Abstract：
:Given the known behavior effects of oxytocin,and in particular its putative effect on trust, affiliation and anxiety, we hypothesized that oxytocin may be involved in the development and expression of callous-unemotional traits in children with aggressive antisocial behavior. We recruited 162 children between the ages of 6 and 16. The majority of subjects were Caucasian (84.0%) compared to African-Canadian (4.9%) and others (11.1%). The oxytocin and oxytocin receptor gene polymorphisms were genotyped and analyzed for possible association with child aggression in a case–control study design as well as with callous-unemotional traits in a within cases analysis. We did not have significant findings with our tested OXTR markers in the case–control analysis. We found the OXTR_rs237885 AA genotype carriers to score higher than AC or CC genotype carriers on the callous-unemotional traits. This result remained significant following correction for multiple testing. No other markers were found to be significant. However, the haplotype consisting of the OXTR_rs237885 A allele and OXTR_rs2268493 A allele was associated with significantly higher callous-unemotionals cores than other haplotypes. This is the first known study to show a significant association between callous unemotional traits in children and adolescents with extreme, persistent pervasive aggression and a polymorphism on the oxytocin receptor. Given the small sample size and the possibility of false positive effects, the need to replicate and verify these findings is required.
journal_name
Eur Child Adolesc Psychiatryjournal_title
European child & adolescent psychiatryauthors
Beitchman JH,Zai CC,Muir K,Berall L,Nowrouzi B,Choi E,Kennedy JLdoi
10.1007/s00787-012-0240-6subject
Has Abstractpub_date
2012-03-01 00:00:00pages
125-32issue
3eissn
1018-8827issn
1435-165Xjournal_volume
21pub_type
杂志文章abstract：:Previous studies have demonstrated that many children with conduct problems (CP) also show internalising psychopathology (IP). However, it remains unclear whether the presence of IP serves as a protective or risk factor for the severity and development of CP. The aim of the present study was to assess the prevalence a...
journal_title：European child & adolescent psychiatry
pub_type： 杂志文章
doi：10.1007/s00787-011-0229-6
更新日期：2012-01-01 00:00:00
abstract：:This study prospectively examined predicting factors and depressive antecedents of depression in early adulthood and determined differences by sex. 199 adolescents aged 11-12 from the general community were followed up annually for 4 years and reassessed at 18 years of age. Sociodemographic data, depressive symptomato...
journal_title：European child & adolescent psychiatry
pub_type： 杂志文章
doi：10.1007/s00787-002-0286-y
更新日期：2002-10-01 00:00:00
abstract：:What dimensions of maternal psychopathology predict internalising or externalising disorder in children? We conducted a study of maternal axis I and axis II psychopathology in a group of children 8-12 years of age with Generalised Anxiety Disorder (GAD), Oppositional Defiant Disorder (ODD) and non-patient controls (NC...
journal_title：European child & adolescent psychiatry
pub_type： 杂志文章
doi：10.1007/s00787-006-0578-8
更新日期：2007-03-01 00:00:00
abstract：BACKGROUND:This study aimed to examine prevalence and risk factors of deliberate self-harm in Dutch and Dutch-speaking Belgian adolescents. METHOD:A cross sectional survey using an anonymous self report questionnaire was performed in both countries. Data on 4,431 Belgian and 4,458 Dutch 15-16 year-old school pupils we...
journal_title：European child & adolescent psychiatry
pub_type： 杂志文章
doi：10.1007/s00787-007-0652-x
更新日期：2008-04-01 00:00:00
abstract：:Children with social anxiety disorder (SAD) have been reported to display reduced social skills. Less attention has been paid to whether neurodevelopmental deficits/delays (NDD's) in language and motor function may contribute to their impaired social skills. The present study aimed to assess the extent of language and...
journal_title：European child & adolescent psychiatry
pub_type： 杂志文章
doi：10.1007/s00787-007-0642-z
更新日期：2008-03-01 00:00:00
abstract：BACKGROUND:In Tourette syndrome (TS) as a neurodevelopmental disorder not only the tics but also the comorbid conditions change with increasing age. ADHD is highly comorbid with TS and usually impairs psychosocial functioning more than the tics. Its impact on further comorbidity during development is important for clin...
journal_title：European child & adolescent psychiatry
pub_type： 杂志文章
doi：10.1007/s00787-007-1004-6
更新日期：2007-06-01 00:00:00
abstract：:Functional enuresis is a heterogeneous group of syndromes with different aetiology and pathophysiology. The aim was to identify specific somatic correlates of enuresis non-invasively in child psychiatric patients after exclusion of neurologic and structural forms of incontinence. One hundred sixty-seven consecutive ch...
journal_title：European child & adolescent psychiatry
pub_type： 杂志文章
doi：10.1007/s007870050092
更新日期：1999-06-01 00:00:00
abstract：:Adolescence is a vulnerable period for psychological distress. This study aimed to comprehensively investigate the distribution of major stress-causing factors and their correlates in a large population of adolescents. A computerized self-report questionnaire was completed by 291,110 participating adolescents over a 4...
