,评审

    doi:10.1007/s00787-017-1020-0

    authors: Muskens JB,Velders FP,Staal WG

    更新日期:2017-09-01 00:00:00

  • Does maternal psychopathology discriminate between children with DSM-IV generalised anxiety disorder or oppositional defiant disorder? The predictive validity of maternal axis I and axis II psychopathology.

    abstract::What dimensions of maternal psychopathology predict internalising or externalising disorder in children? We conducted a study of maternal axis I and axis II psychopathology in a group of children 8-12 years of age with Generalised Anxiety Disorder (GAD), Oppositional Defiant Disorder (ODD) and non-patient controls (NC...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章

    doi:10.1007/s00787-006-0578-8

    authors: Nordahl HM,Ingul JM,Nordvik H,Wells A

    更新日期:2007-03-01 00:00:00

  • Elevated daytime melatonin concentrations in autism: A pilot study.

    abstract::Concentrations of melatonin in overnight and first-voiding urine samples from 10 people with autism, 15 parents, 1 grandparent, 9 sibs without autism, and 10 healthy, unrelated volunteers, were measured by radioimmunoassay. Those with autism had significantly higher melatonin concentrations in the first voiding sample...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章

    doi:10.1007/BF02098862

    authors: Ritvo ER,Ritvo R,Yuwiler A,Brothers A,Freeman BJ,Plotkin S

    更新日期:1993-04-01 00:00:00

  • Gestational age and chronic 'body-mind' health problems in childhood: dose-response association and risk factors.

    abstract::Understanding the developmental course of all health issues associated with preterm birth is important from an individual, clinical and public health point-of-view. Both the number of preterm births and proportion of survivors have increased steadily in recent years. The UK Millennium Cohort Study (n = 18,818) was use...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章

    doi:10.1007/s00787-016-0872-z

    authors: Cronin FM,Segurado R,McAuliffe FM,Kelleher CC,Tremblay RE

    更新日期:2017-01-01 00:00:00

  • Living with conduct problem youth: family functioning and parental perceptions of their child.

    abstract::Parenting children with conduct problems (CP) is challenging, yet very little is known about the impact of the child's behaviour on family functioning or how parents of children with CP perceive their child. The aim of this research was to examine whether families with children with CP and high vs. low levels of callo...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章

    doi:10.1007/s00787-017-1088-6

    authors: Roberts R,McCrory E,Joffe H,De Lima N,Viding E

    更新日期:2018-05-01 00:00:00

  • Comparative efficacy of once-a-day extended-release methylphenidate, two-times-daily immediate-release methylphenidate, and placebo in a laboratory school setting.

    abstract:BACKGROUND:Given the dosing limitations of methylphenidate short-acting preparations in treating ADHD, galenics with longer release of the substance were developed mainly to avoid drug intake during school hours. OBJECTIVES:This investigation was conducted to assess the efficacy and the duration of action of a new ext...

    journal_title:European child & adolescent psychiatry

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1007/s00787-004-1009-3

    authors: Döpfner M,Gerber WD,Banaschewski T,Breuer D,Freisleder FJ,Gerber-von Müller G,Günter M,Hässler F,Ose C,Rothenberger A,Schmeck K,Sinzig J,Stadler C,Uebel H,Lehmkuhl G

    更新日期:2004-01-01 00:00:00

  • Pedigree analysis of Hungarian Rett syndrome girls.

    abstract::Twenty-two Hungarian families with Rett syndrome girls were genealogically examined. None of our 23 probands was born to first-cousin couples, but we established increased number of consanguineous marriages among the ancestors of the patients. Observing the places where the Rett families originate from, we found a pre...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章

    doi:

    authors: Hollody K,Borvendég K,Kosztolányi G

    更新日期:1997-01-01 00:00:00

  • Neuroanatomical changes associated with conduct disorder in boys: influence of childhood maltreatment.

