Abstract：
:Cancer pain is highly prevalent and often severe. Fortunately, most cancer pain can be readily managed, with up to 90% of patients responding well to standard interventions. However, breakthrough cancer pain-brief flares of severe pain superimposed on baseline pain-is common, difficult to manage, and often negatively impacts patients' quality of life. Breakthrough cancer pain is traditionally managed with oral, immediate-release opioids. However, because of its sudden onset and severity, oral opioids often fall short of providing adequate control. Research into novel approaches to pain management has identified several innovative strategies for this difficult cancer pain problem. We describe current approaches to assess, define, characterize, and treat breakthrough cancer pain, and summarize recent clinical research on novel agents, novel routes of drug delivery, and other advances in its management.
journal_name
Curr Pain Headache Repjournal_title
Current pain and headache reportsauthors
Hagen NA,Biondo P,Stiles Cdoi
10.1007/s11916-008-0042-1subject
Has Abstractpub_date
2008-08-01 00:00:00pages
241-8issue
4eissn
1531-3433issn
1534-3081journal_volume
12pub_type
杂志文章,评审abstract：PURPOSE OF REVIEW:CGRP is a key neuropeptide in migraine pathophysiology. The blockade of the CGRP pathway at the side of the CGRP receptor of the CGRP peptide leads to the interruption of trigeminal nerve system-mediated headache syndromes such as migraine. Monoclonal antibodies (mAbs) targeting the CGRP pathway have ...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-018-0686-4
更新日期：2018-04-06 00:00:00
abstract：:This paper identifies legal issues of relevance to the diagnosis and treatment of cluster headache, including areas of actual and potential malpractice liability. Legal topics that are relevant to cluster headache can be divided into five categories: diagnostic-related issues, risks inherent in the disease process, pr...
journal_title：Current pain and headache reports
pub_type： 杂志文章
doi：10.1007/s11916-004-0029-5
更新日期：2004-04-01 00:00:00
abstract：PURPOSE OF REVIEW:The purpose of this review is to summarise the current state of knowledge concerning known types of gain, the reasons why patients might seek it, as well as implications for headache disorders. RECENT FINDINGS:Even though the subject has been studied in the past, it received less attention in recent ...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-019-0829-2
更新日期：2019-11-16 00:00:00
abstract：:Neuropathic pain remains a serious medical problem because of patient morbidity and the absence of effective therapeutic interventions. Recent evidence suggests that this type of pain may be particularly difficult to manage because underlying mechanisms are influenced by a variety of factors, including type of injury,...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-009-0034-9
更新日期：2009-06-01 00:00:00
abstract：PURPOSE OF REVIEW:Athletic neurosurgical emergencies are injuries that can lead to mortality or significant morbidity and require immediate recognition and treatment. This review article discusses the epidemiology of sports-related traumatic brain injury (TBI) with an attempt to quantify the incidence of neurosurgical ...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-016-0586-4
更新日期：2016-09-01 00:00:00
abstract：:Dissection refers to a tear in the wall of an artery, with the two main types being intracranial or extracranial. Dissections tend to occur most commonly in the young, sometimes secondary to trauma involving the neck. To confirm a dissection, some type of vessel imaging is necessary, including magnetic resonance angio...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-016-0544-1
更新日期：2016-02-01 00:00:00
abstract：:A family history of migraine is very frequently noted when evaluating a child for recurrent headaches. This implies an inherited or genetic basis as a component to the underlying pathophysiology. A variety of techniques have begun to elucidate this contribution, including historical observation, population-based studi...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-007-0222-4
更新日期：2007-10-01 00:00:00
abstract：:Hormonal and nonhormonal factors play a role in the pathophysiology of menstrual migraine, but estrogen withdrawal appears to be the most potent of these factors. It is postulated that estrogen withdrawal directly enhances excitability of trigeminal afferents, modulates the synthesis of neuropeptides, activates/deacti...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-008-0077-3
更新日期：2008-12-01 00:00:00
abstract：:Most patients who have been diagnosed with cancer will experience pain at some point during the course of their disease. Often, opioid analgesics are not enough to completely alleviate the patient's pain and the selection of appropriate adjunct analgesic agents is critical. This article reviews the mechanisms of actio...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-001-0036-8
更新日期：2001-06-01 00:00:00
abstract：:Numerous treatment strategies for myofascial pain syndrome are available, including physical therapy, behavioral pain management techniques, acupuncture, various types of injections, and the use of various pharmacotherapeutic approaches. The use of topical analgesics for myofascial pain syndrome is the focus of this r...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-002-0079-5
更新日期：2002-10-01 00:00:00
abstract：:Nociceptive nerve endings in muscles and other tissues are equipped with a multitude of receptor molecules for endogenous pain-producing and sensitizing agents. Particularly interesting molecules are the purinergic receptors, which can be activated by adenosine triphosphate (ATP), and the vanilloid receptor, which is ...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-003-0057-6
更新日期：2003-12-01 00:00:00
abstract：:Although the comorbidity of migraine has been extensively studied, the relationships between cluster headache and psychiatric disease have not been well-addressed. In this review the available literature concerning cluster headache and depression, anxiety, bipolar disorder, aggression, suicide, and their implications ...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-012-0313-8
更新日期：2013-02-01 00:00:00
abstract：:While pain is a common symptom among older adults, it often is underdiagnosed and undertreated. Aging-related physiological changes, misperceptions about the use of pain medications by both patients and providers, and the lack of evidence-based clinical research on pain management in older adults are some of the reaso...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-010-0148-0
更新日期：2010-12-01 00:00:00
abstract：PURPOSE OF REVIEW:Total knee arthroplasty traditionally has been associated with significant postoperative pain that can limit recovery and prolong hospital length of stay. Recently, however, due to financial pressures and an emphasis on improving patient satisfaction, many institutions are implementing outpatient and ...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-017-0623-y
