Abstract:
:Cancer pain is a well-documented and prevalent healthcare problem, with current treatment strategies often failing to achieve acceptable efficacy. One of the major difficulties in treating cancer pain owes to the complex interplay between the cancer microenvironment, cancer therapy, and the body's own responses to these biochemical changes. A better understanding of the molecular pathways of nociception that are activated during cancer progression and treatment is necessary for better pain management and increased quality of life. This article reviews the current research that implicates oxidative stress as an important target for attenuating cancer pain. Sources of oxidative stress are first established, followed by a discussion of the various pathways that are affected by oxidative stress and that ultimately cause cancer pain.
journal_name
Curr Pain Headache Repjournal_title
Current pain and headache reportsauthors
Nashed MG,Balenko MD,Singh Gdoi
10.1007/s11916-013-0384-1subject
Has Abstractpub_date
2014-01-01 00:00:00pages
384issue
1eissn
1531-3433issn
1534-3081journal_volume
18pub_type
杂志文章,评审abstract::Opioids have become the unequivocal therapy of choice in treating many varieties of chronic pain. With the increased prescription of opioids, some unintended consequences have occurred. After prolonged opioid exposure, opioid-induced hyperalgesia (OIH), the paradoxical effect that opioid therapy may in fact enhance or...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-010-0171-1
更新日期:2011-04-01 00:00:00
abstract::Although the majority of children with cancer are cured of their illness, the children who die from their disease or complications require special care at the end of life. We present special issues and challenges unique to pediatric palliative care and suggest ways in which we can face these issues and address the cha...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-005-0032-5
更新日期:2005-08-01 00:00:00
abstract::A number of patients attending specialty headache centers complain of very frequent, almost continuous headaches, which are usually grouped together under the term chronic daily headache (CDH), a category which does not appear in the International Headache Society (IHS) classification published in 1988. More than 10 y...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-001-0072-4
更新日期:2001-12-01 00:00:00
abstract::The experience of chronic pain can be associated with significant distress and disability; however, this is not always the case. Although attempts to control or reduce pain can be helpful for many pain sufferers, on some occasions this is not an effective option and a different response is required. This different res...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-006-0018-y
更新日期:2006-04-01 00:00:00
abstract::The vast majority of menstruating women experience uncomfortable symptoms during the premenstrual phase of their menstrual cycles. Although many women do not require specific treatment of their symptoms, approximately 20% to 50% report moderate to severe premenstrual symptoms and about 5% meet the diagnostic criteria ...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-010-0131-9
更新日期:2010-10-01 00:00:00
abstract::Pain is a feared component of cancer for a patient. The patient's prior experience with cancer pain will affect how he or she deals with ongoing and acute onset new pain. Radiation therapy has been and continues to be a major component in the management of cancer pain. New technologies are rapidly becoming available t...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-007-0203-7
更新日期:2007-08-01 00:00:00
abstract::Fibromyalgia syndrome, a chronic condition typically characterized by widespread pain, nonrestorative sleep, fatigue, cognitive dysfunction, and other somatic symptoms, negatively impacts physical and emotional function and reduces quality of life. Exercise is commonly recommended in the management of people with fibr...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-011-0214-2
更新日期:2011-10-01 00:00:00
abstract::Migraine is a debilitating neurological disorder with grave consequences for both the individual and society. This review will focus on recent literature investigating how brain structures implicated in reward and aversion contribute to the genesis of migraine pain. There exist many overlapping and interacting brain r...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-014-0410-y
更新日期:2014-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Chronic venous disease (CVD), although affecting up to 40% of the US population, is often underdiagnosed by healthcare professionals due to an incomplete understanding of the presenting symptoms. CVD is a common cause of lower extremity pain and discomfort, including aching, cramping, tingling, burnin...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-019-0759-z
更新日期:2019-03-04 00:00:00
abstract::Nociceptive nerve endings in muscles and other tissues are equipped with a multitude of receptor molecules for endogenous pain-producing and sensitizing agents. Particularly interesting molecules are the purinergic receptors, which can be activated by adenosine triphosphate (ATP), and the vanilloid receptor, which is ...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-003-0057-6
更新日期:2003-12-01 00:00:00
abstract::The Chiari I malformation is a cerebellar anomaly of uncertain origin, defined in part as tonsillar herniation of at least 3 to 5 mm below the foramen magnum; it is associated with crowding of the craniocervical junction. It is the most frequent of the Chiari malformations and is associated with headaches, syringohydr...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-002-0056-z
更新日期:2002-08-01 00:00:00
abstract::New imaging technology allows us to study neurologic disorders that have had no previous structural basis. There have been recent reports on the involvement of nociceptive pathways in daily headache. A systematic review was performed using key words "chronic daily headache" and "imaging." This paper reviews the litera...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-003-0074-5
更新日期:2003-06-01 00:00:00
abstract:PURPOSE OF REVIEW:The purpose of the present systematic review is to provide a current understanding of the mechanism of action and the evidence available to support clinical decision-making. The focus is to summarize randomized controlled trials (RCTs) and nonrandomized or observational studies of spinal cord stimulat...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-020-00907-2
更新日期:2020-09-30 00:00:00
abstract:PURPOSE OF REVIEW:CGRP is a key neuropeptide in migraine pathophysiology. The blockade of the CGRP pathway at the side of the CGRP receptor of the CGRP peptide leads to the interruption of trigeminal nerve system-mediated headache syndromes such as migraine. Monoclonal antibodies (mAbs) targeting the CGRP pathway have ...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-018-0686-4
