Migraine and reward system-or is it aversive?

Abstract:

:Migraine is a debilitating neurological disorder with grave consequences for both the individual and society. This review will focus on recent literature investigating how brain structures implicated in reward and aversion contribute to the genesis of migraine pain. There exist many overlapping and interacting brain regions within pain and reward circuitry that contribute to negative affect and subjective experience of pain. The emotional component of pain has been argued to be a greater metric of quality of life than its sensory component, and thus understanding the processes that influence this pain characteristic is essential to developing novel treatment strategies for mitigating migraine pain. We emphasize and provide evidence that abnormalities within the mesolimbic cortical reward pathways contribute to migraine pain and that there are structural and functional neuroplasticity within the overlapping brain regions common to both pain and reward.

journal_name

Curr Pain Headache Rep

authors

Cahill CM,Cook C,Pickens S

doi

10.1007/s11916-014-0410-y

subject

Has Abstract

pub_date

2014-05-01 00:00:00

pages

410

issue

5

eissn

1531-3433

issn

1534-3081

journal_volume

18

pub_type

杂志文章,评审
  • Recommendations for Substance Abuse and Pain Control in Patients with Chronic Pain.

    abstract:PURPOSE OF REVIEW:In the present investigation, current literature on the relationship between substance abuse and pain is evaluated in order to improve clinical management and its implications on the increasingly challenging chronic pain and substance abuse epidemic. The relationship between substance abuse and chroni...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-018-0679-3

    authors: Vadivelu N,Kai AM,Kodumudi G,Haddad D,Kodumudi V,Kuruvilla N,Kaye AD,Urman RD

    更新日期:2018-03-19 00:00:00

  • Contribution of primary afferent channels to neuropathic pain.

    abstract::Neuropathic pain remains a serious medical problem because of patient morbidity and the absence of effective therapeutic interventions. Recent evidence suggests that this type of pain may be particularly difficult to manage because underlying mechanisms are influenced by a variety of factors, including type of injury,...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-009-0034-9

    authors: Harriott AM,Gold MS

    更新日期:2009-06-01 00:00:00

  • The use of complementary medical therapies in the management of myofascial pain disorders.

    abstract::Complementary medical therapies are commonly used for the treatment and management of myofascial pain. No universally accepted therapy for this condition exists; consequently, patients often seek alternative and complementary therapies. Many complementary treatments are available.This article focuses on acupuncture, b...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-002-0078-6

    authors: Harris RE,Clauw DJ

    更新日期:2002-10-01 00:00:00

  • The psychiatric comorbidities of cluster headache.

    abstract::Although the comorbidity of migraine has been extensively studied, the relationships between cluster headache and psychiatric disease have not been well-addressed. In this review the available literature concerning cluster headache and depression, anxiety, bipolar disorder, aggression, suicide, and their implications ...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-012-0313-8

    authors: Robbins MS

    更新日期:2013-02-01 00:00:00

  • Management of fatigue in cancer patients.

    abstract::Cancer-related fatigue (CRF) is either a symptom or a syndrome depending on criteria for diagnosis. CRF is present in 20% to 30% of long-term cancer survivors and 80% to 90% during treatment and at the end of life. Assessment requires determining the presence, severity, and interference with daily activities. Differen...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-006-0030-2

    authors: Davis MP,Khoshknabi D,Yue GH

    更新日期:2006-08-01 00:00:00

  • Is there genetic polymorphism evidence for individual human sensitivity to opiates?

    abstract::Opiate analgesics have been widely used for severe acute pain and chronic cancer-related pain. Individual differences in the effectiveness of opiates and their side effects limit the clinical benefits and increase risks of drug abuse. Genetic factors might affect variations of opiate sensitivity. The mu opioid peptide...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-007-0008-8

    authors: Nagashima M,Katoh R,Sato Y,Tagami M,Kasai S,Ikeda K

    更新日期:2007-04-01 00:00:00

  • Pharmacologic therapies for complex regional pain syndrome.

    abstract::Complex regional pain syndrome (CRPS) remains a challenging condition to diagnose and treat. There are few large-scale, randomized trials of pharmacologic agents, and most published studies are small, uncontrolled, or presented only in abstract form at meetings. The most commonly used agents, such as anticonvulsants, ...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-007-0020-z

    authors: Mackey S,Feinberg S

    更新日期:2007-02-01 00:00:00

  • Temperament, character, and personality disorders in chronic pain.

    abstract::In the past decades investigators have used personality inventories to help explain the relationship between personality and pain experience. This article reviews empirical research, which has examined temperament and character features in chronic pain patients. Robert Cloninger's temperament and character model of pe...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-012-0318-3

    authors: Conrad R,Wegener I,Geiser F,Kleiman A

    更新日期:2013-03-01 00:00:00

  • Pain and opioid addiction: what is the connection?

