Subclinical autism spectrum symptoms in pediatric obsessive-compulsive disorder.


:The literature on subclinical autism spectrum (ASD) symptoms in pediatric obsessive-compulsive disorder (OCD) is scarce, and it remains unclear whether ASD symptoms are related to OCD severity. The aims of the present study were to assess the prevalence of ASD symptoms and age and sex differences in children and adolescents with OCD, and to explore the relation between ASD symptoms and OCD severity. This is the largest study of ASD symptoms in an OCD population to date, and the first directly aimed at elucidating sex and age differences in this matter. The study used baseline data from the Nordic Long-term OCD Treatment Study in which parents of 257 children and adolescents with OCD aged 7-17 completed the Autism Spectrum Screening Questionnaire. OCD severity was assessed with the Children's Yale-Brown Obsessive Compulsive Scale. Pediatric OCD patients were found to exhibit elevated rates of ASD symptoms compared to a norm group of school-age children. ASD symptoms were concentrated in a subgroup with a prevalence of 10-17 %. This subgroup was characterized by a male preponderance with a sex ratio of approximately 2.6:1, while children versus adolescents with OCD exhibited similar rates. Autism-specific social and communication difficulties were not related to OCD severity, while restricted repetitive behavior was positively related to OCD severity. The results indicate that clinicians need to be aware of ASD symptoms in children and adolescents with OCD since one out of ten exhibits such symptoms at a clinical sub-threshold.


Arildskov TW,Højgaard DR,Skarphedinsson G,Thomsen PH,Ivarsson T,Weidle B,Melin KH,Hybel KA




Has Abstract


2016-07-01 00:00:00














  • Serum brain-derived neurotrophic factor, glial-derived neurotrophic factor, nerve growth factor, and neurotrophin-3 levels in children with attention-deficit/hyperactivity disorder.

    abstract::It has been suggested that neurotrophins are involved in the etiopathogenesis of attention-deficit/hyperactivity disorder (ADHD). This study aimed to investigate whether there are differences in serum brain-derived neurotrophic factor (BDNF), glial-derived neurotrophic factor (GDNF), nerve growth factor (NGF), and neu...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章


    authors: Bilgiç A,Toker A,Işık Ü,Kılınç İ

    更新日期:2017-03-01 00:00:00

  • Involvement of fear, incompleteness, and disgust during symptoms of pediatric obsessive-compulsive disorder.

    abstract::Fear has been assigned a central role in models of obsessive-compulsive disorder (OCD), but empirical investigations into the emotions that underpin OCD symptoms are few, especially in pediatric samples. Using validated, clinician-led structured interviews, 124 youth with OCD reported on the presence and severity of s...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章


    authors: Cervin M,Perrin S,Olsson E,Claesdotter-Knutsson E,Lindvall M

    更新日期:2020-03-24 00:00:00

  • Medical comorbidities in children and adolescents with autism spectrum disorders and attention deficit hyperactivity disorders: a systematic review.

    abstract::Somatic disorders occur more often in adult psychiatric patients than in the general adult population. However, in child and adolescent psychiatry this association is unclear, mainly due to a lack of integration of existing data. To address this issue, we here present a systematic review on medical comorbidity in the ...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章,评审


    authors: Muskens JB,Velders FP,Staal WG

    更新日期:2017-09-01 00:00:00

  • Interest towards human, animal and object in children with autism spectrum disorders: an ethological approach at home.

    abstract::Autistic spectrum disorders (ASD) are characterised by attention deficits in communication and social interactions and a lack of interest in people. Data are mostly based on clinical situations. However, recent studies have shown a more mixed situation where children with ASD (ASD children) displayed interest towards ...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章


    authors: Grandgeorge M,Bourreau Y,Alavi Z,Lemonnier E,Tordjman S,Deleau M,Hausberger M

    更新日期:2015-01-01 00:00:00

  • Identification of behaviour profiles with a population of autistic children using multivariate statistical methods.

    abstract::The Revised Behaviour Summarized Evaluation Scale (BSE-R) was developed for the objective evaluation of autistic behaviours in order to facilitate the recording of the evolution of developmentally disabled children. Among its 29 items, 13 items that precisely describe the degree of autistic behaviours were extracted b...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章


    authors: Roux S,Malvy J,Bruneau N,Garreau B,Guérin P,Sauvage D,Barthélémy C

    更新日期:1995-10-01 00:00:00

  • Brain changes in early-onset bipolar and unipolar depressive disorders: a systematic review in children and adolescents.

