Abstract:
BACKGROUND:Retinol binding protein 4 (RBP4), as an adipocyte secreted cytokine, was recently found to be inversely correlated with expression of glucose transporter 4 (GLUT4) in insulin resistance (IR) state and to have an intimate relationship with IR and type 2 diabetes mellitus (T2DM). The present study aimed to evaluate the anti-diabetic efficacy of cinnamaldehyde (Cin), berberine (Ber), and metformin (Met) as well as their impacts on the RBP4-GLUT4 system. METHODS:Rat models of T2DM were established by combination of intraperitoneal injection of low-dose streptozotocin and high fat diet induction. Rats were divided into five groups: the control group, the diabetes group, the diabetes + Ber group, the diabetes + Cin group, and the diabetes + Met group. Western blotting was used to detect the serum or tissue RBP4 and GLUT4 protein levels. RESULTS:After treatment for four weeks, both Cin and Ber displayed significant hypolipidemic, hypoglycemic, and insulin sensitizing functions (P < 0.01) compared with the control group. Their effects on lowering fasting plasma glucose (FPG), low density lipoprotein-cholesterol (LDL-C) and homeostasis model assessment of insulin resistance (HOMA-IR) seem even better than that of Met. Cin and Ber markedly lowered serum RBP4 levels and up-regulated the expression of tissue GLUT4 protein, and Cin seemed more notable in affecting these two proteins. CONCLUSIONS:Both Cin and Ber display an exciting anti-diabetic efficacy in this study and may be of great value for the treatment of type 2 diabetes. Their mechanisms involve the RBP4-GLUT4 system, during which the serum RBP4 levels are lowered and the expression of tissue GLUT4 protein is up-regulated.
journal_name
Chin Med J (Engl)journal_title
Chinese medical journalauthors
Zhang W,Xu YC,Guo FJ,Meng Y,Li MLsubject
Has Abstractpub_date
2008-11-05 00:00:00pages
2124-8issue
21eissn
0366-6999issn
2542-5641journal_volume
121pub_type
杂志文章abstract::The imaging quality of the portal vein was obviously improved with prostaglandin E1 (PGE1) indirect portal vein digital subtraction angiography (DSA) in 23 cases. The time-density curve showed that the occurrence rate of opposite hepatic blood flow of splenic vein (SV) was the highest (17.4%). The total visualization ...
journal_title:Chinese medical journal
pub_type: 杂志文章
doi:
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abstract:OBJECTIVE:To identify novel tumor suppressor genes at chromosome 3p24-26 in human nasopharyngeal carcinoma (NPC). METHODS:Twenty epithelial-derived expressed sequence tags (EST) were selected from chromosome 3p24-26. RT-PCR and Northern blot were used to detect the expression of the ESTs in NPC cell line, HNE-1, and p...
journal_title:Chinese medical journal
pub_type: 杂志文章
doi:
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journal_title:Chinese medical journal
pub_type: 杂志文章,评审
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pub_type: 杂志文章
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journal_title:Chinese medical journal
pub_type: 杂志文章
doi:
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journal_title:Chinese medical journal
pub_type: 杂志文章
doi:
更新日期:2002-04-01 00:00:00
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pub_type: 杂志文章
doi:
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journal_title:Chinese medical journal
pub_type: 杂志文章
doi:
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pub_type: 杂志文章
doi:
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pub_type: 杂志文章
doi:
更新日期:2011-08-01 00:00:00
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journal_title:Chinese medical journal
pub_type: 杂志文章
doi:
更新日期:1999-01-01 00:00:00
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pub_type: 杂志文章
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doi:
更新日期:2009-08-05 00:00:00
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pub_type: 杂志文章
doi:
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pub_type: 杂志文章
doi:
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pub_type: 杂志文章
doi:
更新日期:2013-03-01 00:00:00
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pub_type: 杂志文章
doi:
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pub_type: 杂志文章
doi:
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pub_type: 杂志文章,meta分析
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doi:
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pub_type: 杂志文章
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abstract:: ...
journal_title:Chinese medical journal
pub_type: 社论
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