Localization and function of cannabinoid receptors in the corpus cavernosum: basis for modulation of nitric oxide synthase nerve activity.


BACKGROUND:Anandamide, a proposed endogenous cannabinoid (CB) agonist, has been shown to enhance neurogenic responses in vitro of the rat corpus cavernosal tissue (CC). However, no information is available on the distribution of CB-receptors or effects by anandamide in CC from primates or humans. OBJECTIVE:To characterize the distribution of CB-receptor isoforms in the human and primate CC and to investigate the effects of anandamide on isolated CC preparations. DESIGN, SETTING, AND PARTICIPANTS:CC tissue was excised from the crura penis of six rhesus monkeys and five patients. Expression and distribution of CB1 and CB2 receptors were characterized with Western blot analyses and immunohistochemical investigations. The effects of anandamide on isolated CC preparations were analyzed during pharmacologic and nerve-mediated activation of primate tissue in aerated organ baths. MEASUREMENTS:The expression and localization of CB1 and CB2 receptors in the primate CC and effects of anandamide on nerve-mediated relaxations and pharmacologically evoked contractions. RESULTS AND LIMITATIONS:Western blot experiments revealed CB1 and CB2 receptors at expected band weights. Within and between strands of CC smooth muscle, CB1 and CB2 immunoreactivity (IR) was found in nerve fibers that also expressed IR for nitric oxide synthase (NOS) or transient receptor potential V1 (TRPV1). Neither CB1-IR nor CB2-IR nerves were colocalized with calcitonin-gene-related peptide (CGRP)-containing or tyrosine hydroxylase-containing nerves. No differences were observed between primate and human CC sections. Anandamide (10(-9) to 10(-4) M) had no contractile effects on CC smooth muscle, no relaxant effects on precontracted preparations, and no effect on phenylephrine-induced contractions. However, anandamide (10muM) inhibited electrically evoked smooth-muscle relaxations (34-48%; p


Eur Urol


European urology


Gratzke C,Christ GJ,Stief CG,Andersson KE,Hedlund P




Has Abstract


2010-02-01 00:00:00














  • The Probability of Aggressive Versus Indolent Histology Based on Renal Tumor Size: Implications for Surveillance and Treatment.

    abstract:BACKGROUND:While the probability of malignant versus benign histology based on renal tumor size has been described, this alone does not sufficiently inform decision-making in the modern era since indolent malignant tumors can be managed with active surveillance. OBJECTIVE:To characterize the probability of aggressive ...

    journal_title:European urology

    pub_type: 杂志文章


    authors: Bhindi B,Thompson RH,Lohse CM,Mason RJ,Frank I,Costello BA,Potretzke AM,Hartman RP,Potretzke TA,Boorjian SA,Cheville JC,Leibovich BC

    更新日期:2018-10-01 00:00:00

  • Thermoregulation during transurethral microwave thermotherapy: experimental and clinical fundamentals.

    abstract::Transurethral microwave thermotherapy of 340 patients treated at our center for benign prostatic hypertrophy shows the importance of the role played by two thermoregulation processes during the procedure. The first one is artificial and automatically driven by the machine (the power output and cooling rate are adjuste...

    journal_title:European urology

    pub_type: 杂志文章


    authors: Devonec M,Berger N,Fendler JP,Joubert P,Nasser M,Perrin P

    更新日期:1993-01-01 00:00:00

  • Functional evaluation of bladder neck disease.

    abstract::22 patients diagnosed as having bladder neck disease were evaluated retrospectively point of view. Urodynamic study including intravesical pressure, rectal pressure, intrinsic detrusor pressure and urine flow was performed in every case. A relation was established between the findings and the definite etiology. Two ur...

    journal_title:European urology

    pub_type: 杂志文章


    authors: Romero-Maroto J,Tallada-Buñuel M,Verdú-Tartajo F,Perales-Cabanas L,Escudero-Barrilero A,Romero-Aguirre C

    更新日期:1982-01-01 00:00:00

  • Improved suprapubic vesical drainage in transvesical prostatectomy.

    abstract::An improved drainage is used in transvesical prostatectomy in order to avoid urinary retention after removal of the Novak-type suprapubic drainage with bladder neck cerclage haemostasis (described by some authors in 1975). The causes of urinary retention are analysed, the drainage technique as well as the mechanisms e...

