Abstract:
:The nomogram reported by Gandaglia et al (The key combined value of multiparametric magnetic resonance imaging, and magnetic resonance imaging-targeted and concomitant systematic biopsies for the prediction of adverse pathological features in prostate cancer patients undergoing radical prostatectomy. Eur Urol 2020;77:733-41) predicting extracapsular extension (ECE) or seminal vesicle invasion (SVI) has been developed using multiparametric magnetic resonance imaging (MRI) parameters and MRI-targeted biopsy. We aimed to validate this nomogram externally by analyzing 566 patients harboring prostate cancer diagnosed on MRI-targeted biopsy followed by radical prostatectomy. At final pathology, 37% and 12% patients had ECE and SVI, respectively. Performance of the nomogram, in comparison with the Memorial Sloan Kettering Cancer Center (MSKCC) model and Partin tables, was evaluated using discrimination, calibration, and decision curve analysis. Regarding ECE prediction, the nomogram showed higher discrimination (71.8% vs 69.8%, p = 0.3 and 71.8% vs 61.3%, p < 0.001), and similar miscalibration and net benefit for probability threshold above 30% when compared with MSKCC model and Partin tables, respectively. Performance of the nomogram with regard to SVI was comparable in terms of discrimination (68.5% vs 70.4% vs 67.8%, p ≥ 0.6), presenting a slight overestimation on calibration plots and a net benefit for probability threshold above 7.5%. This is the first multicentric study that externally validates a nomogram predicting ECE and SVI in patients diagnosed with MRI-targeted biopsy. Its performance was less optimistic than expected, and implementation of MRI in this setting was not associated with a clear improvement in patient selection and clinical usefulness when compared with available models. We proposed an updated version of the nomogram predicting ECE using the recalibration method, which leads to an improvement in its performance and needs to be validated in another external set. PATIENT SUMMARY: We validate a prediction tool based on multiparametric magnetic resonance imaging (MRI) parameters and MRI-targeted biopsy predicting extracapsular extension and seminal vesicle invasion at radical prostatectomy. An improvement of patient selection was not clearly demonstrated when compared with available models based on clinical parameters, and implementation of MRI in this setting still needs to be clarified.
journal_name
Eur Uroljournal_title
European urologyauthors
Diamand R,Ploussard G,Roumiguié M,Oderda M,Benamran D,Fiard G,Quackels T,Assenmacher G,Simone G,Van Damme J,Malavaud B,Iselin C,Descotes JL,Roche JB,Peltier A,Roumeguère T,Albisinni Sdoi
10.1016/j.eururo.2020.09.037subject
Has Abstractpub_date
2021-02-01 00:00:00pages
180-185issue
2eissn
0302-2838issn
1873-7560pii
S0302-2838(20)30764-8journal_volume
79pub_type
杂志文章相关文献
EUROPEAN UROLOGY文献大全abstract::Ninety-one patients with unstable detrusor and urge incontinence were treated with maximal electrical stimulation. There were 17 dropouts. From the remaining 74 patients 51 were subjectively cured or significantly improved, this effect lasted for more than 6 weeks in 40. Objectively a significant decrease in frequency...
journal_title:European urology
pub_type: 杂志文章
doi:10.1159/000463887
更新日期:1990-01-01 00:00:00
abstract::Behavior of transitional cell carcinoma of the bladder during the third decade of life remains a controversial subject. During the period 1980-1988, we treated 7 patients (4 male and 3 female), 25 years of age or less (mean age 19.3, range 14-25), with transitional cell carcinoma of the bladder. Until now, all patient...
journal_title:European urology
pub_type: 杂志文章
doi:10.1159/000471682
更新日期:1991-01-01 00:00:00
abstract:OBJECTIVES:A strip test for the semi-quantitative determination of prostate specific antigen (PSA) based on whole blood was evaluated by the Working Group on Laboratory Diagnostics of the German Urological Association. METHODS:In 301 men (156 volunteers and 145 referred patients, mean ages 57 years and 64 years) handl...
