Abstract：
:One third of children with autistic spectrum disorders (or pervasive developmental disorders) enter that state by regression from a more normal prior development at the onset of epilepsy or epileptiform abnormality in the electroencephalogram. In a very small proportion structural lesions of the temporal lobes are discovered. These form part of the sample of children coming to a surgical treatment programme. Ninety-eight child candidates for epilepsy surgery were seen by one neuropsychiatrist. Their psychiatric diagnoses were coded on DSM IV schedules. Other variables of interest were the age at onset of epilepsy; the nature, the side, and time of acquisition of the lesion; intelligence, and sex. There were 19 children with autistic spectrum disorders including eight with Asperger's syndrome. Ten of the children in the autistic group had right brain lesions; six were dysembryoplastic neuroepithelial tumours (DNETs); two were cortical dysplasias; one tuberous sclerosis; one hemi-cortical defect; and 1 mesial temporal sclerosis. Nine started epilepsy in their first year; nine had IQs in the retarded range; nine of the 11 were male. Six of eight Asperger's children had right brain lesions; two DNETs; four mesial temporal sclerosis; one Rasmussen encephalitis. Four started epilepsy in their first year; one was retarded; five were female. Children who had no, or other, psychiatric disorder also showed "mass" lesions, or temporal sclerosis but with different biases as to side, sex, and very early onset of epilepsy from the autistic spectrum group. Very early onset of epilepsy, with lesions of embryonal origin, in the right temporal lobe, strongly predisposed males towards autistic regression. Such patients should be referred very early for consideration of urgent surgical treatment.
journal_name
Eur Child Adolesc Psychiatryjournal_title
European child & adolescent psychiatryauthors
Taylor DC,Neville BG,Cross JHdoi
10.1007/s007870050128keywords:
subject
Has Abstractpub_date
1999-09-01 00:00:00pages
189-92issue
3eissn
1018-8827issn
1435-165Xpii
90080189.787journal_volume
8pub_type
杂志文章abstract：:Despite the fact that juvenile fire involvement is associated with significant injuries and is highly correlated with diverse maladjustment characteristics, firesetting has never been empirically evaluated in Italy. Participants included 567 youth between 11 and 18 years of age. This investigation attempted to address...
journal_title：European child & adolescent psychiatry
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journal_title：European child & adolescent psychiatry
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journal_title：European child & adolescent psychiatry
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pub_type： 杂志文章,评审
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更新日期：2000-01-01 00:00:00
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pub_type： 杂志文章,评审
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