Abstract：
:Neurones in the trigeminocervical complex are the major relay neurones for nociceptive afferent input from the meninges and cervical structures; therefore, they are the neural substrates of head pain. This review highlights the importance of two basic mechanisms in headache physiology: convergence of nociceptive afferents and sensitization of trigeminocervical neurones. These physiologic findings have clinical correlates such as hypersensitivity and spread and referral of pain frequently seen in patients with primary headache, such as migraine. Special reference is made to the influence of structures from the upper cervical spine in generating and contributing to migraine headaches. The pathophysiology and functional relevance of these basic mechanisms to headaches is discussed in the context of recent experimental findings with regard to pain processing.
journal_name
Curr Pain Headache Repjournal_title
Current pain and headache reportsauthors
Bartsch T,Goadsby PJdoi
10.1007/s11916-003-0036-ykeywords:
subject
Has Abstractpub_date
2003-10-01 00:00:00pages
371-6issue
5eissn
1531-3433issn
1534-3081journal_volume
7pub_type
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