Growth characteristics of cultured human normal bladder epithelial cells: a comparison with urothelial carcinoma cell cultures.

Abstract:

:We present the in vitro growth characteristics and morphology of the first established long-term culture of human normal bladder epithelium. Normal bladder cells were grown with a mean generation time of 44 h and a life span of 33 population doublings in 12 weeks. The cells exhibited contact inhibition of growth. The cultures were morphologically examined and compared with transitional cell carcinoma in culture.

journal_name

Eur Urol

journal_title

European urology

authors

Logothetou-Rella H,Nesland JM,Karayiannis A,Dimopoulos C

doi

10.1159/000473448

subject

Has Abstract

pub_date

1988-01-01 00:00:00

pages

259-63

issue

3-4

eissn

0302-2838

issn

1873-7560

journal_volume

15

pub_type

杂志文章
  • Computerized quantification and planimetry of prostatic capsular nerves in relation to adjacent prostate cancer foci.

    abstract:BACKGROUND:Perineural invasion is discussed as a significant route of extraprostatic extension in prostate cancer (PCa). Recent in vitro studies suggested a complex mechanism of neuroepithelial interaction. OBJECTIVE:The present study was intended to investigate whether the concept of neuroepithelial interaction can b...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2013.04.043

    authors: Bründl J,Schneider S,Weber F,Zeman F,Wieland WF,Ganzer R

    更新日期:2014-04-01 00:00:00

  • Reassessing the current UICC/AJCC TNM staging for renal cell carcinoma.

    abstract:CONTEXT:The outcome prediction for renal cell cancer (RCC) remains controversial, and although many parameters have been tested for prognostic significance, only a few have achieved widespread acceptance in clinical practice. The TNM staging system defines local extension of the primary tumour (T), involvement of regio...

    journal_title:European urology

    pub_type: 杂志文章,评审

    doi:10.1016/j.eururo.2009.06.036

    authors: Moch H,Artibani W,Delahunt B,Ficarra V,Knuechel R,Montorsi F,Patard JJ,Stief CG,Sulser T,Wild PJ

    更新日期:2009-10-01 00:00:00

  • Increased expression of connexin 43 in the overactive neurogenic detrusor.

    abstract:PURPOSE:The cellular mechanisms involved in unstable uncontrolled detrusor contractions in the human bladder remain unknown. One hypothesis, based on electron microscopical observations and animal studies, is that gap junctions are present in the human detrusor and are increased in patients with detrusor overactivity. ...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2004.08.020

    authors: Haferkamp A,Mundhenk J,Bastian PJ,Reitz A,Dörsam J,Pannek J,Schumacher S,Schurch B,Büttner R,Müller SC

    更新日期:2004-12-01 00:00:00

  • Corticosteroids and tamsulosin in the medical expulsive therapy for symptomatic distal ureter stones: single drug or association?

    abstract:OBJECTIVES:To assess the clinical role of corticosteroids in the medical expulsive therapy of symptomatic distal ureteral stones. METHODS:Between January 2004 and September 2005, 114 patients with symptomatic distal ureteral stones with a >/=5mm diameter were enrolled in this prospective study and divided into four gr...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2006.02.023

    authors: Porpiglia F,Vaccino D,Billia M,Renard J,Cracco C,Ghignone G,Scoffone C,Terrone C,Scarpa RM

    更新日期:2006-08-01 00:00:00

  • Metastasectomy in renal cell carcinoma: A multicenter retrospective analysis.

    abstract:OBJECTIVE:In 60-70% of patients with renal cell carcinoma (RCC), metastases develop in the course of the disease. In the present analysis, the surgical management of metastases is described, and survival data are presented. This retrospective analysis may help in the management of future cases. Due to the retrospective...

    journal_title:European urology

    pub_type: 杂志文章,多中心研究

    doi:10.1159/000019849

    authors: van der Poel HG,Roukema JA,Horenblas S,van Geel AN,Debruyne FM

    更新日期:1999-01-01 00:00:00

  • Benign prostatic hyperplasia: symptoms and objective interpretation.