    abstract::Addiction to opioid analgesics is an important and yet underinvestigated clinical issue, which has substantial implications in opioid therapy for chronic pain management. Problematic opioid use, including compulsive opioid seeking and addiction, arises in some fraction of opioid-treated chronic pain patients. The conn...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-009-0086-x

    authors: Carinci AJ,Mao J

    更新日期:2010-02-01 00:00:00

  • Gynecological management of premenstrual symptoms.

    abstract::The vast majority of menstruating women experience uncomfortable symptoms during the premenstrual phase of their menstrual cycles. Although many women do not require specific treatment of their symptoms, approximately 20% to 50% report moderate to severe premenstrual symptoms and about 5% meet the diagnostic criteria ...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-010-0131-9

    authors: Shulman LP

    更新日期:2010-10-01 00:00:00

  • N-methyl-D-aspartate- enhanced analgesia.

    abstract::A greater understanding of the mechanisms that produce chronic pain states has led to a search for novel agents with the potential to produce analgesia by directly modulating specific processes involved in the transduction, transmission, modulation, perception, and encoding of pain. It is hoped that compounds directed...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-003-0009-1

    authors: Hewitt DJ

    更新日期:2003-02-01 00:00:00

  • Systematic Review of Radiofrequency Ablation and Pulsed Radiofrequency for Management of Cervicogenic Headaches.

    abstract:PURPOSE OF REVIEW:Cervicogenic headache (CHA) is a secondary headache which has a source in the upper cervical spine. Many traditional analgesic choices lack good efficacy in managing the associated pain. As a result, in management of CHA, radiofrequency ablation (RFA) or pulse radiofrequency (PRF) has been tried with ...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-018-0673-9

    authors: Grandhi RK,Kaye AD,Abd-Elsayed A

    更新日期:2018-02-23 00:00:00

  • Preventative treatment of menstrual migraine.

    abstract::More than 20 million US women suffer with migraine, two thirds of whom experience menstrually related migraine. Estrogen plays an important role in triggering migraine, and given the numerous hormonal fluctuations throughout a woman's lifetime, there are many opportunities for a hormonal impact. Accurate diagnosis is ...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-007-0194-4

    authors: Lay CL,Broner SW

    更新日期:2007-06-01 00:00:00

  • Neuroimaging and the clinical manifestations of Chiari Malformation Type I (CMI).

    abstract::Chiari malformation type I (CMI) involves the caudal displacement of the cerebellar tonsils through the foramen magnum with resultant brainstem compression in some individuals. Due to pathophysiologic changes, secondary conditions may arise, such as syringohydromyelia (SH) and scoliosis. This disorder is unique, as th...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-015-0491-2

    authors: McVige JW,Leonardo J

    更新日期:2015-06-01 00:00:00

  • The hypothalamus: specific or nonspecific role in the pathophysiology of trigeminal autonomic cephalalgias?

    abstract::The clinical features of trigeminal autonomic cephalalgias (TACs), such as trigeminal distribution of pain, circadian/circannual rhythmicity, and ipsilateral cranial autonomic features, suggest a crucial role of the hypothalamus in the underlying pathophysiology of these primary headache disorders. Hypothalamic involv...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-010-0166-y

    authors: Holle D,Katsarava Z,Obermann M

    更新日期:2011-04-01 00:00:00

  • New daily persistent headache.

    abstract::New daily persistent headache (NDPH), which is the acute onset of headache within 3 days and is persistent for 15 days or more each month for at least 3 months, is a predominantly female heterogeneous subtype of chronic daily headache, typically with migraine features of unknown etiology. NDPH may be a presentation of...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-003-0051-z

    authors: Evans RW

    更新日期:2003-08-01 00:00:00

  • Stereotactic radiosurgery in the management of cancer pain.

    abstract::Pain can be a significant problem for the patient with advanced cancer, particularly if bone metastases are present. Radiation therapy is efficacious and has been a mainstay in the treatment of pain from bone metastases. In the past decade, radiosurgery has developed into a successful adjunct treatment for these patie...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-009-0044-7

    authors: Haley M,Gerszten PC

    更新日期:2009-08-01 00:00:00

  • Role of nitric oxide in cluster headache.

    abstract::Nitric oxide (NO) is an important molecule in headache pathophysiology. NO regulates vascular tone and acts as a potent vasodilator, and thus participates in regulating blood flow. NO is also considered to play a role in processing sensory information and pain sensitization. In this article, we review the role of NO i...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-012-0250-6

    authors: Steinberg A,Nilsson Remahl AI

    更新日期:2012-04-01 00:00:00

  • Exercise therapy for fibromyalgia.

    abstract::Fibromyalgia syndrome, a chronic condition typically characterized by widespread pain, nonrestorative sleep, fatigue, cognitive dysfunction, and other somatic symptoms, negatively impacts physical and emotional function and reduces quality of life. Exercise is commonly recommended in the management of people with fibr...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-011-0214-2

    authors: Busch AJ,Webber SC,Brachaniec M,Bidonde J,Bello-Haas VD,Danyliw AD,Overend TJ,Richards RS,Sawant A,Schachter CL

