Migraine and reward system-or is it aversive?

Abstract:

:Migraine is a debilitating neurological disorder with grave consequences for both the individual and society. This review will focus on recent literature investigating how brain structures implicated in reward and aversion contribute to the genesis of migraine pain. There exist many overlapping and interacting brain regions within pain and reward circuitry that contribute to negative affect and subjective experience of pain. The emotional component of pain has been argued to be a greater metric of quality of life than its sensory component, and thus understanding the processes that influence this pain characteristic is essential to developing novel treatment strategies for mitigating migraine pain. We emphasize and provide evidence that abnormalities within the mesolimbic cortical reward pathways contribute to migraine pain and that there are structural and functional neuroplasticity within the overlapping brain regions common to both pain and reward.

journal_name

Curr Pain Headache Rep

authors

Cahill CM,Cook C,Pickens S

doi

10.1007/s11916-014-0410-y

subject

Has Abstract

pub_date

2014-05-01 00:00:00

pages

410

issue

5

eissn

1531-3433

issn

1534-3081

journal_volume

18

pub_type

杂志文章,评审
  • Peripheral and central sensitization in fibromyalgia: pathogenetic role.

    abstract::Characteristic symptoms of fibromyalgia syndrome include widespread pain, fatigue, sleep abnormalities, and distress. Patients with fibromyalgia show psychophysical evidence of mechanical, thermal, and electrical hyperalgesia. Peripheral and central abnormalities of nociception have been described in fibromyalgia. Imp...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-002-0046-1

    authors: Staud R,Smitherman ML

    更新日期:2002-08-01 00:00:00

  • A review of the use of topical analgesics for myofascial pain.

    abstract::Numerous treatment strategies for myofascial pain syndrome are available, including physical therapy, behavioral pain management techniques, acupuncture, various types of injections, and the use of various pharmacotherapeutic approaches. The use of topical analgesics for myofascial pain syndrome is the focus of this r...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-002-0079-5

    authors: Argoff CE

    更新日期:2002-10-01 00:00:00

  • Systematic Review of Radiofrequency Ablation and Pulsed Radiofrequency for Management of Cervicogenic Headaches.

    abstract:PURPOSE OF REVIEW:Cervicogenic headache (CHA) is a secondary headache which has a source in the upper cervical spine. Many traditional analgesic choices lack good efficacy in managing the associated pain. As a result, in management of CHA, radiofrequency ablation (RFA) or pulse radiofrequency (PRF) has been tried with ...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-018-0673-9

    authors: Grandhi RK,Kaye AD,Abd-Elsayed A

    更新日期:2018-02-23 00:00:00

  • Pain perception during menstrual cycle.

    abstract::Sexual hormones influence complex brain function and pain perception. Many psychophysical studies attempted to establish pain perception changes across menstrual cycle in animal models and healthy women or those with chronic pain. General results are quite uncertain in regard to consistent menstrual-related fluctuatio...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-011-0207-1

    authors: de Tommaso M

    更新日期:2011-10-01 00:00:00

  • Imaging chronic daily headache.

    abstract::New imaging technology allows us to study neurologic disorders that have had no previous structural basis. There have been recent reports on the involvement of nociceptive pathways in daily headache. A systematic review was performed using key words "chronic daily headache" and "imaging." This paper reviews the litera...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-003-0074-5

    authors: Aurora SK

    更新日期:2003-06-01 00:00:00

  • Animal models of chronic migraine.

    abstract::Many animal models of migraine have been described. Some of them have been useful in the development of new therapies. All of them have their shortcomings. Animal models of chronic migraine have been relatively less frequently described. Whether a rigid distinction between episodic and chronic migraine is useful when ...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-014-0467-7

    authors: Storer RJ,Supronsinchai W,Srikiatkhachorn A

    更新日期:2015-01-01 00:00:00

  • Headache in Intracranial and Cervical Artery Dissections.

    abstract::Dissection refers to a tear in the wall of an artery, with the two main types being intracranial or extracranial. Dissections tend to occur most commonly in the young, sometimes secondary to trauma involving the neck. To confirm a dissection, some type of vessel imaging is necessary, including magnetic resonance angio...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-016-0544-1

    authors: Sheikh HU

    更新日期:2016-02-01 00:00:00

  • CGRP Monoclonal Antibodies for the Preventative Treatment of Migraine.

    abstract:PURPOSE OF REVIEW:CGRP is a key neuropeptide in migraine pathophysiology. The blockade of the CGRP pathway at the side of the CGRP receptor of the CGRP peptide leads to the interruption of trigeminal nerve system-mediated headache syndromes such as migraine. Monoclonal antibodies (mAbs) targeting the CGRP pathway have ...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-018-0686-4

    authors: Israel H,Neeb L,Reuter U

    更新日期:2018-04-06 00:00:00

  • Fibromyalgia: progress in diagnosis and treatment.

