Abstract：
:During gestation, cells of the brain and gut develop almost simultaneously into the central nervous system (CNS) and enteric nervous system (ENS), respectively. They remain connected via the vagal nerve lifelong. While it is well known that the brain sends signal to the gut, communication is in fact bidirectional. Just as the brain can modulate gut functioning, the gut, and likely what we ingest, can in fact influence our brain functioning. We will first review both gastrointestinal (GI) function and migraine pathophysiology and then discuss evidence linking the migraine brain to various GI disorders. Lastly, we discuss the effects of gut microbiota on brain functioning and speculate how the gut and particularly diet may affect migraine.
journal_name
Curr Pain Headache Repjournal_title
Current pain and headache reportsauthors
Hindiyeh N,Aurora SKdoi
10.1007/s11916-015-0501-4subject
Has Abstractpub_date
2015-07-01 00:00:00pages
33issue
7eissn
1531-3433issn
1534-3081journal_volume
19pub_type
杂志文章,评审abstract：PURPOSE OF REVIEW:Chronic venous disease (CVD), although affecting up to 40% of the US population, is often underdiagnosed by healthcare professionals due to an incomplete understanding of the presenting symptoms. CVD is a common cause of lower extremity pain and discomfort, including aching, cramping, tingling, burnin...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-019-0759-z
更新日期：2019-03-04 00:00:00
abstract：PURPOSE OF REVIEW:The purpose of the present systematic review is to provide a current understanding of the mechanism of action and the evidence available to support clinical decision-making. The focus is to summarize randomized controlled trials (RCTs) and nonrandomized or observational studies of spinal cord stimulat...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-020-00907-2
更新日期：2020-09-30 00:00:00
abstract：:Involvement by psychiatrists in the care of patients who are terminally ill has been limited historically; however, psychiatrists increasingly are participating in the care of these people who are facing the most challenging times of their lives. Pain management is considered to be an area of subspecialization for psy...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-003-0018-0
更新日期：2003-04-01 00:00:00
abstract：:Pain is a feared component of cancer for a patient. The patient's prior experience with cancer pain will affect how he or she deals with ongoing and acute onset new pain. Radiation therapy has been and continues to be a major component in the management of cancer pain. New technologies are rapidly becoming available t...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-007-0203-7
更新日期：2007-08-01 00:00:00
abstract：PURPOSE OF REVIEW:Neuromyelitis optica (NMO) classically features a clinical presentation that includes longitudinally extensive transverse myelitis and optic neuritis. However, many other pathognomonic phenomena have more recently been described in patients diagnosed with NMO, including intractable hiccups, vomiting, ...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-017-0620-1
更新日期：2017-04-01 00:00:00
abstract：:Chiari malformation type I (CMI) involves the caudal displacement of the cerebellar tonsils through the foramen magnum with resultant brainstem compression in some individuals. Due to pathophysiologic changes, secondary conditions may arise, such as syringohydromyelia (SH) and scoliosis. This disorder is unique, as th...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-015-0491-2
更新日期：2015-06-01 00:00:00
abstract：:The lumbar spine forms the foundation and infrastructure of an organic skyscraper equipped with the physiologic capacity to act as a crane for lifting and a crankshaft for walking. Subjected to aging like other "human machinery," the lumbar spine adapts to the wear and tear of gravity and biomechanical loading through...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-002-0005-x
更新日期：2002-04-01 00:00:00
abstract：PURPOSE OF REVIEW:Athletic neurosurgical emergencies are injuries that can lead to mortality or significant morbidity and require immediate recognition and treatment. This review article discusses the epidemiology of sports-related traumatic brain injury (TBI) with an attempt to quantify the incidence of neurosurgical ...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-016-0586-4
更新日期：2016-09-01 00:00:00
abstract：:Infantile colic is a self-limiting disorder of excessive infant crying or fussiness that peaks at 6 weeks of age and typically improves by 3 months of age. The etiology of infantile colic has yet to be definitively elucidated, but there is increasing research to support its relationship to migraine. The aims of this r...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-016-0558-8
更新日期：2016-05-01 00:00:00
abstract：:Nociceptive nerve endings in muscles and other tissues are equipped with a multitude of receptor molecules for endogenous pain-producing and sensitizing agents. Particularly interesting molecules are the purinergic receptors, which can be activated by adenosine triphosphate (ATP), and the vanilloid receptor, which is ...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-003-0057-6
更新日期：2003-12-01 00:00:00
abstract：:Empathy is a provider attribute that has been a topic of increased clinical interest, particularly as it relates to pain. This article examines various dimensions of the pain and empathy literature: definitions of empathy, research regarding the psychophysiology of empathy for pain, and research related to empathy in ...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-008-0021-6
更新日期：2008-04-01 00:00:00
abstract：PURPOSE OF REVIEW:The purpose of this review is to summarise the current state of knowledge concerning known types of gain, the reasons why patients might seek it, as well as implications for headache disorders. RECENT FINDINGS:Even though the subject has been studied in the past, it received less attention in recent ...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-019-0829-2
更新日期：2019-11-16 00:00:00
abstract：PURPOSE OF REVIEW:Sickle cell disease (SCD) is a hematological disorder which leads to serious complications in multiple organ systems. While significant research has addressed many of the effects of acute pain episodes and end-organ damage connected to this disease, little has approached the chronic pain state associa...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-020-00854-y
更新日期：2020-03-21 00:00:00
abstract：:Numerous treatment strategies for myofascial pain syndrome are available, including physical therapy, behavioral pain management techniques, acupuncture, various types of injections, and the use of various pharmacotherapeutic approaches. The use of topical analgesics for myofascial pain syndrome is the focus of this r...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-002-0079-5
