Abstract：
:Anorexia nervosa (AN) and bulimia nervosa (BN) are complex disorders characterized by disordered eating behavior where the patient's attitude towards weight and shape, as well as their perception of body shape, are disturbed. Formal genetic studies on twins and families suggested a substantial genetic influence for AN and BN. Candidate gene studies have initially focused on the serotonergic and other central neurotransmitter systems and on genes involved in body weight regulation. Hardly any of the positive findings achieved in these studies were unequivocally confirmed or substantiated in meta-analyses. This might be due to too small sample sizes and thus low power and/or the genes underlying eating disorders have not yet been analyzed. However, some studies that also used subphenotypes (e.g., restricting type of AN) led to more specific results; however, confirmation is as yet mostly lacking. Systematic genome-wide linkage scans based on families with at least two individuals with an eating disorder (AN or BN) revealed initial linkage regions on chromosomes 1, 3 and 4 (AN) and 10p (BN). Analyses on candidate genes in the chromosome 1 linkage region led to the (as yet unconfirmed) identification of certain variants associated with AN. Genome-wide association studies are under way and will presumably help to identify genes and pathways involved in these eating disorders. The elucidation of the molecular mechanisms underlying eating disorders might improve therapeutic approaches.
journal_name
Eur Child Adolesc Psychiatryjournal_title
European child & adolescent psychiatryauthors
Scherag S,Hebebrand J,Hinney Adoi
10.1007/s00787-009-0085-9subject
Has Abstractpub_date
2010-03-01 00:00:00pages
211-26issue
3eissn
1018-8827issn
1435-165Xjournal_volume
19pub_type
杂志文章,评审abstract：:A substantial proportion of adolescents with attention deficit hyperactivity disorder (ADHD) do not appropriately adhere to prescribed treatments, especially to pharmacological treatments. It is important to disentangle the specific attitudes that contribute to treatment adherence. A 33-item questionnaire was applied ...
journal_title：European child & adolescent psychiatry
pub_type： 杂志文章
doi：10.1007/s00787-012-0277-6
更新日期：2012-07-01 00:00:00
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journal_title：European child & adolescent psychiatry
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更新日期：2013-11-01 00:00:00
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journal_title：European child & adolescent psychiatry
pub_type： 杂志文章
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journal_title：European child & adolescent psychiatry
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更新日期：2019-07-01 00:00:00
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journal_title：European child & adolescent psychiatry
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更新日期：2004-01-01 00:00:00
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journal_title：European child & adolescent psychiatry
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journal_title：European child & adolescent psychiatry
pub_type： 杂志文章
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journal_title：European child & adolescent psychiatry
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journal_title：European child & adolescent psychiatry
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更新日期：2016-07-01 00:00:00
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journal_title：European child & adolescent psychiatry
pub_type： 杂志文章
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更新日期：2014-07-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s00787-020-01642-0
更新日期：2020-09-17 00:00:00
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journal_title：European child & adolescent psychiatry
pub_type： 杂志文章
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更新日期：2015-10-01 00:00:00
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journal_title：European child & adolescent psychiatry
pub_type： 杂志文章
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更新日期：2005-07-01 00:00:00
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journal_title：European child & adolescent psychiatry
pub_type： 杂志文章
doi：10.1007/s00787-012-0369-3
更新日期：2013-05-01 00:00:00
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journal_title：European child & adolescent psychiatry
pub_type： 杂志文章,随机对照试验
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更新日期：2016-11-01 00:00:00
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journal_title：European child & adolescent psychiatry
pub_type： 杂志文章
doi：10.1007/s00787-007-0640-1
更新日期：2008-08-01 00:00:00
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journal_title：European child & adolescent psychiatry
pub_type： 杂志文章
doi：10.1007/s00787-016-0890-x
更新日期：2017-03-01 00:00:00
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journal_title：European child & adolescent psychiatry
pub_type： 杂志文章,评审
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journal_title：European child & adolescent psychiatry
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journal_title：European child & adolescent psychiatry
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doi：10.1007/s007870070028
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更新日期：2014-11-01 00:00:00
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journal_title：European child & adolescent psychiatry
pub_type： 杂志文章,多中心研究
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更新日期：2018-10-01 00:00:00
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journal_title：European child & adolescent psychiatry
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更新日期：2005-10-01 00:00:00
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journal_title：European child & adolescent psychiatry
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journal_title：European child & adolescent psychiatry
pub_type： 杂志文章
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更新日期：2010-02-01 00:00:00
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journal_title：European child & adolescent psychiatry
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journal_title：European child & adolescent psychiatry
pub_type： 杂志文章,评审
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abstract：BACKGROUND:This study aimed to examine prevalence and risk factors of deliberate self-harm in Dutch and Dutch-speaking Belgian adolescents. METHOD:A cross sectional survey using an anonymous self report questionnaire was performed in both countries. Data on 4,431 Belgian and 4,458 Dutch 15-16 year-old school pupils we...
journal_title：European child & adolescent psychiatry
pub_type： 杂志文章
doi：10.1007/s00787-007-0652-x
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