    abstract::Fibromyalgia is a frequent cause of chronic widespread pain and affects up to 5% of the general population. Diagnosis and treatment have been especially challenging due to limited knowledge of etiology and poor response to conventional treatment of pain. Appreciation for the interactions of neurobiologic, psychologic,...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-005-0019-2

    authors: Dadabhoy D,Clauw DJ

    更新日期:2005-12-01 00:00:00

  • The Pathophysiology of Concussion.

    abstract::Concussion is a significant issue in medicine and the media today. With growing interest on the long-term effects of sports participation, it is important to understand what occurs in the brain after an impact of any degree. While some of the basic pathophysiology has been elucidated, much is still unknown about what ...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-016-0573-9

    authors: Choe MC

    更新日期:2016-06-01 00:00:00

  • Preventive treatment of migraine: effect on weight.

    abstract::Weight gain is a common side effect of drugs used for headache prevention. Weight gain can adversely affect patient health, exacerbate comorbid metabolic disorders, and encourage noncompliance. Additionally, obesity may promote the chronification of episodic migraine. Few studies have looked specifically at the effect...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-008-0035-0

    authors: Young WB

    更新日期:2008-06-01 00:00:00

  • The hypothalamus: specific or nonspecific role in the pathophysiology of trigeminal autonomic cephalalgias?

    abstract::The clinical features of trigeminal autonomic cephalalgias (TACs), such as trigeminal distribution of pain, circadian/circannual rhythmicity, and ipsilateral cranial autonomic features, suggest a crucial role of the hypothalamus in the underlying pathophysiology of these primary headache disorders. Hypothalamic involv...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-010-0166-y

    authors: Holle D,Katsarava Z,Obermann M

    更新日期:2011-04-01 00:00:00

  • Sedation for comfort at end of life.

    abstract::Treatment for patients who are dying from cancer and are suffering with physiologic and existential symptoms is an important and valuable skill for health care providers. However, the treatment for suffering at the end of life and the use of sedation for comfort often are misunderstood. The following is a discussion o...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-002-0035-4

    authors: Walton O,Weinstein SM

    更新日期:2002-06-01 00:00:00

  • An update on botulinum toxin A injections of trigger points for myofascial pain.

    abstract::Myofascial pain syndrome (MPS) is a common chronic pain condition that is characterized by distinct "trigger points." Despite current treatments with physical therapy, analgesics, anti-depressants and trigger-point injections, myofascial pain remains a challenging chronic pain condition in clinical practice. Botulinum...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-013-0386-z

    authors: Zhou JY,Wang D

    更新日期:2014-01-01 00:00:00

  • CSF-Venous Fistula.

    abstract:PURPOSE OF REVIEW:To provide an update on recent developments in the understanding, diagnosis, and treatment of CSF-venous fistula (CVF). RECENT FINDING:CVF is a recently recognized cause of spontaneous intracranial hypotension (SIH), an important secondary headache, in which an aberrant connection is formed between t...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-020-00921-4

    authors: Roytman M,Salama G,Robbins MS,Chazen JL

    更新日期:2021-01-21 00:00:00

  • Quantitative sensory testing of neuropathic pain patients: potential mechanistic and therapeutic implications.

    abstract::Quantitative sensory testing (QST) is a widely accepted tool to investigate somatosensory changes in pain patients. Many different protocols have been developed in clinical pain research within recent years. In this review, we provide an overview of QST and tested neuroanatomical pathways, including peripheral and cen...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-012-0261-3

    authors: Pfau DB,Geber C,Birklein F,Treede RD

    更新日期:2012-06-01 00:00:00

  • Subarachnoid Hemorrhage and Headache.

    abstract:PURPOSE FOR REVIEW:Subarachnoid hemorrhage is a serious and life-threatening medical condition which commonly presents with an acute headache. Unfortunately, it remains frequently misdiagnosed at initial presentation with dire consequences in terms of patient morbidity and mortality. The goal of this paper is to review...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-019-0785-x

    authors: Ogunlaja OI,Cowan R

    更新日期:2019-05-23 00:00:00

  • How to investigate and treat: headache and hyperprolactinemia.

    abstract::Hyperprolactinemia is a condition characterised by an increase of prolactin blood levels (more than 100-200 ng/ml). It is the most common endocrine disorder of the hypothalamic-pituitary axis. The clinical characteristics of the headache-hyperprolactinemia-hypophyseal-adenoma association are discussed, the various dia...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-012-0267-x

    authors: Bussone G,Usai S,Moschiano F

    更新日期:2012-08-01 00:00:00

  • Is migraine a neuropathic pain syndrome?

    abstract::The understanding of migraine pathophysiology has evolved from the belief that migraine is a vascular disorder, to evidence that better defines migraine as a neurogenic disorder associated with secondary changes in brain perfusion. There is evidence to suggest that the early phase of migraine pain results from neuroge...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-006-0042-y

    authors: Biondi DM

    更新日期:2006-06-01 00:00:00

  • Medicolegal issues in cluster headache.

