The learning curve of robot-assisted radical cystectomy: results from the International Robotic Cystectomy Consortium.

Abstract:

BACKGROUND:Robot-assisted radical cystectomy (RARC) has evolved as a minimally invasive alternative to open radical cystectomy for patients with invasive bladder cancer. OBJECTIVE:We sought to define the learning curve for RARC by evaluating results from a multicenter, contemporary, consecutive series of patients who underwent this procedure. DESIGN, SETTING, AND PARTICIPANTS:Utilizing the International Robotic Cystectomy Consortium database, a prospectively maintained and institutional review board-approved database, we identified 496 patients who underwent RARC by 21 surgeons at 14 institutions from 2003 to 2009. MEASUREMENTS:Cut-off points for operative time, lymph node yield (LNY), estimated blood loss (EBL), and margin positivity were identified. Using specifically designed statistical mixed models, we were able to inversely predict the number of patients required for an institution to reach the predetermined cut-off points. RESULTS AND LIMITATIONS:Mean operative time was 386 min, mean EBL was 408 ml, and mean LNY was 18. Overall, 34 of 482 patients (7%) had a positive surgical margin (PSM). Using statistical models, it was estimated that 21 patients were required for operative time to reach 6.5h and 8, 20, and 30 patients were required to reach an LNY of 12, 16, and 20, respectively. For all patients, PSM rates of <5% were achieved after 30 patients. For patients with pathologic stage higher than T2, PSM rates of <15% were achieved after 24 patients. CONCLUSIONS:RARC is a challenging procedure but is a technique that is reproducible throughout multiple centers. This report helps to define the learning curve for RARC and demonstrates an acceptable level of proficiency by the 30th case for proxy measures of RARC quality.

journal_name

Eur Urol

journal_title

European urology

authors

Hayn MH,Hussain A,Mansour AM,Andrews PE,Carpentier P,Castle E,Dasgupta P,Rimington P,Thomas R,Khan S,Kibel A,Kim H,Manoharan M,Menon M,Mottrie A,Ornstein D,Peabody J,Pruthi R,Palou Redorta J,Richstone L,Schanne F

doi

10.1016/j.eururo.2010.04.024

subject

Has Abstract

pub_date

2010-08-01 00:00:00

pages

197-202

issue

2

eissn

0302-2838

issn

1873-7560

pii

S0302-2838(10)00372-6

journal_volume

58

pub_type

杂志文章,多中心研究
  • Scandinavian clinical study of finasteride in the treatment of benign prostatic hyperplasia.

    abstract::The effects of finasteride, a potent 5 alpha-reductase inhibitor, were assessed in patients with benign prostatic hyperplasia. Patients were treated with finasteride or placebo for 24 weeks in a double-blind multicenter study followed by a 12-month open-extension period. After 24 weeks, finasteride-treated patients, w...

    journal_title:European urology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1159/000474771

    authors: Beisland HO,Binkowitz B,Brekkan E,Ekman P,Kontturi M,Lehtonen T,Lundmo P,Pappas F,Round E,Shapiro D

    更新日期:1992-01-01 00:00:00

  • Clues to the aetiology of testicular germ cell tumours from descriptive epidemiology.

    abstract::The descriptive epidemiology of testicular cancer in Denmark shows that the incidence of both seminoma and non-seminoma has increased gradually since the 1940s to the present. The age-incidence pattern has remained unchanged, and is the same in the Nordic countries despite variation in the overall incidence level. Men...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000474564

    authors: Møller H

    更新日期:1993-01-01 00:00:00

  • Trans-obturator vaginal tape (TOT) for female stress incontinence: one year follow-up in 120 patients.

    abstract:OBJECTIVES:The aim of this study was to evaluate the effectiveness of a new minimally invasive surgical procedure, the Trans-obturator Vaginal Tape (TOT) in the treatment of female urodynamic stress incontinence (USI) and to analyse functional results and quality of life after one year of follow up. MATERIAL AND METHO...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2005.08.003

    authors: Roumeguère T,Quackels T,Bollens R,de Groote A,Zlotta A,Bossche MV,Schulman C

