Abstract:
:Many animal models of migraine have been described. Some of them have been useful in the development of new therapies. All of them have their shortcomings. Animal models of chronic migraine have been relatively less frequently described. Whether a rigid distinction between episodic and chronic migraine is useful when their underlying pathophysiology is likely to be the same and that migraine frequency probably depends on complex polygenic influences remains to be determined. Any model of chronic migraine must reflect the chronicity of the disorder and be reliable and validated with pharmacological interventions. Future animal models of chronic migraine are likely to involve recurrent activation of the trigeminal nociceptive system. Valid models would provide a means for investigating pathophysiological mechanism of the transformation from episodic to chronic migraine and may also be used to test the efficacy of potential preventive medications.
journal_name
Curr Pain Headache Repjournal_title
Current pain and headache reportsauthors
Storer RJ,Supronsinchai W,Srikiatkhachorn Adoi
10.1007/s11916-014-0467-7subject
Has Abstractpub_date
2015-01-01 00:00:00pages
467issue
1eissn
1531-3433issn
1534-3081journal_volume
19pub_type
杂志文章,评审abstract:PURPOSE OF THE REVIEW:The goals of this review are to evaluate recent studies regarding comorbidity between migraine and different metabolic and endocrine disorders and to discuss the role of insulin resistance as a common pathogenetic mechanism of these diseases. RECENT FINDINGS:Recently, several studies showed that ...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-018-0691-7
更新日期:2018-04-04 00:00:00
abstract::Chiari malformation type I (CMI) involves the caudal displacement of the cerebellar tonsils through the foramen magnum with resultant brainstem compression in some individuals. Due to pathophysiologic changes, secondary conditions may arise, such as syringohydromyelia (SH) and scoliosis. This disorder is unique, as th...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-015-0491-2
更新日期:2015-06-01 00:00:00
abstract::Weight gain is a common side effect of drugs used for headache prevention. Weight gain can adversely affect patient health, exacerbate comorbid metabolic disorders, and encourage noncompliance. Additionally, obesity may promote the chronification of episodic migraine. Few studies have looked specifically at the effect...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-008-0035-0
更新日期:2008-06-01 00:00:00
abstract::Whereas most pain due to cancer can be relieved with relatively simple methods using oral analgesics, as suggested by WHO guidelines, some patients may have difficult pain situations that require more complex approaches. It is estimated that 10-20 % of cancer patients suffer from pain that is not easily relieved. Ther...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-013-0395-y
更新日期:2014-02-01 00:00:00
abstract::Concussion is a significant issue in medicine and the media today. With growing interest on the long-term effects of sports participation, it is important to understand what occurs in the brain after an impact of any degree. While some of the basic pathophysiology has been elucidated, much is still unknown about what ...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-016-0573-9
更新日期:2016-06-01 00:00:00
abstract::Paroxysmal hemicrania (PH) is an underreported and underdiagnosed primary headache disorder. It usually begins in the third or fourth decade of life. The recent observations indicate that it is equally prevalent in both males and females. PH is characterized by severe, strictly unilateral head pain attacks that occur ...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-014-0407-6
更新日期:2014-04-01 00:00:00
abstract::Headache, a common and disabling symptom in Behçet's syndrome, may be associated with a variety of neurologic syndromes and ocular inflammation, or may present as an isolated feature. Our objective is to describe the various neurologic and ocular syndromes of Behçet's syndrome of which headache is a symptom, and to re...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-014-0445-0
更新日期:2014-09-01 00:00:00
abstract::Complementary medical therapies are commonly used for the treatment and management of myofascial pain. No universally accepted therapy for this condition exists; consequently, patients often seek alternative and complementary therapies. Many complementary treatments are available.This article focuses on acupuncture, b...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-002-0078-6
更新日期:2002-10-01 00:00:00
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journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-009-0034-9
更新日期:2009-06-01 00:00:00
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journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-009-0057-2
更新日期:2009-10-01 00:00:00
abstract::Fibromyalgia is a frequent cause of chronic widespread pain and affects up to 5% of the general population. Diagnosis and treatment have been especially challenging due to limited knowledge of etiology and poor response to conventional treatment of pain. Appreciation for the interactions of neurobiologic, psychologic,...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-005-0019-2
更新日期:2005-12-01 00:00:00
abstract::Alcoholic drinks are a migraine trigger in about one third of patients with migraine in retrospective studies on trigger factors. Many population studies show that patients with migraine consume alcohol in a smaller percentage than the general population. Moreover, research has shown a decreased prevalence of headache...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-011-0184-4
更新日期:2011-06-01 00:00:00
abstract::The vast majority of menstruating women experience uncomfortable symptoms during the premenstrual phase of their menstrual cycles. Although many women do not require specific treatment of their symptoms, approximately 20% to 50% report moderate to severe premenstrual symptoms and about 5% meet the diagnostic criteria ...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-010-0131-9
更新日期:2010-10-01 00:00:00
abstract::Fibromyalgia syndrome, a chronic condition typically characterized by widespread pain, nonrestorative sleep, fatigue, cognitive dysfunction, and other somatic symptoms, negatively impacts physical and emotional function and reduces quality of life. Exercise is commonly recommended in the management of people with fibr...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-011-0214-2
更新日期:2011-10-01 00:00:00
abstract::Chronic pain affects more individuals than does cancer, heart disease, and diabetes combined. Yet, our treatment options remain remarkably limited. Often, highly effective psychotherapeutic approaches are limited by many barriers such as access, reimbursement, and acceptability; however, resilience-based positive acti...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-016-0567-7
更新日期:2016-06-01 00:00:00
abstract:PURPOSE OF REVIEW:CGRP is a key neuropeptide in migraine pathophysiology. The blockade of the CGRP pathway at the side of the CGRP receptor of the CGRP peptide leads to the interruption of trigeminal nerve system-mediated headache syndromes such as migraine. Monoclonal antibodies (mAbs) targeting the CGRP pathway have ...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-018-0686-4
更新日期:2018-04-06 00:00:00
abstract::The lumbar spine forms the foundation and infrastructure of an organic skyscraper equipped with the physiologic capacity to act as a crane for lifting and a crankshaft for walking. Subjected to aging like other "human machinery," the lumbar spine adapts to the wear and tear of gravity and biomechanical loading through...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-002-0005-x
更新日期:2002-04-01 00:00:00
abstract::Infantile colic is a self-limiting disorder of excessive infant crying or fussiness that peaks at 6 weeks of age and typically improves by 3 months of age. The etiology of infantile colic has yet to be definitively elucidated, but there is increasing research to support its relationship to migraine. The aims of this r...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-016-0558-8
更新日期:2016-05-01 00:00:00
abstract::Migraine and cluster headache have been considered entirely separate clinical syndromes, both in routine clinical practice and in the 1988 International Headache Society classification. Neurologists seeing large numbers of patients soon realize, however, that there is a considerable overlap between the two conditions....