    abstract::Pediatric bipolar disorder (BD) and unipolar disorder (UD) share common symptomatic and functional impairments. Various brain imaging techniques have been used to investigate the integrity of brain white matter (WM) and gray matter (GM) in these disorders. Despite promising preliminary findings, it is still unclear wh...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章,评审


    authors: Serafini G,Pompili M,Borgwardt S,Houenou J,Geoffroy PA,Jardri R,Girardi P,Amore M

    更新日期:2014-11-01 00:00:00

  • Salivary oxytocin in adolescents with conduct problems and callous-unemotional traits.

    abstract::Callous-unemotional (CU) traits correlate with the severity and prognosis of conduct disorder in youth. The neuropeptide oxytocin (OT) has been linked to prosocial behaviors, including empathy and collaboration with others. This study discusses a possible role for OT in the biology of delinquent behavior. We hypothesi...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章


    authors: Levy T,Bloch Y,Bar-Maisels M,Gat-Yablonski G,Djalovski A,Borodkin K,Apter A

    更新日期:2015-12-01 00:00:00

  • Characteristics of child psychiatric outpatients with slow processing speed and potential mechanisms of academic impact.

    abstract::While slow processing speed (PS) is well documented in youth with ADHD, growing evidence suggests that this difficulty affects children with other neuropsychiatric conditions. Clarifying the relationship between slow PS and different forms of psychopathology is important clinically, given the potential impact of PS on...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章


    authors: Braaten EB,Ward AK,Forchelli G,Vuijk PJ,Cook NE,McGuinness P,Lee BA,Samkavitz A,Lind H,O'Keefe SM,Doyle AE

    更新日期:2020-10-01 00:00:00

  • Anxiety risk SNPs on chromosome 2 modulate arousal in children in a fear generalization paradigm.

    abstract::Alterations in fear learning/generalization are considered to be relevant mechanisms engendering the development of anxiety disorders being the most prevalent mental disorders. Although anxiety disorders almost exclusively have their first onset in childhood and adolescence, etiological research focuses on adult indiv...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章


    authors: Reinhard J,Drepper C,Weber H,Schiele MA,Kneer K,Mittermeier A,Frey L,Reif A,Pauli P,Domschke K,Deckert J,Romanos M

    更新日期:2020-09-01 00:00:00

  • Evaluation of attitudes towards treatment in adolescents with attention deficit hyperactivity disorder (ADHD).

    abstract::A substantial proportion of adolescents with attention deficit hyperactivity disorder (ADHD) do not appropriately adhere to prescribed treatments, especially to pharmacological treatments. It is important to disentangle the specific attitudes that contribute to treatment adherence. A 33-item questionnaire was applied ...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章


    authors: Ferrin M,Ruiz-Veguilla M,Blanc-Betes M,Abd SE,Lax-Pericall T,Sinclair M,Taylor E

    更新日期:2012-07-01 00:00:00

  • Prenatal anxiety, maternal stroking in infancy, and symptoms of emotional and behavioral disorders at 3.5 years.

    abstract::Animal findings of long-term effects of maternal behaviors mediated via altered GR gene expression will, if translated into humans, have far reaching implications for our understanding of child and adolescent psychopathology. We have previously shown that mothers' self-reported stroking of their infants modifies assoc...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章


    authors: Pickles A,Sharp H,Hellier J,Hill J

    更新日期:2017-03-01 00:00:00

  • Young children with Velo-Cardio-Facial syndrome (CATCH-22). Psychological and language phenotypes.

    abstract::This is the first clinical description of a detailed psychological, speech, and language phenotype of four young children (< 5 years) with Velo-Cardio-Facial syndrome (VCFS) due to a deletion on chromosome 22 (22q11.2). The reported elevated risk of developing schizophrenia or bipolar disorder in adolescence for indiv...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章


    authors: Eliez S,Palacio-Espasa F,Spira A,Lacroix M,Pont C,Luthi F,Robert-Tissot C,Feinstein C,Schorderet DF,Antonarakis SE,Cramer B

    更新日期:2000-06-01 00:00:00

  • Adolescents' somatic complaints in eight countries: what influence do parental rearing styles have?

    abstract::Medically unexplained physical symptoms are frequently named by adolescents in both clinical and normative samples. This study analyzed the associations between parental rearing styles and adolescents' body complaints in diverse cultural contexts. In a cross-cultural study of 2415 adolescents from eight countries (Arg...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章


    authors: Seiffge-Krenke I,Sattel H,Cavdar D,Öncü B

    更新日期:2020-09-07 00:00:00

  • The mental health module (BELLA study) within the German Health Interview and Examination Survey of Children and Adolescents (KiGGS): study design and methods.

    abstract::The BELLA study on mental health and well-being in children and adolescents is the mental health module of the German Health Interview and Examination Survey for Children and Adolescents (KiGGS). The cross-sectional KiGGS survey collected comprehensive data on the health status of 17,641 children and adolescents, aged...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章,评审


    authors: Ravens-Sieberer U,Kurth BM,KiGGS study group.,BELLA study group.

