Is there genetic polymorphism evidence for individual human sensitivity to opiates?

Abstract:

:Opiate analgesics have been widely used for severe acute pain and chronic cancer-related pain. Individual differences in the effectiveness of opiates and their side effects limit the clinical benefits and increase risks of drug abuse. Genetic factors might affect variations of opiate sensitivity. The mu opioid peptide receptor (MOP) is the principal site of pharmacologic actions for most clinically important opiate drugs. Recent studies using various knockout mice and recombinant-inbred strain CXBK mice have indicated that the analgesic effect of morphine is dependent on the amount of the MOP. There are more than 100 polymorphisms identified in the human MOP (OPRM1) gene. These polymorphisms might be correlated with OPRM1 mRNA stability and opiate sensitivity, including opiate analgesia, tolerance, and dependence. More precise studies on the relationship between gene polymorphisms and opiate sensitivity will enable realization of personalized pain treatment by predicting opiate sensitivity and requirement for each patient.

journal_name

Curr Pain Headache Rep

authors

Nagashima M,Katoh R,Sato Y,Tagami M,Kasai S,Ikeda K

doi

10.1007/s11916-007-0008-8

subject

Has Abstract

pub_date

2007-04-01 00:00:00

pages

115-23

issue

2

eissn

1531-3433

issn

1534-3081

journal_volume

11

pub_type

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