    abstract::This paper identifies legal issues of relevance to the diagnosis and treatment of cluster headache, including areas of actual and potential malpractice liability. Legal topics that are relevant to cluster headache can be divided into five categories: diagnostic-related issues, risks inherent in the disease process, pr...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章

    doi:10.1007/s11916-004-0029-5

    authors: Loder E,Loder J

    更新日期:2004-04-01 00:00:00

  • Psychological issues in the evaluation and treatment of tension-type headache.

    abstract::Tension-type headache is the most common headache disorder, affecting approximately 40 % of Americans within a one-year span. Although the most common form, episodic tension-type headache, is rarely impairing, more frequent tension-type headache can occur with significant disability and psychological comorbidity. Appr...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-012-0301-z

    authors: Rosen NL

    更新日期:2012-12-01 00:00:00

  • Alcohol and migraine: what should we tell patients?

    abstract::Alcoholic drinks are a migraine trigger in about one third of patients with migraine in retrospective studies on trigger factors. Many population studies show that patients with migraine consume alcohol in a smaller percentage than the general population. Moreover, research has shown a decreased prevalence of headache...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-011-0184-4

    authors: Panconesi A,Bartolozzi ML,Guidi L

    更新日期:2011-06-01 00:00:00

  • The trigeminocervical complex and migraine: current concepts and synthesis.

    abstract::Neurones in the trigeminocervical complex are the major relay neurones for nociceptive afferent input from the meninges and cervical structures; therefore, they are the neural substrates of head pain. This review highlights the importance of two basic mechanisms in headache physiology: convergence of nociceptive affer...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-003-0036-y

    authors: Bartsch T,Goadsby PJ

    更新日期:2003-10-01 00:00:00

  • Antidepressants in the management of cancer pain.

    abstract::Most patients who have been diagnosed with cancer will experience pain at some point during the course of their disease. Often, opioid analgesics are not enough to completely alleviate the patient's pain and the selection of appropriate adjunct analgesic agents is critical. This article reviews the mechanisms of actio...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-001-0036-8

    authors: Mays TA

    更新日期:2001-06-01 00:00:00

  • Migraine and epilepsy in the pediatric population.

    abstract::Individually, childhood epilepsy and migraine are two of the most common conditions seen in pediatric neurology. What complicates matters is that there can be marked similarities between migraine and epilepsy as well as a variety of underlying conditions that predispose children to both seizures and headache. Thus, se...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-013-0402-3

    authors: Oakley CB,Kossoff EH

    更新日期:2014-03-01 00:00:00

  • The role of extraocular and facial muscle trigger points in cephalalgia.

    abstract::Trigger points play a part in the development and maintenance of chronic headache states. This article reviews the physiology of trigger points, with a focus on the -latest understanding of their biochemistry. The importance of facial muscle and extraocular muscle trigger points is only beginning to be understood; the...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-008-0059-5

    authors: McMurray CA,Bajwa ZH

    更新日期:2008-10-01 00:00:00

  • Nerve Blocks in Pediatric and Adolescent Headache Disorders.

    abstract:PURPOSE OF REVIEW:Peripheral nerve blocks of the scalp, mainly greater occipital nerve blocks, have received a renewed interest amongst pediatric providers as they offer an alternate option to provide both acute and chronic relief from the suffering of children with difficult to treat headaches. This narrative review w...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-017-0650-8

    authors: Dubrovsky AS

    更新日期:2017-11-09 00:00:00

  • Role of nitric oxide in cluster headache.

    abstract::Nitric oxide (NO) is an important molecule in headache pathophysiology. NO regulates vascular tone and acts as a potent vasodilator, and thus participates in regulating blood flow. NO is also considered to play a role in processing sensory information and pain sensitization. In this article, we review the role of NO i...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-012-0250-6

    authors: Steinberg A,Nilsson Remahl AI

    更新日期:2012-04-01 00:00:00

  • Advances in radiation therapy for oncologic pain.

    abstract::Pain is a feared component of cancer for a patient. The patient's prior experience with cancer pain will affect how he or she deals with ongoing and acute onset new pain. Radiation therapy has been and continues to be a major component in the management of cancer pain. New technologies are rapidly becoming available t...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-007-0203-7

    authors: Rockhill JK

    更新日期:2007-08-01 00:00:00

  • Update on neuropathic pain treatment: ion channel blockers and gabapentinoids.

    abstract::Neuropathic pain is a debilitating chronic pain condition, which remains difficult to treat. The current mainstays of treatment include physical therapy, interventional procedures and medications. Among medications, ion channel blockers and gabapentinoids are the 2 classes of drugs commonly used to treat neuropathic p...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-013-0359-2

    authors: Chen L,Mao J

    更新日期:2013-09-01 00:00:00