    abstract::Childhood maltreatment (CM) poses a serious risk to the physical, emotional and psychological well-being of children, and can advance the development of maladaptive behaviors, including conduct disorder (CD). CD involves repetitive, persistent violations of others' basic rights and societal norms. Little is known abou...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章

    doi:10.1007/s00787-020-01697-z

    authors: Gao Y,Jiang Y,Ming Q,Zhang J,Ma R,Wu Q,Dong D,Sun X,He J,Cao W,Yuan S,Yao S

    更新日期:2021-01-04 00:00:00

  • Familial risk factors in social anxiety disorder: calling for a family-oriented approach for targeted prevention and early intervention.

    abstract::Within the last decade, social anxiety disorder (SAD) has been identified as a highly prevalent and burdensome disorder. Both the characterization of its symptomatology and effective treatment options are widely documented. Studies particularly indicate that SAD aggregates in families and has its onset in early adoles...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章,评审

    doi:10.1007/s00787-010-0138-0

    authors: Knappe S,Beesdo-Baum K,Wittchen HU

    更新日期:2010-12-01 00:00:00

  • The combined self- and parent-rated SDQ score profile predicts care use and psychiatric diagnoses.

    abstract::The Strengths and Difficulties Questionnaire (SDQ) is widely used, based on evidence of its value for screening. This evidence primarily regards the single informant total difficulties scale and separate difficulties subscales. We assessed to what degree adolescents' SDQ profiles that combined all self- and parent-rat...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章

    doi:10.1007/s00787-020-01667-5

    authors: Vugteveen J,de Bildt A,Hartman CA,Reijneveld SA,Timmerman ME

    更新日期:2020-10-30 00:00:00

  • Health-related quality of life of children with attention-deficit/hyperactivity disorder versus children with diabetes and healthy controls.

    abstract::The impact of attention-deficit/hyperactivity disorder (ADHD) on health-related quality of life (HRQoL) is reported to be similar to that of other mental health and physical disorders. In this cross-sectional study, we hypothesized that children with ADHD and children with type 1 diabetes mellitus (T1DM) would have si...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章

    doi:10.1007/s00787-015-0728-y

    authors: Coghill D,Hodgkins P

    更新日期:2016-03-01 00:00:00

  • Amfetamine and methylphenidate medications for attention-deficit/hyperactivity disorder: complementary treatment options.

    abstract::Attention-deficit/hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders among school-aged children. It is highly symptomatic and associated with significant impairment. This review examines the role of stimulant medications in the treatment of children and adolescents with ADHD. Publishe...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章,评审

    doi:10.1007/s00787-012-0286-5

    authors: Hodgkins P,Shaw M,Coghill D,Hechtman L

    更新日期:2012-09-01 00:00:00

  • The use of the ADI-R as a diagnostic tool in the differential diagnosis of children with infantile autism and children with a receptive language disorder.

    abstract::Children with infantile autism and children with a specific receptive language disorder often show similar behavioural problems, making the differentiation between these two diagnostic categories difficult. The purpose of this study is to evaluate the usefulness of parental information in the differential diagnosis of...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章

    doi:10.1007/s007870170014

    authors: Mildenberger K,Sitter S,Noterdaeme M,Amorosa H

    更新日期:2001-12-01 00:00:00

  • Folie à famille and separation-individuation.

    abstract::The case history, treatment and follow-up of a family sharing the same delusion are presented in this article. The characteristics of separation-individuation of this pathological condition and its treatment are discussed. ...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章

    doi:10.1007/s007870170026

    authors: Cuhadaroğlu Cetin F

    更新日期:2001-09-01 00:00:00

  • The British approach to child and adolescent psychiatry: a course for Russian postgraduates.

    abstract::A two week course in Child and Adolescent Psychiatry was given in St. Petersburg as part of the partnership between the City's Child and Adolescent Psychiatry Service and Division of Child and Adolescent Psychiatry at Leicester University Medical School. In such a short course, it was necessary to focus on areas of pa...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章

    doi:10.1007/BF00538848

    authors: Nicol R

    更新日期:1996-12-01 00:00:00

  • Comorbidity of conduct disorder symptoms and internalising problems in children: investigating a community and a clinical sample.