    更新日期:2008-12-01 00:00:00

  • Pedigree analysis of Hungarian Rett syndrome girls.

    abstract::Twenty-two Hungarian families with Rett syndrome girls were genealogically examined. None of our 23 probands was born to first-cousin couples, but we established increased number of consanguineous marriages among the ancestors of the patients. Observing the places where the Rett families originate from, we found a pre...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章


    authors: Hollody K,Borvendég K,Kosztolányi G

    更新日期:1997-01-01 00:00:00

  • Using DSM diagnoses for clinical, research, and administrative purposes.

    abstract::DSM data are often used to build statistics on the types of patients to whom mental health services are offered. These statistics are normally based on broad categories that cluster finer subcategories for specific diagnoses. These broad categories can be built in a number of ways. The purpose of this study is to dete...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章


    authors: van Yperen TA,van Engeland H,Cohen-Kettenis PT,Rispens J

    更新日期:2000-12-01 00:00:00

  • Developmental psychopathology of children and adolescents with Tourette syndrome--impact of ADHD.

    abstract:BACKGROUND:In Tourette syndrome (TS) as a neurodevelopmental disorder not only the tics but also the comorbid conditions change with increasing age. ADHD is highly comorbid with TS and usually impairs psychosocial functioning more than the tics. Its impact on further comorbidity during development is important for clin...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章


    authors: Roessner V,Becker A,Banaschewski T,Freeman RD,Rothenberger A,Tourette Syndrome International Database Consortium.

    更新日期:2007-06-01 00:00:00

  • The script model in relation to autism.

    abstract::The primary purpose of this study was to investigate autistic children's scripts for social routines. Scripts specify familiar events in terms of who does what, when, to whom, and why. Scripts are verbalizations of mental event representations, containing and organizing generalized knowledge of how the world works. Sc...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章


    authors: Trillingsgaard A

    更新日期:1999-03-01 00:00:00

  • Depression, anxiety, and obsessionality in long-term recovered patients with adolescent-onset anorexia nervosa.

    abstract::Anorexia nervosa (AN) is frequently associated with symptoms of depression, anxiety, and obsessive-compulsive behavior which also develop secondary to semistarvation. It is less certain if these symptoms persist after recovery. A few studies have already reported on high prevalence rates of anxious, depressive, and ob...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章


    authors: Holtkamp K,Müller B,Heussen N,Remschmidt H,Herpertz-Dahlmann B

    更新日期:2005-03-01 00:00:00

  • Maternal depression symptoms and internalising problems in the offspring: the role of maternal and family factors.

    abstract::Maternal depression symptoms (MDS) are a robust risk factor for internalising problems (IP) in the offspring. However, the relative importance of MDS and other factors associated with it (i.e. other types of maternal psychopathology, maternal parenting practices, family characteristics) is not well understood. To (a) ...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章


    authors: Ahun MN,Consoli A,Pingault JB,Falissard B,Battaglia M,Boivin M,Tremblay RE,Côté SM

    更新日期:2018-07-01 00:00:00

  • Psychological outcomes in midadulthood associated with mother's child-rearing attitudes in early childhood--evidence from the 1970 British birth cohort.

    abstract::This study used longitudinal data from the 1970 British Cohort Study (BCS70) to examine the role of mother's child-rearing attitudes assessed when cohort members were aged 5 in children's psychological well-being (psychological functioning, psychological distress, life satisfaction and self-efficacy) at age 30. Althou...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章


    authors: Flouri E

    更新日期:2004-02-01 00:00:00

  • Comparative efficacy of once-a-day extended-release methylphenidate, two-times-daily immediate-release methylphenidate, and placebo in a laboratory school setting.

    abstract:BACKGROUND:Given the dosing limitations of methylphenidate short-acting preparations in treating ADHD, galenics with longer release of the substance were developed mainly to avoid drug intake during school hours. OBJECTIVES:This investigation was conducted to assess the efficacy and the duration of action of a new ext...

    journal_title:European child & adolescent psychiatry

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Döpfner M,Gerber WD,Banaschewski T,Breuer D,Freisleder FJ,Gerber-von Müller G,Günter M,Hässler F,Ose C,Rothenberger A,Schmeck K,Sinzig J,Stadler C,Uebel H,Lehmkuhl G

    更新日期:2004-01-01 00:00:00

  • Parental experiences of homeschooling during the COVID-19 pandemic: differences between seven European countries and between children with and without mental health conditions.