    更新日期:2005-11-01 00:00:00

  • Transient receptor potential vanilloid type 1 (TRPV1) expression changes from normal urothelium to transitional cell carcinoma of human bladder.

    abstract:OBJECTIVE:To investigate possible changes in the expression of the transient receptor potential vanilloid type 1 (TRPV1) from normal urothelium to transitional cell carcinoma (TCC) of human bladder. METHODS:Specimens from normal bladder (n=13, mean age 62 yrs), superficial TCC (n=16, mean age 62,4 yrs) and muscle inva...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2005.05.018

    authors: Lazzeri M,Vannucchi MG,Spinelli M,Bizzoco E,Beneforti P,Turini D,Faussone-Pellegrini MS

    更新日期:2005-10-01 00:00:00

  • Oncologic outcome and patterns of recurrence after salvage radical prostatectomy.

    abstract:BACKGROUND:Limited data on patterns of recurrence (local or metastatic) after salvage radical prostatectomy (SP) is available. OBJECTIVE:To examine biochemical, local and metastatic patterns of recurrence in patients undergoing SP for radiation-recurrent prostate cancer. DESIGN, SETTING, AND PARTICIPANTS:146 patients...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2008.07.007

    authors: Paparel P,Cronin AM,Savage C,Scardino PT,Eastham JA

    更新日期:2009-02-01 00:00:00

  • The radius surgical system - a new device for complex minimally invasive procedures in urology?

    abstract:OBJECTIVE:Complex laparoscopic procedures in urology are technically demanding with an extended learning curve. Robotic systems add significant cost to laparoscopic procedures. We therefore evaluated the use of the Radius Surgical System (RSS), a mechanical manipulator, for complex laparoscopic cases in urology. MATER...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2006.11.046

    authors: Frede T,Hammady A,Klein J,Teber D,Inaki N,Waseda M,Buess G,Rassweiler J

    更新日期:2007-04-01 00:00:00

  • Tamoxifen treatment in oligozoospermia.

    abstract::This study of the effects of long-term tamoxifen administration on semen analysis of oligospermic males confirms the potential therapeutic efficacy in normogonadotrophic oligospermia. 38 out of the 56 patients responded well to long-term treatment with 30 mg tamoxifen daily. According to the nomenclature of Eliasson, ...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000473241

    authors: Bartsch G,Scheiber K

    更新日期:1981-01-01 00:00:00

  • Laparoscopic partial nephrectomy for tumour excision in a horseshoe kidney.

    abstract::A 62-yr-old woman with a 2-cm enhancing renal mass in the right moiety of a horseshoe kidney was treated via a four-port transperitoneal laparoscopic approach. The tumour was excised by cold scissors, and the parenchyma was sutured with Vicryl 1 sutures with Surgicel bolster and by using pledgets of Hem-o-lok((R)) cli...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2006.10.052

    authors: Tsivian A,Shtricker A,Benjamin S,Sidi AA

    更新日期:2007-04-01 00:00:00

  • Relationship between prostatic cytoplasmic and nuclear androgen receptors in patients with carcinoma of the prostate.

    abstract::Cytoplasmic and nuclear androgen receptors were measured in benign prostatic hypertrophy, untreated malignant prostates and diethylstilboestrol-treated malignant prostates. The levels of total androgen receptors in benign prostatic hypertrophy were not statistically different from those in the untreated or treated mal...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000473170

    authors: Ghanadian R,Auf G,Williams G

    更新日期:1981-01-01 00:00:00

  • Benign prostatic hyperplasia: symptoms and objective interpretation.

    abstract::Considerable new knowledge about benign prostatic hyperplasia has been gained over the past two decades, particularly with regard to its natural history, hydrodynamic changes in the lower urinary tract, and the symptomatic and urodynamic results of treatment. A survey of the literature has been undertaken with special...

    journal_title:European urology

    pub_type: 杂志文章,评审

    doi:10.1159/000471744

    authors: Andersen JT

    更新日期:1991-01-01 00:00:00

  • Retroperitoneoscopic transureteroureterostomy with cutaneous ureterostomy to salvage failed ileal conduit urinary diversion.

