当前位置： SCI文献检索 > PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA期刊下所有文献 > Regulation of cytotoxic T lymphocyte triggering by PIR-B on dendritic cells.

Regulation of cytotoxic T lymphocyte triggering by PIR-B on dendritic cells.

Abstract：

:Priming of cytotoxic T lymphocytes (CTLs) by dendritic cells (DCs) is crucial for elimination of pathogens and malignant cells. To activate CTLs, DCs present antigenic peptide-complexed MHC class I molecules (MHC-I) that will be recognized by the CTLs with T cell receptors and CD8 molecules. Here we show that paired Ig-like receptor (PIR)-B, an MHC-I receptor expressed on antigen-presenting cells, can regulate CTL triggering by blocking the access of CD8 molecules to MHC-I. PIR-B-deficient DCs evoked CTLs more efficiently, leading to accelerated graft and tumor rejection. PIR-B(+) non-DC transfectant cells served as less efficient stimulators and targets for CTLs than PIR-B(-) cells at the effector phase in vitro. On surface plasmon resonance analysis, PIR-B and CD8alpha alpha were revealed to compete in binding to MHC-I. Our results may provide a novel strategy for regulating CTL-mediated immunity and diseases in a sterical manner.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Endo S,Sakamoto Y,Kobayashi E,Nakamura A,Takai T

doi

10.1073/pnas.0804571105

subject

Has Abstract

pub_date

2008-09-23 00:00:00

pages

14515-20

issue

38

eissn

0027-8424

issn

1091-6490

pii

0804571105

journal_volume

105

pub_type

杂志文章

相关文献

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA文献大全
  • Germ-line chimerism and paternal care in marmosets (Callithrix kuhlii).

    abstract：:The formation of viable genetic chimeras in mammals through the transfer of cells between siblings in utero is rare. Using microsatellite DNA markers, we show here that chimerism in marmoset (Callithrix kuhlii) twins is not limited to blood-derived hematopoietic tissues as was previously described. All somatic tissue ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0607426104

    authors： Ross CN,French JA,Ortí G

    更新日期：2007-04-10 00:00:00

  • Chromosomal mapping of the mink cell focus-inducing and xenotropic env gene family in the mouse.

    abstract：:Chromosomal locations of members of the xenotropic-related env gene family in the mouse genome have been determined. Endonuclease restriction site polymorphisms detected by molecular hybridization were used to study the inheritance of mink cell-focus inducing and xenotropic env gene-related sequences in recombinant in...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.80.20.6298

    authors： Blatt C,Mileham K,Haas M,Nesbitt MN,Harper ME,Simon MI

    更新日期：1983-10-01 00:00:00

  • Complex genetic interactions underlying expression differences between Drosophila races: analysis of chromosome substitutions.

    abstract：:Regulation of gene expression is usually separated into cis and trans components. The separation may become artificial if much of the variation in expression is under multigenic and epistatic (e.g., cis-by-trans) control. There is hence a need to quantify the relative contribution of cis, trans, and cis-by-trans effec...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0711774105

    authors： Wang HY,Fu Y,McPeek MS,Lu X,Nuzhdin S,Xu A,Lu J,Wu ML,Wu CI

    更新日期：2008-04-29 00:00:00

  • NOD2 contributes to cutaneous defense against Staphylococcus aureus through alpha-toxin-dependent innate immune activation.

    abstract：:Staphylococcus aureus is a major cause of community-acquired and nosocomial infections including the life-threatening conditions endocarditis, necrotizing pneumonia, necrotizing fasciitis, and septicemia. Toll-like receptor (TLR)-2, a membrane-bound microbial sensor, detects staphylococcal components, but macrophages ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0904958106

    authors： Hruz P,Zinkernagel AS,Jenikova G,Botwin GJ,Hugot JP,Karin M,Nizet V,Eckmann L

    更新日期：2009-08-04 00:00:00

  • Detection of a major gene for resistance to fusiform rust disease in loblolly pine by genomic mapping.

    abstract：:Genomic mapping has been used to identify a region of the host genome that determines resistance to fusiform rust disease in loblolly pine where no discrete, simply inherited resistance factors had been previously found by conventional genetic analysis over four decades. A resistance locus, behaving as a single domina...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.93.9.3859

    authors： Wilcox PL,Amerson HV,Kuhlman EG,Liu BH,O'Malley DM,Sederoff RR

    更新日期：1996-04-30 00:00:00

  • Transgenes are dispensable for the RNA degradation step of cosuppression.