    journal_title:European urology

    pub_type: 杂志文章


    authors: Nicolescu D,Ioanid P,Galesanu M,Boja R,Neagu V

    更新日期:1978-01-01 00:00:00

  • Combination of diffusion-weighted magnetic resonance imaging and extended prostate biopsy predicts lobes without significant cancer: application in patient selection for hemiablative focal therapy.

    abstract:BACKGROUND:Significant cancer in contralateral sides of the prostate that was missed on prostate biopsy (PBx) is a concern in hemiablative focal therapy (FT) of prostate cancer (PCa). However, extended PBx, a common diagnostic procedure, has a limited predictive ability for lobes without significant cancer. OBJECTIVE:...

    journal_title:European urology

    pub_type: 杂志文章


    authors: Matsuoka Y,Numao N,Saito K,Tanaka H,Kumagai J,Yoshida S,Koga F,Masuda H,Kawakami S,Fujii Y,Kihara K

    更新日期:2014-01-01 00:00:00

  • Absence of brain parenchymal damage following intravascular injection of polytetrafluoroethylene paste.

    abstract:OBJECTIVE:Polytetrafluoroethylene (PTFE) paste has been used for over 30 years to treat urinary incontinence and for 14 years to treat vesicoureteral reflux with little reported morbidity. Some investigators have been concerned by the use of PTFE as the implanted substance, because migration of PTFE particles from the ...

    journal_title:European urology

    pub_type: 杂志文章


    authors: Miyakita H,O'Briain DS,Puri P

    更新日期:1998-09-01 00:00:00

  • Physiology of ejaculation: emphasis on serotonergic control.

    abstract::Ejaculation is constituted by two distinct phases, emission and expulsion. Orgasm, a feature perhaps unique in humans, is a cerebral process that occurs, in normal conditions, concomitantly to expulsion of semen. Normal antegrade ejaculation is a highly coordinated physiological process with emission and expulsion pha...

    journal_title:European urology

    pub_type: 杂志文章,评审


    authors: Giuliano F,Clément P

    更新日期:2005-09-01 00:00:00

  • Current microbiological and clinical aspects of urinary tract infections.

    abstract:OBJECTIVES:To evaluate some risk factors which could affect the isolation rates of various uropathogens and their in vitro susceptibility to antibiotics in ambulatory and hospitalized patients. PATIENTS AND METHODS:A prospective study was conducted in a microbiological laboratory at Pisa Hospital. Nine-hundred and sev...

    journal_title:European urology

    pub_type: 杂志文章


    authors: Bonadio M,Meini M,Spitaleri P,Gigli C

    更新日期:2001-10-01 00:00:00

  • Squamous cell carcinoma of bladder diverticulum with initial symptoms produced by metastasis to maxillary sinus.

    abstract::A rare case of squamous cell carcinoma in the bladder diverticula of a 74-year-old man with initial clinical symptoms caused by metastasis to the maxillary sinus is reported. The histopathological examination at autopsy confirmed the metastatic squamous cell carcinoma in the maxillary sinus from the bladder diverticul...

    journal_title:European urology

    pub_type: 杂志文章


    authors: Nanbu A,Tsukamoto T,Kumamoto Y,Aoki M,Hirose T,Asakura K,Kataura A

    更新日期:1988-01-01 00:00:00

  • A proposal for reclassification of the Fuhrman grading system in patients with clear cell renal cell carcinoma.

    abstract:BACKGROUND:The conventional Fuhrman grading system, which categorizes renal cell carcinoma (RCC) with grades I, II, III, and IV, is the most widely used predictor assessment of RCC cancer-specific mortality (CSM). OBJECTIVES:The aim of this study was to test the prognostic ability of simplified Fuhrman grading schemes...

    journal_title:European urology

    pub_type: 杂志文章


    authors: Sun M,Lughezzani G,Jeldres C,Isbarn H,Shariat SF,Arjane P,Widmer H,Pharand D,Latour M,Perrotte P,Patard JJ,Karakiewicz PI

    更新日期:2009-11-01 00:00:00

  • EAU guidelines on iatrogenic trauma.

    abstract:CONTEXT:The European Association of Urology (EAU) Trauma Guidelines Panel presents an updated iatrogenic trauma section of their guidelines. Iatrogenic injuries are known complications of surgery to the urinary tract. Timely and adequate intervention is key to their management. OBJECTIVE:To assess the optimal evaluati...

    journal_title:European urology

    pub_type: 杂志文章,实务指引


    authors: Summerton DJ,Kitrey ND,Lumen N,Serafetinidis E,Djakovic N,European Association of Urology.