    abstract::Reconstruction for failed urinary diversion is technically challenging, due to severe tissue adhesion around the anastomotic site. We report successful laparoscopic transureteroureterostomy with cutaneous ureterostomy via a completely extraperitoneal approach to salvage failed ileal conduit in two patients with necrot...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2009.06.003

    authors: Kaiho Y,Ito A,Numahata K,Ishidoya S,Arai Y

    更新日期:2011-05-01 00:00:00

  • Crossed chemoprophylaxis assay between adriamycin and cis-platinum in recurrent superficial bladder tumor.

    abstract::Of 146 patients with superficial bladder carcinoma, 66 (35 primary and 31 recurrent from failure of thiotepa chemoprophylaxis) relapsed following transurethral resection (TUR) and chemotherapy with adriamycin or cis-platinum. A new TUR was carried out. In case of progression in the number of tumors, size, stage or gra...

    journal_title:European urology

    pub_type: 临床试验,杂志文章

    doi:10.1159/000472630

    authors: Llopis B,Gallego J,Mompó JA,Boronat F,Alonso M,Moreno B,Jiménez JF

    更新日期:1986-01-01 00:00:00

  • Next-generation RNA sequencing of archival formalin-fixed paraffin-embedded urothelial bladder cancer.

    abstract:UNLABELLED:Molecular profiling of individual cancers is key to personalised medicine. While sequencing technologies have required stringent sample collection and handling, recent technical advances offer sequencing from tissues collected in routine practice and tissues already stored in archives. In this paper, we esta...

    journal_title:European urology

    pub_type: 信件

    doi:10.1016/j.eururo.2014.07.045

    authors: Liu Y,Noon AP,Aguiar Cabeza E,Shen J,Kuk C,Ilczynski C,Ni R,Sukhu B,Chan K,Barbosa-Morais NL,Hermanns T,Blencowe BJ,Azad A,van der Kwast TH,Catto JW,Zlotta AR,Wrana JL

    更新日期:2014-12-01 00:00:00

  • Support ellagic acid therapy in patients with hormone refractory prostate cancer (HRPC) on standard chemotherapy using vinorelbine and estramustine phosphate.

    abstract:BACKGROUND:Recent phase III studies in hormone refractory prostate cancer (HRPC) showed an improvement in terms of overall survival (OS), objective response (OR) and biochemical response (BR); however, chemotherapy is usually accompanied by negative side effects that determines poor quality of life (QoL) and only margi...

    journal_title:European urology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/j.eururo.2004.12.001

    authors: Falsaperla M,Morgia G,Tartarone A,Ardito R,Romano G

    更新日期:2005-04-01 00:00:00

  • Training and general and financial conditions of European residents in urology: an international survey.

    abstract:OBJECTIVE:To assess the training and the general and financial conditions of European residents in urology. METHODS:Between February and April 2004 a questionnaire was sent by e-mail to 351 residents in urology in 30 different European countries. The questionnaire was divided into four different sections concerning ge...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2004.07.003

    authors: Ballario R,Rubilotta E

    更新日期:2004-10-01 00:00:00

  • Tissue adhesives: their use in urology.

    abstract::Tissue adhesives have certain advantages and should be used only for nephropexy and urethropexy but not for orchiopexy. Because of possible incrustation it should be avoided in the urinary collecting system. ...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000471999

    authors: Kelâmi A

    更新日期:1976-01-01 00:00:00

  • A comparison of the efficacy and tolerability of solifenacin succinate and extended release tolterodine at treating overactive bladder syndrome: results of the STAR trial.

    abstract:OBJECTIVE:To compare two new generation antimuscarinics at their recommended doses for treatment of overactive bladder syndrome (OAB). METHODS:A prospective, double blind, double-dummy, two-arm, parallel-group, 12-week study was conducted to compare the efficacy and safety of solifenacin 5 or 10 mg and tolterodine ext...

    journal_title:European urology

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.eururo.2005.05.015

    authors: Chapple CR,Martinez-Garcia R,Selvaggi L,Toozs-Hobson P,Warnack W,Drogendijk T,Wright DM,Bolodeoku J,STAR study group.

