Cannabinoids for neuropathic pain.

Abstract:

:Treatment options for neuropathic pain have limited efficacy and use is fraught with dose-limiting adverse effects. The endocannabinoid system has been elucidated over the last several years, demonstrating a significant interface with pain homeostasis. Exogenous cannabinoids have been demonstrated to be effective in a range of experimental neuropathic pain models, and there is mounting evidence for therapeutic use in human neuropathic pain conditions. This article reviews the history, pharmacologic development, clinical trials results, and the future potential of nonsmoked, orally bioavailable, nonpsychoactive cannabinoids in the management of neuropathic pain.

journal_name

Curr Pain Headache Rep

authors

Fine PG,Rosenfeld MJ

doi

10.1007/s11916-014-0451-2

subject

Has Abstract

pub_date

2014-10-01 00:00:00

pages

451

issue

10

eissn

1531-3433

issn

1534-3081

journal_volume

18

pub_type

杂志文章,评审
  • Migrainous features in cluster headache.

    abstract::Migraine and cluster headache have been considered entirely separate clinical syndromes, both in routine clinical practice and in the 1988 International Headache Society classification. Neurologists seeing large numbers of patients soon realize, however, that there is a considerable overlap between the two conditions....

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-001-0012-3

    authors: Peatfield R

    更新日期:2001-02-01 00:00:00

  • It IS a tumor -- current review of headache and brain tumor.

    abstract::"Do I have a tumor?" This is a question in every person's mind when first confronted with a new-onset headache, a question that causes considerable anxiety among patients, leading them to seek medical evaluation. This publication reviews the current literature with respect to the epidemiology, pathophysiology presenta...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-014-0421-8

    authors: Kahn K,Finkel A

    更新日期:2014-06-01 00:00:00

  • Systematic Review of Radiofrequency Ablation and Pulsed Radiofrequency for Management of Cervicogenic Headaches.

    abstract:PURPOSE OF REVIEW:Cervicogenic headache (CHA) is a secondary headache which has a source in the upper cervical spine. Many traditional analgesic choices lack good efficacy in managing the associated pain. As a result, in management of CHA, radiofrequency ablation (RFA) or pulse radiofrequency (PRF) has been tried with ...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-018-0673-9

    authors: Grandhi RK,Kaye AD,Abd-Elsayed A

    更新日期:2018-02-23 00:00:00

  • Cognitive Behavioral Therapy (CBT) for Subacute Low Back Pain: a Systematic Review.

    abstract:PURPOSE OF REVIEW:Chronic low back pain (CLBP) is a major source of physical and psychiatric morbidity and mortality, and the current overreliance on opioid analgesics has contributed to a burgeoning epidemic in the USA. Cognitive behavioral therapy (CBT) is an empirically supported treatment for CLBP, but little infor...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-018-0669-5

    authors: Mariano TY,Urman RD,Hutchison CA,Jamison RN,Edwards RR

    更新日期:2018-02-23 00:00:00

  • Spinal cord stimulation in cluster headache.

    abstract::Neurostimulation techniques for the treatment of primary headache syndromes, particularly for chronic cluster headache (CCH), have received much interest in the recent years. Occipital nerve stimulation (ONS) has yielded favourable clinical results, and is becoming a routine treatment for refractory chronic cluster he...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-013-0324-0

    authors: Wolter T,Kaube H

    更新日期:2013-05-01 00:00:00

  • The Pathophysiology of Concussion.

    abstract::Concussion is a significant issue in medicine and the media today. With growing interest on the long-term effects of sports participation, it is important to understand what occurs in the brain after an impact of any degree. While some of the basic pathophysiology has been elucidated, much is still unknown about what ...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-016-0573-9

    authors: Choe MC

    更新日期:2016-06-01 00:00:00

  • Neurosurgical Emergencies in Sports Neurology.

    abstract:PURPOSE OF REVIEW:Athletic neurosurgical emergencies are injuries that can lead to mortality or significant morbidity and require immediate recognition and treatment. This review article discusses the epidemiology of sports-related traumatic brain injury (TBI) with an attempt to quantify the incidence of neurosurgical ...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-016-0586-4

    authors: Ban VS,Botros JA,Madden CJ,Batjer HH

    更新日期:2016-09-01 00:00:00

  • Pharmacologic therapies for complex regional pain syndrome.

    abstract::Complex regional pain syndrome (CRPS) remains a challenging condition to diagnose and treat. There are few large-scale, randomized trials of pharmacologic agents, and most published studies are small, uncontrolled, or presented only in abstract form at meetings. The most commonly used agents, such as anticonvulsants, ...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-007-0020-z

    authors: Mackey S,Feinberg S

    更新日期:2007-02-01 00:00:00

  • Complementary medicine in cancer care: adding a therapy dog to the team.