    更新日期:2011-10-01 00:00:00

  • Tension type headache in adolescence and childhood: where are we now?

    abstract::Tension type headache (TTH) is a primary headache disorder considered common in children and adolescents. It remains debatable whether TTH and migraine are separate biological entities. This review summarizes the most recent literature of TTH with regards to children and adolescents. Further studies of TTH are needed ...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-010-0149-z

    authors: Monteith TS,Sprenger T

    更新日期:2010-12-01 00:00:00

  • Pragmatic consideration of recent randomized, placebo-controlled clinical trials for treatment of fibromyalgia.

    abstract::A flurry of recent randomized, placebo-controlled trials assessing dissimilar pharmacotherapeutic treatment options for fibromyalgia (FM) have been presented in the past few years. This review evaluates these trials in light of recent pathophysiological concepts germane to FM, including mood disorders, autonomic dysre...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-008-0067-5

    authors: Holman AJ

    更新日期:2008-12-01 00:00:00

  • Tension-type headache in the elderly.

    abstract::Tension-type headache (TTH) is the most common type of headache in the general population, including individuals over the age of 65 years. Although the prevalence of migraine decreases markedly with age, TTH has a greater tendency to persist later in life. Less commonly, TTH can present for the first time after the ag...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-009-0076-z

    authors: Crystal SC,Grosberg BM

    更新日期:2009-12-01 00:00:00

  • Chronic headache and sleep disturbance.

    abstract::Headache and sleep disturbance are common health complaints. Both complaints often co-exist in the same patient, leading some to suspect a causal relationship or common underlying pathology. However, the empirical literature in this area is limited. Some attempts have been made to explore the relationship between head...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-002-0070-1

    authors: Rains JC,Penzien DB

    更新日期:2002-12-01 00:00:00

  • Opioid-induced hyperalgesia: clinically relevant or extraneous research phenomenon?

    abstract::Opioids have become the unequivocal therapy of choice in treating many varieties of chronic pain. With the increased prescription of opioids, some unintended consequences have occurred. After prolonged opioid exposure, opioid-induced hyperalgesia (OIH), the paradoxical effect that opioid therapy may in fact enhance or...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-010-0171-1

    authors: Tompkins DA,Campbell CM

    更新日期:2011-04-01 00:00:00

  • The Role of Resilience in the Clinical Management of Chronic Pain.

    abstract::Chronic pain affects more individuals than does cancer, heart disease, and diabetes combined. Yet, our treatment options remain remarkably limited. Often, highly effective psychotherapeutic approaches are limited by many barriers such as access, reimbursement, and acceptability; however, resilience-based positive acti...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-016-0567-7

    authors: Hassett AL,Finan PH

    更新日期:2016-06-01 00:00:00

  • Migraine variants.

    abstract::The term "migrant variant" is not used in the headache classification of the International Headache Society (IHS), but it includes those forms of migraine that are not typical of migraine with or without aura. Headaches that do not quite fulfill all of the IHS criteria are termed "migrainous disorder." Migraine associ...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-001-0084-0

    authors: Solomon S

    更新日期:2001-04-01 00:00:00

  • It IS a tumor -- current review of headache and brain tumor.

    abstract::"Do I have a tumor?" This is a question in every person's mind when first confronted with a new-onset headache, a question that causes considerable anxiety among patients, leading them to seek medical evaluation. This publication reviews the current literature with respect to the epidemiology, pathophysiology presenta...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-014-0421-8

    authors: Kahn K,Finkel A

    更新日期:2014-06-01 00:00:00

  • Is migraine a neuropathic pain syndrome?

    abstract::The understanding of migraine pathophysiology has evolved from the belief that migraine is a vascular disorder, to evidence that better defines migraine as a neurogenic disorder associated with secondary changes in brain perfusion. There is evidence to suggest that the early phase of migraine pain results from neuroge...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-006-0042-y

    authors: Biondi DM

    更新日期:2006-06-01 00:00:00

  • Sports-related headache.

    abstract::Sports-related or sports-associated headaches are common. They can be benign as in primary exertional headache or may signal serious pathology as in headache associated with traumatic subdural hematoma. Specific sports activities are associated with unique headache conditions such as decompression sickness headache or...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-004-0012-1

    authors: Ramadan NM

    更新日期:2004-08-01 00:00:00

  • What the Gut Can Teach Us About Migraine.

    abstract::During gestation, cells of the brain and gut develop almost simultaneously into the central nervous system (CNS) and enteric nervous system (ENS), respectively. They remain connected via the vagal nerve lifelong. While it is well known that the brain sends signal to the gut, communication is in fact bidirectional. Jus...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-015-0501-4

    authors: Hindiyeh N,Aurora SK

    更新日期:2015-07-01 00:00:00