Abstract:
:Lung cancer is the leading cause of cancer death in the world. However, there is large geographic variation internationally and within nations. Despite the fact that many causes of lung cancer have been established, cigarette smoking is the principal cause. Accounting for historical prevalence of cigarette smoking is a useful predictor of the lung cancer burden in most populations. The populations at high present risk of lung cancer can usually be predicted based on historical patterns of the prevalence of cigarette smoking, and the high-risk populations of the future can be predicted based on the current prevalence of cigarette smoking. Lung cancer rates are consistently higher among men than women and are particularly high among African American men and among those of lower socioeconomic status. At the individual level, some segments of the population (e.g., African Americans, females) have been hypothesized to have greater susceptibility to lung cancer for a given degree of cigarette smoking. Common variants in genes that encode for enzymes involved in carcinogen metabolism and detoxification and in repairing DNA damage are likely to be important determinants of interindividual susceptibility to smoking-caused lung carcinogenesis. Many lung cancer risk factors have been identified, but active cigarette smoking is the predominant cause of lung cancer and the principal marker of both high-risk populations and high-risk individuals. In the absence of cigarette smoking, lung cancer would be a rare disease. Strategies that effectively prevent youths from starting to smoke and that promote cessation among dependent smokers can transform populations from high risk to low risk.
journal_name
Semin Respir Crit Care Medjournal_title
Seminars in respiratory and critical care medicineauthors
Alberg AJ,Nonemaker Jdoi
10.1055/s-2008-1076742subject
Has Abstractpub_date
2008-06-01 00:00:00pages
223-32issue
3eissn
1069-3424issn
1098-9048journal_volume
29pub_type
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journal_title:Seminars in respiratory and critical care medicine
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journal_title:Seminars in respiratory and critical care medicine
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journal_title:Seminars in respiratory and critical care medicine
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journal_title:Seminars in respiratory and critical care medicine
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journal_title:Seminars in respiratory and critical care medicine
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journal_title:Seminars in respiratory and critical care medicine
pub_type: 杂志文章,评审
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journal_title:Seminars in respiratory and critical care medicine
pub_type: 杂志文章
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更新日期:2004-06-01 00:00:00
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journal_title:Seminars in respiratory and critical care medicine
pub_type: 杂志文章,评审
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更新日期:2015-06-01 00:00:00
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journal_title:Seminars in respiratory and critical care medicine
pub_type: 杂志文章,评审
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更新日期:2007-02-01 00:00:00
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journal_title:Seminars in respiratory and critical care medicine
pub_type: 杂志文章,评审
doi:10.1055/s-0028-1085708
更新日期:2008-10-01 00:00:00
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journal_title:Seminars in respiratory and critical care medicine
pub_type: 杂志文章
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更新日期:2010-02-01 00:00:00
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journal_title:Seminars in respiratory and critical care medicine
pub_type: 杂志文章
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更新日期:2008-12-01 00:00:00
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journal_title:Seminars in respiratory and critical care medicine
pub_type: 杂志文章
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更新日期:2000-01-01 00:00:00
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journal_title:Seminars in respiratory and critical care medicine
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更新日期:2019-12-01 00:00:00
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journal_title:Seminars in respiratory and critical care medicine
pub_type: 杂志文章
doi:10.1055/s-2002-34332
更新日期:2002-08-01 00:00:00
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journal_title:Seminars in respiratory and critical care medicine
pub_type: 杂志文章,评审
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更新日期:2019-12-01 00:00:00
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journal_title:Seminars in respiratory and critical care medicine
pub_type: 杂志文章,评审
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更新日期:2005-12-01 00:00:00
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journal_title:Seminars in respiratory and critical care medicine
pub_type: 杂志文章
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abstract::Asthma is a heterogeneous disorder with a complex etiology. Prevalence rates for asthma have been increasing in many countries over the past few decades. While it is unclear why this increase is occurring, the variation reported in asthma prevalence and severity associated with ethnicity offers some insight into the d...
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pub_type: 杂志文章,评审
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journal_title:Seminars in respiratory and critical care medicine
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journal_title:Seminars in respiratory and critical care medicine
pub_type: 杂志文章
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更新日期:2004-02-01 00:00:00
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journal_title:Seminars in respiratory and critical care medicine
pub_type: 杂志文章,评审
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更新日期:2016-02-01 00:00:00
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journal_title:Seminars in respiratory and critical care medicine
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journal_title:Seminars in respiratory and critical care medicine
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更新日期:2005-04-01 00:00:00
abstract::Delivery of medication to sites of action through airways has been used for centuries but has gained momentum in recent decades. Currently available modes of aerosol delivery offer advantages but still there are shortcomings. Delivery of active agents to sites of action is affected by many factors beyond the character...
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pub_type: 杂志文章,评审
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更新日期:2015-08-01 00:00:00
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journal_title:Seminars in respiratory and critical care medicine
pub_type: 杂志文章,评审
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更新日期:2017-12-01 00:00:00
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journal_title:Seminars in respiratory and critical care medicine
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更新日期:2018-10-01 00:00:00
abstract::Lung-protective ventilator strategies are considered standard practice in the care of patients with the acute respiratory distress syndrome (ARDS). To minimize ventilator-induced lung injury, attention is directed at avoidance of alveolar overdistention and cyclical opening and closing. The lowest possible plateau pre...
journal_title:Seminars in respiratory and critical care medicine
pub_type: 杂志文章,评审
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更新日期:2014-08-01 00:00:00
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journal_title:Seminars in respiratory and critical care medicine
pub_type: 杂志文章,评审
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