    abstract::Animal-assisted therapy, including visits from certified therapy dogs, offer a valuable and often underutilized resource for addressing unmet needs in cancer patients. Prospective research studies have documented symptomatic benefits for reducing pain, psychological distress, and fatigue in a variety of patient popula...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章

    doi:10.1007/s11916-012-0264-0

    authors: Marcus DA

    更新日期:2012-08-01 00:00:00

  • The use of complementary medical therapies in the management of myofascial pain disorders.

    abstract::Complementary medical therapies are commonly used for the treatment and management of myofascial pain. No universally accepted therapy for this condition exists; consequently, patients often seek alternative and complementary therapies. Many complementary treatments are available.This article focuses on acupuncture, b...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-002-0078-6

    authors: Harris RE,Clauw DJ

    更新日期:2002-10-01 00:00:00

  • Pain and opioid addiction: what is the connection?

    abstract::Addiction to opioid analgesics is an important and yet underinvestigated clinical issue, which has substantial implications in opioid therapy for chronic pain management. Problematic opioid use, including compulsive opioid seeking and addiction, arises in some fraction of opioid-treated chronic pain patients. The conn...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-009-0086-x

    authors: Carinci AJ,Mao J

    更新日期:2010-02-01 00:00:00

  • Neuromodulating drugs for the symptomatic treatment of neuropathic pain.

    abstract::Significant improvement of neuropathic pain has been achieved with studies that have demonstrated efficacy of newer anticonvulsants in relieving this type of pain, by having a neuromodulatory effect on the hyperexcitable damaged nervous system. Two drugs from this class, gabapentin and lamotrigine, have been submitted...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-004-0054-4

    authors: Backonja M

    更新日期:2004-06-01 00:00:00

  • Spinal agents for acute pain management.

    abstract::This article describes the current and investigational agents for use in the treatment of acute pain. The use of spinal and epidural routes also are discussed. ...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-004-0037-5

    authors: Bowen G,Viscusi ER,Andonakakis A

    更新日期:2004-02-01 00:00:00

  • Sedation for comfort at end of life.

    abstract::Treatment for patients who are dying from cancer and are suffering with physiologic and existential symptoms is an important and valuable skill for health care providers. However, the treatment for suffering at the end of life and the use of sedation for comfort often are misunderstood. The following is a discussion o...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-002-0035-4

    authors: Walton O,Weinstein SM

    更新日期:2002-06-01 00:00:00

  • Animal models of chronic migraine.

    abstract::Many animal models of migraine have been described. Some of them have been useful in the development of new therapies. All of them have their shortcomings. Animal models of chronic migraine have been relatively less frequently described. Whether a rigid distinction between episodic and chronic migraine is useful when ...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-014-0467-7

    authors: Storer RJ,Supronsinchai W,Srikiatkhachorn A

    更新日期:2015-01-01 00:00:00

  • Intravenous treatment of chronic daily headaches in the outpatient headache clinic.

    abstract::The most likely future of aggressive headache treatment will reside in the sphere of the specialist's clinic. This is a far more cost- and time-effective mode of treating intractable chronic daily headaches (CDH), including chronic migraines. We have used this technique successfully in our clinic for many years. Our e...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-006-0009-z

    authors: Krusz JC

    更新日期:2006-02-01 00:00:00

  • Psychological trauma in chronic pain: implications of PTSD for fibromyalgia and headache disorders.

    abstract::The association of traumatic exposures with posttraumatic stress disorder (PTSD) and other mental health conditions is well known. Patients with chronic pain, particularly headache disorders and fibromyalgia (FM), associated with psychological traumas need a special management strategy. Diagnosis of headache disorders...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-009-0057-2

    authors: Peres JF,Gonçalves AL,Peres MF

    更新日期:2009-10-01 00:00:00

  • A review of the use of topical analgesics for myofascial pain.

    abstract::Numerous treatment strategies for myofascial pain syndrome are available, including physical therapy, behavioral pain management techniques, acupuncture, various types of injections, and the use of various pharmacotherapeutic approaches. The use of topical analgesics for myofascial pain syndrome is the focus of this r...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-002-0079-5

    authors: Argoff CE

    更新日期:2002-10-01 00:00:00

  • Pragmatic consideration of recent randomized, placebo-controlled clinical trials for treatment of fibromyalgia.

    abstract::A flurry of recent randomized, placebo-controlled trials assessing dissimilar pharmacotherapeutic treatment options for fibromyalgia (FM) have been presented in the past few years. This review evaluates these trials in light of recent pathophysiological concepts germane to FM, including mood disorders, autonomic dysre...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-008-0067-5

    authors: Holman AJ

    更新日期:2008-12-01 00:00:00

  • Invasive and Non-invasive Electrical Pericranial Nerve Stimulation for the Treatment of Chronic Primary Headaches.