    更新日期:2005-09-01 00:00:00

  • Neuroendocrine differentiation in hormone refractory prostate cancer following androgen deprivation therapy.

    abstract:OBJECTIVE:To evaluate the relationship between neuroendocrine differentiation (NED) status and hormone refractory prostate cancer (HRPC) following hormone therapy based on immunohistochemical study. METHODS:Seventy-two prostate cancer specimens obtained at radical prostatectomy and 21 prostate cancer autopsy specimens...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2003.11.032

    authors: Hirano D,Okada Y,Minei S,Takimoto Y,Nemoto N

    更新日期:2004-05-01 00:00:00

  • Renal lesions in Von Hippel-Lindau disease: the benign, the malignant, the unknown.

    abstract:OBJECTIVES:To describe the features and treatment of renal lesions in von Hippel-Lindau disease (VHL) from a series of patients, to highlight important issues in the management of these lesions. MATERIALS AND METHODS:We performed a retrospective study in 7 patients with VHL who underwent surgery for renal lesions betw...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000019771

    authors: Salomé F,Colombeau P,Fermeaux V,Cazaux P,Dumas JP,Pfeifer P,Moreau JJ,Richard S,Labrousse F

    更新日期:1998-01-01 00:00:00

  • A new marker for early detection and indicator of progression of cancer of the bladder. Preliminary results with Ag-NOR index in 38 cases of superficial bladder cancer.

    abstract::The multiform biology of superficial bladder tumors, both morphologically and evolutively, and the lack of reliable predictors of progression have led the authors to study the Ag-NOR proteins as a new marker of these tumors. It is well known that particularly the low-grade superficial tumors frequently relapse on the ...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000474884

    authors: Marandola P,Lardennois B,Ploton D,Derenzini M,Treré D,Campo B,Valentino V,Tronci A,Roggia A,Broggini P

    更新日期:1992-01-01 00:00:00

  • Renal cell carcinoma (RCC) in patients with end-stage renal disease exhibits many favourable clinical, pathologic, and outcome features compared with RCC in the general population.

    abstract:BACKGROUND:Patients with end-stage renal disease (ESRD) are at risk of developing renal tumours. OBJECTIVE:Compare clinical, pathologic, and outcome features of renal cell carcinomas (RCCs) in ESRD patients and in patients from the general population. DESIGN, SETTING, AND PARTICIPANTS:Twenty-four French university de...

    journal_title:European urology

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.eururo.2011.02.035

    authors: Neuzillet Y,Tillou X,Mathieu R,Long JA,Gigante M,Paparel P,Poissonnier L,Baumert H,Escudier B,Lang H,Rioux-Leclercq N,Bigot P,Bernhard JC,Albiges L,Bastien L,Petit J,Saint F,Bruyere F,Boutin JM,Brichart N,Karam G

    更新日期:2011-08-01 00:00:00

  • Comparison of an LH-RH analogue (Goeserelin acetate, 'Zoladex') with combined androgen blockade in advanced prostate cancer: final survival results of an international multicentre randomized-trial. International Prostate Cancer Study Group.

    abstract:OBJECTIVE:The aim of this study was to compare the effects of the nonsteroidal antiandrogen flutamide plus the LH-RH analogue goserelin acetate (combined androgen blockade [CAB]) with goserelin acetate alone in patients with advanced prostate cancer. The original analyses at 25 and 56 months of follow-up have been repo...

    journal_title:European urology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1159/000020119

    authors: Tyrrell CJ,Altwein JE,Klippel F,Jurincic-Winkler C,Varenhorst E,Lunglmayr G,Boccardo F,Holdaway IM,Haefliger JM,Jordaan JP

    更新日期:2000-02-01 00:00:00

  • Ureteroureterostomy in complete ureteral duplication.

    abstract::Homolateral pelvic ureteroureterostomies were performed in 25 patients presenting with complete duplication of the pyeloureteric tract. The procedure was performed in 16 cases of ureteroceles, in 7 cases of reflux in duplicated ureters, in 1 case of ectopic ureter and in 1 postoperative stenosis of one segment of a do...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000473152

    authors: Bracci U,Miano L,Laurenti C

    更新日期:1979-01-01 00:00:00

  • New method of postprostatectomy bladder irrigation.