    更新日期:2012-10-01 00:00:00

  • Ileal conduit and orthotopic renal transplantation. An alternative in pathology of the nonviable lower urinary tract.

    abstract::The technique of orthotopic renal transplantation with urinary shunt, using the ileal conduit as an alternative in cases of pathologically nonviable lower urinary tract, is described. Various techniques for heterotopic renal transplantation using the ileal conduit have been used. We feel that orthotopic renal transpla...

    journal_title:European urology

    pub_type: 杂志文章


    authors: Cornejo F,Arango O,Talbot-Wright R,Carretero P,Gil-Vernet JM

    更新日期:1988-01-01 00:00:00

  • Adherence to European Association of Urology Guidelines on Prophylactic Antibiotics: An Important Step in Antimicrobial Stewardship.

    abstract:BACKGROUND:The evolution of resistant pathogens is a worldwide health crisis and adherence to European Association of Urology (EAU) guidelines on antibiotic prophylaxis may be an important way to improve antibiotic stewardship and reduce patient harm and costs. OBJECTIVE:To evaluate the prevalence of antibiotic-resist...

    journal_title:European urology

    pub_type: 杂志文章


    authors: Cai T,Verze P,Brugnolli A,Tiscione D,Luciani LG,Eccher C,Lanzafame P,Malossini G,Wagenlehner FM,Mirone V,Bjerklund Johansen TE,Pickard R,Bartoletti R

    更新日期:2016-02-01 00:00:00

  • Five-year results of a randomized trial comparing retropubic and transobturator midurethral slings for stress incontinence.

    abstract:BACKGROUND:Midurethral slings have become the most preferred surgical treatment for female urinary incontinence. OBJECTIVE:To compare the efficacy and safety of two midurethral sling procedures with a different technique of sling insertion 5 yr after intervention. DESIGN, SETTING, AND PARTICIPANTS:Multicenter randomi...

    journal_title:European urology

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Laurikainen E,Valpas A,Aukee P,Kivelä A,Rinne K,Takala T,Nilsson CG

    更新日期:2014-06-01 00:00:00

  • Ultrasound-guided biopsy of homogenous solid renal masses.

    abstract:OBJECTIVES:We evaluated the reliability of sonographic criteria in selecting solid renal masses for percutaneous fine-needle biopsy. METHODS:In study 1 (intraoperative ultrasound study), we prospectively examined 100 consecutive patients scheduled for partial/radical nephrectomy by using two different high-resolution ...

    journal_title:European urology

    pub_type: 杂志文章


    authors: Reichelt O,Gajda M,Chyhrai A,Wunderlich H,Junker K,Schubert J

    更新日期:2007-11-01 00:00:00

  • A multicountry ecologic study of risk and risk reduction factors for prostate cancer mortality.

    abstract:OBJECTIVE:The objective of this research is to identify and determine the relative importance of dietary and environmental risk and risk reduction factors for prostate cancer mortality. MATERIALS AND METHODS:A multicountry ecologic approach was used in multivariate regression analyses with prostate cancer mortality ra...

    journal_title:European urology

    pub_type: 杂志文章,多中心研究


    authors: Grant WB

    更新日期:2004-03-01 00:00:00

  • Double-J ureteral stents: an alternative to external urinary stents in orthotopic bladder substitution.

    abstract:OBJECTIVE:The aim of this study was to compare advantages and disadvantages of using double-J or external stents to preserve the uretero-ileal anastomosis in patients receiving an orthotopic neobladder. METHODS:77 consecutive patients with bladder cancer who underwent radical cystoprostatectomy and Studer neobladder w...

    journal_title:European urology

    pub_type: 杂志文章


    authors: Micali S,De Carli P,Miano R,O'Sullivan D,Lamanna L,Micali F

    更新日期:2001-05-01 00:00:00

  • Urological evaluation of Behçet patients and the effect of colchicine on fertility.