journal_title:European urology
pub_type: 杂志文章
doi:10.1016/s0302-2838(03)00095-2
更新日期:2003-05-01 00:00:00
abstract:CONTEXT:The use of neoadjuvant and adjuvant chemotherapy in the treatment of muscle-invasive bladder cancer is still controversial. OBJECTIVE:To determine the optimal use of chemotherapy in the neoadjuvant and adjuvant settings in patients with advanced urothelial cell carcinoma. Bladder preservation is also discussed...
journal_title:European urology
pub_type: 杂志文章,评审
doi:10.1016/j.eururo.2008.10.016
更新日期:2009-02-01 00:00:00
abstract::Consultant Outcomes Publication aims to drive up standards of care by greater transparency and peer comparison of surgical practice and outcomes. This is despite difficulties of data entry and bias, and potential for risk avoidance and diminished training. ...
journal_title:European urology
pub_type: 社论
doi:10.1016/j.eururo.2018.02.015
更新日期:2018-07-01 00:00:00
abstract:BACKGROUND:It has been suggested that changes in prostate-specific antigen (PSA) over time (ie, PSA velocity [PSAV]) aid prostate cancer detection. Some guidelines do incorporate PSAV cut points as an indication for biopsy. OBJECTIVE:To evaluate whether PSAV enhances prediction of biopsy outcome in a large, representa...
journal_title:European urology
pub_type: 杂志文章
doi:10.1016/j.eururo.2009.07.047
更新日期:2009-11-01 00:00:00
abstract:BACKGROUND:Limited data exist on long-term outcomes among men with prostate cancer (PCa) from population-based cohorts incorporating information on clinical risk category. OBJECTIVE:To assess 15-yr mortality for men with PCa treated with noncurative intent according to clinical stage, Gleason score (GS), serum levels ...
journal_title:European urology
pub_type: 杂志文章
doi:10.1016/j.eururo.2012.08.001
更新日期:2013-01-01 00:00:00
abstract:CONTEXT AND OBJECTIVES:Interest in laparoscopic assisted radical cystectomy (LRC) and robotic assisted radical cystectomy (RRC) is increasing at select centers worldwide. In this update we present the recent worldwide experience and critically evaluate the role of minimally invasive radical surgery for patients with bl...
journal_title:European urology
pub_type: 杂志文章,评审
doi:10.1016/j.eururo.2008.03.076
更新日期:2008-07-01 00:00:00
abstract::A 32-year-old male who presented with idiopathic retroperitoneal fibrosis developed peritesticular fibrosis 4 years later. The lesion appeared as a diffuse, uniform thickening without a tendency to form nodules. Histologic examination revealed a densely collagenized tissue with scattered cells, consisting mainly of fi...
journal_title:European urology
pub_type: 杂志文章
doi:10.1159/000472580
更新日期:1986-01-01 00:00:00
abstract:OBJECTIVE:Open surgery is increasingly replaced by endoscopic techniques. In urology, endoscopic procedures of the upper urinary tract are still evolving. The surgical techniques imply high accuracy and are difficult to teach since they are "one man" procedures. Training on bench models has essentially given promising ...
journal_title:European urology
pub_type: 杂志文章
doi:10.1016/s0302-2838(02)00265-8
更新日期:2002-08-01 00:00:00
abstract::The management of benign prostatic hyperplasia (BPH), although based on the best available evidence, should be individualised to patients' circumstances and personal choices. Subjective symptoms (LUTS), bothersomeness and negative impact on the quality of life are the main reasons for the patient to seek treatment for...
journal_title:European urology
pub_type: 杂志文章
doi:10.1159/000052348
更新日期:1999-01-01 00:00:00
abstract::In some renal calculi whose structure was studied in thin sections, we have found large numbers of rods of the size and shape of bacteria, included in a material consisting of defective apatite calcium phosphates and organic matter. Electron transmission microscopy showed patterns of partially calcified bacteria. With...