    abstract::The aim of the present study was to examine parental experiences of homeschooling during the COVID-19 pandemic in families with or without a child with a mental health condition across Europe. The study included 6720 parents recruited through schools, patient organizations and social media platforms (2002 parents with...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章


    authors: Thorell LB,Skoglund C,de la Peña AG,Baeyens D,Fuermaier ABM,Groom MJ,Mammarella IC,van der Oord S,van den Hoofdakker BJ,Luman M,de Miranda DM,Siu AFY,Steinmayr R,Idrees I,Soares LS,Sörlin M,Luque JL,Moscardino UM,Roch

    更新日期:2021-01-07 00:00:00

  • Factors affecting nightmares in children: parents' vs. children's ratings.

    abstract:OBJECTIVE:The present study investigated the relationship between daytime symptomatology and nightmare frequency in school-aged children by eliciting daytime symptoms and nightmare frequency from children directly in addition to questionnaires completed by their parents. METHODS:A sample of 4,834 parents and 4,531 of ...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章


    authors: Schredl M,Fricke-Oerkermann L,Mitschke A,Wiater A,Lehmkuhl G

    更新日期:2009-01-01 00:00:00

  • Development of schizotypal symptoms following psychiatric disorders in childhood or adolescence.

    abstract::It was examined how juvenile psychiatric disorders and adult schizotypal symptoms are associated. 731 patients of the Department of Child and Adolescent Psychiatry of the University Medical Centre Utrecht, the Netherlands, with mean age of 12.1 years (SD = 4.0) were reassessed at the mean age of 27.9 years (SD = 5.7) ...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章


    authors: Fagel SS,Swaab H,De Sonneville LM,Van Rijn S,Pieterse JK,Scheepers F,Van Engeland H

    更新日期:2013-11-01 00:00:00

  • Effectiveness of outpatient cognitive-behavioral therapy for adolescents under routine care conditions on behavioral and emotional problems rated by parents and patients: an observational study.

    abstract::Few studies have examined the effectiveness of outpatient cognitive-behavioral therapy (CBT) delivered in routine care settings for children and adolescents with mental disorders. This observational study examined changes in behavioral and emotional problems of adolescents with mental disorders during routine outpatie...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章


    authors: Walter D,Dachs L,Faber M,Goletz H,Goertz-Dorten A,Hautmann C,Kinnen C,Rademacher C,Schuermann S,Metternich-Kaizman TW,Doepfner M

    更新日期:2018-01-01 00:00:00

  • The role of genetic and environmental factors in covariation between anxiety and anger in childhood.

    abstract::Higher levels of anger expression, as well as lower levels of anger control, have been reported for adults with anxiety disorders compared to individuals without anxiety disorders. Different to the research on adults, very few studies examined the relationship between anxiety and anger in childhood. In our study, we i...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章


    authors: Scaini S,Centorame G,Lissandrello F,Sardella S,Stazi MA,Fagnani C,Brombin C,Battaglia M

    更新日期:2020-05-07 00:00:00

  • Health care consumption and psychiatric diagnoses among adolescent girls 1 and 2 years after a first-time registered child sexual abuse experience: a cohort study in the Stockholm Region.

    abstract::Child sexual abuse (CSA) is a crime against human rights with severe health consequences, and suicidal actions, stress, eating disorders, and borderline disorder are common among survivors of CSA. The objective of this study was to analyze how health care consumption patterns developed among adolescent girls in the St...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章


    authors: Rajan G,Syding S,Ljunggren G,Wändell P,Wahlström L,Philips B,Svedin CG,Carlsson AC

    更新日期:2020-11-01 00:00:00

  • Does maternal psychopathology discriminate between children with DSM-IV generalised anxiety disorder or oppositional defiant disorder? The predictive validity of maternal axis I and axis II psychopathology.

    abstract::What dimensions of maternal psychopathology predict internalising or externalising disorder in children? We conducted a study of maternal axis I and axis II psychopathology in a group of children 8-12 years of age with Generalised Anxiety Disorder (GAD), Oppositional Defiant Disorder (ODD) and non-patient controls (NC...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章


    authors: Nordahl HM,Ingul JM,Nordvik H,Wells A

    更新日期:2007-03-01 00:00:00

  • Olanzapine compared to quetiapine in adolescents with a first psychotic episode.

    abstract:OBJECTIVE:To compare the efficacy, safety, and tolerability of olanzapine and quetiapine in adolescents with first episode psychosis. METHOD:Fifty adolescents (age 16 +/- 1.25) with a first episode of psychosis were randomized to quetiapine or olanzapine in a 6-month open label study. Efficacy and side effect scales, ...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章,随机对照试验


    authors: Arango C,Robles O,Parellada M,Fraguas D,Ruiz-Sancho A,Medina O,Zabala A,Bombín I,Moreno D

    更新日期:2009-07-01 00:00:00