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-001-0012-3
更新日期:2001-02-01 00:00:00
abstract::Characteristic symptoms of fibromyalgia syndrome include widespread pain, fatigue, sleep abnormalities, and distress. Patients with fibromyalgia show psychophysical evidence of mechanical, thermal, and electrical hyperalgesia. Peripheral and central abnormalities of nociception have been described in fibromyalgia. Imp...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-002-0046-1
更新日期:2002-08-01 00:00:00
abstract::The most likely future of aggressive headache treatment will reside in the sphere of the specialist's clinic. This is a far more cost- and time-effective mode of treating intractable chronic daily headaches (CDH), including chronic migraines. We have used this technique successfully in our clinic for many years. Our e...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-006-0009-z
更新日期:2006-02-01 00:00:00
abstract::Treatment options for neuropathic pain have limited efficacy and use is fraught with dose-limiting adverse effects. The endocannabinoid system has been elucidated over the last several years, demonstrating a significant interface with pain homeostasis. Exogenous cannabinoids have been demonstrated to be effective in a...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-014-0451-2
更新日期:2014-10-01 00:00:00
abstract:PURPOSE OF REVIEW:Peripheral nerve blocks of the scalp, mainly greater occipital nerve blocks, have received a renewed interest amongst pediatric providers as they offer an alternate option to provide both acute and chronic relief from the suffering of children with difficult to treat headaches. This narrative review w...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-017-0650-8
更新日期:2017-11-09 00:00:00
abstract::The use of analgesic and anti-inflammatory injections in athletics has a long and sometimes controversial history. They have been and will continue to be utilized to decrease inflammation and pain, improve healing time, and ultimately decrease the amount of time missed from sports competition. Several authors have eva...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-005-0069-5
更新日期:2005-02-01 00:00:00
abstract::The term "migrant variant" is not used in the headache classification of the International Headache Society (IHS), but it includes those forms of migraine that are not typical of migraine with or without aura. Headaches that do not quite fulfill all of the IHS criteria are termed "migrainous disorder." Migraine associ...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-001-0084-0
更新日期:2001-04-01 00:00:00
abstract::Chronic primary headaches are widespread disorders which cause significant quality of life and socioprofessional impairment. Available pharmacological treatments have often a limited efficacy and/or can generate unbearable side effects. Electrical nerve stimulation is a well-known non-destructive method of pain modula...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-016-0589-1
更新日期:2016-11-01 00:00:00
abstract:PURPOSE OF REVIEW:To provide an update on recent developments in the understanding, diagnosis, and treatment of CSF-venous fistula (CVF). RECENT FINDING:CVF is a recently recognized cause of spontaneous intracranial hypotension (SIH), an important secondary headache, in which an aberrant connection is formed between t...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-020-00921-4
更新日期:2021-01-21 00:00:00
abstract::Trigger points play a part in the development and maintenance of chronic headache states. This article reviews the physiology of trigger points, with a focus on the -latest understanding of their biochemistry. The importance of facial muscle and extraocular muscle trigger points is only beginning to be understood; the...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-008-0059-5
更新日期:2008-10-01 00:00:00
abstract::Quantitative sensory testing (QST) is a widely accepted tool to investigate somatosensory changes in pain patients. Many different protocols have been developed in clinical pain research within recent years. In this review, we provide an overview of QST and tested neuroanatomical pathways, including peripheral and cen...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-012-0261-3
更新日期:2012-06-01 00:00:00
abstract::Opiate analgesics have been widely used for severe acute pain and chronic cancer-related pain. Individual differences in the effectiveness of opiates and their side effects limit the clinical benefits and increase risks of drug abuse. Genetic factors might affect variations of opiate sensitivity. The mu opioid peptide...
journal_title:Current pain and headache reports
pub_type: 杂志文章,评审
doi:10.1007/s11916-007-0008-8
更新日期:2007-04-01 00:00:00