Abstract：
PURPOSE OF REVIEW:CGRP is a key neuropeptide in migraine pathophysiology. The blockade of the CGRP pathway at the side of the CGRP receptor of the CGRP peptide leads to the interruption of trigeminal nerve system-mediated headache syndromes such as migraine. Monoclonal antibodies (mAbs) targeting the CGRP pathway have been developed and are currently under investigation for episodic (EM) and chronic migraine (CM) prevention. Here, we report data from these clinical trials. RECENT FINDINGS:Placebo-controlled, randomized double-blind phase studies of CGRP mAbs in episodic and chronic migraine have shown that the specific blockade of the peptide or the CGRP receptor are both powerful mechanisms to reduce migraine frequency. Along with the reduction of acute migraine-specific medication intake, early onset of efficacy of mAbs has been demonstrated. Most common adverse events are injection sider reactions. Depending on the mAb, the administration mode is a monthly or even less frequently s.c. or I.V. formulation. Phase II studies in EM and CM demonstrate that CGRP mAbs are effective anti-migraine preventatives with a beneficial adverse event profile. Further detailed results from larger phase III clinical trials are expected soon.
journal_name
Curr Pain Headache Repjournal_title
Current pain and headache reportsauthors
Israel H,Neeb L,Reuter Udoi
10.1007/s11916-018-0686-4subject
Has Abstractpub_date
2018-04-06 00:00:00pages
38issue
5eissn
1531-3433issn
1534-3081pii
10.1007/s11916-018-0686-4journal_volume
22pub_type
杂志文章,评审abstract：PURPOSE FOR REVIEW:Subarachnoid hemorrhage is a serious and life-threatening medical condition which commonly presents with an acute headache. Unfortunately, it remains frequently misdiagnosed at initial presentation with dire consequences in terms of patient morbidity and mortality. The goal of this paper is to review...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-019-0785-x
更新日期：2019-05-23 00:00:00
abstract：:More than 20 million US women suffer with migraine, two thirds of whom experience menstrually related migraine. Estrogen plays an important role in triggering migraine, and given the numerous hormonal fluctuations throughout a woman's lifetime, there are many opportunities for a hormonal impact. Accurate diagnosis is ...
journal_title：Current pain and headache reports
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doi：10.1007/s11916-007-0194-4
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abstract：:Sports-related or sports-associated headaches are common. They can be benign as in primary exertional headache or may signal serious pathology as in headache associated with traumatic subdural hematoma. Specific sports activities are associated with unique headache conditions such as decompression sickness headache or...
journal_title：Current pain and headache reports
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doi：10.1007/s11916-004-0012-1
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journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-009-0009-x
更新日期：2009-02-01 00:00:00
abstract：:Tension-type headache (TTH) is the most common type of headache in the general population, including individuals over the age of 65 years. Although the prevalence of migraine decreases markedly with age, TTH has a greater tendency to persist later in life. Less commonly, TTH can present for the first time after the ag...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-009-0076-z
更新日期：2009-12-01 00:00:00
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journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-015-0501-4
更新日期：2015-07-01 00:00:00
abstract：:The Chiari I malformation is a cerebellar anomaly of uncertain origin, defined in part as tonsillar herniation of at least 3 to 5 mm below the foramen magnum; it is associated with crowding of the craniocervical junction. It is the most frequent of the Chiari malformations and is associated with headaches, syringohydr...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
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更新日期：2002-08-01 00:00:00
abstract：:Chronic pain is one of the most commonly reported symptoms among sarcoidosis patients. Not only does it significantly affect quality of life, but it also is a source of frustration for both the patient and physician because the etiology for pain often is unknown. Although patients typically complain of neuropathic-typ...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-011-0180-8
更新日期：2011-06-01 00:00:00
abstract：:Migraine is a debilitating neurological disorder with grave consequences for both the individual and society. This review will focus on recent literature investigating how brain structures implicated in reward and aversion contribute to the genesis of migraine pain. There exist many overlapping and interacting brain r...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
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更新日期：2014-05-01 00:00:00
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journal_title：Current pain and headache reports
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更新日期：2018-04-04 00:00:00
abstract：:Trigger points play a part in the development and maintenance of chronic headache states. This article reviews the physiology of trigger points, with a focus on the -latest understanding of their biochemistry. The importance of facial muscle and extraocular muscle trigger points is only beginning to be understood; the...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
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更新日期：2008-10-01 00:00:00
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journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-017-0620-1
更新日期：2017-04-01 00:00:00
abstract：:Migraine and stroke are related in more than one way. Migraine with aura is a risk factor for ischemic stroke in women under age 45 years, particularly when combined with other risk factors such as smoking and oral contraceptives. Further, individuals with migraine with aura seem to have more white matter lesions and ...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-012-0262-2
更新日期：2012-06-01 00:00:00