    abstract::Behçet's disease is a multisystem disorder in which urogenital involvement mainly consists of genital aphthous ulcers, epididymitis, urethritis and recurrent cystitis. Colchicine is commonly used in these patients for the prevention of arthritic episodes. In this prospective study, 62 male patients under colchicine th...

    journal_title:European urology

    pub_type: 杂志文章


    authors: Sarica K,Süzer O,Gürler A,Baltaci S,Ozdiler E,Dinçel C

    更新日期:1995-01-01 00:00:00

  • Familial and hereditary prostate cancer by definition in an italian surgical series: clinical features and outcome.

    abstract:OBJECTIVE:To evaluate the clinical impact of different definitions of hereditary prostate cancer (PCa), the relative risk (RR) of relatives of PCa cases and differences in clinical-pathological features and outcome as function of a family history in a surgical series exposed to Mediterranean diet. METHODS:We classifie...

    journal_title:European urology

    pub_type: 杂志文章


    authors: Sacco E,Prayer-Galetti T,Pinto F,Ciaccia M,Fracalanza S,Betto G,Pagano F

    更新日期:2005-06-01 00:00:00

  • Prevention and management of postprostatectomy sexual dysfunctions part 2: recovery and preservation of erectile function, sexual desire, and orgasmic function.

    abstract:CONTEXT:Sexual dysfunction is common in patients who undergo radical prostatectomy (RP) for prostate cancer (PCa). OBJECTIVE:Review the available literature concerning prevention of, and management strategies for, post-RP sexual dysfunction in terms of postoperative treatments for erectile function (EF), sexual desire...

    journal_title:European urology

    pub_type: 杂志文章,评审


    authors: Salonia A,Burnett AL,Graefen M,Hatzimouratidis K,Montorsi F,Mulhall JP,Stief C

    更新日期:2012-08-01 00:00:00

  • Double pigtail ureteric stent versus percutaneous nephrostomy: effects on stone transit and ureteric motility.

    abstract:OBJECTIVES AND METHODS:The effects of double pigtail ureteric catheters (JJS) and percutaneous nephrostomies (PN) on ureteric motility and artificial stone transit was assessed in 12 dogs. Each animal underwent bilateral nephrostomies and an artificial stone insertion into each upper ureter (n = 20). A 4-Fr JJS was ins...

    journal_title:European urology

    pub_type: 杂志文章


    authors: Lennon GM,Thornhill JA,Grainger R,McDermott TE,Butler MR

    更新日期:1997-01-01 00:00:00

  • Diagnostic accuracy of noninvasive tests to evaluate bladder outlet obstruction in men: detrusor wall thickness, uroflowmetry, postvoid residual urine, and prostate volume.

    abstract:OBJECTIVES:The aim of this prospective study was to compare the diagnostic accuracy of detrusor wall thickness (DWT), free uroflowmetry, postvoid residual urine, and prostate volume (index tests) with pressure-flow studies (reference standard) to detect bladder outlet obstruction (BOO) in men. METHODS:During a 2-yr pe...

    journal_title:European urology

    pub_type: 杂志文章


    authors: Oelke M,Höfner K,Jonas U,de la Rosette JJ,Ubbink DT,Wijkstra H

    更新日期:2007-09-01 00:00:00

  • Retrospective evaluation of the outcome of open versus laparoscopic adrenalectomy for stage I and II adrenocortical cancer.

    abstract:BACKGROUND:Although there is consensus that laparoscopy is the standard of care for the resection of benign adrenal tumours, there is controversy regarding the role of laparoscopy for the resection of adrenocortical cancer (ACC). OBJECTIVE:The aim of the present study was to review the ACC database of the San Luigi Ho...

    journal_title:European urology

    pub_type: 杂志文章


    authors: Porpiglia F,Fiori C,Daffara F,Zaggia B,Bollito E,Volante M,Berruti A,Terzolo M

    更新日期:2010-05-01 00:00:00

  • Long-term safety and tolerability of tadalafil in the treatment of erectile dysfunction.

