Abstract:
:Cytogenetic and flow cytometric DNA analyses were performed on 37 tumor samples from 16 patients with renal cell carcinoma. 36 cultures were chromosomally abnormal and 1 was normal. The most frequent abnormality was trisomy or tetrasomy of chromosome 7 (13 of 16 tumors), suggesting that this abnormality might be a primary change in renal cell carcinoma. Abnormalities of chromosome 3 were seen in 9 of 16 tumors (56%). Eight of 11 tumors (73%) with cytogenetic results from multiple tumor samples showed intratumor cytogenetic heterogeneity. Twelve of the 16 patients had aneuploid tumors, and 4 had homogeneously diploid tumors. DNA index correlated with chromosome number. No association was found between cytogenetic results and clinical stage.
journal_name
Eur Uroljournal_title
European urologyauthors
Ljungberg B,Nordenson I,Roos Gdoi
10.1159/000473581subject
Has Abstractpub_date
1991-01-01 00:00:00pages
59-64issue
1eissn
0302-2838issn
1873-7560journal_volume
19pub_type
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