    abstract::Considerable new knowledge about benign prostatic hyperplasia has been gained over the past two decades, particularly with regard to its natural history, hydrodynamic changes in the lower urinary tract, and the symptomatic and urodynamic results of treatment. A survey of the literature has been undertaken with special...

    journal_title:European urology

    pub_type: 杂志文章,评审

    doi:10.1159/000471744

    authors: Andersen JT

    更新日期:1991-01-01 00:00:00

  • Renal cell carcinoma guideline.

    abstract:OBJECTIVES:The European Association of Urology (EAU) Guideline Group for renal cell carcinoma (RCC) prepared this guideline to help urologists assess the evidence-based management of RCC and to incorporate the guideline recommendations into their clinical practice. METHODS:The recommendations provided in the current g...

    journal_title:European urology

    pub_type: 杂志文章,实务指引

    doi:10.1016/j.eururo.2007.03.035

    authors: Ljungberg B,Hanbury DC,Kuczyk MA,Merseburger AS,Mulders PF,Patard JJ,Sinescu IC,European Association of Urology Guideline Group for renal cell carcinoma.

    更新日期:2007-06-01 00:00:00

  • Long-term alpha-adrenergic-blocking therapy in detrusor-urethra dyssynergia.

    abstract::Neurogenic dyssynergia was treated with alpha-adrenergic blockers. Only 21 of 43 highly selected patients with residual urines and low flow rates continued therapy with phenoxybenzamine for more than 6 months, despite initial benefits. The causes of therapy discontinuation are discussed. A combination of 5 mg dibenzyl...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000474074

    authors: Vereecken RL,Van Poppel H,Boeckx G,Leruitte A

    更新日期:1983-01-01 00:00:00

  • Trans-obturator vaginal tape (TOT) for female stress incontinence: one year follow-up in 120 patients.

    abstract:OBJECTIVES:The aim of this study was to evaluate the effectiveness of a new minimally invasive surgical procedure, the Trans-obturator Vaginal Tape (TOT) in the treatment of female urodynamic stress incontinence (USI) and to analyse functional results and quality of life after one year of follow up. MATERIAL AND METHO...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2005.08.003

    authors: Roumeguère T,Quackels T,Bollens R,de Groote A,Zlotta A,Bossche MV,Schulman C

    更新日期:2005-11-01 00:00:00

  • Value of duplex Doppler ultrasonography in renal colic.

    abstract:OBJECTIVES:The aim of our study was to determine the value of duplex Doppler ultrasonography (DDU) in the patients' evolution with renal colic. The study of the resistive index (RI), difference of the RI (ARI) associated with a DDU intravesical recording (ureteral jets) were compared with renographic findings in renal ...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/s0302-2838(01)00005-7

    authors: Geavlete P,Georgescu D,Cauni V,Niţa G

    更新日期:2002-01-01 00:00:00

  • Combined effect of tumor necrosis factor alpha and anticancer chemotherapeutic agents against human renal carcinoma cell lines.

    abstract::Antitumor effect of recombinant human tumor necrosis factor alpha (TNF) alone or in combination with various anticancer chemotherapeutic agents was tested using an in vitro antiproliferative assay on four human renal carcinoma cell lines (VMRC-RCW, VMRC-RCZ, Caki-1 and A-498). When the dose-dependent effect of TNF was...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000473628

    authors: Ikemoto S,Hayahara N,Wada S,Nishio S,Maekawa M

    更新日期:1991-01-01 00:00:00

  • Correlation between history and urodynamics in neurologically normal incontinent women.

    abstract::We compared the history of 100 consecutive women complaining of incontinence with their urodynamic findings. The real urodynamic situation proved unpredictable on the basis of the medical history. A good correlation between history and urodynamics was found in 80% of the women complaining of stress incontinence. The i...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000472986

    authors: Maes D,Wyndaele JJ

    更新日期:1988-01-01 00:00:00

  • Ureteral reimplantation for management of ureteral strictures: a retrospective comparison of laparoscopic and open techniques.