journal_title:European urology
pub_type: 杂志文章
doi:10.1159/000472067
更新日期:1977-01-01 00:00:00
abstract::A double-blind trial was conducted in 138 patients with superficial transitional cell carcinoma of the bladder following transurethral resection to evaluate the prophylaxis of recurrence by an oral Lactobacillus casei preparation (BLP). Patients were stratified into the following 3 subgroups: (A) with primary multiple...
journal_title:European urology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1159/000475138
更新日期:1995-01-01 00:00:00
abstract:OBJECTIVES:We present a multicenter, population-based epidemiological survey aimed at assessing the prevalence of Peyronie's disease (PD) and its potential risk factors in the general population. METHODS:In each of the ten centers throughout Italy, a uroandrologist contacted all the men in the age range 50-69 years re...
journal_title:European urology
pub_type: 杂志文章,多中心研究
doi:10.1159/000049830
更新日期:2001-11-01 00:00:00
abstract::In previous reports, neuron-specific enolase (NSE) has been considered to be a useful tumor marker in renal cell carcinoma (RCC). This led us to perform a prospective clinical trial in this field. NSE was checked as a tumor marker for diagnosis and monitoring of patients with RCC. We report on 55 patients and their NS...
journal_title:European urology
pub_type: 杂志文章
doi:10.1159/000474336
更新日期:1993-01-01 00:00:00
abstract:PURPOSE:To determine whether preservation of accessory pudendal arteries (APAs) adversely influences the rate of positive surgical margins (PSMs) during laparoscopic radical prostatectomy (LRP). MATERIAL AND METHODS:Between January 2003 and January 2005, 377 men with clinically localized prostate cancer underwent a LR...
journal_title:European urology
pub_type: 杂志文章
doi:10.1016/j.eururo.2005.08.006
更新日期:2005-11-01 00:00:00
abstract:BACKGROUND:Chronic kidney disease (CKD) can be associated with a higher risk of progression to end-stage renal disease and mortality, but the etiology of nephron loss may modify this. Previous studies suggested that CKD primarily due to surgical removal of nephrons (CKD-S) may be more stable and associated with better ...
journal_title:European urology
pub_type: 杂志文章
doi:10.1016/j.eururo.2015.04.043
更新日期:2015-12-01 00:00:00
abstract:OBJECTIVE:The role of estrogens and androgens in the etiology and progression of testicular germ cell cancer is poorly understood. To gain insight into the role of sex steroid action in testicular tumorigenesis, we have measured mRNAs encoding estrogen receptor beta (ERbeta), androgen receptor (AR), and their coregulat...
journal_title:European urology
pub_type: 杂志文章
doi:10.1016/s0302-2838(03)00382-8
更新日期:2003-12-01 00:00:00
abstract:OBJECTIVE:To evaluate the clinical impact of different definitions of hereditary prostate cancer (PCa), the relative risk (RR) of relatives of PCa cases and differences in clinical-pathological features and outcome as function of a family history in a surgical series exposed to Mediterranean diet. METHODS:We classifie...
journal_title:European urology
pub_type: 杂志文章
doi:10.1016/j.eururo.2005.01.016
更新日期:2005-06-01 00:00:00
abstract:BACKGROUND:Patients with metastatic urothelial carcinoma (mUC) who progress after platinum-based chemotherapy have had few treatment options and uniformly poor outcomes. Atezolizumab (anti-programmed death-ligand 1) was approved in the USA for cisplatin-ineligible and platinum-treated mUC based on IMvigor210, a phase 2...
journal_title:European urology
pub_type: 杂志文章
doi:10.1016/j.eururo.2017.11.023
更新日期:2018-03-01 00:00:00
abstract::Sentinel lymph node (SLN) detection techniques have the potential to change the standard of surgical care for patients with prostate cancer. We performed a lymphatic mapping study and determined the value of fluorescence SLN detection with indocyanine green (ICG) for the detection of lymph node metastases in intermedi...
