Contribution of primary afferent channels to neuropathic pain.

Abstract:

:Neuropathic pain remains a serious medical problem because of patient morbidity and the absence of effective therapeutic interventions. Recent evidence suggests that this type of pain may be particularly difficult to manage because underlying mechanisms are influenced by a variety of factors, including type of injury, site of injury, and time after injury. This situation is exacerbated by the fact that different mechanisms may contribute to unique aspects of neuropathic pain, including ongoing pain as well as mechanical and thermal hypersensitivity. The different ion channels present in primary afferent neurons implicated in each of these aspects of neuropathic pain are reviewed.

journal_name

Curr Pain Headache Rep

authors

Harriott AM,Gold MS

doi

10.1007/s11916-009-0034-9

subject

Has Abstract

pub_date

2009-06-01 00:00:00

pages

197-207

issue

3

eissn

1531-3433

issn

1534-3081

journal_volume

13

pub_type

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