    abstract:OBJECTIVE:To assess the long-term safety and tolerability of tadalafil for patients with erectile dysfunction (ED). PATIENTS AND METHODS:This was a multicentre, open-label, 24-month extension trial involving 1173 men with ED. The mean age was 57 (range 23-83) years and 74.8% of patients were taking concomitant medicat...

    journal_title:European urology

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Montorsi F,Verheyden B,Meuleman E,Jünemann KP,Moncada I,Valiquette L,Casabé A,Pacheco C,Denne J,Knight J,Segal S,Watkins VS

    更新日期:2004-03-01 00:00:00

  • Acute pancreatitis following transurethral resection of prostate.

    abstract::Three cases of acute pancreatitis following transurethral resection of the prostate are reported. The incidence is rare. A review of perioperative data failed to disclose any unique factor except in 1 patient who had an underlying biliary tract disease. Hyperamylasemia or hyperlipaemia in association with abdominal pa...

    journal_title:European urology

    pub_type: 杂志文章


    authors: Lee MH,Chen KK,Lin AT,Lee YH,Chen MT,Chang LS

    更新日期:1993-01-01 00:00:00

  • p53 immunoreactivity as prognostic marker for cancer-specific survival in prostate cancer.

    abstract:OBJECTIVES:The objective of this study was to evaluate the role of p53 immunoreactivity as a prognostic marker in prostate cancer. METHODS:The nuclear accumulation of the aberrant p53 protein was determined by immunohisto-chemistry on surgical specimens and related to stage, grade and cancer-specific survival in 186 p...

    journal_title:European urology

    pub_type: 杂志文章


    authors: Stattin P,Bergh A,Karlberg L,Nordgren H,Damber JE

    更新日期:1996-01-01 00:00:00

  • Effect of lectins on 3H-uridine and 3H-thymidine uptake by cultured renal cell carcinoma and normal renal cells.

    abstract::The effect of lectins on cultured renal cell carcinoma and normal renal cells was studied. Ricin II showed effective inhibition of 3H-uridine and 3H-thymidine uptake by renal cell carcinoma and normal renal cells in all cases. Normal renal cells were more resistant to the inhibitory effect of ricin II as compared to r...

    journal_title:European urology

    pub_type: 杂志文章


    authors: Bazeed MA,Becht E,Schärfe T,Schmidt J,Jacobi GH,Thüroff JW

    更新日期:1986-01-01 00:00:00

  • Medical therapy to facilitate the passage of stones: what is the evidence?

    abstract:CONTEXT:Medical expulsive therapy (MET) for urolithiasis has gained increasing attention in the last years. It has been suggested that the administration of alpha-adrenoreceptor antagonists (alpha-blockers) or calcium channel blockers augments stone expulsion rates and reduces colic events. OBJECTIVE:To evaluate the e...

    journal_title:European urology

    pub_type: 杂志文章,评审


    authors: Seitz C,Liatsikos E,Porpiglia F,Tiselius HG,Zwergel U

    更新日期:2009-09-01 00:00:00

  • Deep Learning Predicts Molecular Subtype of Muscle-invasive Bladder Cancer from Conventional Histopathological Slides.

    abstract:BACKGROUND:Muscle-invasive bladder cancer (MIBC) is the second most common genitourinary malignancy, and is associated with high morbidity and mortality. Recently, molecular subtypes of MIBC have been identified, which have important clinical implications. OBJECTIVE:In the current study, we tried to predict the molecu...

    journal_title:European urology

    pub_type: 杂志文章


    authors: Woerl AC,Eckstein M,Geiger J,Wagner DC,Daher T,Stenzel P,Fernandez A,Hartmann A,Wand M,Roth W,Foersch S

    更新日期:2020-08-01 00:00:00

  • Preoperative serum testosterone level as an independent predictor of treatment failure following radical prostatectomy.

    abstract:OBJECTIVES:Preoperative low serum testosterone (TS) level has been reported to be associated with adverse pathologic results in patients with clinically localized prostate cancer (pCA) treated with radical prostatectomy (RP). However, prior studies failed to show prognostic impact of preoperative low TS in these patien...

    journal_title:European urology

    pub_type: 杂志文章


    authors: Yamamoto S,Yonese J,Kawakami S,Ohkubo Y,Tatokoro M,Komai Y,Takeshita H,Ishikawa Y,Fukui I

    更新日期:2007-09-01 00:00:00