    abstract::Previous studies have demonstrated that many children with conduct problems (CP) also show internalising psychopathology (IP). However, it remains unclear whether the presence of IP serves as a protective or risk factor for the severity and development of CP. The aim of the present study was to assess the prevalence a...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章

    doi:10.1007/s00787-011-0229-6

    authors: Polier GG,Vloet TD,Herpertz-Dahlmann B,Laurens KR,Hodgins S

    更新日期:2012-01-01 00:00:00

  • Family stress, family functioning and emotional/behavioural problems following child psychiatric treatment.

    abstract::This study assesses family stress, family functioning and emotional/behavioural problems in a sample of 80 formerly daytreated or residentially treated boys after a mean discharge period of four years. Family stress was assessed with a Questionnaire of Life Events (QLE) and family functioning with the Family Adaptabil...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章

    doi:10.1007/BF01987963

    authors: Veerman JW

    更新日期:1995-01-01 00:00:00

  • Pediatric use of prescribed melatonin in Sweden 2006-2017: a register based study.

    abstract::Sleep disturbances are common in the pediatric population and should primarily be treated non-pharmacologically. Most medicines for sleep disturbances are not approved for pediatric use and data on long-term safety is scarce. In Sweden, melatonin is classified as a prescription medicine. The aim of the present study w...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章

    doi:10.1007/s00787-020-01598-1

    authors: Kimland EE,Bardage C,Collin J,Järleborg A,Ljung R,Iliadou AN

    更新日期:2020-07-22 00:00:00

  • Selective mutism among second-graders in elementary school.

    abstract:OBJECTIVE:This study assessed the prevalence of selective mutism among second graders in elementary school, and examined related issues such as the situations in which the children refuse to speak, their performance level at school, and some temperamental/behavioural characteristics of these children. METHOD:A definit...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章

    doi:10.1007/s007870050041

    authors: Kumpulainen K,Räsänen E,Raaska H,Somppi V

    更新日期:1998-03-01 00:00:00

  • Taking a closer look: autonomic dysregulation in socially anxious children.

    abstract::Previous research on autonomic characteristics of social anxiety in children and adolescents has produced highly inconsistent results which may partially be due to task differences and a limited breadth of autonomic measurement. Here we investigated a sample of high (HSA) and low socially anxious (LSA) children, aged ...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章

    doi:10.1007/s00787-013-0405-y

    authors: Schmitz J,Tuschen-Caffier B,Wilhelm FH,Blechert J

    更新日期:2013-10-01 00:00:00

  • Papa was a rollin' stone: how father's psychological distress impacts child's internalizing and externalizing symptoms.

    abstract::While parental psychological distress is a commonly examined risk factor in the development and maintenance of child's emotional and behavioral problems, there is an incomplete understanding of the unique contribution of the father. The current study examines whether paternal psychological distress (i.e., depression, ...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章

    doi:10.1007/s00787-020-01613-5

    authors: Bailey EN,Marker CD

    更新日期:2020-08-09 00:00:00

  • Maternal pre-pregnancy weight status and health care use for mental health conditions in the offspring.

    abstract::The objective of this study was to examine the relationship between pre-pregnancy maternal weight status and offspring physician visits for mental health conditions in childhood and adolescence. We conducted a population-based retrospective cohort study of singleton infants born between the years of 1989 and 1993 usin...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章

    doi:10.1007/s00787-019-01312-w

    authors: Grudzinski A,Campbell LA,Liu L,Brown MM,Dodds L,Kuhle S

    更新日期:2019-11-01 00:00:00

  • Mental health problems in children of somatically ill parents, e.g. multiple sclerosis.

    abstract:OBJECTIVES:Based on the investigation of 144 families (144 patients affected by Multiple Sclerosis (MS), 109 partners, and 192 children) examined in three different European child and adolescent psychiatric University centres by means of questionnaires, we evaluated the prevalence of psychological symptoms in the offsp...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章

    doi:10.1007/s00787-006-0589-5

    authors: Steck B,Amsler F,Grether A,Dillier AS,Baldus C,Haagen M,Diareme L,Tsiantis J,Kappos L,Bürgin D,Romer G

