Animal models of chronic migraine.

Abstract:

:Many animal models of migraine have been described. Some of them have been useful in the development of new therapies. All of them have their shortcomings. Animal models of chronic migraine have been relatively less frequently described. Whether a rigid distinction between episodic and chronic migraine is useful when their underlying pathophysiology is likely to be the same and that migraine frequency probably depends on complex polygenic influences remains to be determined. Any model of chronic migraine must reflect the chronicity of the disorder and be reliable and validated with pharmacological interventions. Future animal models of chronic migraine are likely to involve recurrent activation of the trigeminal nociceptive system. Valid models would provide a means for investigating pathophysiological mechanism of the transformation from episodic to chronic migraine and may also be used to test the efficacy of potential preventive medications.

journal_name

Curr Pain Headache Rep

authors

Storer RJ,Supronsinchai W,Srikiatkhachorn A

doi

10.1007/s11916-014-0467-7

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

467

issue

1

eissn

1531-3433

issn

1534-3081

journal_volume

19

pub_type

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