Abstract:
:Neuropathic pain remains a serious medical problem because of patient morbidity and the absence of effective therapeutic interventions. Recent evidence suggests that this type of pain may be particularly difficult to manage because underlying mechanisms are influenced by a variety of factors, including type of injury, site of injury, and time after injury. This situation is exacerbated by the fact that different mechanisms may contribute to unique aspects of neuropathic pain, including ongoing pain as well as mechanical and thermal hypersensitivity. The different ion channels present in primary afferent neurons implicated in each of these aspects of neuropathic pain are reviewed.
journal_name
Curr Pain Headache Repjournal_title
Current pain and headache reportsauthors
Harriott AM,Gold MSdoi
10.1007/s11916-009-0034-9subject
Has Abstractpub_date
2009-06-01 00:00:00pages
197-207issue
3eissn
1531-3433issn
1534-3081journal_volume
13pub_type
杂志文章,评审abstract::Opiate analgesics have been widely used for severe acute pain and chronic cancer-related pain. Individual differences in the effectiveness of opiates and their side effects limit the clinical benefits and increase risks of drug abuse. Genetic factors might affect variations of opiate sensitivity. The mu opioid peptide...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-007-0008-8
更新日期:2007-04-01 00:00:00
abstract::The association of traumatic exposures with posttraumatic stress disorder (PTSD) and other mental health conditions is well known. Patients with chronic pain, particularly headache disorders and fibromyalgia (FM), associated with psychological traumas need a special management strategy. Diagnosis of headache disorders...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-009-0057-2
更新日期:2009-10-01 00:00:00
abstract::More than 20 million US women suffer with migraine, two thirds of whom experience menstrually related migraine. Estrogen plays an important role in triggering migraine, and given the numerous hormonal fluctuations throughout a woman's lifetime, there are many opportunities for a hormonal impact. Accurate diagnosis is ...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-007-0194-4
更新日期:2007-06-01 00:00:00
abstract::Concussion is a significant issue in medicine and the media today. With growing interest on the long-term effects of sports participation, it is important to understand what occurs in the brain after an impact of any degree. While some of the basic pathophysiology has been elucidated, much is still unknown about what ...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-016-0573-9
更新日期:2016-06-01 00:00:00
abstract::Pain is a feared component of cancer for a patient. The patient's prior experience with cancer pain will affect how he or she deals with ongoing and acute onset new pain. Radiation therapy has been and continues to be a major component in the management of cancer pain. New technologies are rapidly becoming available t...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-007-0203-7
更新日期:2007-08-01 00:00:00
abstract::Dissection refers to a tear in the wall of an artery, with the two main types being intracranial or extracranial. Dissections tend to occur most commonly in the young, sometimes secondary to trauma involving the neck. To confirm a dissection, some type of vessel imaging is necessary, including magnetic resonance angio...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-016-0544-1
更新日期:2016-02-01 00:00:00
abstract::Tension-type headache (TTH) is the most common type of headache in the general population, including individuals over the age of 65 years. Although the prevalence of migraine decreases markedly with age, TTH has a greater tendency to persist later in life. Less commonly, TTH can present for the first time after the ag...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-009-0076-z
更新日期:2009-12-01 00:00:00
abstract:PURPOSE OF REVIEW:Total knee arthroplasty traditionally has been associated with significant postoperative pain that can limit recovery and prolong hospital length of stay. Recently, however, due to financial pressures and an emphasis on improving patient satisfaction, many institutions are implementing outpatient and ...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-017-0623-y
更新日期:2017-05-01 00:00:00
abstract::Many animal models of migraine have been described. Some of them have been useful in the development of new therapies. All of them have their shortcomings. Animal models of chronic migraine have been relatively less frequently described. Whether a rigid distinction between episodic and chronic migraine is useful when ...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-014-0467-7
更新日期:2015-01-01 00:00:00
abstract::During gestation, cells of the brain and gut develop almost simultaneously into the central nervous system (CNS) and enteric nervous system (ENS), respectively. They remain connected via the vagal nerve lifelong. While it is well known that the brain sends signal to the gut, communication is in fact bidirectional. Jus...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-015-0501-4
更新日期:2015-07-01 00:00:00
abstract::Health care professionals caring for neonates (birth to 28 days of life) and infants up to 1 year of age have a professional and ethical responsibility to provide safe and effective pain management during painful procedures. Despite 14 years of research reports highlighting that sick infants are exposed to large numbe...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-009-0091-0
更新日期:2010-04-01 00:00:00
abstract::The vast majority of menstruating women experience uncomfortable symptoms during the premenstrual phase of their menstrual cycles. Although many women do not require specific treatment of their symptoms, approximately 20% to 50% report moderate to severe premenstrual symptoms and about 5% meet the diagnostic criteria ...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-010-0131-9
更新日期:2010-10-01 00:00:00
abstract::Cluster headache was first described over 300 years ago, but in the last century our knowledge of the disorder has exploded through both clinical observation and epidemiological data. Although some of the data are conflicting and more need to be obtained, much is known about the disorder. This article reviews the data...