journal_title：European child & adolescent psychiatry
pub_type： 杂志文章
doi：10.1007/s00787-020-01520-9
更新日期：2020-03-30 00:00:00
abstract：:Sixteen studies of the prevalence of autism in childhood, using epidemiological methods in defined populations in Europe, the USA and Japan, in English or with English summaries, were found in the published literature. Age specific rates varied from 3.3 to 16.0 per 10,000. Eight studies gave rates for a sub-group of '...
journal_title：European child & adolescent psychiatry
pub_type： 杂志文章
doi：10.1007/BF02098832
更新日期：1993-01-01 00:00:00
abstract：OBJECTIVE:The aims of this study were to determine the prevalence of eating disorders (ED) in a representative school population of early adolescents of both sexes and to evaluate persistence and incidence after two years. METHOD:An initial sample of 1336 (mean age = 11.37) was assessed in a two-phase design. The Chil...
journal_title：European child & adolescent psychiatry
pub_type： 杂志文章
doi：10.1007/s00787-007-0625-0
更新日期：2007-12-01 00:00:00
abstract：:Infant mental health problems include difficulties to regulate emotions or attention, crying, sleeping or feeding problems as well as aggressive behavior. Early identifications of these problems help to change developmental trajectories and improve developmental outcomes. Psychiatric assessment and classification have...
journal_title：European child & adolescent psychiatry
pub_type： 杂志文章,评审
doi：10.1007/s00787-012-0364-8
更新日期：2013-02-01 00:00:00
abstract：:A substantial proportion of adolescents with attention deficit hyperactivity disorder (ADHD) do not appropriately adhere to prescribed treatments, especially to pharmacological treatments. It is important to disentangle the specific attitudes that contribute to treatment adherence. A 33-item questionnaire was applied ...
journal_title：European child & adolescent psychiatry
pub_type： 杂志文章
doi：10.1007/s00787-012-0277-6
更新日期：2012-07-01 00:00:00
abstract：:We reviewed the literature of medication trials in ADHD to evaluate the scope of the available non-stimulant treatments. A variety of compounds with a common noradrenergic/ dopaminergic activity have shown documented anti-ADHD activity. There is a substantial body of literature documenting the efficacy of tricyclic an...
journal_title：European child & adolescent psychiatry
pub_type： 杂志文章,评审
doi：10.1007/s007870070019
更新日期：2000-01-01 00:00:00
abstract：:A two week course in Child and Adolescent Psychiatry was given in St. Petersburg as part of the partnership between the City's Child and Adolescent Psychiatry Service and Division of Child and Adolescent Psychiatry at Leicester University Medical School. In such a short course, it was necessary to focus on areas of pa...
journal_title：European child & adolescent psychiatry
pub_type： 杂志文章
doi：10.1007/BF00538848
更新日期：1996-12-01 00:00:00
abstract：:Children meeting the Child Behavior Checklist Dysregulation Profile (CBCL-DP) suffer from high levels of co-occurring internalizing and externalizing problems. Little is known about the cognitive abilities of these children with CBCL-DP. We examined the relationship between CBCL-DP and nonverbal intelligence. Parents ...
journal_title：European child & adolescent psychiatry
pub_type： 杂志文章
doi：10.1007/s00787-014-0551-x
更新日期：2014-11-01 00:00:00
abstract：:This is the first clinical description of a detailed psychological, speech, and language phenotype of four young children (< 5 years) with Velo-Cardio-Facial syndrome (VCFS) due to a deletion on chromosome 22 (22q11.2). The reported elevated risk of developing schizophrenia or bipolar disorder in adolescence for indiv...
journal_title：European child & adolescent psychiatry
pub_type： 杂志文章
doi：10.1007/s007870050005
更新日期：2000-06-01 00:00:00
abstract：:We compared the predictability of the behaviour of hyperactive children with that of aggressive children, combined hyperactive/aggressive children and normal children. Detailed behaviour measurements relating to each child and an experimenter were recorded during playroom session. Predictability was expressed in infor...
journal_title：European child & adolescent psychiatry
pub_type： 杂志文章
doi：10.1007/BF00571673
更新日期：1996-09-01 00:00:00
abstract：:This paper describes the effect of pre-migration and post-migration experiences on the mental health of a sample of 40 refugee children aged 8-16 who lived in London with at least one parent or a refugee relative. Children's post-traumatic stress disorder (PTSD) and depression symptoms were assessed with standardised ...
journal_title：European child & adolescent psychiatry
pub_type： 杂志文章
doi：10.1007/s00787-004-0422-y
更新日期：2004-12-01 00:00:00
abstract：:The aim of this study was to assess the relation between the diagnosis of encopresis at 8 and 10 years of age, and mental and somatic health 10 years later. The importance of type of encopresis (primary or secondary) at 8 years was also studied. Subjects were a non-clinical encopretic sample (N=73) and control subject...
