Abstract：
:Quantitative sensory testing (QST) is a widely accepted tool to investigate somatosensory changes in pain patients. Many different protocols have been developed in clinical pain research within recent years. In this review, we provide an overview of QST and tested neuroanatomical pathways, including peripheral and central structures. Based on research studies using animal and human surrogate models of neuropathic pain, possible underlying mechanisms of chronic pain are discussed. Clinically, QST may be useful for 1) the identification of subgroups of patients with different underlying pain mechanisms; 2) prediction of therapeutic outcomes; and 3) quantification of therapeutic interventions in pain therapy. Combined with sensory mapping, QST may provide useful information on the site of neural damage and on mechanisms of positive and negative somatosensory abnormalities. The use of QST in individual patients for diagnostic purposes leading to individualized therapy is an interesting concept, but needs further validation.
journal_name
Curr Pain Headache Repjournal_title
Current pain and headache reportsauthors
Pfau DB,Geber C,Birklein F,Treede RDdoi
10.1007/s11916-012-0261-3subject
Has Abstractpub_date
2012-06-01 00:00:00pages
199-206issue
3eissn
1531-3433issn
1534-3081journal_volume
16pub_type
杂志文章,评审abstract：:Pain can be a significant problem for the patient with advanced cancer, particularly if bone metastases are present. Radiation therapy is efficacious and has been a mainstay in the treatment of pain from bone metastases. In the past decade, radiosurgery has developed into a successful adjunct treatment for these patie...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-009-0044-7
更新日期：2009-08-01 00:00:00
abstract：:Electrical stimulation has been used since ancient times to treat painful conditions. Electrotherapy for pain was largely consigned to the realm of quackery until the introduction of the Gate Control Theory by Melzack and Wall in 1965 provided a rationale for direct stimulation of peripheral nerves. Since that time, p...
journal_title：Current pain and headache reports
pub_type： 历史文章,杂志文章,评审
doi：10.1007/s11916-008-0006-5
更新日期：2008-01-01 00:00:00
abstract：:Individually, childhood epilepsy and migraine are two of the most common conditions seen in pediatric neurology. What complicates matters is that there can be marked similarities between migraine and epilepsy as well as a variety of underlying conditions that predispose children to both seizures and headache. Thus, se...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-013-0402-3
更新日期：2014-03-01 00:00:00
abstract：:While pain is a common symptom among older adults, it often is underdiagnosed and undertreated. Aging-related physiological changes, misperceptions about the use of pain medications by both patients and providers, and the lack of evidence-based clinical research on pain management in older adults are some of the reaso...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-010-0148-0
更新日期：2010-12-01 00:00:00
abstract：:Chronic pain is a complex disorder to which medical and psychological factors both contribute and react. While there are numerous chronic pain conditions, they share certain experiences. This review examines some of the psychological factors that are common to the pain experience and some of the psychologically-based ...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-015-0517-9
更新日期：2015-09-01 00:00:00
abstract：:The use of analgesic and anti-inflammatory injections in athletics has a long and sometimes controversial history. They have been and will continue to be utilized to decrease inflammation and pain, improve healing time, and ultimately decrease the amount of time missed from sports competition. Several authors have eva...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-005-0069-5
更新日期：2005-02-01 00:00:00
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journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-012-0262-2
更新日期：2012-06-01 00:00:00
abstract：:This paper identifies legal issues of relevance to the diagnosis and treatment of cluster headache, including areas of actual and potential malpractice liability. Legal topics that are relevant to cluster headache can be divided into five categories: diagnostic-related issues, risks inherent in the disease process, pr...
