Intravesical administration of EGF- dextran conjugates in patients with superficial bladder cancer.

Abstract:

OBJECTIVES:Overexpression of the epidermal growth factor receptor (EGFR) has been reported in bladder cancer and is a potential target for therapy with radionuclides. In this study, we investigated the binding of EGF-dextran-(99m)Tc to the EGFR. The aim of this study was to determine if intravesically administered EGF-dextran conjungate selectively accumulated in the tumor tissue and to correlate the uptake to tumor characteristics. METHODS:Eight patients received the conjugate intravesically for about 30 min followed by bladder irrigation and then transurethral resection. Radioactivity of the biopsy specimens from normal urothelium and tumor areas was measured in a gamma counter. RESULTS:Five patients received EGF-dextran-(99m)Tc, three received dextran-(99m)Tc and one received only (99m)Tc. The 5 patients who received the complete conjugate had a mean ratio of radioactivity between tumor and normal urothelium of 664:1 (range: 2.4-1,710). The dextran-(99m)Tc showed a slightly increased ratio and (99m)Tc did not bind at all. CONCLUSION:The results are encouraging and further studies are warranted to investigate if EGF-dextran could be effective as intravesical therapy, either conjugated with cystostatic drugs or labeled with suitable radionuclides.

journal_name

Eur Urol

journal_title

European urology

authors

Bue P,Holmberg AR,Márquez M,Westlin JE,Nilsson S,Malmström PU

doi

10.1159/000020335

keywords:

subject

Has Abstract

pub_date

2000-11-01 00:00:00

pages

584-9

issue

5

eissn

0302-2838

issn

1873-7560

pii

20335

journal_volume

38

pub_type

临床试验,杂志文章
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    pub_type: 杂志文章,评审

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    pub_type: 杂志文章

    doi:10.1159/000473448

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    pub_type: 杂志文章

    doi:10.1016/j.eururo.2007.01.040

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    更新日期:2007-12-01 00:00:00

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    pub_type: 杂志文章

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    journal_title:European urology

    pub_type: 杂志文章

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    pub_type: 杂志文章,多中心研究

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