Abstract:
:Most patients who have been diagnosed with cancer will experience pain at some point during the course of their disease. Often, opioid analgesics are not enough to completely alleviate the patient's pain and the selection of appropriate adjunct analgesic agents is critical. This article reviews the mechanisms of action and analgesic effects of several classes of antidepressants to enable the clinician to select the appropriate agent for the patient.
journal_name
Curr Pain Headache Repjournal_title
Current pain and headache reportsauthors
Mays TAdoi
10.1007/s11916-001-0036-8keywords:
subject
Has Abstractpub_date
2001-06-01 00:00:00pages
227-36issue
3eissn
1531-3433issn
1534-3081journal_volume
5pub_type
杂志文章,评审abstract:PURPOSE OF REVIEW:CGRP is a key neuropeptide in migraine pathophysiology. The blockade of the CGRP pathway at the side of the CGRP receptor of the CGRP peptide leads to the interruption of trigeminal nerve system-mediated headache syndromes such as migraine. Monoclonal antibodies (mAbs) targeting the CGRP pathway have ...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-018-0686-4
更新日期:2018-04-06 00:00:00
abstract::Nociceptive nerve endings in muscles and other tissues are equipped with a multitude of receptor molecules for endogenous pain-producing and sensitizing agents. Particularly interesting molecules are the purinergic receptors, which can be activated by adenosine triphosphate (ATP), and the vanilloid receptor, which is ...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-003-0057-6
更新日期:2003-12-01 00:00:00
abstract:PURPOSE OF REVIEW:The purpose of this review is to provide a summary of the perioperative studies that have examined transdermal lidocaine (lidocaine patch) as an analgesic and put the evidence in context of the likely overall benefit of transdermal lidocaine in the perioperative period. RECENT FINDINGS:Several random...
journal_title:Current pain and headache reports
pub_type: 杂志文章
doi:10.1007/s11916-019-0830-9
更新日期:2019-11-14 00:00:00
abstract:PURPOSE OF REVIEW:Athletic neurosurgical emergencies are injuries that can lead to mortality or significant morbidity and require immediate recognition and treatment. This review article discusses the epidemiology of sports-related traumatic brain injury (TBI) with an attempt to quantify the incidence of neurosurgical ...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-016-0586-4
更新日期:2016-09-01 00:00:00
abstract::Myofascial pain syndrome (MPS) is caused by myofascial trigger points (MTrPs) located within taut bands of skeletal muscle fibers. Treating the underlying etiologic lesion responsible for MTrP activation is the most important strategy in MPS therapy. If the underlying pathology is not given the appropriate treatment, ...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-006-0058-3
更新日期:2006-10-01 00:00:00
abstract::A number of patients attending specialty headache centers complain of very frequent, almost continuous headaches, which are usually grouped together under the term chronic daily headache (CDH), a category which does not appear in the International Headache Society (IHS) classification published in 1988. More than 10 y...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-001-0072-4
更新日期:2001-12-01 00:00:00
abstract::Chronic primary headaches are widespread disorders which cause significant quality of life and socioprofessional impairment. Available pharmacological treatments have often a limited efficacy and/or can generate unbearable side effects. Electrical nerve stimulation is a well-known non-destructive method of pain modula...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-016-0589-1
更新日期:2016-11-01 00:00:00
abstract::This article describes the current and investigational agents for use in the treatment of acute pain. The use of spinal and epidural routes also are discussed. ...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-004-0037-5
更新日期:2004-02-01 00:00:00
abstract:PURPOSE OF REVIEW:Sickle cell disease (SCD) is a hematological disorder which leads to serious complications in multiple organ systems. While significant research has addressed many of the effects of acute pain episodes and end-organ damage connected to this disease, little has approached the chronic pain state associa...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-020-00854-y
更新日期:2020-03-21 00:00:00
abstract::Headache and sleep disturbance are common health complaints. Both complaints often co-exist in the same patient, leading some to suspect a causal relationship or common underlying pathology. However, the empirical literature in this area is limited. Some attempts have been made to explore the relationship between head...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-002-0070-1
更新日期:2002-12-01 00:00:00
abstract::Little is known about specific changes of cognitive processing in cluster headache. Studies on event-related potentials (ERP) suggest that stimulus evaluation is impaired in chronic cluster headache and in episodic cluster headache during the cluster period, but not in the interval between two periods. Patients with c...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-005-0047-y
更新日期:2005-04-01 00:00:00
abstract::Cancer pain is highly prevalent and often severe. Fortunately, most cancer pain can be readily managed, with up to 90% of patients responding well to standard interventions. However, breakthrough cancer pain-brief flares of severe pain superimposed on baseline pain-is common, difficult to manage, and often negatively ...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-008-0042-1
更新日期:2008-08-01 00:00:00
abstract::Empathy is a provider attribute that has been a topic of increased clinical interest, particularly as it relates to pain. This article examines various dimensions of the pain and empathy literature: definitions of empathy, research regarding the psychophysiology of empathy for pain, and research related to empathy in ...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-008-0021-6
更新日期:2008-04-01 00:00:00
abstract::Sports-related or sports-associated headaches are common. They can be benign as in primary exertional headache or may signal serious pathology as in headache associated with traumatic subdural hematoma. Specific sports activities are associated with unique headache conditions such as decompression sickness headache or...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-004-0012-1
更新日期:2004-08-01 00:00:00