journal_title:Current pain and headache reports
pub_type: 历史文章,杂志文章,评审
doi:10.1007/s11916-009-0024-y
更新日期:2009-04-01 00:00:00
abstract::"Do I have a tumor?" This is a question in every person's mind when first confronted with a new-onset headache, a question that causes considerable anxiety among patients, leading them to seek medical evaluation. This publication reviews the current literature with respect to the epidemiology, pathophysiology presenta...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-014-0421-8
更新日期:2014-06-01 00:00:00
abstract::Tension-type headache is the most common primary headache disorder seen in adults. Although the prevalence peaks in the fourth and fifth decades of life, significant fractions of the elderly continue to experience either episodic or chronic tension-type headaches. Many secondary headache disorders may present with hea...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-006-0076-1
更新日期:2006-12-01 00:00:00
abstract:PURPOSE OF REVIEW:Fibromyalgia (FM) is the second most common rheumatologic pain disorder after osteoarthritis with a multisystem presentation. While the treatment of FM in a clinical setting incorporates both pharmacologic and non-pharmacologic modalities, the present investigation reviews evolving literature on cogni...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-018-0688-2
更新日期:2018-04-04 00:00:00
abstract::The experience of chronic pain can be associated with significant distress and disability; however, this is not always the case. Although attempts to control or reduce pain can be helpful for many pain sufferers, on some occasions this is not an effective option and a different response is required. This different res...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-006-0018-y
更新日期:2006-04-01 00:00:00
abstract::Characteristic symptoms of fibromyalgia syndrome include widespread pain, fatigue, sleep abnormalities, and distress. Patients with fibromyalgia show psychophysical evidence of mechanical, thermal, and electrical hyperalgesia. Peripheral and central abnormalities of nociception have been described in fibromyalgia. Imp...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-002-0046-1
更新日期:2002-08-01 00:00:00
abstract::Cancer-related fatigue (CRF) is either a symptom or a syndrome depending on criteria for diagnosis. CRF is present in 20% to 30% of long-term cancer survivors and 80% to 90% during treatment and at the end of life. Assessment requires determining the presence, severity, and interference with daily activities. Differen...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-006-0030-2
更新日期:2006-08-01 00:00:00
abstract::Over the last few years, attention has increasingly been focused on the evolution of cluster headache over time. Predictive factors have been identified that are correlated with an increased risk of unfavorable evolution from the episodic form to the chronic form of cluster headache. Late onset, the presence of sporad...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-002-0026-5
更新日期:2002-02-01 00:00:00
abstract::Fibromyalgia is a frequent cause of chronic widespread pain and affects up to 5% of the general population. Diagnosis and treatment have been especially challenging due to limited knowledge of etiology and poor response to conventional treatment of pain. Appreciation for the interactions of neurobiologic, psychologic,...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-005-0019-2
更新日期:2005-12-01 00:00:00
abstract::Tension type headache (TTH) is a primary headache disorder considered common in children and adolescents. It remains debatable whether TTH and migraine are separate biological entities. This review summarizes the most recent literature of TTH with regards to children and adolescents. Further studies of TTH are needed ...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-010-0149-z
更新日期:2010-12-01 00:00:00
abstract::A family history of migraine is very frequently noted when evaluating a child for recurrent headaches. This implies an inherited or genetic basis as a component to the underlying pathophysiology. A variety of techniques have begun to elucidate this contribution, including historical observation, population-based studi...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-007-0222-4
更新日期:2007-10-01 00:00:00
abstract::Chiari malformation type I (CMI) involves the caudal displacement of the cerebellar tonsils through the foramen magnum with resultant brainstem compression in some individuals. Due to pathophysiologic changes, secondary conditions may arise, such as syringohydromyelia (SH) and scoliosis. This disorder is unique, as th...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-015-0491-2
更新日期:2015-06-01 00:00:00
abstract:PURPOSE OF REVIEW:Peripheral nerve blocks of the scalp, mainly greater occipital nerve blocks, have received a renewed interest amongst pediatric providers as they offer an alternate option to provide both acute and chronic relief from the suffering of children with difficult to treat headaches. This narrative review w...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-017-0650-8
更新日期:2017-11-09 00:00:00
abstract::Cancer pain is highly prevalent and often severe. Fortunately, most cancer pain can be readily managed, with up to 90% of patients responding well to standard interventions. However, breakthrough cancer pain-brief flares of severe pain superimposed on baseline pain-is common, difficult to manage, and often negatively ...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-008-0042-1
更新日期:2008-08-01 00:00:00
abstract::Chronic pain affects more individuals than does cancer, heart disease, and diabetes combined. Yet, our treatment options remain remarkably limited. Often, highly effective psychotherapeutic approaches are limited by many barriers such as access, reimbursement, and acceptability; however, resilience-based positive acti...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-016-0567-7
更新日期:2016-06-01 00:00:00
abstract:PURPOSE FOR REVIEW:Subarachnoid hemorrhage is a serious and life-threatening medical condition which commonly presents with an acute headache. Unfortunately, it remains frequently misdiagnosed at initial presentation with dire consequences in terms of patient morbidity and mortality. The goal of this paper is to review...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-019-0785-x
更新日期:2019-05-23 00:00:00
abstract:PURPOSE OF REVIEW:This review highlights the importance of osteopathic manipulative treatment (OMT) in headache sufferers. OMT is a viable option for patients who either do not wish to use pharmaceuticals or who have contraindications to pharmaceuticals. Patients with headaches that are refractory to other treatment op...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-018-0736-y
更新日期:2018-10-05 00:00:00
abstract::Although the majority of children with cancer are cured of their illness, the children who die from their disease or complications require special care at the end of life. We present special issues and challenges unique to pediatric palliative care and suggest ways in which we can face these issues and address the cha...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-005-0032-5
更新日期:2005-08-01 00:00:00