更新日期：2002-10-01 00:00:00
abstract：:The most likely future of aggressive headache treatment will reside in the sphere of the specialist's clinic. This is a far more cost- and time-effective mode of treating intractable chronic daily headaches (CDH), including chronic migraines. We have used this technique successfully in our clinic for many years. Our e...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-006-0009-z
更新日期：2006-02-01 00:00:00
abstract：PURPOSE OF REVIEW:Fibromyalgia (FM) is the second most common rheumatologic pain disorder after osteoarthritis with a multisystem presentation. While the treatment of FM in a clinical setting incorporates both pharmacologic and non-pharmacologic modalities, the present investigation reviews evolving literature on cogni...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-018-0688-2
更新日期：2018-04-04 00:00:00
abstract：:Hyperprolactinemia is a condition characterised by an increase of prolactin blood levels (more than 100-200 ng/ml). It is the most common endocrine disorder of the hypothalamic-pituitary axis. The clinical characteristics of the headache-hyperprolactinemia-hypophyseal-adenoma association are discussed, the various dia...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-012-0267-x
更新日期：2012-08-01 00:00:00
abstract：:Tension-type headache is the most common primary headache disorder seen in adults. Although the prevalence peaks in the fourth and fifth decades of life, significant fractions of the elderly continue to experience either episodic or chronic tension-type headaches. Many secondary headache disorders may present with hea...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-006-0076-1
更新日期：2006-12-01 00:00:00
abstract：:Opioids have become the unequivocal therapy of choice in treating many varieties of chronic pain. With the increased prescription of opioids, some unintended consequences have occurred. After prolonged opioid exposure, opioid-induced hyperalgesia (OIH), the paradoxical effect that opioid therapy may in fact enhance or...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-010-0171-1
更新日期：2011-04-01 00:00:00
abstract：PURPOSE OF THE REVIEW:The goals of this review are to evaluate recent studies regarding comorbidity between migraine and different metabolic and endocrine disorders and to discuss the role of insulin resistance as a common pathogenetic mechanism of these diseases. RECENT FINDINGS:Recently, several studies showed that ...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-018-0691-7
更新日期：2018-04-04 00:00:00
abstract：:Chronic pain affects more individuals than does cancer, heart disease, and diabetes combined. Yet, our treatment options remain remarkably limited. Often, highly effective psychotherapeutic approaches are limited by many barriers such as access, reimbursement, and acceptability; however, resilience-based positive acti...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-016-0567-7
更新日期：2016-06-01 00:00:00
abstract：:Quantitative sensory testing (QST) is a widely accepted tool to investigate somatosensory changes in pain patients. Many different protocols have been developed in clinical pain research within recent years. In this review, we provide an overview of QST and tested neuroanatomical pathways, including peripheral and cen...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-012-0261-3
更新日期：2012-06-01 00:00:00
abstract：:A flurry of recent randomized, placebo-controlled trials assessing dissimilar pharmacotherapeutic treatment options for fibromyalgia (FM) have been presented in the past few years. This review evaluates these trials in light of recent pathophysiological concepts germane to FM, including mood disorders, autonomic dysre...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-008-0067-5
更新日期：2008-12-01 00:00:00
abstract：:Pediatric and adolescence headache is one of the most common causes of access in emergency departments (ED). Primary headache and headache secondary to self-limited conditions are the majority of cases. Secondary life-threatening headaches are less frequent and may be recognized by a careful history and physical exami...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-015-0480-5
更新日期：2015-03-01 00:00:00
abstract：:Chronic pain is a complex disorder to which medical and psychological factors both contribute and react. While there are numerous chronic pain conditions, they share certain experiences. This review examines some of the psychological factors that are common to the pain experience and some of the psychologically-based ...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-015-0517-9
更新日期：2015-09-01 00:00:00
abstract：:Sports-related or sports-associated headaches are common. They can be benign as in primary exertional headache or may signal serious pathology as in headache associated with traumatic subdural hematoma. Specific sports activities are associated with unique headache conditions such as decompression sickness headache or...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-004-0012-1
更新日期：2004-08-01 00:00:00
abstract：:Neuropathic pain remains a serious medical problem because of patient morbidity and the absence of effective therapeutic interventions. Recent evidence suggests that this type of pain may be particularly difficult to manage because underlying mechanisms are influenced by a variety of factors, including type of injury,...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-009-0034-9
更新日期：2009-06-01 00:00:00
abstract：:This article describes the current and investigational agents for use in the treatment of acute pain. The use of spinal and epidural routes also are discussed. ...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-004-0037-5
更新日期：2004-02-01 00:00:00
abstract：:Pain is a difficult outcome to measure due to its multifaceted and subjective nature. The need for selecting proper outcome measures is high because of the increasing demand for scientifically valid demonstrations of treatment efficacy. This article discusses some basic topics in the measurement of pain outcomes and a...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-009-0009-x
更新日期：2009-02-01 00:00:00
abstract：:Although the comorbidity of migraine has been extensively studied, the relationships between cluster headache and psychiatric disease have not been well-addressed. In this review the available literature concerning cluster headache and depression, anxiety, bipolar disorder, aggression, suicide, and their implications ...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-012-0313-8
更新日期：2013-02-01 00:00:00