    abstract:OBJECTIVES:To compare the results of laparoscopic ureteral reimplantation with a previous series of open surgery. MATERIALS AND METHODS:We compared ten patients who underwent laparoscopic vesicopsoas-hitch with (n=4) or without Boari-flap (n=6) technique for ureteral obstructions with ten patients treated by open uret...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2006.08.004

    authors: Rassweiler JJ,Gözen AS,Erdogru T,Sugiono M,Teber D

    更新日期:2007-02-01 00:00:00

  • Incidence of tumoural pathology in horseshoe kidneys.

    abstract:OBJECTIVES:To know the incidence of tumoural pathology among our cases of horseshoe kidney (HK), a congenital anomaly occurring in 0.25% of the population, as well as their prognostic factors and follow-up. METHODS:A total of 82 patients admitted at our Centre between 1967 and 1996 with an HK diagnosis were retrospect...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000019551

    authors: Rubio Briones J,Regalado Pareja R,Sánchez Martín F,Chéchile Toniolo G,Huguet Pérez J,Villavicencio Mavrich H

    更新日期:1998-01-01 00:00:00

  • Retrocaval ureter.

    abstract::3 cases of retrocaval ureter (one of them presenting multiple urological anomalies) are discussed. In the presence of hydronephrosis, early operative reposition of the ureter is essential. Provided that the condition is diagnosed before extreme renal deterioration, the surgical repair can salvage remaining renal funct...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000473971

    authors: Eidelman A,Yuval E,Simon D,Sibi Y

    更新日期:1978-01-01 00:00:00

  • Subsequent Chemotherapy and Treatment Patterns After Abiraterone Acetate in Patients with Metastatic Castration-resistant Prostate Cancer: Post Hoc Analysis of COU-AA-302.

    abstract:BACKGROUND:Treatment patterns for metastatic castration-resistant prostate cancer (mCRPC) have changed substantially in the last few years. In trial COU-AA-302 (chemotherapy-naïve men with mCRPC), abiraterone acetate plus prednisone (AA) significantly improved radiographic progression-free survival and overall survival...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2016.06.033

    authors: de Bono JS,Smith MR,Saad F,Rathkopf DE,Mulders PFA,Small EJ,Shore ND,Fizazi K,De Porre P,Kheoh T,Li J,Todd MB,Ryan CJ,Flaig TW

    更新日期:2017-04-01 00:00:00

  • Efficacy and Safety of Mirabegron Add-on Therapy to Solifenacin in Incontinent Overactive Bladder Patients with an Inadequate Response to Initial 4-Week Solifenacin Monotherapy: A Randomised Double-blind Multicentre Phase 3B Study (BESIDE).

    abstract:BACKGROUND:Incontinence has a greater detrimental effect on quality of life than other symptoms of overactive bladder (OAB) and is often difficult to treat with antimuscarinic monotherapy. OBJECTIVE:To evaluate the efficacy and the safety and tolerability of combination (solifenacin 5mg and mirabegron 50mg) versus sol...

    journal_title:European urology

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.eururo.2016.02.030

    authors: Drake MJ,Chapple C,Esen AA,Athanasiou S,Cambronero J,Mitcheson D,Herschorn S,Saleem T,Huang M,Siddiqui E,Stölzel M,Herholdt C,MacDiarmid S,BESIDE study investigators.