    abstract：:Cosuppression results in the degradation of RNA from host genes and homologous transgenes after transcription in the nucleus. By using grafting experiments, we have shown previously that a systemic signal mediates the propagation of cosuppression of Nia host genes and 35S-Nia2 transgenes from silenced 35S-Nia2 transge...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.95.16.9675

    authors： Palauqui JC,Vaucheret H

    更新日期：1998-08-04 00:00:00

  • Colloquium paper: working toward a synthesis of archaeological, linguistic, and genetic data for inferring African population history.

    abstract：:Although Africa is the origin of modern humans, the pattern and distribution of genetic variation and correlations with cultural and linguistic diversity in Africa have been understudied. Recent advances in genomic technology, however, have led to genomewide studies of African samples. In this article, we discuss gene...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1002563107

    authors： Scheinfeldt LB,Soi S,Tishkoff SA

    更新日期：2010-05-11 00:00:00

  • Nucleotide sequencing of DNA: preliminary characterization of the products of specific cleavages at guanine, cytosine, or adenine residues (bacteriophage M13-ribosubstitution-DNA polymerase I-electrophoresis-two-dimensional fingerprinting).

    abstract：:DNA synthesized in vitro from a phage M13 template has been cleaved at either guanine, adenine, or cytosine residues by ribosubstitution techniques. Fingerprints of the fragments obtained suggest that DNA sequencing will be possible with this technique. ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.69.1.238

    authors： Salser W,Fry K,Brunk C,Poon R

    更新日期：1972-01-01 00:00:00

  • Kv4.2 autism and epilepsy mutation enhances inactivation of closed channels but impairs access to inactivated state after opening.

    abstract：:A de novo mutation in the KCND2 gene, which encodes the Kv4.2 K+ channel, was identified in twin boys with intractable, infant-onset epilepsy and autism. Kv4.2 channels undergo closed-state inactivation (CSI), a mechanism by which channels inactivate without opening during subthreshold depolarizations. CSI dynamically...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1717082115

    authors： Lin MA,Cannon SC,Papazian DM

    更新日期：2018-04-10 00:00:00

  • Homoserine and asparagine are host signals that trigger in planta expression of a pathogenesis gene in Nectria haematococca.

    abstract：:Some pathogenesis-related genes are expressed in fungi only when the pathogen is in the host, but the host signals that trigger these gene expressions have not been identified. Virulent Nectria haematococca infects pea plants and requires either pelA, which is induced by pectin, or pelD, which is induced only in plant...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0500312102

    authors： Yang Z,Rogers LM,Song Y,Guo W,Kolattukudy PE

    更新日期：2005-03-15 00:00:00

  • Crystal structure of a translation termination complex formed with release factor RF2.

    abstract：:We report the crystal structure of a translation termination complex formed by the Thermus thermophilus 70S ribosome bound with release factor RF2, in response to a UAA stop codon, solved at 3 A resolution. The backbone of helix alpha5 and the side chain of serine of the conserved SPF motif of RF2 recognize U1 and A2 ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0810953105

    authors： Korostelev A,Asahara H,Lancaster L,Laurberg M,Hirschi A,Zhu J,Trakhanov S,Scott WG,Noller HF

    更新日期：2008-12-16 00:00:00

  • Lewis base catalysis of bromo- and iodolactonization, and cycloetherification.

    abstract：:Lewis base catalyzed bromo- and iodolactonization reactions have been developed and the effects of catalyst structure on rate and cyclization selectivity have been systematically explored. The effects of substrate structure on halolactonization reactions and the interaction of those effects with the effects of catalys...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1005296107

    authors： Denmark SE,Burk MT

    更新日期：2010-11-30 00:00:00

  • Theorems of Barth-Lefschetz type for complex subspaces of homogeneous complex manifolds.

    abstract：:Barth, Larsen, and others showed that complex submanifolds of complex projective space, CP(N), of small codimension strongly resemble CP(N) both homotopically and cohomologically. These results are generalized to yield analogous results for complex subspaces of arbitrary homogeneous complex manifolds. One very special...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.74.4.1332

    authors： Sommese AJ

    更新日期：1977-04-01 00:00:00

  • Genetic requirements for mycobacterial survival during infection.

    abstract：:Despite the importance of tuberculosis as a public health problem, we know relatively little about the molecular mechanisms used by the causative organism, Mycobacterium tuberculosis, to persist in the host. To define these mechanisms, we have mutated virtually every nonessential gene of M. tuberculosis and determined...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.2134250100

    authors： Sassetti CM,Rubin EJ

    更新日期：2003-10-28 00:00:00

  • Activation of murine c-abl protooncogene: effect of a point mutation on oncogenic activation.

