Peripheral neuropathy associated with hypereosinophilia.

Abstract:

:Three patients with hypereosinophilia showed different forms of peripheral neuropathy: severe polyneuropathy of prevalently sensory type (case 1), mild sensory neuropathy (case 2), acute mononeuropathy of the median nerve with subclinical polyneuropathy (case 3). Hypereosinophilia was probably idiopathic, however the presence of atypical findings suggested transition to vasculitides or collagen disease. Sural nerve biopsy in cases 1 and 2 showed features of axonopathy in both, although of different severity, reflecting the variability of clinical involvement and, probably, heterogeneous pathogenic mechanisms. Peripheral nerve involvement associated with hypereosinophilia may be related to neurotoxicity of eosinophils, or to vascular damage.

journal_name

Acta Neurol Belg

journal_title

Acta neurologica Belgica

authors

Guidetti D,Gemignani F,Terenziani S,Ragni P,Fornaciari G,Dall'Asta D,Marbini A

subject

Has Abstract

pub_date

1991-01-01 00:00:00

pages

12-9

issue

1

eissn

0300-9009

issn

2240-2993

journal_volume

91

pub_type

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