更新日期:2018-04-06 00:00:00
abstract:PURPOSE OF REVIEW:Cervicogenic headache (CHA) is a secondary headache which has a source in the upper cervical spine. Many traditional analgesic choices lack good efficacy in managing the associated pain. As a result, in management of CHA, radiofrequency ablation (RFA) or pulse radiofrequency (PRF) has been tried with ...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-018-0673-9
更新日期:2018-02-23 00:00:00
abstract::Chronic pain is a complex disorder to which medical and psychological factors both contribute and react. While there are numerous chronic pain conditions, they share certain experiences. This review examines some of the psychological factors that are common to the pain experience and some of the psychologically-based ...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-015-0517-9
更新日期:2015-09-01 00:00:00
abstract::Neuropathic pain remains a serious medical problem because of patient morbidity and the absence of effective therapeutic interventions. Recent evidence suggests that this type of pain may be particularly difficult to manage because underlying mechanisms are influenced by a variety of factors, including type of injury,...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-009-0034-9
更新日期:2009-06-01 00:00:00
abstract::Hormonal and nonhormonal factors play a role in the pathophysiology of menstrual migraine, but estrogen withdrawal appears to be the most potent of these factors. It is postulated that estrogen withdrawal directly enhances excitability of trigeminal afferents, modulates the synthesis of neuropeptides, activates/deacti...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-008-0077-3
更新日期:2008-12-01 00:00:00
abstract:PURPOSE OF REVIEW:The purpose of this review is to provide a summary of the perioperative studies that have examined transdermal lidocaine (lidocaine patch) as an analgesic and put the evidence in context of the likely overall benefit of transdermal lidocaine in the perioperative period. RECENT FINDINGS:Several random...
journal_title:Current pain and headache reports
pub_type: 杂志文章
doi:10.1007/s11916-019-0830-9
更新日期:2019-11-14 00:00:00
abstract::Addiction to opioid analgesics is an important and yet underinvestigated clinical issue, which has substantial implications in opioid therapy for chronic pain management. Problematic opioid use, including compulsive opioid seeking and addiction, arises in some fraction of opioid-treated chronic pain patients. The conn...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-009-0086-x
更新日期:2010-02-01 00:00:00
abstract::Treatment options for neuropathic pain have limited efficacy and use is fraught with dose-limiting adverse effects. The endocannabinoid system has been elucidated over the last several years, demonstrating a significant interface with pain homeostasis. Exogenous cannabinoids have been demonstrated to be effective in a...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-014-0451-2
更新日期:2014-10-01 00:00:00
abstract::Migraine and stroke are related in more than one way. Migraine with aura is a risk factor for ischemic stroke in women under age 45 years, particularly when combined with other risk factors such as smoking and oral contraceptives. Further, individuals with migraine with aura seem to have more white matter lesions and ...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-012-0262-2
更新日期:2012-06-01 00:00:00
abstract::Weight gain is a common side effect of drugs used for headache prevention. Weight gain can adversely affect patient health, exacerbate comorbid metabolic disorders, and encourage noncompliance. Additionally, obesity may promote the chronification of episodic migraine. Few studies have looked specifically at the effect...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-008-0035-0
更新日期:2008-06-01 00:00:00
abstract:PURPOSE OF THE REVIEW:The goals of this review are to evaluate recent studies regarding comorbidity between migraine and different metabolic and endocrine disorders and to discuss the role of insulin resistance as a common pathogenetic mechanism of these diseases. RECENT FINDINGS:Recently, several studies showed that ...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-018-0691-7
更新日期:2018-04-04 00:00:00
abstract::Tension-type headache is the most common primary headache disorder seen in adults. Although the prevalence peaks in the fourth and fifth decades of life, significant fractions of the elderly continue to experience either episodic or chronic tension-type headaches. Many secondary headache disorders may present with hea...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-006-0076-1
更新日期:2006-12-01 00:00:00
abstract::Empathy is a provider attribute that has been a topic of increased clinical interest, particularly as it relates to pain. This article examines various dimensions of the pain and empathy literature: definitions of empathy, research regarding the psychophysiology of empathy for pain, and research related to empathy in ...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-008-0021-6
更新日期:2008-04-01 00:00:00
abstract::Dissection refers to a tear in the wall of an artery, with the two main types being intracranial or extracranial. Dissections tend to occur most commonly in the young, sometimes secondary to trauma involving the neck. To confirm a dissection, some type of vessel imaging is necessary, including magnetic resonance angio...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-016-0544-1
更新日期:2016-02-01 00:00:00
abstract::The understanding of migraine pathophysiology has evolved from the belief that migraine is a vascular disorder, to evidence that better defines migraine as a neurogenic disorder associated with secondary changes in brain perfusion. There is evidence to suggest that the early phase of migraine pain results from neuroge...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-006-0042-y
更新日期:2006-06-01 00:00:00
abstract::The most likely future of aggressive headache treatment will reside in the sphere of the specialist's clinic. This is a far more cost- and time-effective mode of treating intractable chronic daily headaches (CDH), including chronic migraines. We have used this technique successfully in our clinic for many years. Our e...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-006-0009-z
更新日期:2006-02-01 00:00:00
abstract::Pain can be a significant problem for the patient with advanced cancer, particularly if bone metastases are present. Radiation therapy is efficacious and has been a mainstay in the treatment of pain from bone metastases. In the past decade, radiosurgery has developed into a successful adjunct treatment for these patie...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-009-0044-7
更新日期:2009-08-01 00:00:00