    abstract：:Activation of the c-abl protooncogene occurs in Abelson murine leukemia virus, in Hardy-Zuckerman 2 feline sarcoma virus, and during the chromosomal translocations that generate BCR-ABL gene fusion products. To study the molecular mechanism involved in the c-abl activation, we have created a series of modifications in...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.87.17.6502

    authors： Shore SK,Bogart SL,Reddy EP

    更新日期：1990-09-01 00:00:00

  • Dynamical principles in biological processes: a model of charge migration in proteins and DNA.

    abstract：:The generalized master equations (GMEs) that contain multiple time scales have been derived quantum mechanically. The GME method has then been applied to a model of charge migration in proteins that invokes the hole hopping between local amino acid sites driven by the torsional motions of the floppy backbones. This mo...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.140196597

    authors： Schlag EW,Yang DY,Sheu SY,Selzle HL,Lin SH,Rentzepis PM

    更新日期：2000-08-29 00:00:00

  • Affiliation, empathy, and the origins of theory of mind.

    abstract：:To understand the evolution of a Theory of Mind, we need to understand the selective factors that might have jumpstarted its initial evolution. We argue that a subconscious, reflexive appreciation of others' intentions, emotions, and perspectives is at the roots of even the most complex forms of Theory of Mind and tha...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1301223110

    authors： Seyfarth RM,Cheney DL

    更新日期：2013-06-18 00:00:00

  • Induction of heat shock and stress proteins in promastigotes of three Leishmania species.

    abstract：:The induction of heat shock proteins in three species of Leishmania, L. tropica, L. enrietti, and L. donovani is reported. When cultures of promastigotes are shifted from 26 degrees C to 37 degrees C or 40 degrees C, the synthesis of proteins with apparent molecular weights of 88,000, 74,000, and 54,000 is stimulated....

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.82.13.4414

    authors： Lawrence F,Robert-Gero M

    更新日期：1985-07-01 00:00:00

  • Rat cardiac ventricle has two Na+,K+-ATPases with different affinities for ouabain: developmental changes in immunologically different catalytic subunits.

    abstract：:The mechanism of the inotropic effect of cardiac glycosides on the heart has long been controversial. Inotropic effects at low concentrations of cardiac glycosides indicate more than one class of receptor or more than one cellular mechanism. In the brain of the rat, high- and low-affinity cardiac glycoside receptors h...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.84.23.8404

    authors： Sweadner KJ,Farshi SK

    更新日期：1987-12-01 00:00:00

  • Double-stranded RNA induces mRNA degradation in Trypanosoma brucei.

    abstract：:Double-stranded RNA (dsRNA) recently has been shown to give rise to genetic interference in Caenorhabditis elegans and also is likely to be the basis for phenotypic cosuppression in plants in certain instances. While constructing a plasmid vector for transfection of trypanosome cells, we serendipitously discovered tha...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.95.25.14687

    authors： Ngô H,Tschudi C,Gull K,Ullu E

    更新日期：1998-12-08 00:00:00

  • The zinc fingers of the SR-like protein ZRANB2 are single-stranded RNA-binding domains that recognize 5' splice site-like sequences.

    abstract：:The alternative splicing of mRNA is a critical process in higher eukaryotes that generates substantial proteomic diversity. Many of the proteins that are essential to this process contain arginine/serine-rich (RS) domains. ZRANB2 is a widely-expressed and highly-conserved RS-domain protein that can regulate alternativ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0802466106

    authors： Loughlin FE,Mansfield RE,Vaz PM,McGrath AP,Setiyaputra S,Gamsjaeger R,Chen ES,Morris BJ,Guss JM,Mackay JP

    更新日期：2009-04-07 00:00:00

  • Sarcomeres regulate murine cardiomyocyte maturation through MRTF-SRF signaling.

    abstract：:The paucity of knowledge about cardiomyocyte maturation is a major bottleneck in cardiac regenerative medicine. In development, cardiomyocyte maturation is characterized by orchestrated structural, transcriptional, and functional specializations that occur mainly at the perinatal stage. Sarcomeres are the key cytoskel...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.2008861118

    authors： Guo Y,Cao Y,Jardin BD,Sethi I,Ma Q,Moghadaszadeh B,Troiano EC,Mazumdar N,Trembley MA,Small EM,Yuan GC,Beggs AH,Pu WT