journal_title：European child & adolescent psychiatry
pub_type： 杂志文章
doi：10.1007/s00787-005-0495-2
更新日期：2005-12-01 00:00:00
abstract：OBJECTIVE:To compare the efficacy, safety, and tolerability of olanzapine and quetiapine in adolescents with first episode psychosis. METHOD:Fifty adolescents (age 16 +/- 1.25) with a first episode of psychosis were randomized to quetiapine or olanzapine in a 6-month open label study. Efficacy and side effect scales, ...
journal_title：European child & adolescent psychiatry
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00787-009-0749-5
更新日期：2009-07-01 00:00:00
abstract：:The importance of paying attention to scale levels is emphasized and it is pointed out that Steven's hierarchy of ratio, interval, ordinal, and nominal scales is too narrow; other important scale properties have to be considered. For instance, sometimes a carefully constructed variable on a nominal scale contains more...
journal_title：European child & adolescent psychiatry
pub_type： 杂志文章
doi：10.1007/BF00538540
更新日期：1996-01-01 00:00:00
abstract：:Non-suicidal self-injury (NSSI) is a considerable health problem among adolescents. Affect regulation by means of self-injury may promote the maintenance of NSSI. However, existing findings have limited ecological validity. The present study aimed to assess emotional and interpersonal states preceding and following in...
journal_title：European child & adolescent psychiatry
pub_type： 杂志文章
doi：10.1007/s00787-020-01626-0
更新日期：2020-08-29 00:00:00
abstract：:The Revised Behaviour Summarized Evaluation Scale (BSE-R) was developed for the objective evaluation of autistic behaviours in order to facilitate the recording of the evolution of developmentally disabled children. Among its 29 items, 13 items that precisely describe the degree of autistic behaviours were extracted b...
journal_title：European child & adolescent psychiatry
pub_type： 杂志文章
doi：10.1007/BF01980489
更新日期：1995-10-01 00:00:00
abstract：:Parental psychopathology is associated with increased psychosocial maladjustment in adolescents. We examined, from a psychosocial perspective, the association between parental psychological distress and psychosocial maladjustment in adolescents and assessed the mediating role of psychosocial covariates. This is a cros...
journal_title：European child & adolescent psychiatry
pub_type： 杂志文章
doi：10.1007/s00787-010-0094-8
更新日期：2010-07-01 00:00:00
abstract：:Alterations in fear learning/generalization are considered to be relevant mechanisms engendering the development of anxiety disorders being the most prevalent mental disorders. Although anxiety disorders almost exclusively have their first onset in childhood and adolescence, etiological research focuses on adult indiv...
journal_title：European child & adolescent psychiatry
pub_type： 杂志文章
doi：10.1007/s00787-019-01458-7
更新日期：2020-09-01 00:00:00
abstract：:The purpose of this study was to test child and adolescent psychosocial and psychopathological risk factors as predictors of adult criminal outcomes in a Swiss community sample. In particular, the role of active and avoidant problem coping in youths was analysed. Prevalence rates of young adult crime convictions based...
journal_title：European child & adolescent psychiatry
pub_type： 杂志文章
doi：10.1007/s00787-013-0458-y
更新日期：2014-05-01 00:00:00
abstract：BACKGROUND:To develop an evidence base for using antipsychotic medications for schizophrenia in children and adolescents. METHOD:Data sources were identified in PsychINFO (1872-2003), MEDLINE (1966-2003), and articles in reference lists. Study selection criteria: (1) treatment with antipsychotics; (2) ages were betwee...
journal_title：European child & adolescent psychiatry
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00787-005-0515-2
更新日期：2006-03-01 00:00:00
abstract：:The functional Val158Met COMT polymorphism appears to affect a host of behaviours mediated by the pre-frontal cortex, and has been found associated to the risk for disruptive behaviours including ADHD. Parental socioeconomic status (SES) has also been reported as a predictor for the same childhood disorders. In a gene...
journal_title：European child & adolescent psychiatry
pub_type： 杂志文章
doi：10.1007/s00787-009-0080-1
更新日期：2010-07-01 00:00:00
abstract：:Attention Deficit and Hyperactive Disorder (ADHD) and Autism Spectrum Disorders (ASD) are frequent comorbid neurodevelopmental conditions and the overlap between both disorders remains to be delineated. A more complete understanding of the shared genetic and environmental factors is needed. Using a family-based method...
journal_title：European child & adolescent psychiatry
pub_type： 杂志文章
doi：10.1007/s00787-018-1206-0
更新日期：2019-02-01 00:00:00
abstract：:A Dutch translation of the Strengths and Difficulties Questionnaire (SDQ) was made. In the first wave of data collection, self-report data of 11- to 16-yearolds (N = 970) were collected on the SDQ and other measures of psychopathology. In the second wave of data collection, extended versions of the SDQ were completed ...
journal_title：European child & adolescent psychiatry
pub_type： 杂志文章
doi：10.1007/s00787-003-0341-3
更新日期：2003-12-01 00:00:00