journal_title:European urology
pub_type: 杂志文章
doi:10.1016/j.eururo.2016.01.034
更新日期:2016-11-01 00:00:00
abstract:OBJECTIVES:To summarize monoinstitutional experience with gastrointestinal (GI) presentations of germ cell malignancy and to review recent medical literature on this issue. METHODS:Retrospective review of 5 cases with advanced germ cell malignancy (testicular 2 and retroperitoneal 3) and involvement of the upper GI tr...
journal_title:European urology
pub_type: 杂志文章,评审
doi:10.1159/000020368
更新日期:2000-12-01 00:00:00
abstract::The autoimmune features of interstitial cystitis are reviewed. Despite some controversy, interstitial cystitis should be grouped to the connective tissue diseases but as a separate entity. ...
journal_title:European urology
pub_type: 杂志文章,评审
doi:10.1159/000473278
更新日期:1980-01-01 00:00:00
abstract::Mucosal biopsies were obtained for histological and electron microscopical studies from 20 patients with ileal urinary conduits. Special interest was focused on problems of urinary tract infections and their possible role in the pathogenesis of these changes. Chronic inflammation with mild to total villous atrophy was...
journal_title:European urology
pub_type: 杂志文章
doi:10.1159/000472616
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND:Intradetrusor onabotulinumtoxinA (BoNT-ONA) injections have become a well-established therapy for refractory neurogenic detrusor overactivity (NDO). However, little is known about long-term outcome and patients' adherence to this treatment. OBJECTIVE:To assess long-term outcomes of intradetrusor BoNT-ONA in...
journal_title:European urology
pub_type: 杂志文章
doi:10.1016/j.eururo.2016.03.052
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND:Several studies have shown that robot-assisted laparoscopic radical prostatectomy (RALP) is feasible, with favorable complication rates and short hospital times. However, the early recovery of urinary continence remains a challenge to be overcome. OBJECTIVE:We describe our technique of periurethral retropub...
journal_title:European urology
pub_type: 杂志文章
doi:10.1016/j.eururo.2009.06.007
更新日期:2009-09-01 00:00:00
abstract:PURPOSE:Perioperative morbidity is an essential indicator for the quality of an operative technique. This fact is especially important in radical prostatectomy since different treatment modalities may provide similar outcome in terms of local tumor control. MATERIALS AND METHODS:The conventional type of radical perine...
journal_title:European urology
pub_type: 杂志文章
doi:10.1159/000049764
更新日期:2001-08-01 00:00:00
abstract:OBJECTIVES:We review important aspects of nanotechnology, and discuss the wide range of research and clinical applications of nanomedicine in the field of urology. There is particular emphasis on key clinical and pre-clinical studies to provide an update on recent and potential applications in the care of urological pa...
journal_title:European urology
pub_type: 杂志文章,评审
doi:10.1016/j.eururo.2007.04.065
更新日期:2007-08-01 00:00:00
abstract::Aminoglutethimide (AG) and hydrocortisone (HC) were given to 20 patients with advanced prostatic cancer resistant to conventional hormonal therapy. Most patients had painful bone metastases and were heavily pretreated. 12 of 16 patients required narcotic analgetics. 8 of 20 were bedridden. AG + HC produced relief of b...
journal_title:European urology
pub_type: 杂志文章
doi:10.1159/000472913
更新日期:1988-01-01 00:00:00
abstract:BACKGROUND:Active surveillance (AS) has been proposed as an effective strategy to reduce overtreatment among men with lower risk prostate cancers. However, historical rates of initial surveillance are low (4-20%), and little is known about its application among community-based urology practices. OBJECTIVE:To describe ...
journal_title:European urology
pub_type: 杂志文章
doi:10.1016/j.eururo.2014.08.024
更新日期:2015-01-01 00:00:00