    更新日期：2021-01-12 00:00:00

  • ATF6alpha-Rheb-mTOR signaling promotes survival of dormant tumor cells in vivo.

    abstract：:The pathways that allow quiescent disseminated cancer cells to survive during prolonged dormancy periods are unknown. Here, we identify the transcription factor ATF6alpha as a pivotal survival factor for quiescent but not proliferative squamous carcinoma cells. ATF6alpha is essential for the adaptation of dormant cell...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0800939105

    authors： Schewe DM,Aguirre-Ghiso JA

    更新日期：2008-07-29 00:00:00

  • Integrated logic circuits using single-atom transistors.

    abstract：:Scaling down the size of computing circuits is about to reach the limitations imposed by the discrete atomic structure of matter. Reducing the power requirements and thereby dissipation of integrated circuits is also essential. New paradigms are needed to sustain the rate of progress that society has become used to. S...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1109935108

    authors： Mol JA,Verduijn J,Levine RD,Remacle F,Rogge S

    更新日期：2011-08-23 00:00:00

  • The old problems of glass and the glass transition, and the many new twists.

    abstract：:In this paper I review the ways in which the glassy state is obtained both in nature and in materials science and highlight a "new twist"--the recent recognition of polymorphism within the glassy state. The formation of glass by continuous cooling (viscous slowdown) is then examined, the strong/fragile liquids classif...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.92.15.6675

    authors： Angell CA

    更新日期：1995-07-18 00:00:00

  • Population genomic analysis of elongated skulls reveals extensive female-biased immigration in Early Medieval Bavaria.

    abstract：:Modern European genetic structure demonstrates strong correlations with geography, while genetic analysis of prehistoric humans has indicated at least two major waves of immigration from outside the continent during periods of cultural change. However, population-level genome data that could shed light on the demograp...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 历史文章,杂志文章

    doi：10.1073/pnas.1719880115

    authors： Veeramah KR,Rott A,Groß M,van Dorp L,López S,Kirsanow K,Sell C,Blöcher J,Wegmann D,Link V,Hofmanová Z,Peters J,Trautmann B,Gairhos A,Haberstroh J,Päffgen B,Hellenthal G,Haas-Gebhard B,Harbeck M,Burger J

    更新日期：2018-03-27 00:00:00

  • Absence of histones from the chromosomal proteins of fungi.

    abstract：:Interphase chromosomes were isolated in good yield from four species of fungi. In no case does the chromatin contain histones such as are characteristic of the chromosomes of other eukaryotic organisms. ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.68.3.677

    authors： Leighton TJ,Dill BC,Stock JJ,Phillips C

    更新日期：1971-03-01 00:00:00

  • Resistance to human immunodeficiency virus type 1 infection conferred by transduction of human peripheral blood lymphocytes with ribozyme, antisense, or polymeric trans-activation response element constructs.

    abstract：:Human peripheral blood lymphocytes (PBLs) were transduced with a number of recombinant retroviruses including RRz2, an LNL6-based virus with a ribozyme targeted to the human immunodeficiency virus (HIV) tat gene transcript inserted within the 3' region of the neomycin-resistance gene; RASH5, and LNHL-based virus conta...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.92.16.7272

    authors： Sun LQ,Pyati J,Smythe J,Wang L,Macpherson J,Gerlach W,Symonds G

    更新日期：1995-08-01 00:00:00

  • Sequence determination and modeling of structural motifs for the smallest monomeric aminoacyl-tRNA synthetase.

    abstract：:Polypeptide chains of 19 previously studied Escherichia coli aminoacyl-tRNA synthetases are as large as 951 amino acids and, depending on the enzyme, have quaternary structures of alpha, alpha 2, alpha 2 beta 2, and alpha 4. These enzymes have been organized into two classes which are defined by sequence motifs that a...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.88.3.976

    authors： Hou YM,Shiba K,Mottes C,Schimmel P

    更新日期：1991-02-01 00:00:00

  • Suppression of 19S proteasome subunits marks emergence of an altered cell state in diverse cancers.

    abstract：:The use of proteasome inhibitors to target cancer's dependence on altered protein homeostasis has been greatly limited by intrinsic and acquired resistance. Analyzing data from thousands of cancer lines and tumors, we find that those with suppressed expression of one or more 19S proteasome subunits show intrinsic prot...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1619067114

    authors： Tsvetkov P,Sokol E,Jin D,Brune Z,Thiru P,Ghandi M,Garraway LA,Gupta PB,Santagata S,Whitesell L,Lindquist S

    更新日期：2017-01-10 00:00:00