Abstract:
OBJECTIVES:To describe the features and treatment of renal lesions in von Hippel-Lindau disease (VHL) from a series of patients, to highlight important issues in the management of these lesions. MATERIALS AND METHODS:We performed a retrospective study in 7 patients with VHL who underwent surgery for renal lesions between January 1990 and July 1996. The initial evaluation consisted of an abdominal CT scan and renal arteriography. RESULTS:The mean age of patients at the time of discovery was 38 (+/- 12.01 years). All cases were of type 1. Radiology assessment underestimated the gravity of the lesions in 5 patients. In all patients, unilateral surgery was performed with the kidney being conserved in 4 cases. Of the 44 lesions removed, 23 had signs of progressiveness (atypical or malignant cyst, renal cell carcinoma), most of the cancers were of low grade. 84% of the lesions did not exceed 3 cm and 48% were =1 cm. During follow-up (42 months), 2 patients relapsed. CONCLUSION:The clinical and pathological features of renal lesions in VHL require strict and early follow-up (from the age of 15). Only under these circumstances should primary conservative surgery be performed, however, recurrences are frequent. This conservative approach remains to be validated by multicentric prospective studies.
journal_name
Eur Uroljournal_title
European urologyauthors
Salomé F,Colombeau P,Fermeaux V,Cazaux P,Dumas JP,Pfeifer P,Moreau JJ,Richard S,Labrousse Fdoi
10.1159/000019771subject
Has Abstractpub_date
1998-01-01 00:00:00pages
383-92issue
5eissn
0302-2838issn
1873-7560pii
eur34383journal_volume
34pub_type
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