Abstract：
:Opioids have become the unequivocal therapy of choice in treating many varieties of chronic pain. With the increased prescription of opioids, some unintended consequences have occurred. After prolonged opioid exposure, opioid-induced hyperalgesia (OIH), the paradoxical effect that opioid therapy may in fact enhance or aggravate preexisting pain, may occur. Over the past several decades, an increasing number of laboratory and clinical reports have suggested lowered pain thresholds and heightened atypical pain unrelated to the original perceived pain sensations as hallmarks of OIH. However, not all evidence supports the clinical importance of OIH, and some question whether the phenomenon exists at all. Here, we present a nonexhaustive, brief review of the recent literature. OIH will be reviewed in terms of preclinical and clinical evidence for and against its existence; recommendations for clinical evaluation and intervention also will be discussed.
journal_name
Curr Pain Headache Repjournal_title
Current pain and headache reportsauthors
Tompkins DA,Campbell CMdoi
10.1007/s11916-010-0171-1subject
Has Abstractpub_date
2011-04-01 00:00:00pages
129-36issue
2eissn
1531-3433issn
1534-3081journal_volume
15pub_type
杂志文章,评审abstract：:Chronic pain affects more individuals than does cancer, heart disease, and diabetes combined. Yet, our treatment options remain remarkably limited. Often, highly effective psychotherapeutic approaches are limited by many barriers such as access, reimbursement, and acceptability; however, resilience-based positive acti...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-016-0567-7
更新日期：2016-06-01 00:00:00
abstract：:Pediatric and adolescence headache is one of the most common causes of access in emergency departments (ED). Primary headache and headache secondary to self-limited conditions are the majority of cases. Secondary life-threatening headaches are less frequent and may be recognized by a careful history and physical exami...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-015-0480-5
更新日期：2015-03-01 00:00:00
abstract：:Alcoholic drinks are a migraine trigger in about one third of patients with migraine in retrospective studies on trigger factors. Many population studies show that patients with migraine consume alcohol in a smaller percentage than the general population. Moreover, research has shown a decreased prevalence of headache...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-011-0184-4
更新日期：2011-06-01 00:00:00
abstract：:Complex regional pain syndrome (CRPS) remains a challenging condition to diagnose and treat. There are few large-scale, randomized trials of pharmacologic agents, and most published studies are small, uncontrolled, or presented only in abstract form at meetings. The most commonly used agents, such as anticonvulsants, ...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-007-0020-z
更新日期：2007-02-01 00:00:00
abstract：:Migraine and stroke are related in more than one way. Migraine with aura is a risk factor for ischemic stroke in women under age 45 years, particularly when combined with other risk factors such as smoking and oral contraceptives. Further, individuals with migraine with aura seem to have more white matter lesions and ...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-012-0262-2
更新日期：2012-06-01 00:00:00
abstract：:The term "migrant variant" is not used in the headache classification of the International Headache Society (IHS), but it includes those forms of migraine that are not typical of migraine with or without aura. Headaches that do not quite fulfill all of the IHS criteria are termed "migrainous disorder." Migraine associ...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-001-0084-0
更新日期：2001-04-01 00:00:00
abstract：:Most patients who have been diagnosed with cancer will experience pain at some point during the course of their disease. Often, opioid analgesics are not enough to completely alleviate the patient's pain and the selection of appropriate adjunct analgesic agents is critical. This article reviews the mechanisms of actio...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-001-0036-8
更新日期：2001-06-01 00:00:00
abstract：: ...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-019-0746-4
更新日期：2019-01-19 00:00:00
abstract：PURPOSE OF REVIEW:In the present investigation, current literature on the relationship between substance abuse and pain is evaluated in order to improve clinical management and its implications on the increasingly challenging chronic pain and substance abuse epidemic. The relationship between substance abuse and chroni...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-018-0679-3
更新日期：2018-03-19 00:00:00
abstract：:Complementary medical therapies are commonly used for the treatment and management of myofascial pain. No universally accepted therapy for this condition exists; consequently, patients often seek alternative and complementary therapies. Many complementary treatments are available.This article focuses on acupuncture, b...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-002-0078-6
更新日期：2002-10-01 00:00:00
abstract：PURPOSE OF REVIEW:Chronic venous disease (CVD), although affecting up to 40% of the US population, is often underdiagnosed by healthcare professionals due to an incomplete understanding of the presenting symptoms. CVD is a common cause of lower extremity pain and discomfort, including aching, cramping, tingling, burnin...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-019-0759-z
更新日期：2019-03-04 00:00:00
abstract：PURPOSE OF REVIEW:Fibromyalgia (FM) is the second most common rheumatologic pain disorder after osteoarthritis with a multisystem presentation. While the treatment of FM in a clinical setting incorporates both pharmacologic and non-pharmacologic modalities, the present investigation reviews evolving literature on cogni...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-018-0688-2
更新日期：2018-04-04 00:00:00
abstract：:Cervicogenic headache is a chronic, hemicranial pain syndrome in which the source of pain is located in the cervical spine or soft tissues of the neck but the sensation of pain is referred to the head. The trigeminocervical nucleus is a region of the upper cervical spinal cord where sensory nerve fibers in the descend...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-001-0026-x
更新日期：2001-08-01 00:00:00
abstract：PURPOSE OF REVIEW:The purpose of this review is to provide a summary of the perioperative studies that have examined transdermal lidocaine (lidocaine patch) as an analgesic and put the evidence in context of the likely overall benefit of transdermal lidocaine in the perioperative period. RECENT FINDINGS:Several random...