abstract：PURPOSE OF REVIEW:Chronic low back pain (CLBP) is a major source of physical and psychiatric morbidity and mortality, and the current overreliance on opioid analgesics has contributed to a burgeoning epidemic in the USA. Cognitive behavioral therapy (CBT) is an empirically supported treatment for CLBP, but little infor...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-018-0669-5
更新日期：2018-02-23 00:00:00
abstract：:Involvement by psychiatrists in the care of patients who are terminally ill has been limited historically; however, psychiatrists increasingly are participating in the care of these people who are facing the most challenging times of their lives. Pain management is considered to be an area of subspecialization for psy...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-003-0018-0
更新日期：2003-04-01 00:00:00
abstract：:Significant improvement of neuropathic pain has been achieved with studies that have demonstrated efficacy of newer anticonvulsants in relieving this type of pain, by having a neuromodulatory effect on the hyperexcitable damaged nervous system. Two drugs from this class, gabapentin and lamotrigine, have been submitted...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-004-0054-4
更新日期：2004-06-01 00:00:00
abstract：:Little is known about specific changes of cognitive processing in cluster headache. Studies on event-related potentials (ERP) suggest that stimulus evaluation is impaired in chronic cluster headache and in episodic cluster headache during the cluster period, but not in the interval between two periods. Patients with c...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-005-0047-y
更新日期：2005-04-01 00:00:00
abstract：:A number of patients attending specialty headache centers complain of very frequent, almost continuous headaches, which are usually grouped together under the term chronic daily headache (CDH), a category which does not appear in the International Headache Society (IHS) classification published in 1988. More than 10 y...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-001-0072-4
更新日期：2001-12-01 00:00:00
abstract：:The clinical features of trigeminal autonomic cephalalgias (TACs), such as trigeminal distribution of pain, circadian/circannual rhythmicity, and ipsilateral cranial autonomic features, suggest a crucial role of the hypothalamus in the underlying pathophysiology of these primary headache disorders. Hypothalamic involv...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-010-0166-y
更新日期：2011-04-01 00:00:00
abstract：:Fibromyalgia syndrome, a chronic condition typically characterized by widespread pain, nonrestorative sleep, fatigue, cognitive dysfunction, and other somatic symptoms, negatively impacts physical and emotional function and reduces quality of life. Exercise is commonly recommended in the management of people with fibr...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
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更新日期：2011-10-01 00:00:00
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journal_title：Current pain and headache reports
pub_type： 杂志文章
doi：10.1007/s11916-019-0830-9
更新日期：2019-11-14 00:00:00
abstract：:Neurostimulation techniques for the treatment of primary headache syndromes, particularly for chronic cluster headache (CCH), have received much interest in the recent years. Occipital nerve stimulation (ONS) has yielded favourable clinical results, and is becoming a routine treatment for refractory chronic cluster he...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-013-0324-0
更新日期：2013-05-01 00:00:00
abstract：:Migraine and cluster headache have been considered entirely separate clinical syndromes, both in routine clinical practice and in the 1988 International Headache Society classification. Neurologists seeing large numbers of patients soon realize, however, that there is a considerable overlap between the two conditions....
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-001-0012-3
更新日期：2001-02-01 00:00:00
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journal_title：Current pain and headache reports
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doi：10.1007/s11916-020-0843-4
更新日期：2020-03-12 00:00:00
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journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
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更新日期：2019-03-04 00:00:00
abstract：PURPOSE OF THE REVIEW:The goals of this review are to evaluate recent studies regarding comorbidity between migraine and different metabolic and endocrine disorders and to discuss the role of insulin resistance as a common pathogenetic mechanism of these diseases. RECENT FINDINGS:Recently, several studies showed that ...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-018-0691-7
更新日期：2018-04-04 00:00:00
abstract：:Chronic primary headaches are widespread disorders which cause significant quality of life and socioprofessional impairment. Available pharmacological treatments have often a limited efficacy and/or can generate unbearable side effects. Electrical nerve stimulation is a well-known non-destructive method of pain modula...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
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更新日期：2016-11-01 00:00:00
abstract：:Pain can be a significant problem for the patient with advanced cancer, particularly if bone metastases are present. Radiation therapy is efficacious and has been a mainstay in the treatment of pain from bone metastases. In the past decade, radiosurgery has developed into a successful adjunct treatment for these patie...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-009-0044-7
更新日期：2009-08-01 00:00:00
abstract：:Most patients who have been diagnosed with cancer will experience pain at some point during the course of their disease. Often, opioid analgesics are not enough to completely alleviate the patient's pain and the selection of appropriate adjunct analgesic agents is critical. This article reviews the mechanisms of actio...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-001-0036-8
更新日期：2001-06-01 00:00:00
abstract：:Health care professionals caring for neonates (birth to 28 days of life) and infants up to 1 year of age have a professional and ethical responsibility to provide safe and effective pain management during painful procedures. Despite 14 years of research reports highlighting that sick infants are exposed to large numbe...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-009-0091-0
更新日期：2010-04-01 00:00:00