    更新日期:2016-07-01 00:00:00

  • Mechanisms of prostate atrophy after glandular botulinum neurotoxin type a injection: an experimental study in the rat.

    abstract:BACKGROUND:Previous studies in humans, dogs, and rats have shown that intraprostatic injection of botulinum neurotoxin type A (BoNTA) reduces gland size. OBJECTIVE:To investigate the role of eventual impairment of sympathetic, parasympathetic, and sensory nerves to gland atrophy after intraprostatic BoNTA administrati...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2008.07.003

    authors: Silva J,Pinto R,Carvallho T,Coelho A,Avelino A,Dinis P,Cruz F

    更新日期:2009-07-01 00:00:00

  • Comparison of partial nephrectomy and percutaneous ablation for cT1 renal masses.

    abstract:BACKGROUND:Partial nephrectomy (PN) is a preferred treatment for cT1 renal masses, whereas thermal ablation represents an alternative nephron-sparing option, albeit with higher reported rates of recurrence. OBJECTIVE:To review our experience with PN, percutaneous radiofrequency ablation (RFA), and percutaneous cryoabl...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2014.07.021

    authors: Thompson RH,Atwell T,Schmit G,Lohse CM,Kurup AN,Weisbrod A,Psutka SP,Stewart SB,Callstrom MR,Cheville JC,Boorjian SA,Leibovich BC

    更新日期:2015-02-01 00:00:00

  • Prognostic value of Ki-67 expression in renal cell carcinomas.

    abstract:OBJECTIVE:The aim of the study was to determine the prognostic power of Ki-67 immunostaining in renal cell carcinomas (RCC). METHODS:Clinical follow-up data were reviewed in 111 RCC and the results of Ki-67 immunolabelling were correlated to standard prognostic factors and survival data of the patients. RESULTS:Ki-67...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000474482

    authors: Aaltomaa S,Lipponen P,Ala-Opas M,Eskelinen M,Syrjänen K

    更新日期:1997-01-01 00:00:00

  • Efficacy and Safety of Tamsulosin in Medical Expulsive Therapy for Distal Ureteral Stones with Renal Colic: A Multicenter, Randomized, Double-blind, Placebo-controlled Trial.

    abstract:BACKGROUND:Recent large high-quality trials have questioned the clinical effectiveness of medical expulsive therapy using tamsulosin for ureteral stones. OBJECTIVE:To evaluate the efficacy and safety of tamsulosin for distal ureteral stones compared with placebo. DESIGN, SETTING, AND PARTICIPANTS:We conducted a doubl...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2017.10.033

    authors: Ye Z,Zeng G,Yang H,Tang K,Zhang X,Li H,Li W,Wu Z,Chen L,Chen X,Liu X,Deng Y,Pan T,Xing J,Wang S,Cheng Y,Gu X,Gao W,Yang J,Zhang Y,Mi Q,Qi L,Li J,Hu W,Liang P,Sun Z,Xu C,Long Y,Liao Y,Liu S,Liu

    更新日期:2018-03-01 00:00:00

  • Does internal urethrotomy prevent urethral stricture after transurethral prostatectomy. Early and late results.

    abstract::In a randomized study of 200 consecutive patients undergoing transurethral prostatectomy (TURP), the combination of internal urethrotomy and TURP (the trial group) was compared with TURP alone (the control group) with regard to the development of urethral strictures postoperatively. Three months after resection, 14% i...

    journal_title:European urology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000471587

    authors: Nielsen KK,Kjoergaard B,Kristensen ES,Jeppesen L,Krarup T

    更新日期:1989-01-01 00:00:00

  • Does the extent of lymphadenectomy in radical cystectomy for bladder cancer influence disease-free survival? A prospective single-center study.

    abstract:BACKGROUND:Controversy exists regarding the optimal extent of lymphadenectomy and the number of lymph nodes to be retrieved at radical cystectomy (RC). OBJECTIVE:To compare the disease-free survival of patients with standard lymphadenectomy (endopelvic region composed of the internal, external iliac, and obturator gro...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2011.05.062

    authors: Abol-Enein H,Tilki D,Mosbah A,El-Baz M,Shokeir A,Nabeeh A,Ghoneim MA

    更新日期:2011-09-01 00:00:00

  • The prognostic significance of capsular incision into tumor during radical prostatectomy.

