Abstract:
:Previously we uncovered a critical role for norepinephrine and beta(1)-adrenergic signaling in hippocampus-dependent memory retrieval. Because the beta(1) receptor couples to G(s), we examine here whether cAMP is also required for contextual memory retrieval. Using pharmacologic and genetic approaches to manipulate cAMP and downstream signaling, we demonstrate that cAMP and two of its targets, protein kinase A (PKA) and exchange protein activated by cAMP (Epac), are both required for retrieval. These findings demonstrate that cAMP signaling through Epac (as well as PKA) plays an essential role in cognition.
journal_name
Proc Natl Acad Sci U S Aauthors
Ouyang M,Zhang L,Zhu JJ,Schwede F,Thomas SAdoi
10.1073/pnas.0804172105subject
Has Abstractpub_date
2008-08-19 00:00:00pages
11993-7issue
33eissn
0027-8424issn
1091-6490pii
0804172105journal_volume
105pub_type
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