更新日期：2017-05-01 00:00:00
abstract：:Infantile colic is a self-limiting disorder of excessive infant crying or fussiness that peaks at 6 weeks of age and typically improves by 3 months of age. The etiology of infantile colic has yet to be definitively elucidated, but there is increasing research to support its relationship to migraine. The aims of this r...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-016-0558-8
更新日期：2016-05-01 00:00:00
abstract：:Migraine and tension-type headache (TTH) are highly prevalent primary headaches that remain underdiagnosed and undertreated in clinical practice. The similarities and differences between migraine and TTH may impose diagnostic challenges as well as management difficulties. In addition, the possibility of migraine chron...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-007-0232-2
更新日期：2007-12-01 00:00:00
abstract：:Chronic pain is one of the most commonly reported symptoms among sarcoidosis patients. Not only does it significantly affect quality of life, but it also is a source of frustration for both the patient and physician because the etiology for pain often is unknown. Although patients typically complain of neuropathic-typ...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-011-0180-8
更新日期：2011-06-01 00:00:00
abstract：:Treatment options for neuropathic pain have limited efficacy and use is fraught with dose-limiting adverse effects. The endocannabinoid system has been elucidated over the last several years, demonstrating a significant interface with pain homeostasis. Exogenous cannabinoids have been demonstrated to be effective in a...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-014-0451-2
更新日期：2014-10-01 00:00:00
abstract：:In the past decades investigators have used personality inventories to help explain the relationship between personality and pain experience. This article reviews empirical research, which has examined temperament and character features in chronic pain patients. Robert Cloninger's temperament and character model of pe...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-012-0318-3
更新日期：2013-03-01 00:00:00
abstract：:Tension type headache (TTH) is a primary headache disorder considered common in children and adolescents. It remains debatable whether TTH and migraine are separate biological entities. This review summarizes the most recent literature of TTH with regards to children and adolescents. Further studies of TTH are needed ...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-010-0149-z
更新日期：2010-12-01 00:00:00
abstract：:Although the majority of children with cancer are cured of their illness, the children who die from their disease or complications require special care at the end of life. We present special issues and challenges unique to pediatric palliative care and suggest ways in which we can face these issues and address the cha...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-005-0032-5
更新日期：2005-08-01 00:00:00
abstract：:Opiate analgesics have been widely used for severe acute pain and chronic cancer-related pain. Individual differences in the effectiveness of opiates and their side effects limit the clinical benefits and increase risks of drug abuse. Genetic factors might affect variations of opiate sensitivity. The mu opioid peptide...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-007-0008-8
更新日期：2007-04-01 00:00:00
abstract：PURPOSE OF REVIEW:Neuropathic pain is often debilitating, severely limiting the daily lives of patients who are affected. Typically, neuropathic pain is difficult to manage and, as a result, leads to progression into a chronic condition that is, in many instances, refractory to medical management. RECENT FINDINGS:Gaba...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-019-0774-0
更新日期：2019-05-01 00:00:00
abstract：PURPOSE OF REVIEW:To provide an update on recent developments in the understanding, diagnosis, and treatment of CSF-venous fistula (CVF). RECENT FINDING:CVF is a recently recognized cause of spontaneous intracranial hypotension (SIH), an important secondary headache, in which an aberrant connection is formed between t...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-020-00921-4
更新日期：2021-01-21 00:00:00
abstract：:Cancer pain is a well-documented and prevalent healthcare problem, with current treatment strategies often failing to achieve acceptable efficacy. One of the major difficulties in treating cancer pain owes to the complex interplay between the cancer microenvironment, cancer therapy, and the body's own responses to the...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-013-0384-1
更新日期：2014-01-01 00:00:00
abstract：:Chronic primary headaches are widespread disorders which cause significant quality of life and socioprofessional impairment. Available pharmacological treatments have often a limited efficacy and/or can generate unbearable side effects. Electrical nerve stimulation is a well-known non-destructive method of pain modula...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-016-0589-1
更新日期：2016-11-01 00:00:00
abstract：:Individually, childhood epilepsy and migraine are two of the most common conditions seen in pediatric neurology. What complicates matters is that there can be marked similarities between migraine and epilepsy as well as a variety of underlying conditions that predispose children to both seizures and headache. Thus, se...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-013-0402-3
更新日期：2014-03-01 00:00:00
abstract：:Fibromyalgia is a frequent cause of chronic widespread pain and affects up to 5% of the general population. Diagnosis and treatment have been especially challenging due to limited knowledge of etiology and poor response to conventional treatment of pain. Appreciation for the interactions of neurobiologic, psychologic,...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-005-0019-2
更新日期：2005-12-01 00:00:00
abstract：:The term "migrant variant" is not used in the headache classification of the International Headache Society (IHS), but it includes those forms of migraine that are not typical of migraine with or without aura. Headaches that do not quite fulfill all of the IHS criteria are termed "migrainous disorder." Migraine associ...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-001-0084-0
更新日期：2001-04-01 00:00:00
abstract：:Tension-type headache is the most common primary headache disorder seen in adults. Although the prevalence peaks in the fourth and fifth decades of life, significant fractions of the elderly continue to experience either episodic or chronic tension-type headaches. Many secondary headache disorders may present with hea...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-006-0076-1
更新日期：2006-12-01 00:00:00