journal_title：Current pain and headache reports
pub_type： 杂志文章
doi：10.1007/s11916-019-0830-9
更新日期：2019-11-14 00:00:00
abstract：:Quantitative sensory testing (QST) is a widely accepted tool to investigate somatosensory changes in pain patients. Many different protocols have been developed in clinical pain research within recent years. In this review, we provide an overview of QST and tested neuroanatomical pathways, including peripheral and cen...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-012-0261-3
更新日期：2012-06-01 00:00:00
abstract：:In the past decades investigators have used personality inventories to help explain the relationship between personality and pain experience. This article reviews empirical research, which has examined temperament and character features in chronic pain patients. Robert Cloninger's temperament and character model of pe...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-012-0318-3
更新日期：2013-03-01 00:00:00
abstract：:Pain is a difficult outcome to measure due to its multifaceted and subjective nature. The need for selecting proper outcome measures is high because of the increasing demand for scientifically valid demonstrations of treatment efficacy. This article discusses some basic topics in the measurement of pain outcomes and a...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-009-0009-x
更新日期：2009-02-01 00:00:00
abstract：:Weight gain is a common side effect of drugs used for headache prevention. Weight gain can adversely affect patient health, exacerbate comorbid metabolic disorders, and encourage noncompliance. Additionally, obesity may promote the chronification of episodic migraine. Few studies have looked specifically at the effect...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-008-0035-0
更新日期：2008-06-01 00:00:00
abstract：:The use of analgesic and anti-inflammatory injections in athletics has a long and sometimes controversial history. They have been and will continue to be utilized to decrease inflammation and pain, improve healing time, and ultimately decrease the amount of time missed from sports competition. Several authors have eva...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-005-0069-5
更新日期：2005-02-01 00:00:00
abstract：:Nociceptive nerve endings in muscles and other tissues are equipped with a multitude of receptor molecules for endogenous pain-producing and sensitizing agents. Particularly interesting molecules are the purinergic receptors, which can be activated by adenosine triphosphate (ATP), and the vanilloid receptor, which is ...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-003-0057-6
更新日期：2003-12-01 00:00:00
abstract：:Cluster headache was first described over 300 years ago, but in the last century our knowledge of the disorder has exploded through both clinical observation and epidemiological data. Although some of the data are conflicting and more need to be obtained, much is known about the disorder. This article reviews the data...
journal_title：Current pain and headache reports
pub_type： 历史文章,杂志文章,评审
doi：10.1007/s11916-009-0024-y
更新日期：2009-04-01 00:00:00
abstract：:Hormonal and nonhormonal factors play a role in the pathophysiology of menstrual migraine, but estrogen withdrawal appears to be the most potent of these factors. It is postulated that estrogen withdrawal directly enhances excitability of trigeminal afferents, modulates the synthesis of neuropeptides, activates/deacti...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-008-0077-3
更新日期：2008-12-01 00:00:00
abstract：:Chiari malformation type I (CMI) involves the caudal displacement of the cerebellar tonsils through the foramen magnum with resultant brainstem compression in some individuals. Due to pathophysiologic changes, secondary conditions may arise, such as syringohydromyelia (SH) and scoliosis. This disorder is unique, as th...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-015-0491-2
更新日期：2015-06-01 00:00:00
abstract：:Little is known about specific changes of cognitive processing in cluster headache. Studies on event-related potentials (ERP) suggest that stimulus evaluation is impaired in chronic cluster headache and in episodic cluster headache during the cluster period, but not in the interval between two periods. Patients with c...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-005-0047-y
更新日期：2005-04-01 00:00:00
abstract：:While pain is a common symptom among older adults, it often is underdiagnosed and undertreated. Aging-related physiological changes, misperceptions about the use of pain medications by both patients and providers, and the lack of evidence-based clinical research on pain management in older adults are some of the reaso...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-010-0148-0
更新日期：2010-12-01 00:00:00
abstract：:Fibromyalgia syndrome, a chronic condition typically characterized by widespread pain, nonrestorative sleep, fatigue, cognitive dysfunction, and other somatic symptoms, negatively impacts physical and emotional function and reduces quality of life. Exercise is commonly recommended in the management of people with fibr...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-011-0214-2
更新日期：2011-10-01 00:00:00
abstract：:Neurostimulation techniques for the treatment of primary headache syndromes, particularly for chronic cluster headache (CCH), have received much interest in the recent years. Occipital nerve stimulation (ONS) has yielded favourable clinical results, and is becoming a routine treatment for refractory chronic cluster he...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-013-0324-0
更新日期：2013-05-01 00:00:00
abstract：:Individually, childhood epilepsy and migraine are two of the most common conditions seen in pediatric neurology. What complicates matters is that there can be marked similarities between migraine and epilepsy as well as a variety of underlying conditions that predispose children to both seizures and headache. Thus, se...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-013-0402-3
更新日期：2014-03-01 00:00:00
abstract：PURPOSE OF REVIEW:Neuromyelitis optica (NMO) classically features a clinical presentation that includes longitudinally extensive transverse myelitis and optic neuritis. However, many other pathognomonic phenomena have more recently been described in patients diagnosed with NMO, including intractable hiccups, vomiting, ...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-017-0620-1
更新日期：2017-04-01 00:00:00
abstract：:Sexual hormones influence complex brain function and pain perception. Many psychophysical studies attempted to establish pain perception changes across menstrual cycle in animal models and healthy women or those with chronic pain. General results are quite uncertain in regard to consistent menstrual-related fluctuatio...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-011-0207-1
更新日期：2011-10-01 00:00:00