    abstract::Chronic primary headaches are widespread disorders which cause significant quality of life and socioprofessional impairment. Available pharmacological treatments have often a limited efficacy and/or can generate unbearable side effects. Electrical nerve stimulation is a well-known non-destructive method of pain modula...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-016-0589-1

    authors: D'Ostilio K,Magis D

    更新日期:2016-11-01 00:00:00

  • Quantitative sensory testing of neuropathic pain patients: potential mechanistic and therapeutic implications.

    abstract::Quantitative sensory testing (QST) is a widely accepted tool to investigate somatosensory changes in pain patients. Many different protocols have been developed in clinical pain research within recent years. In this review, we provide an overview of QST and tested neuroanatomical pathways, including peripheral and cen...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-012-0261-3

    authors: Pfau DB,Geber C,Birklein F,Treede RD

    更新日期:2012-06-01 00:00:00

  • Non-oral formulations of triptans and their use in acute migraine.

    abstract::The introduction of triptans (5-HT (1B/1D) agonists) into clinical practice has expanded the therapeutic options for doctors treating migraine sufferers. The triptans are available in several different formulations such as conventional oral tablets, orally disintegrating wafers, subcutaneous injections, nasal sprays, ...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-005-0064-x

    authors: Dahlöf CG

    更新日期:2005-06-01 00:00:00

  • Alcohol and migraine: what should we tell patients?

    abstract::Alcoholic drinks are a migraine trigger in about one third of patients with migraine in retrospective studies on trigger factors. Many population studies show that patients with migraine consume alcohol in a smaller percentage than the general population. Moreover, research has shown a decreased prevalence of headache...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-011-0184-4

    authors: Panconesi A,Bartolozzi ML,Guidi L

    更新日期:2011-06-01 00:00:00

  • Managing difficult pain conditions in the cancer patient.

    abstract::Whereas most pain due to cancer can be relieved with relatively simple methods using oral analgesics, as suggested by WHO guidelines, some patients may have difficult pain situations that require more complex approaches. It is estimated that 10-20 % of cancer patients suffer from pain that is not easily relieved. Ther...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-013-0395-y

    authors: Mercadante S

    更新日期:2014-02-01 00:00:00

  • Issues and challenges in palliative care for children with cancer.

    abstract::Although the majority of children with cancer are cured of their illness, the children who die from their disease or complications require special care at the end of life. We present special issues and challenges unique to pediatric palliative care and suggest ways in which we can face these issues and address the cha...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-005-0032-5

    authors: Friedman DL,Hilden JM,Powaski K

    更新日期:2005-08-01 00:00:00

  • Peripheral nerve stimulation for chronic pain.

    abstract::Electrical stimulation has been used since ancient times to treat painful conditions. Electrotherapy for pain was largely consigned to the realm of quackery until the introduction of the Gate Control Theory by Melzack and Wall in 1965 provided a rationale for direct stimulation of peripheral nerves. Since that time, p...

    journal_title:Current pain and headache reports

    pub_type: 历史文章,杂志文章,评审

    doi:10.1007/s11916-008-0006-5

    authors: Henderson JM

    更新日期:2008-01-01 00:00:00

  • Cancer-induced oxidative stress and pain.

    abstract::Cancer pain is a well-documented and prevalent healthcare problem, with current treatment strategies often failing to achieve acceptable efficacy. One of the major difficulties in treating cancer pain owes to the complex interplay between the cancer microenvironment, cancer therapy, and the body's own responses to the...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-013-0384-1

    authors: Nashed MG,Balenko MD,Singh G

    更新日期:2014-01-01 00:00:00

  • Headache and Chiari I malformation: clinical presentation, diagnosis, and controversies in management.

    abstract::The Chiari I malformation is a cerebellar anomaly of uncertain origin, defined in part as tonsillar herniation of at least 3 to 5 mm below the foramen magnum; it is associated with crowding of the craniocervical junction. It is the most frequent of the Chiari malformations and is associated with headaches, syringohydr...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-002-0056-z

    authors: Taylor FR,Larkins MV

    更新日期:2002-08-01 00:00:00

  • Empathy: necessary for effective pain management?

    abstract::Empathy is a provider attribute that has been a topic of increased clinical interest, particularly as it relates to pain. This article examines various dimensions of the pain and empathy literature: definitions of empathy, research regarding the psychophysiology of empathy for pain, and research related to empathy in ...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-008-0021-6

    authors: Tait RC

    更新日期:2008-04-01 00:00:00

  • The hypothalamus: specific or nonspecific role in the pathophysiology of trigeminal autonomic cephalalgias?

    abstract::The clinical features of trigeminal autonomic cephalalgias (TACs), such as trigeminal distribution of pain, circadian/circannual rhythmicity, and ipsilateral cranial autonomic features, suggest a crucial role of the hypothalamus in the underlying pathophysiology of these primary headache disorders. Hypothalamic involv...

    journal_title:Current pain and headache reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11916-010-0166-y

    authors: Holle D,Katsarava Z,Obermann M

    更新日期:2011-04-01 00:00:00