    更新日期:2007-04-01 00:00:00

  • Prevalence and risk factors for child mental disorders in a population-based cohort of HIV-exposed and unexposed African children aged 7-11 years.

    abstract::Despite being home to a large population of vulnerable children there is a dearth of population-based evidence on childhood mental disorders in sub-Saharan Africa. Parent and child mental health are rarely measured concurrently, despite potential for confounding with other risk factors, including parental HIV. Using t...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章

    doi:10.1007/s00787-018-1146-8

    authors: Rochat TJ,Houle B,Stein A,Pearson RM,Bland RM

    更新日期:2018-12-01 00:00:00

  • Factors affecting nightmares in children: parents' vs. children's ratings.

    abstract:OBJECTIVE:The present study investigated the relationship between daytime symptomatology and nightmare frequency in school-aged children by eliciting daytime symptoms and nightmare frequency from children directly in addition to questionnaires completed by their parents. METHODS:A sample of 4,834 parents and 4,531 of ...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章

    doi:10.1007/s00787-008-0697-5

    authors: Schredl M,Fricke-Oerkermann L,Mitschke A,Wiater A,Lehmkuhl G

    更新日期:2009-01-01 00:00:00

  • When does the Autism Spectrum Screening Questionnaire (ASSQ) predict autism spectrum disorders in primary school-aged children?

    abstract::The aims of this study were, firstly, to study the association between parents' and teachers' ratings for the Finnish version of the Autism Spectrum Screening Questionnaire (ASSQ), secondly, to find out whether the original cut-off scores of the ASSQ identify primary school-aged children with Asperger syndrome (AS) or...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章

    doi:10.1007/s00787-009-0044-5

    authors: Mattila ML,Jussila K,Kuusikko S,Kielinen M,Linna SL,Ebeling H,Bloigu R,Joskitt L,Pauls D,Moilanen I

    更新日期:2009-08-01 00:00:00

  • Comorbidity and subgroups in childhood autism.

    abstract::The objective of this study was to identify clinical subgroups in children with childhood autism and to examine comorbidity in each subgroup. The study was based on medical records of 30 inpatients referred to a specialist ward for children with pervasive developmental disorders. Eighteen consecutive patients with an ...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章

    doi:10.1007/s007870050110

    authors: Bonde E

    更新日期:2000-03-01 00:00:00

  • Subclinical autism spectrum symptoms in pediatric obsessive-compulsive disorder.

    abstract::The literature on subclinical autism spectrum (ASD) symptoms in pediatric obsessive-compulsive disorder (OCD) is scarce, and it remains unclear whether ASD symptoms are related to OCD severity. The aims of the present study were to assess the prevalence of ASD symptoms and age and sex differences in children and adole...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章

    doi:10.1007/s00787-015-0782-5

    authors: Arildskov TW,Højgaard DR,Skarphedinsson G,Thomsen PH,Ivarsson T,Weidle B,Melin KH,Hybel KA

    更新日期:2016-07-01 00:00:00

  • Adaptation and adjustment in children of transsexual parents.

    abstract::It is a relatively uncommon event that children find themselves in a situation with a parent who undergoes a transition from one sex to another. Unlike situations of divorce or a parent with a medical or major psychiatric disorder, it is unlikely that the children will know of other children who encounter similar situ...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章

    doi:10.1007/s00787-006-0591-y

    authors: White T,Ettner R

    更新日期:2007-06-01 00:00:00

  • Psychosocial factors and adequacy of services for children in children's homes.

    abstract::Risk and protective factors of psychosocial development in children in different residential care settings need to be further studied internationally, in order to develop working methods for social and health care services. Standardized methods of the CBCL, TRF, and CGAS, were used to evaluate psychosocial functioning...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章

    doi:10.1007/s007870050101

    authors: Hukkanen R,Sourander A,Bergroth L,Piha J

    更新日期:1999-12-01 00:00:00