    abstract::Bacterial filters have been used to sterilise the hospital water supply in order to provide irrigant for postprostatectomy irrigation. This method was compared retrospectively to bladder irrigation derived from a still on the ward. Postoperative bacteriuria was similar in both groups of 75 patients, occurring in 23.7%...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000471532

    authors: MacDermott JP,Ewing R,Gray BK

    更新日期:1989-01-01 00:00:00

  • Salvage cystectomy: the case for a combined abdominoperineal approach.

    abstract::Salvage cystectomy, after failed radical radiotherapy for infiltrating bladder cancer, is a major procedure in which rectal laceration can lead to life-threatening complications. The advantages of a combined abdominoperineal approach are emphasized in a series of 14 patients. ...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000463836

    authors: Boccon Gibod L,Leleu C,Steg A

    更新日期:1984-01-01 00:00:00

  • Intravesical administration of EGF- dextran conjugates in patients with superficial bladder cancer.

    abstract:OBJECTIVES:Overexpression of the epidermal growth factor receptor (EGFR) has been reported in bladder cancer and is a potential target for therapy with radionuclides. In this study, we investigated the binding of EGF-dextran-(99m)Tc to the EGFR. The aim of this study was to determine if intravesically administered EGF-...

    journal_title:European urology

    pub_type: 临床试验,杂志文章

    doi:10.1159/000020335

    authors: Bue P,Holmberg AR,Márquez M,Westlin JE,Nilsson S,Malmström PU

    更新日期:2000-11-01 00:00:00

  • Retroperitoneal fibrosis and chronic periaortitis: a new hypothesis.

    abstract::The etiology of retroperitoneal fibrosis (Ormond's disease) has still not been clarified. A new hypothesis postulates chronic fibrosing periaortitis. Atherosclerosis of the abdominal aorta and plaque rupture lead to the liberation of oxidized lipoproteins through the adventitia into the periaortic fatty tissue. This r...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000474632

    authors: Martina FB,Nüech R,Gasser TC

    更新日期:1993-01-01 00:00:00

  • Laparoendoscopic single-site nephrectomy compared with conventional laparoscopic nephrectomy: a systematic review and meta-analysis of comparative studies.

    abstract:CONTEXT:Laparoendoscopic single-site (LESS) surgery has increasingly been used to perform radical, partial, simple, or donor nephrectomy to reduce the morbidity and scarring associated with surgical intervention. Studies comparing LESS nephrectomy (LESS-N) and conventional laparoscopic nephrectomy (CL-N) have reported ...

    journal_title:European urology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.eururo.2012.05.055

    authors: Fan X,Lin T,Xu K,Yin Z,Huang H,Dong W,Huang J

    更新日期:2012-10-01 00:00:00

  • Aminoglutethimide for advanced prostatic cancer resistant to conventional hormonal therapy.

    abstract::Aminoglutethimide (AG) and hydrocortisone (HC) were given to 20 patients with advanced prostatic cancer resistant to conventional hormonal therapy. Most patients had painful bone metastases and were heavily pretreated. 12 of 16 patients required narcotic analgetics. 8 of 20 were bedridden. AG + HC produced relief of b...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000472913

    authors: Elomaa I,Taube T,Blomqvist C,Rissanen P,Rannikko S,Alfthan O

    更新日期:1988-01-01 00:00:00

  • Best practices in robot-assisted radical cystectomy and urinary reconstruction: recommendations of the Pasadena Consensus Panel.

    abstract:CONTEXT:Robot-assisted surgery is increasingly used for radical cystectomy (RC) and urinary reconstruction. Sufficient data have accumulated to allow evidence-based consensus on key issues such as perioperative management, comparative effectiveness on surgical complications, and oncologic short- to midterm outcomes. O...

    journal_title:European urology

    pub_type: 共识发展会议,杂志文章,实务指引,评审

    doi:10.1016/j.eururo.2014.12.009

    authors: Wilson TG,Guru K,Rosen RC,Wiklund P,Annerstedt M,Bochner BH,Chan KG,Montorsi F,Mottrie A,Murphy D,Novara G,Peabody JO,Palou Redorta J,Skinner EC,Thalmann G,Stenzl A,Yuh B,Catto J,Pasadena Consensus Panel.

    更新日期:2015-03-01 00:00:00