journal_title：Current pain and headache reports
pub_type： 杂志文章
doi：10.1007/s11916-004-0029-5
更新日期：2004-04-01 00:00:00
abstract：:Nociceptive nerve endings in muscles and other tissues are equipped with a multitude of receptor molecules for endogenous pain-producing and sensitizing agents. Particularly interesting molecules are the purinergic receptors, which can be activated by adenosine triphosphate (ATP), and the vanilloid receptor, which is ...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-003-0057-6
更新日期：2003-12-01 00:00:00
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journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-011-0184-4
更新日期：2011-06-01 00:00:00
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journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-008-0035-0
更新日期：2008-06-01 00:00:00
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journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-012-0250-6
更新日期：2012-04-01 00:00:00
abstract：:Fibromyalgia syndrome, a chronic condition typically characterized by widespread pain, nonrestorative sleep, fatigue, cognitive dysfunction, and other somatic symptoms, negatively impacts physical and emotional function and reduces quality of life. Exercise is commonly recommended in the management of people with fibr...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-011-0214-2
更新日期：2011-10-01 00:00:00
abstract：:The understanding of migraine pathophysiology has evolved from the belief that migraine is a vascular disorder, to evidence that better defines migraine as a neurogenic disorder associated with secondary changes in brain perfusion. There is evidence to suggest that the early phase of migraine pain results from neuroge...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-006-0042-y
更新日期：2006-06-01 00:00:00
abstract：:Cancer pain is a well-documented and prevalent healthcare problem, with current treatment strategies often failing to achieve acceptable efficacy. One of the major difficulties in treating cancer pain owes to the complex interplay between the cancer microenvironment, cancer therapy, and the body's own responses to the...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-013-0384-1
更新日期：2014-01-01 00:00:00
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journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-001-0036-8
更新日期：2001-06-01 00:00:00
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journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-014-0421-8
更新日期：2014-06-01 00:00:00
abstract：:The lumbar spine forms the foundation and infrastructure of an organic skyscraper equipped with the physiologic capacity to act as a crane for lifting and a crankshaft for walking. Subjected to aging like other "human machinery," the lumbar spine adapts to the wear and tear of gravity and biomechanical loading through...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-002-0005-x
更新日期：2002-04-01 00:00:00
abstract：:Trigger points play a part in the development and maintenance of chronic headache states. This article reviews the physiology of trigger points, with a focus on the -latest understanding of their biochemistry. The importance of facial muscle and extraocular muscle trigger points is only beginning to be understood; the...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-008-0059-5
更新日期：2008-10-01 00:00:00
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journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-013-0324-0
更新日期：2013-05-01 00:00:00
abstract：PURPOSE OF REVIEW:Athletic neurosurgical emergencies are injuries that can lead to mortality or significant morbidity and require immediate recognition and treatment. This review article discusses the epidemiology of sports-related traumatic brain injury (TBI) with an attempt to quantify the incidence of neurosurgical ...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-016-0586-4
更新日期：2016-09-01 00:00:00
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journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-001-0026-x
更新日期：2001-08-01 00:00:00
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journal_title：Current pain and headache reports
pub_type： 杂志文章
doi：10.1007/s11916-020-0843-4
更新日期：2020-03-12 00:00:00
abstract：:New imaging technology allows us to study neurologic disorders that have had no previous structural basis. There have been recent reports on the involvement of nociceptive pathways in daily headache. A systematic review was performed using key words "chronic daily headache" and "imaging." This paper reviews the litera...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-003-0074-5
更新日期：2003-06-01 00:00:00
abstract：:Sports-related or sports-associated headaches are common. They can be benign as in primary exertional headache or may signal serious pathology as in headache associated with traumatic subdural hematoma. Specific sports activities are associated with unique headache conditions such as decompression sickness headache or...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-004-0012-1
更新日期：2004-08-01 00:00:00
abstract：:Migraine and tension-type headache (TTH) are highly prevalent primary headaches that remain underdiagnosed and undertreated in clinical practice. The similarities and differences between migraine and TTH may impose diagnostic challenges as well as management difficulties. In addition, the possibility of migraine chron...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-007-0232-2
更新日期：2007-12-01 00:00:00
abstract：:Addiction to opioid analgesics is an important and yet underinvestigated clinical issue, which has substantial implications in opioid therapy for chronic pain management. Problematic opioid use, including compulsive opioid seeking and addiction, arises in some fraction of opioid-treated chronic pain patients. The conn...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-009-0086-x
更新日期：2010-02-01 00:00:00
abstract：:Empathy is a provider attribute that has been a topic of increased clinical interest, particularly as it relates to pain. This article examines various dimensions of the pain and empathy literature: definitions of empathy, research regarding the psychophysiology of empathy for pain, and research related to empathy in ...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-008-0021-6
更新日期：2008-04-01 00:00:00
abstract：:Opioids have become the unequivocal therapy of choice in treating many varieties of chronic pain. With the increased prescription of opioids, some unintended consequences have occurred. After prolonged opioid exposure, opioid-induced hyperalgesia (OIH), the paradoxical effect that opioid therapy may in fact enhance or...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-010-0171-1
更新日期：2011-04-01 00:00:00
abstract：:Little is known about specific changes of cognitive processing in cluster headache. Studies on event-related potentials (ERP) suggest that stimulus evaluation is impaired in chronic cluster headache and in episodic cluster headache during the cluster period, but not in the interval between two periods. Patients with c...
journal_title：Current pain and headache reports
pub_type： 杂志文章,评审
doi：10.1007/s11916-005-0047-y
更新日期：2005-04-01 00:00:00