    abstract:BACKGROUND:The prognostic significance of capsular incision (CapI) into tumor during radical prostatectomy (RP) with otherwise organ-confined disease remains uncertain. OBJECTIVE:To evaluate the impact of CapI into tumor on oncologic outcome. DESIGN, SETTING, AND PARTICIPANTS:A retrospective review of 8110 consecutiv...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2010.12.005

    authors: Preston MA,Carrière M,Raju G,Morash C,Doucette S,Gerridzen RG,Bella AJ,Eastham JA,Scardino PT,Cagiannos I

    更新日期:2011-04-01 00:00:00

  • Inhibitors of stone formation in hypercalciuric children with and without stone disease.

    abstract::The extretion of two inhibitors of urinary stone formation (citrate, magnesium) was evaluated in 71 hypercalciuric children and 50 controls. Patients were classified into two groups: 42 nonstone former (NSF), 22 boys and 20 girls, 3-14 years old, and 29 stone formers (SF), 18 boys and 11 girls, 2.5-18 years old. Our s...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000474843

    authors: al-Qadreh A,Athanasopoulou H,Voskaki I

    更新日期:1992-01-01 00:00:00

  • Prognostic significance of incidental renal cell carcinoma.

    abstract::From 1980 to 1991, 236 patients with renal cell carcinoma were treated in our department. We studied the characteristics and the prognostic significance of 74 patients with incidental renal cancer in comparison with those with symptomatic tumors. The mean age of the patients was 59.8 years and the sex ratio 2 males/1 ...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000475189

    authors: Bretheau D,Lechevallier E,Eghazarian C,Grisoni V,Coulange C

    更新日期:1995-01-01 00:00:00

  • Relation of in vitro drug activity to clinical response in a prospective trial for advanced germ cell testicular tumors.

    abstract::An in vitro assay, which evaluates the effect of drugs on labelled DNA precursor incorporation into fresh specimens after 3 h of in vitro treatment, was used for a prospective study. Drugs were used as monochemotherapy or in different combinations according to their in vitro activities for salvage or palliation treatm...

    journal_title:European urology

    pub_type: 临床试验,杂志文章

    doi:10.1159/000471638

    authors: Sanfilippo O,Silvestrini R,Salvioni R,Pizzocaro G

    更新日期:1989-01-01 00:00:00

  • Bipolar Androgen Therapy: A Paradoxical Approach for the Treatment of Castration-resistant Prostate Cancer.

    abstract::Bipolar androgen therapy (BAT) is a paradoxical treatment for castrate-resistant prostate cancer whereby testosterone levels are rapidly alternated between supraphysiologic and near-castrate concentrations. Initial studies demonstrated that BAT is safe and produces clinical responses. A trial comparing enzalutamide ag...

    journal_title:European urology

    pub_type: 社论

    doi:10.1016/j.eururo.2017.03.022

    authors: Schweizer MT,Antonarakis ES,Denmeade SR

    更新日期:2017-09-01 00:00:00

  • Effectiveness and morbidity of secondary retroperitoneal lymph node dissection after chemotherapy in testicular tumors.

    abstract::Addition of surgery to cytoreductive chemotherapy has increased the number of patients with complete remission after advanced testicular cancer. In this report, we present the morbidity of complete retroperitoneal lymph node dissection following aggressive chemotherapy in 10 of these patients. Although no mortality an...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000474102

    authors: Solé Balcells F,Villavicencio H,Germá JR,Algaba F

    更新日期:1983-01-01 00:00:00

  • Robotic partial nephrectomy for complex renal tumors: surgical technique.

    abstract:OBJECTIVES:Laparoscopic partial nephrectomy requires advanced training to accomplish tumor resection and renal reconstruction while minimizing warm ischemia times. Complex renal tumors add an additional challenge to a minimally invasive approach to nephron-sparing surgery. We describe our technique, illustrated with vi...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2007.09.047

    authors: Rogers CG,Singh A,Blatt AM,Linehan WM,Pinto PA

    更新日期:2008-03-01 00:00:00