abstract::Pain can be a significant problem for the patient with advanced cancer, particularly if bone metastases are present. Radiation therapy is efficacious and has been a mainstay in the treatment of pain from bone metastases. In the past decade, radiosurgery has developed into a successful adjunct treatment for these patie...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-009-0044-7
更新日期:2009-08-01 00:00:00
abstract::Caffeine is the most widely consumed psychostimulant drug in the world. With intermittent exposures, caffeine may act as a mild analgesic for headache or as an adjuvant for the actions of other analgesics. Chronic repetitive exposures to caffeine increase the risks for development of analgesic-overuse headache, chroni...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-008-0052-z
更新日期:2008-08-01 00:00:00
abstract::Weight gain is a common side effect of drugs used for headache prevention. Weight gain can adversely affect patient health, exacerbate comorbid metabolic disorders, and encourage noncompliance. Additionally, obesity may promote the chronification of episodic migraine. Few studies have looked specifically at the effect...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-008-0035-0
更新日期:2008-06-01 00:00:00
abstract::Infantile colic is a self-limiting disorder of excessive infant crying or fussiness that peaks at 6 weeks of age and typically improves by 3 months of age. The etiology of infantile colic has yet to be definitively elucidated, but there is increasing research to support its relationship to migraine. The aims of this r...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-016-0558-8
更新日期:2016-05-01 00:00:00
abstract::Hormonal and nonhormonal factors play a role in the pathophysiology of menstrual migraine, but estrogen withdrawal appears to be the most potent of these factors. It is postulated that estrogen withdrawal directly enhances excitability of trigeminal afferents, modulates the synthesis of neuropeptides, activates/deacti...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-008-0077-3
更新日期:2008-12-01 00:00:00
abstract:PURPOSE OF REVIEW:Neuromyelitis optica (NMO) classically features a clinical presentation that includes longitudinally extensive transverse myelitis and optic neuritis. However, many other pathognomonic phenomena have more recently been described in patients diagnosed with NMO, including intractable hiccups, vomiting, ...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-017-0620-1
更新日期:2017-04-01 00:00:00
abstract::Treatment for patients who are dying from cancer and are suffering with physiologic and existential symptoms is an important and valuable skill for health care providers. However, the treatment for suffering at the end of life and the use of sedation for comfort often are misunderstood. The following is a discussion o...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-002-0035-4
更新日期:2002-06-01 00:00:00
abstract::During gestation, cells of the brain and gut develop almost simultaneously into the central nervous system (CNS) and enteric nervous system (ENS), respectively. They remain connected via the vagal nerve lifelong. While it is well known that the brain sends signal to the gut, communication is in fact bidirectional. Jus...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-015-0501-4
更新日期:2015-07-01 00:00:00
abstract::Migraine and stroke are related in more than one way. Migraine with aura is a risk factor for ischemic stroke in women under age 45 years, particularly when combined with other risk factors such as smoking and oral contraceptives. Further, individuals with migraine with aura seem to have more white matter lesions and ...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-012-0262-2
更新日期:2012-06-01 00:00:00
abstract::The most likely future of aggressive headache treatment will reside in the sphere of the specialist's clinic. This is a far more cost- and time-effective mode of treating intractable chronic daily headaches (CDH), including chronic migraines. We have used this technique successfully in our clinic for many years. Our e...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-006-0009-z
更新日期:2006-02-01 00:00:00
abstract::Chemotherapy-induced peripheral neuropathy (CIPN) is a major concern in oncology practice given the increasing number of cancer survivors and the lack of effective treatment. The incidence of peripheral neuropathy depends upon the anticancer drug used, but is commonly under-reported in clinical trials. Several animal ...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-013-0364-5
更新日期:2013-10-01 00:00:00
abstract::Migraine and cluster headache have been considered entirely separate clinical syndromes, both in routine clinical practice and in the 1988 International Headache Society classification. Neurologists seeing large numbers of patients soon realize, however, that there is a considerable overlap between the two conditions....
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-001-0012-3
更新日期:2001-02-01 00:00:00
abstract::The clinical features of trigeminal autonomic cephalalgias (TACs), such as trigeminal distribution of pain, circadian/circannual rhythmicity, and ipsilateral cranial autonomic features, suggest a crucial role of the hypothalamus in the underlying pathophysiology of these primary headache disorders. Hypothalamic involv...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-010-0166-y
更新日期:2011-04-01 00:00:00
abstract::The experience of chronic pain can be associated with significant distress and disability; however, this is not always the case. Although attempts to control or reduce pain can be helpful for many pain sufferers, on some occasions this is not an effective option and a different response is required. This different res...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-006-0018-y
更新日期:2006-04-01 00:00:00
abstract::This paper identifies legal issues of relevance to the diagnosis and treatment of cluster headache, including areas of actual and potential malpractice liability. Legal topics that are relevant to cluster headache can be divided into five categories: diagnostic-related issues, risks inherent in the disease process, pr...
journal_title:Current pain and headache reports
pub_type: 杂志文章
doi:10.1007/s11916-004-0029-5
更新日期:2004-04-01 00:00:00
abstract::Health care professionals caring for neonates (birth to 28 days of life) and infants up to 1 year of age have a professional and ethical responsibility to provide safe and effective pain management during painful procedures. Despite 14 years of research reports highlighting that sick infants are exposed to large numbe...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-009-0091-0
更新日期:2010-04-01 00:00:00